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Volumn 102, Issue 3, 2009, Pages 345-354

Prothrombin complex concentrate vs fresh frozen plasma for reversal of dilutional coagulopathy in a porcine trauma model

Author keywords

Blood, haemodilution; Complications, haemorrhagic disorder; Complications, trauma; Fresh frozen plasma; Prothrombin complex concentrate

Indexed keywords

BERIPLEX; FRESH FROZEN PLASMA; HETASTARCH; PLACEBO; PROTHROMBIN; PROTHROMBIN COMPLEX; THROMBIN; UNCLASSIFIED DRUG;

EID: 60249103397     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aen391     Document Type: Article
Times cited : (92)

References (44)
  • 1
    • 31744443130 scopus 로고    scopus 로고
    • The epidemiology and modern management of traumatic hemorrhage: US and international perspectives
    • Kauvar DS, Wade CE. The epidemiology and modern management of traumatic hemorrhage: US and international perspectives. Crit Care 2005; 9: S1-S9
    • (2005) Crit Care , vol.9
    • Kauvar, D.S.1    Wade, C.E.2
  • 3
    • 35848943443 scopus 로고    scopus 로고
    • Acute coagulopathy of trauma: Mechanism, identification and effect
    • Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 2007; 13: 680-5
    • (2007) Curr Opin Crit Care , vol.13 , pp. 680-685
    • Brohi, K.1    Cohen, M.J.2    Davenport, R.A.3
  • 4
    • 23744481012 scopus 로고    scopus 로고
    • Are we giving enough coagulation factors during major trauma resuscitation?
    • Ho AM, Karmakar MK, Dion PW. Are we giving enough coagulation factors during major trauma resuscitation? Am J Surg 2005; 190: 479-84
    • (2005) Am J Surg , vol.190 , pp. 479-484
    • Ho, A.M.1    Karmakar, M.K.2    Dion, P.W.3
  • 5
    • 23844442531 scopus 로고    scopus 로고
    • Coagulopathy and blood component transfusion in trauma
    • Spahn DR, Rossaint R. Coagulopathy and blood component transfusion in trauma. Br J Anaesth 2005; 95: 130-9
    • (2005) Br J Anaesth , vol.95 , pp. 130-139
    • Spahn, D.R.1    Rossaint, R.2
  • 6
    • 33847264379 scopus 로고    scopus 로고
    • Early coagulopathy in multiple injury: An analysis from the German Trauma Registry on 8724 patients
    • Maegele M, Lefering R, Yucel N, et al. Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury 2007; 38: 298-304
    • (2007) Injury , vol.38 , pp. 298-304
    • Maegele, M.1    Lefering, R.2    Yucel, N.3
  • 7
    • 37349082458 scopus 로고    scopus 로고
    • The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    • Borgman MA, Spinella PC, Perkins JG, et al. The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 2007; 63: 805-13
    • (2007) J Trauma , vol.63 , pp. 805-813
    • Borgman, M.A.1    Spinella, P.C.2    Perkins, J.G.3
  • 8
    • 33846248384 scopus 로고    scopus 로고
    • Fresh frozen plasma should be given earlier to patients requiring massive transfusion
    • Gonzalez EA, Moore FA, Holcomb JB, et al. Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma 2007; 62: 112-9
    • (2007) J Trauma , vol.62 , pp. 112-119
    • Gonzalez, E.A.1    Moore, F.A.2    Holcomb, J.B.3
  • 9
    • 34248228655 scopus 로고    scopus 로고
    • Management of bleeding following major trauma: A European guideline
    • Spahn DR, Cerny V, Coats TJ, et al. Management of bleeding following major trauma: a European guideline. Crit Care 2007; 11: R17
    • (2007) Crit Care , vol.11
    • Spahn, D.R.1    Cerny, V.2    Coats, T.J.3
  • 10
    • 33745174161 scopus 로고    scopus 로고
    • Risks of fresh frozen plasma and platelets
    • MacLennan S, Williamson LM. Risks of fresh frozen plasma and platelets. J Trauma 2006; 60: S46-S50
    • (2006) J Trauma , vol.60
    • MacLennan, S.1    Williamson, L.M.2
  • 11
    • 34248587906 scopus 로고    scopus 로고
    • Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients
    • Khan H, Belsher J, Yilmaz M, et al. Fresh-frozen plasma and platelet transfusions are associated with development of acute lung injury in critically ill medical patients. Chest 2007; 131: 1308-14
    • (2007) Chest , vol.131 , pp. 1308-1314
    • Khan, H.1    Belsher, J.2    Yilmaz, M.3
  • 12
    • 0030933639 scopus 로고    scopus 로고
    • Emergency oral anticoagulant reversal: The relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy
    • Makris M, Greaves M, Phillips WS, Kitchen S, Rosendaal FR, Preston EF. Emergency oral anticoagulant reversal: the relative efficacy of infusions of fresh frozen plasma and clotting factor concentrate on correction of the coagulopathy. Thromb Haemost 1997; 77: 477-80
    • (1997) Thromb Haemost , vol.77 , pp. 477-480
    • Makris, M.1    Greaves, M.2    Phillips, W.S.3    Kitchen, S.4    Rosendaal, F.R.5    Preston, E.F.6
  • 13
    • 0035676364 scopus 로고    scopus 로고
    • Beriplex P/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding
    • Evans G, Luddington R, Baglin T. Beriplex P/N reverses severe warfarin-induced overanticoagulation immediately and completely in patients presenting with major bleeding. Br J Haematol 2001; 115: 998-1001
    • (2001) Br J Haematol , vol.115 , pp. 998-1001
    • Evans, G.1    Luddington, R.2    Baglin, T.3
  • 14
    • 0036183415 scopus 로고    scopus 로고
    • Rapid reversal of oral anticoagulation with warfarin by a prothrombin complex concentrate (Beriplex): Efficacy and safety in 42 patients
    • Preston FE, Laidlaw ST, Sampson B, Kitchen S. Rapid reversal of oral anticoagulation with warfarin by a prothrombin complex concentrate (Beriplex): efficacy and safety in 42 patients. Br J Haematol 2002; 116: 619-24
    • (2002) Br J Haematol , vol.116 , pp. 619-624
    • Preston, F.E.1    Laidlaw, S.T.2    Sampson, B.3    Kitchen, S.4
  • 15
    • 8444252608 scopus 로고    scopus 로고
    • Prospective evaluation of a regional protocol for a rapid warfarin reversal in major haemorrhage
    • Sharples R, Burnett C, Murphy M, Hanley JP. Prospective evaluation of a regional protocol for a rapid warfarin reversal in major haemorrhage. Br J Haematol 2003; 121: 3-4
    • (2003) Br J Haematol , vol.121 , pp. 3-4
    • Sharples, R.1    Burnett, C.2    Murphy, M.3    Hanley, J.P.4
  • 16
    • 33746787177 scopus 로고    scopus 로고
    • Individualized dosing regimen for prothrombin complex concentrate more effective than standard treatment in the reversal of oral anticoagulant therapy: An open, prospective randomized controlled trial
    • van Aart L, Eijkhout HW, Kamphuis JS, et al. Individualized dosing regimen for prothrombin complex concentrate more effective than standard treatment in the reversal of oral anticoagulant therapy: An open, prospective randomized controlled trial. Thromb Res 2006; 118: 313-20
    • (2006) Thromb Res , vol.118 , pp. 313-320
    • van Aart, L.1    Eijkhout, H.W.2    Kamphuis, J.S.3
  • 17
    • 34547124855 scopus 로고    scopus 로고
    • Beriplex P/N: An alternative to fresh frozen plasma in severe haemorrhage
    • Bhardwaj M, Bunsell R. Beriplex P/N: an alternative to fresh frozen plasma in severe haemorrhage. Anaesthesia 2007; 62: 832-4
    • (2007) Anaesthesia , vol.62 , pp. 832-834
    • Bhardwaj, M.1    Bunsell, R.2
  • 18
    • 35648991453 scopus 로고    scopus 로고
    • Prothrombin complex concentrate (Octaplexw) in patients requiring immediate reversal of oral anticoagulation
    • Riess HB, Meier-Hellmann A, Motsch J, Elias M, Kursten FW, Dempfle CE. Prothrombin complex concentrate (Octaplexw) in patients requiring immediate reversal of oral anticoagulation. Thromb Res 2007; 121: 9-16
    • (2007) Thromb Res , vol.121 , pp. 9-16
    • Riess, H.B.1    Meier-Hellmann, A.2    Motsch, J.3    Elias, M.4    Kursten, F.W.5    Dempfle, C.E.6
  • 19
    • 33947523772 scopus 로고    scopus 로고
    • Ultra-rapid management of oral anticoagulant therapy-related surgical intracranial hemorrhage
    • Vigué B, Ract C, Tremey B, et al. Ultra-rapid management of oral anticoagulant therapy-related surgical intracranial hemorrhage. Intensive Care Med 2007; 33: 721-5
    • (2007) Intensive Care Med , vol.33 , pp. 721-725
    • Vigué, B.1    Ract, C.2    Tremey, B.3
  • 20
    • 40949148098 scopus 로고    scopus 로고
    • Prothrombin complex concentrate (Beriplex® P/N) for emergency anticoagulation reversal: A prospective multinational clinical trial
    • Pabinger I, Brenner B, Kalina U, Knaub S, Nagy A, Ostermann H. Prothrombin complex concentrate (Beriplex® P/N) for emergency anticoagulation reversal: A prospective multinational clinical trial. J Thromb Haemost 2008; 6: 622-31
    • (2008) J Thromb Haemost , vol.6 , pp. 622-631
    • Pabinger, I.1    Brenner, B.2    Kalina, U.3    Knaub, S.4    Nagy, A.5    Ostermann, H.6
  • 21
    • 44649202211 scopus 로고    scopus 로고
    • Warfarin-reversal: Results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate
    • Pabinger-Fasching I. Warfarin-reversal: results of a phase III study with pasteurised, nanofiltrated prothrombin complex concentrate. Thromb Res 2008; 122: S19-S22
    • (2008) Thromb Res , vol.122
    • Pabinger-Fasching, I.1
  • 22
    • 33644862002 scopus 로고    scopus 로고
    • Baglin TP, Keeling DM, Watson HG. Guidelines on oral anticoagulation (warfarin): third edition - 2005 update. Br J Haematol 2006; 132: 277-85
    • Baglin TP, Keeling DM, Watson HG. Guidelines on oral anticoagulation (warfarin): third edition - 2005 update. Br J Haematol 2006; 132: 277-85
  • 23
    • 33751210094 scopus 로고    scopus 로고
    • Thrombin generation, a function test of the haemostatic-thrombotic system
    • Hemker HC, Al Dieri R, De Smedt E, Beguin S. Thrombin generation, a function test of the haemostatic-thrombotic system. Thromb Haemost 2006; 96: 553-61
    • (2006) Thromb Haemost , vol.96 , pp. 553-561
    • Hemker, H.C.1    Al Dieri, R.2    De Smedt, E.3    Beguin, S.4
  • 24
    • 10744231994 scopus 로고    scopus 로고
    • Factor VIII inhibitor-bypassing agents act by inducing thrombin generation and can be monitored by a thrombin generation assay
    • Turecek PL, Váradi K, Keil B, et al. Factor VIII inhibitor-bypassing agents act by inducing thrombin generation and can be monitored by a thrombin generation assay. Pathophysiol Haemost Thromb 2003; 33: 16-22
    • (2003) Pathophysiol Haemost Thromb , vol.33 , pp. 16-22
    • Turecek, P.L.1    Váradi, K.2    Keil, B.3
  • 25
    • 3242737794 scopus 로고    scopus 로고
    • Monitoring the bioavailability of FEIBA with a thrombin generation assay
    • Váradi K, Négrier C, Berntorp E, et al. Monitoring the bioavailability of FEIBA with a thrombin generation assay. J Thromb Haemost 2003; 1: 2374-80
    • (2003) J Thromb Haemost , vol.1 , pp. 2374-2380
    • Váradi, K.1    Négrier, C.2    Berntorp, E.3
  • 26
    • 15344343052 scopus 로고    scopus 로고
    • Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B
    • Dargaud Y, Béguin S, Lienhart A, et al. Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B. Thromb Haemost 2005; 93: 475-80
    • (2005) Thromb Haemost , vol.93 , pp. 475-480
    • Dargaud, Y.1    Béguin, S.2    Lienhart, A.3
  • 27
    • 61349201697 scopus 로고    scopus 로고
    • The effect of tissue factor concentration on calibrated automated thrombography in the presence of inhibitor bypass agents
    • doi:10.1111/j.1751-553X.2007.01022.x
    • van Veen JJ, Gatt A, Bowyer AE, Cooper PC, Kitchen S, Makris M. The effect of tissue factor concentration on calibrated automated thrombography in the presence of inhibitor bypass agents. Int J Lab Hematol doi:10.1111/j.1751-553X.2007.01022.x
    • Int J Lab Hematol
    • van Veen, J.J.1    Gatt, A.2    Bowyer, A.E.3    Cooper, P.C.4    Kitchen, S.5    Makris, M.6
  • 28
    • 84888530629 scopus 로고    scopus 로고
    • Jose M, Borrell M, Fontcuberta J, Jorquera JI. Thrombin generation assay (TGA) correction in vitro after addition of therapeutic range doses of prothrombin complex concentrate to plasma samples with INR 5. J Thromb Haemost 2007; 5: P-S-052
    • Jose M, Borrell M, Fontcuberta J, Jorquera JI. Thrombin generation assay (TGA) correction in vitro after addition of therapeutic range doses of prothrombin complex concentrate to plasma samples with INR 5. J Thromb Haemost 2007; 5: P-S-052
  • 29
    • 41349092140 scopus 로고    scopus 로고
    • Characterization of the coagulation deficit in porcine dilutional coagulopathy and substitution with a prothrombin complex concentrate
    • Dickneite G, Doerr B, Kaspereit F. Characterization of the coagulation deficit in porcine dilutional coagulopathy and substitution with a prothrombin complex concentrate. Anesth Analg 2008; 106: 1070-7
    • (2008) Anesth Analg , vol.106 , pp. 1070-1077
    • Dickneite, G.1    Doerr, B.2    Kaspereit, F.3
  • 30
    • 0029681575 scopus 로고    scopus 로고
    • Nanofiltration bei der Herstellung von Beriplex® P/N: Erhöhung der Kapazität zur Viruseliminierung unter Beibehaltung der Produktqualität.
    • Römisch J, Gröner A, Bernhardt D, et al. Nanofiltration bei der Herstellung von Beriplex® P/N: Erhöhung der Kapazität zur Viruseliminierung unter Beibehaltung der Produktqualität. Beitr Infusionsther Transfusionsmed 1996; 33: 220-4
    • (1996) Beitr Infusionsther Transfusionsmed , vol.33 , pp. 220-224
    • Römisch, J.1    Gröner, A.2    Bernhardt, D.3
  • 31
    • 35048885969 scopus 로고    scopus 로고
    • Pharmacokinetics of Beriplex P/N prothrombin complex concentrate in healthy volunteers
    • Ostermann H, Haertel S, Knaub S, Kalina U, Jung K, Pabinger I. Pharmacokinetics of Beriplex P/N prothrombin complex concentrate in healthy volunteers. Thromb Haemost 2007; 98: 790-7
    • (2007) Thromb Haemost , vol.98 , pp. 790-797
    • Ostermann, H.1    Haertel, S.2    Knaub, S.3    Kalina, U.4    Jung, K.5    Pabinger, I.6
  • 32
    • 0242401773 scopus 로고    scopus 로고
    • Calibrated automated thrombin generation measurement in clotting plasma
    • Hemker HC, Giesen P, Al Dieri R, et al. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003; 33: 4-15
    • (2003) Pathophysiol Haemost Thromb , vol.33 , pp. 4-15
    • Hemker, H.C.1    Giesen, P.2    Al Dieri, R.3
  • 34
    • 0037206598 scopus 로고    scopus 로고
    • Indications for plasma in massive transfusion
    • Hellstern P, Haubelt H. Indications for plasma in massive transfusion. Thromb Res 2002; 107: S19-S22
    • (2002) Thromb Res , vol.107
    • Hellstern, P.1    Haubelt, H.2
  • 35
    • 1842610163 scopus 로고    scopus 로고
    • Efficacy of standard dose and 30 ml/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients
    • Chowdhury P, Saayman AG, Paulus U, Findlay GP, Collins PW. Efficacy of standard dose and 30 ml/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients. Br J Haematol 2004; 125: 69-73
    • (2004) Br J Haematol , vol.125 , pp. 69-73
    • Chowdhury, P.1    Saayman, A.G.2    Paulus, U.3    Findlay, G.P.4    Collins, P.W.5
  • 37
    • 0035686474 scopus 로고    scopus 로고
    • High-titer screening PCR: A successful strategy for reducing the parvovirus B19 load in plasma pools for fractionation
    • Weimer T, Streichert S, Watson C, Groner A. High-titer screening PCR: a successful strategy for reducing the parvovirus B19 load in plasma pools for fractionation. Transfusion 2001; 41: 1500-4
    • (2001) Transfusion , vol.41 , pp. 1500-1504
    • Weimer, T.1    Streichert, S.2    Watson, C.3    Groner, A.4
  • 38
    • 33746356507 scopus 로고    scopus 로고
    • Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities
    • Abdel-Wahab OI, Healy B, Dzik WH. Effect of fresh-frozen plasma transfusion on prothrombin time and bleeding in patients with mild coagulation abnormalities. Transfusion 2006; 46: 1279-85
    • (2006) Transfusion , vol.46 , pp. 1279-1285
    • Abdel-Wahab, O.I.1    Healy, B.2    Dzik, W.H.3
  • 39
    • 0032694469 scopus 로고    scopus 로고
    • Influence of prothrombin complex concentrates on plasma coagulation in critically ill patients
    • Staudinger T, Frass M, Rintelen C, et al. Influence of prothrombin complex concentrates on plasma coagulation in critically ill patients. Intensive Care Med 1999; 25: 1105-10
    • (1999) Intensive Care Med , vol.25 , pp. 1105-1110
    • Staudinger, T.1    Frass, M.2    Rintelen, C.3
  • 40
    • 33748866625 scopus 로고    scopus 로고
    • Efficacy of fibrinogen and prothrombin complex concentrate used to reverse dilutional coagulopathy - a porcine model
    • Fries D, Haas T, Klingler A, et al. Efficacy of fibrinogen and prothrombin complex concentrate used to reverse dilutional coagulopathy - a porcine model. Br J Anaesth 2006; 97: 460-7
    • (2006) Br J Anaesth , vol.97 , pp. 460-467
    • Fries, D.1    Haas, T.2    Klingler, A.3
  • 41
    • 0035251738 scopus 로고    scopus 로고
    • Effects of agents, used to treat bleeding disorders, on bleeding time prolonged by a very high dose of a direct thrombin inhibitor in anesthesized rats and rabbits
    • Elg M, Carlsson S, Gustafsson D. Effects of agents, used to treat bleeding disorders, on bleeding time prolonged by a very high dose of a direct thrombin inhibitor in anesthesized rats and rabbits. Thromb Res 2001; 101: 159-70
    • (2001) Thromb Res , vol.101 , pp. 159-170
    • Elg, M.1    Carlsson, S.2    Gustafsson, D.3
  • 42
    • 43749091733 scopus 로고    scopus 로고
    • Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: An in vitro study
    • Dargaud Y, Desmurs-Clavel H, Marin S, Bordet J-C, Poplavsky JL, Negrier C. Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study. J Thromb Haemost 2008; 6: 962-8
    • (2008) J Thromb Haemost , vol.6 , pp. 962-968
    • Dargaud, Y.1    Desmurs-Clavel, H.2    Marin, S.3    Bordet, J.-C.4    Poplavsky, J.L.5    Negrier, C.6
  • 43
    • 24644460532 scopus 로고    scopus 로고
    • Major surgery in a severe haemophilia A patient with high titre inhibitor: Use of the thrombin generation test in the therapeutic decision
    • Dargaud Y, Lienhart A, Meunier S, et al. Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decision. Haemophilia 2005; 11: 552-8
    • (2005) Haemophilia , vol.11 , pp. 552-558
    • Dargaud, Y.1    Lienhart, A.2    Meunier, S.3
  • 44
    • 84888564074 scopus 로고    scopus 로고
    • McCormick AN, Sunner T, Rangarajan S, Savidge G. Thrombin generation assay: clinical use in monitoring FVIII bypassing agent therapy during surgery in a severe haemophilia A patient with inhibitor. J Thromb Haemost 2007; 5: P-M-038
    • McCormick AN, Sunner T, Rangarajan S, Savidge G. Thrombin generation assay: clinical use in monitoring FVIII bypassing agent therapy during surgery in a severe haemophilia A patient with inhibitor. J Thromb Haemost 2007; 5: P-M-038


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