Buyang Huanwu decoction increases angiopoietin-1 expression and promotes angiogenesis and functional outcome after focal cerebral ischemia

Journal of Zhejiang University: Science B

Volumn 15, Issue 3, 2014, Pages 272-280

  Shen, Jian ^a   Zhu, Yu ^a   Yu, Hai ^a   Fan, Zuo Xu ^a   Xiao, Feng ^a   Wu, Pan ^a   Zhang, Qi Hui ^b   Xiong, Xiao Xing ^c   Pan, Jian Wei ^a   Zhan, Ren Ya ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

Angiogenesis; Angiopoietin 1; Buyang Huanwu decoction; Chronic brain injury; Neurorestoration

Indexed keywords

ANGIOPOIETIN 1; BUYANG HUANWU DECOCTION; CD31 ANTIGEN; CHINESE DRUG; HERBACEOUS AGENT; UNCLASSIFIED DRUG;

ADULT; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ATROPHY; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CAPILLARY DENSITY; CONTROLLED STUDY; DRUG EFFECT; DRY WEIGHT; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULAR ENDOTHELIAL CELL; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING;

ANGIOPOIETIN-1; ANIMALS; BLOTTING, WESTERN; BRAIN ISCHEMIA; DRUGS, CHINESE HERBAL; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, FLUORESCENCE; NEOVASCULARIZATION, PHYSIOLOGIC; PHYTOTHERAPY; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84897081727     PISSN: 16731581     EISSN: 18621783     Source Type: Journal    
DOI: 10.1631/jzus.B1300166     Document Type: Article

References (31)

1. Bai, Y., Cui, M., Meng, Z., et al., 2009. Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway. Biochem. Biophys. Res. Commun., 378(2):296-301. [doi:10.1016/j.bbrc.2008.11.052]
2. Beck, H., Plate, K.H., 2009. Angiogenesis after cerebral ischemia. Acta Neuropathol., 117(5):481-496. [doi:10.1007/s00401-009-0483-6]
3. Bederson, J.B., Pitts, L.H., Tsuji, M., et al., 1986. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke, 17(3): 472-476. [doi:10.1161/01.STR.17.3.472] (Pubitemid 16085691)
4. Bramlett, H.M., Dietrich, W.D., 2004. Pathophysiology of cerebral ischemia and brain trauma: similarities and differences. J. Cereb. Blood Flow Metab., 24(2):133-150. [doi:10.1097/01.WCB.0000111614.19196.04] (Pubitemid 38199107)
5. Cai, G.X., Liu, B.Y., 2010. Buyang Huanwu decoction increases vascular endothelial growth factor expression and promotes angiogenesis in a rat model of local cerebral ischemia. Neural. Regen. Res., 5:1733-1738 (in Chinese).
6. Cai, G.X., Liu, B.Y., Liu, W., et al., 2007. Buyang Huanwu decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains. J. Ethnopharmacol., 113(2):292-299. [doi:10.1016/j.jep.2007.06.007] (Pubitemid 47239253)
7. Chen, J., Chopp, M., 2006. Neurorestorative treatment of stroke: cell and pharmacological approaches. NeuroRX, 3(4):466-473. [doi:10.1016/j.nurx.2006.07. 007] (Pubitemid 44443015)
8. Chen, Y.S., Cheng, W.C., Yao, C.H., et al., 2001. Effects of Buyang Huanwu decoction on peripheral nerve regeneration using silicone rubber chambers. Am. J. Chin. Med., 29(03n04):423-432. [doi:10.1142/S0192415X01000447]
9. Fan, Y., Yang, G.Y., 2007. Therapeutic angiogenesis for brain ischemia: a brief review. J. Neuroimmune Pharmacol., 2(3):284-289. [doi:10.1007/s11481-007- 9073-3]
10. Gu, L., Xiong, X., Wei, D., et al., 2013. T cells contribute to stroke-induced lymphopenia in rats. PLoS ONE, 8(3): e59602. [doi:10.1371/ journal.pone.0059602]
11. Hao, C.Z., Wu, F., Shen, J., et al., 2012. Clinical efficacy and safety of Buyang Huanwu decoction for acute ischemic stroke: a systematic review and meta-analysis of 19 randomized controlled trials. Evid. Based Complement. Alternat. Med., 2012:630124. [doi:10.1155/2012/630124]
12. Kosacka, J., Figiel, M., Engele, J., et al., 2005. Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor. Cell Tissue Res., 320(1): 11-19. [doi:10.1007/s00441-004-1068-2] (Pubitemid 40543758)
13. Li, X.M., Bai, X.C., Qin, L.N., et al., 2003. Neuroprotective effects of Buyang Huanwu decoction on neuronal injury in hippocampus after transient forebrain ischemia in rats. Neurosci. Lett., 346(1-2):29-32. [doi:10.1016/S0304-3940(03)00522-6]
14. Lin, T.N., Wang, C.K., Cheung, W.M., et al., 2000. Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion. J. Cereb. Blood Flow Metab., 20(2):387-395. [doi:10.1097/00004647-200002000-00021]
15. Liu, X.B., Chen, H., Chen, H.Q., et al., 2012. Angiopoietin-1 preconditioning enhances survival and functional recovery of mesenchymal stem cell transplantation. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 13(8):616-623. [doi:10.1631/jzus.B1201004]
16. Pang, L., Ye, W., Che, X.M., et al., 2001. Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor-β1 expression. Stroke, 32(2):544-552. [doi:10.1161/01.STR.32.2.544] (Pubitemid 32155249)
17. Shen, F., Walker, E.J., Jiang, L., et al., 2011. Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume. J. Cereb. Blood Flow Metab., 31(12):2343-2351. [doi:10.1038/jcbfm.2011.97]
18. Shin, H.Y., Kim, J.H., Phi, J.H., et al., 2008. Endogenous neurogenesis and neovascularization in the neocortex of the rat after focal cerebral ischemia. J. Neurosci. Res., 86(2):356-367. [doi:10.1002/jnr.21494]
19. Suri, C., Jones, P.F., Patan, S., et al., 1996. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell, 87(7):1171-1180. [doi:10.1016/S0092-8674(00)81813-9] (Pubitemid 27010101)
20. Suri, C., McClain, J., Thurston, G., et al., 1998. Increased vascularization in mice overexpressing angiopoietin-1. Science, 282(5388):468-471. [doi:10.1126/science.282.5388.468] (Pubitemid 28483672)
21. Thurston, G., Rudge, J.S., Ioffe, E., et al., 2000. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat. Med., 6(4):460-463. [doi:10.1038/74725] (Pubitemid 30208166)
22. Valable, S., Bellail, A., Lesné, S., et al., 2003. Angiopoietin-1-induced phosphatidyl-inositol 3-kinase activation prevents neuronal apoptosis. FASEB J., 17(3):443-445. [doi:10.1096/fj.02-0372fje]
23. Valable, S., Montaner, J., Bellail, A., et al., 2005. VEGF-induced BBB permeability is associated with an MMP-9 activity increase in cerebral ischemia: both effects decreased by Ang-1. J. Cereb. Blood Flow Metab., 25(11):1491-1504. [doi:10.1038/sj.jcbfm.9600148] (Pubitemid 41541959)
24. Wang, H.W., Liou, K.T., Wang, Y.H., et al., 2011. Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. J. Ethnopharmacol., 138(1):22-33. [doi:10.1016/j.jep.2011.06.033]
25. Wei, L., Erinjeri, J.P., Rovainen, C.M., et al., 2001. Collateral growth and angiogenesis around cortical stroke. Stroke, 32(9):2179-2184. [doi:10.1161/hs0901.094282] (Pubitemid 32868119)
26. Weidner, N., 2008. Chapter 14. Measuring intratumoral microvessel density. Methods Enzymol., 444:305-323. [doi:10.1016/S0076-6879(08)02814-0]
27. Weintraub, M.I., 2006. Thrombolysis (tissue plasminogen activator) in stroke: a medicolegal quagmire. Stroke, 37(7): 1917-1922. [doi:10.1161/01.STR. 0000226651.04862.da] (Pubitemid 44297752)
28. Xiong, X.X., Gu, LJ., Zhang, H.F., et al., 2013. The protective effects of T cell deficiency against brain injury are ischemic model-dependent in rats. Neurochem. Int., 62(3): 265-270. [doi:10.1016/j.neuint.2012.11.016]
29. Yamashita, T., Ninomiya, M., Hernandez-Acosta, P., et al., 2006. Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum. J. Neurosci., 26(24):6627-6636. [doi:10.1523/JNEUROSCI.0149-06.2006] (Pubitemid 44318344)
30. Zhang, Z.G., Chopp, M., Lu, D., et al., 1999. Receptor tyrosine kinase tie 1 mRNA is upregulated on cerebral microvessels after embolic middle cerebral artery occlusion in rat. Brain Res., 847(2):338-342. [doi:10.1016/S0006- 8993(99)02013-2]
31. Zhao, L.D., Wang, J.H., Jin, G.R., et al., 2012. Neuroprotective effect of Buyang Huanwu decoction against focal cerebral ischemia/reperfusion injury in rats-time window and mechanism. J. Ethnopharmacol., 140 (2):339-344. [doi:10.1016/j.jep.2012.01.026]