Impact of changes in haematocrit level and platelet count on thromboelastometry parameters

Thrombosis Research

Volumn 131, Issue 3, 2013, Pages 249-253

  Nagler, Michael ^a,d   Kathriner, Silvio ^a   Bachmann, Lucas M ^b   Wuillemin, Walter A ^a,c  

^a Central Haematology Laboratory   (Switzerland)

^b MEDIGNITION INC   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Factors of influence; Haematocrit level; In vitro; Platelet count; Thromboelastometry

Indexed keywords

ALPHA ANGLE; ARTICLE; BLOOD CLOTTING TIME; CALIBRATION; CLOT FORMATION TIME; CONFOUNDING VARIABLE; CORRELATION ANALYSIS; DEVICES; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HUMAN; MAXIMUM CLOT FIRMNESS; NORMAL HUMAN; PRIORITY JOURNAL; THROMBOCYTE COUNT; THROMBOELASTOGRAPHY; THROMBOELASTOMETRY;

BLOOD COAGULATION; HEMATOCRIT; HUMANS; PLATELET COUNT; RESEARCH DESIGN; THROMBELASTOGRAPHY;

EID: 84875260163     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.01.009     Document Type: Article

References (39)

1. T. Haas Point of care diagnostic: thromboelastometry (ROTEM(R)) Wien Klin Wochenschr 122 Suppl. 5 2010 S19 S20
2. R.J. Luddington Thrombelastography/thromboelastometry Clin Lab Haematol 27 2005 81 90
3. C. Fenger-Eriksen, T.M. Jensen, B.S. Kristensen, K.M. Jensen, E. Tonnesen, and J. Ingerslev Fibrinogen substitution improves whole blood clot firmness after dilution with hydroxyethyl starch in bleeding patients undergoing radical cystectomy: a randomized, placebo-controlled clinical trial J Thromb Haemost 7 2009 795 802
4. A. Dick, M. Schwaiger, and C. Jambor Thromboelastography/-metry and external quality control. Results of a pilot study Hamostaseologie 30 2010 91 95
5. C. Huissoud, N. Carrabin, M. Benchaib, O. Fontaine, A. Levrat, and D. Massignon Coagulation assessment by rotation thrombelastometry in normal pregnancy Thromb Haemost 101 2009 755 761
6. G. Kenet, C.B. Stenmo, A. Blemings, W. Wegert, J. Goudemand, and M. Krause Intra-patient variability of thromboelastographic parameters following in vivo and ex vivo administration of recombinant activated factor VII in haemophilia patients. A multi-centre, randomised trial Thromb Haemost 103 2010 351 359
7. R.C. Carroll, R.M. Craft, G.L. Whitaker, C.C. Snider, R.K. Kirby, and R.F. Elder Thrombelastography monitoring of resistance to enoxaparin anticoagulation in thrombophilic pregnancy patients Thromb Res 120 2007 367 370
8. B. Sorensen, H.S. Asvaldsdottir, B.R. Gudmundsdottir, and P.T. Onundarson The combination of recombinant factor VIIa and fibrinogen correct clotting ex vivo in patient samples obtained following cardiopulmonary bypass surgery Thromb Res 124 2009 695 700
9. A. Tripodi, M. Primignani, V. Chantarangkul, Y. Viscardi, A. Dell'Era, and F.M. Fabris The coagulopathy of cirrhosis assessed by thromboelastometry and its correlation with conventional coagulation parameters Thromb Res 124 2009 132 136
10. J.J. van Veen, A. Gatt, A.E. Bowyer, P.C. Cooper, S. Kitchen, and M. Makris Calibrated automated thrombin generation and modified thromboelastometry in haemophilia A Thromb Res 123 2009 895 901
11. L. Rugeri, A. Levrat, J.S. David, E. Delecroix, B. Floccard, and A. Gros Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography J Thromb Haemost 5 2007 289 295
12. L. Shore-Lesserson, H.E. Manspeizer, M. DePerio, S. Francis, F. Vela-Cantos, and M.A. Ergin Thromboelastography-guided transfusion algorithm reduces transfusions in complex cardiac surgery Anesth Analg 88 1999 312 319
13. E. Girdauskas, J. Kempfert, T. Kuntze, M.A. Borger, J. Enders, and J. Fassl Thromboelastometrically guided transfusion protocol during aortic surgery with circulatory arrest: a prospective, randomized trial J Thorac Cardiovasc Surg 140 2010 1117-24.e2
14. C. Fenger-Eriksen, E. Tonnesen, J. Ingerslev, and B. Sorensen Mechanisms of hydroxyethyl starch-induced dilutional coagulopathy J Thromb Haemost 7 2009 1099 1105
15. S. Ogawa, F. Szlam, D. Bolliger, T. Nishimura, E.P. Chen, and K.A. Tanaka The Impact of Hematocrit on Fibrin Clot Formation Assessed by Rotational Thromboelastometry Anesth Analg 115 1 2012 16 21
16. S.A. Smith, M.A. McMichael, S. Gilor, A.J. Galligan, and C.M. Hoh Correlation of hematocrit, platelet concentration, and plasma coagulation factors with results of thromboelastometry in canine whole blood samples Am J Vet Res 73 2012 789 798
17. F. Herbstreit, E.M. Winter, J. Peters, and M. Hartmann Monitoring of haemostasis in liver transplantation: comparison of laboratory based and point of care tests Anaesthesia 65 2010 44 49
18. P. Flisberg, M. Rundgren, and M. Engstrom The effects of platelet transfusions evaluated using rotational thromboelastometry Anesth Analg 108 2009 1430 1432
19. T. Lang, K. Johanning, H. Metzler, S. Piepenbrock, C. Solomon, and N. Rahe-Meyer The effects of fibrinogen levels on thromboelastometric variables in the presence of thrombocytopenia Anesth Analg 108 2009 751 758
20. M. McMichael, S.A. Smith, E.L. McConachie, K. Lascola, and P.A. Wilkins In-vitro hypocoagulability on whole blood thromboelastometry associated with in-vivo expansion of red cell mass in an equine model Blood Coagul Fibrinolysis 22 2011 424 430
21. S. Roullet, J. Pillot, G. Freyburger, M. Biais, A. Quinart, and A. Rault Rotation thromboelastometry detects thrombocytopenia and hypofibrinogenaemia during orthotopic liver transplantation Br J Anaesth 104 2010 422 428
22. L. Spiezia, C. Radu, P. Marchioro, D. Bertini, V. Rossetto, and M. Castelli Peculiar whole blood rotation thromboelastometry (Rotem) profile in 40 sideropenic anaemia patients Thromb Haemost 100 2008 1106 1110
23. M. Coakley, J.E. Hall, C. Evans, E. Duff, V. Billing, and L. Yang Assessment of thrombin generation measured before and after cardiopulmonary bypass surgery and its association with postoperative bleeding J Thromb Haemost 9 2011 282 292
24. D. Frith, J.C. Goslings, C. Gaarder, M. Maegele, M.J. Cohen, and S. Allard Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations J Thromb Haemost 8 2010 1919 1925
25. A.J. Wikkelsoe, A. Afshari, J. Wetterslev, J. Brok, and A.M. Moeller Monitoring patients at risk of massive transfusion with Thrombelastography or Thromboelastometry: a systematic review Acta Anaesthesiol Scand 55 2011 1174 1189
26. A. Afshari, A. Wikkelso, J. Brok, A.M. Moller, and J. Wetterslev Thrombelastography (TEG) or thromboelastometry (ROTEM) to monitor haemotherapy versus usual care in patients with massive transfusion Cochrane Database Syst Rev 2011 CD007871
27. G.C. Lee, A.M. Kicza, K.Y. Liu, C.B. Nyman, R.M. Kaufman, and S.C. Body Does rotational thromboelastometry (ROTEM) improve prediction of bleeding after cardiac surgery? Anesth Analg 115 2012 499 506
28. Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, et al. The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost in press [Electronic publication ahead of print].
29. C.P. Price Evidence-based laboratory medicine: supporting decision-making Clin Chem 46 2000 1041 1050
30. M. Cattaneo, C.P. Hayward, K.A. Moffat, M.T. Pugliano, Y. Liu, and A.D. Michelson Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH J Thromb Haemost 7 2009 1029
31. M. Chitlur, B. Sorensen, G.E. Rivard, G. Young, J. Ingerslev, and M. Othman Standardization of thromboelastography: a report from the TEG-ROTEM working group Haemophilia 17 2011 532 537
32. B.M. Iselin, P.F. Willimann, B. Seifert, M. Casutt, T. Bombeli, and M.P. Zalunardo Isolated reduction of haematocrit does not compromise in vitro blood coagulation Br J Anaesth 87 2001 246 249
33. V.A. Bowbrick, D.P. Mikhailidis, and G. Stansby Influence of platelet count and activity on thromboelastography parameters Platelets 14 2003 219 224
34. W.W. Roeloffzen, H.C. Kluin-Nelemans, A.B. Mulder, and J.T. de Wolf Thrombocytopenia affects plasmatic coagulation as measured by thrombelastography Blood Coagul Fibrinolysis 21 2010 389 397
35. M.K. Horne III, A.M. Cullinane, P.K. Merryman, and E.K. Hoddeson The effect of red blood cells on thrombin generation Br J Haematol 133 2006 403 408
36. S.J. Davidson, D. McGrowder, M. Roughton, and A.A. Kelleher Can ROTEM thromboelastometry predict postoperative bleeding after cardiac surgery? J Cardiothorac Vasc Anesth 22 2008 655 661
37. R. Davenport, J. Manson, H. De'Ath, S. Platton, A. Coates, and S. Allard Functional definition and characterization of acute traumatic coagulopathy Crit Care Med 39 2011 2652 2658
38. H. Schochl, B. Cotton, K. Inaba, U. Nienaber, H. Fischer, and W. Voelckel FIBTEM provides early prediction of massive transfusion in trauma Crit Care 15 2011 R265
39. H. Tauber, P. Innerhofer, R. Breitkopf, I. Westermann, R. Beer, and R. El Attal Prevalence and impact of abnormal ROTEM(R) assays in severe blunt trauma: results of the 'Diagnosis and Treatment of Trauma-Induced Coagulopathy (DIA-TRE-TIC) study' Br J Anaesth 107 2011 378 387