Chapter 14 Measuring Intratumoral Microvessel Density

Methods in Enzymology

Volumn 444, Issue , 2008, Pages 305-323

  Weidner, Noel ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; ANTIANGIOGENIC ACTIVITY; CANCER INHIBITION; CANCER THERAPY; CAPILLARY; CELL CYCLE PHASE; CELL PROLIFERATION; ENDOTHELIUM CELL; HUMAN; MICROVASCULATURE; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR GROWTH; TUMOR VASCULARIZATION; TUMOR VOLUME;

HUMANS; MICROVESSELS; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC;

EID: 55449114219     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(08)02814-0     Document Type: Review

References (134)

1. Abulafia O., Triest W.E., Sherer D.M., Hansen C., and Ghezzi F. Angiogenesis in endometrial hyperplasia and stage I endometrial carcinoma. Obstet. Gynecol. 86 (1995) 479-485
2. Akagi K., Ikeda Y., Sumiyoshi Y., Kimura Y., Kinoshita J., Miyazaki M., and Abe T. Estimation of angiogenesis with anti-CD105 immunostaining in the process of colorectal cancer development. Surgery 131 (2002) S109-S113
3. Albo D., Granick M.S., Jhala N., Atkinson B., and Solomon M.P. The relationship of angiogenesis to biological activity in human squamous cell carcinomas of the head and neck. Ann. Plast. Surg. 32 (1994) 588-594
4. Alcalde R.E., Shintani S., Yoshihama Y., and Matsumura T. Cell proliferation and tumor angiogenesis in oral squamous cell carcinomas. Anticancer Res. 15 (1995) 1417-1422
5. Axelsson K., Ljung B.M.E., Moore D.H., Thor A.D., Chew K.L., Edgerton S.M., Smith H.S., and Mayall B.H. Tumor angiogenesis as a prognostic assay for invasive ductal carcinoma. J. Natl. Cancer Inst. 87 (1995) 997-1008
6. Baeten C.I., Wagstaff J., Verhoeven I.C., Hillen H.F., and Griffioen A.W. Flow cytometric quantification of tumour endothelial cells., an objective alternative for microvessel density assessment. Br. J. Cancer 87 (2002) 344-347
7. Barbareschi M., Gasparini G., Weidner N., Morelli L., Forti S., Eccher C., Fina P., Leonardi E., Mauri F., Bevilacqua P., and Dalla Palma P. Microvessel density quantification in breast carcinomas: Assessment by manual vs. a computer-assisted image analysis system. Appl. Immunohistochem. 3 (1995) 75-84
8. Barnhill R.L., Busam K.J., Berwick M., Blessing K., Cochran A.J., Elder D.E., Fandrey K., Daraoli T., and White W.L. Tumor vascularity is not a prognostic factor for cutaneous melanoma. Lancet 344 (1994) 1237-1238 (letter)
9. Barnhill R.L., and Levy M.A. Regressing thin cutaneous malignant melanomas (<1.0 mm) are associated with angiogenesis. Am. J. Pathol. 143 (1993) 99-104
10. Begum R., Douglas-Jones A.G., and Morgan J.M. Radial intratumoral increase and correlation of microvessels and proliferation in solid breast carcinoma. Histopathology 43 (2003) 244-253
11. Bevilacqua P., Barbareschi M., Verderio P., Boracchi P., Caffo O., Dalla Palma P., Meli S., Weidner N., and Gasparini G. Prognostic value of intratumoral microvessel density, a measure of tumor angiogenesis, in node-negative breast carcinoma-results of a multiparametric study. Breast Cancer Res. Treat. 36 (1995) 205-217
12. Bochner B.H., Cote R.J., Weidner N., Groshen S., Chen S.-C., Skinner D.G., and Nichols P.W. Angiogenesis in bladder cancer: Relationship between microvessel density and tumor prognosis. J. Natl. Cancer Inst. 87 (1995) 1603-1612
13. Bosari S., Lee A.K.C., DeLellis R.A., Wiley B.D., Heatley G.J., and Silverman M.L. Microvessel quantitation and prognosis in invasive breast carcinoma. Hum. Pathol. 23 (1992) 755-761
14. Brawer M.K., Deering R.E., Brown M., Preston S.D., and Bigler S.A. Predictors of pathologic stage in prostate carcinoma. Cancer 73 (1994) 678-687
15. Bremer G.L., Tiebosch A.T., van der Putten H.W., Schouten H.J., de Haans J., and Arends J.W. Tumor angiogenesis: An independent prognostic parameter in cervical cancer. Am. J. Obstet. Gynecol. 174 (1996) 126-131
16. Carnochan P., Briggs J.C., Westbury G., and Davies A.J. The vascularity of cutaneous melanoma: A quantitative histologic study of lesions 0.85-1.25 mm in thickness., B. Br. J. Cancer 64 (1991) 102-107
17. Charpin C., Devictor B., Bergeret D., Andrac L., Boulat J., Horschowski N., Lavaut M.N., and Piana L. CD 31 quantitative immunocytochemical assays in breast carcinomas. Correlation with current prognostic factors. Am. J. Clin. Pathol. 103 (1995) 443-448
18. Chen W.X., Min P.Q., Song B., Xiao B.L., Liu Y., and Ge Y.H. Single-level dynamic spiral CT of hepatocellular carcinoma: Correlation between imaging features and density of tumor microvessels. World J. Gastroenterol. 10 (2004) 67-72
19. Choi H.J., Choi I.H., Cho N.H., and Choi H.K. Color image analysis for quantifying renal tumor angiogenesis. Anal. Quant. Cytol. Histol. 27 (2005) 43-51
20. Costello P., McCann A., Carney D.N., and Dervan P.A. Prognostic significance of microvessel density in lymph node negative breast carcinoma. Hum. Pathol. 26 (1995) 1181-1184
21. Cruz D., Valenti C., Dias A., Seixas M., and Schmitt F. Microvessel density counting in breast cancer. Slider vs-digital images. Anal. Quant. Cytol. Histol. 23 (2001) 15-20
22. Depasquale I., and Thompson W.D. Microvessel density for melanoma prognosis. Histopathology 47 (2005) 186-194
23. DeYoung B.R., Wick M.R., Fitzgibbon J.F., Sirgi K.E., and Swanson P.E. CD31: An immunospecific marker for endothelial differentiation in human neoplasms. Appl. Immunohistochem. 1 (1993) 97-100
24. Dickinson A.J., Fox S.B., Persad R.A., Hollyer J., Sibley G.N., and Harris A.L. Quantification of angiogenesis as an independent predictor of prognosis in invasive bladder carcinomas., B. J. Urol., B. r. J. Urol. 74 (1994) 762-766
25. Ding S., Li C., Lin S., Yang Y., Liu D., Han Y., Zhang Y., Li L., Zhou L., and Kumar S. Comparative evaluation of microvessel density determined by CD34 or CD105 in benign and malignant gastric lesions. Hum. Pathol. 37 (2006) 861-866
26. Dray T.G., Hardin N.J., and Sofferman R.A. Angiogenesis as a prognostic marker in early head and neck cancer. Ann. Otol. Rhinol. Laryngol. 104 (1995) 724-729
27. Esserman L., Hylton N., George T., Yassa L., and Weidner N. Contrast-enhanced magnetic resonance imaging (cMRI) provides a window to visualize anatomic extent and tumor angiogenesis in breast carcinoma. Breast J. 5 (1999) 13-21
28. Fallowfield M.E., and Cook M.G. The vascularity of primary cutaneous melanoma. J. Pathol. 164 (1991) 241-244
29. Folkman J. Angiogenesis and breast cancer. J. Clin. Oncol. 12 (1994) 441-443
30. Folkman J. Angiogenesis and its inhibitors. In: DeVita V.T., Hellman S., and Rosenberg S.A. (Eds). Important Advances in Oncology (1985), J.B. Lippincott, Philadelphia 42-62
31. Fontanini G., Bigini D., Vignati S., Basolo F., Mussi A., Lucchi M., Chine S., Angeletti C.A., and Bevilacqua G. Recurrence and death in non small cell lung carcinomas: A prognostic model using pathological parameters, microvessel count, and gene protein products. J. Pathol. 177 (1995) 57-63
32. Fontanini G., Vignati S., Bigini D., Mussi A., Lucchi M., Chine S., Angeletti C.A., and Bevilacqua G. Recurrence and death in non-small-cell lung carcinomas: A prognostic model using pathological parameters, microvessel count, and gene protein products. Clin. Cancer Res. 2 (1996) 1067-1076
33. Fox S.B., and Harris A.L. Histological quantitation of tumour angiogenesis. APMIS 112 (2004) 413-430
34. Fox S.B., Leek R.D., Smith K., Hollyer J., Greenall M., and Harris A.L. Tumor angiogenesis in node-negative breast carcinomas: Relationship with epidermal growth factor receptor, estrogen receptor, and survival. Breast Res. Treat. 29 (1994) 109-116
35. Fox S.B., Turner G.D.H., Leek R.D., Whitehouse R.M., Gatter K.C., and Harris A.L. The prognostic value of quantitative angiogenesis in breast cancer and role of adhesion molecule expression in tumor endothelium. Breast Res. Treat. 36 (1995) 219-226
36. Fregene T.A., Khanuja P.S., Noto A.C., Gehani S.K., Van Egmont E.M., Luz D.A., and Pienta K.J. Tumor-associated angiogenesis in prostate cancer. Anticancer Res. 13 (1993) 2377-2381
37. Gasparini G., Weidner N., Bevilacqua P., Maluta S., Boracchi P., Testolin A.A., Pozza F., and Folkman J. Intratumoral microvessel density and p53 protein: Correlation with metastasis in head-and-neck squamous-cell carcinoma. Int. J. Cancer. 55 (1993) 739-744
38. Gasparini G., Bevilacqua P., Boracchi P., Maluta S., Pozza F., Barbareschi M., Dalla Palma P., Mezzetti M., and Harris A.L. Prognostic value of p53 expression in early-stage breast carcinoma compared with tumour angiogenesis, epidermal growth factor receptor, c-erbB2, cathepsin D, DNA ploidy, parameters of cell kinetics and conventional features. Int. J. Oncol. 4 (1994) 155-162
39. Gasparini G., Barbareschi M., Boracchi P., Bevilacqua P., Verderio P., Dalla Palma P., and Menard S. 67-kDa laminin-receptor expression adds prognostic information to intra-tumoral microvessel density in node-negative breast cancer. Int. J. Cancer 60 (1995) 7604-7610
40. Gasparini G., Barbareschi M., Boracchi P., Verderio P., Caffo O., Meli S., Palma P.D., Marubini E., and Bevilacqua P. Tumor angiogenesis may predict clinical outcome of node-positive breast cancer patients treated either with adjuvant hormone therapy or chemotherapy. Cancer J. Sci. Am. 1 (1995) 131-141
41. Gasparini G., Barbareschi M., Boracchi P., Verderio P., Caffo O., Meli S., Palma P.D., Marubini E., and Bevilacqua P. Tumor angiogenesis predicts clinical outcome of node-positive breast cancer patients treated with adjuvant hormone therapy or chemotherapy. Cancer J. Sci. Am. 1 (1995) 131-141
42. Goulding H., Rashid N.F.N.A., Robertson J.F., Bell J.A., Elston C.A., Elston C.W., Blamey R.W., and Ellis I.O. Assessment of angiogenesis in breast carcinoma: An important factor in prognosis?. Hum. Pathol. 26 (1995) 1196-1200
43. Graham C.H., Rivers J., Kerbel R.S., Stankiewicz K.S., and White W.L. Extent of vascularization as a prgnostic indicator in thin (<0.76 mm) malignant melanomas. Am. J. Pathol. 145 (1994) 510-514
44. Hall M.C., Troncoso P., Pollack A., Zhau H.Y., Zagars G.K., Chung L.W., and von Eschenbach A.A. Significance of tumor angiogenesis in clinically localized prostate carcinoma treated with external beam radiotherapy. Urology 44 (1994) 869-875
45. Hall N.R., Fish D.E., Hunt N., Goldin R.D., Gillou P.J., and Monson J.R.T. Is the relationship between angiogenesis and metastasis in breast cancer real?. Surg. Oncol. 1 (1992) 223-229
46. Hanabata N., Sasaki Y., Tanaka M., Tsuji T., Hatada Y., Hada R., and Munakata A. Vascular endothelial growth factor expression and microvessel parameters of colonic mucosa correlate with sensitivity to steroid in patients with ulcerative colitis. Scand. J. Gastroenterol. 40 (2005) 188-193
47. Hansen S., Sorensen F.B., Vach W., Grabau D.A., Bak M., and Rose C. Microvessel density compared with the Chalkley count in a prognostic study of angiogenesis in breast cancer patients. Histopathology 44 (2004) 428-436
48. Ho J.W., Poon R.T., Sun C.K., Xue W.C., and Fan S.T. Clinicopathological and prognostic implications of endoglin (CD105) expression in hepatocellular carcinoma and its adjacent non-tumorous liver. World J. Gastroenterol. 11 (2005) 176-181
49. Hollingsworth H.C., Kohn E.C., Steinberg S.M., Rothenberg M.L., and Merino M.J. Tumor angiogenesis in advanced stage ovarian carcinoma. Am. J. Pathol. 147 (1995) 33-41
50. Horak E., Leek R., Klenk N., LeJeune S., Smith K., Stuart N., Greenall M., Stepniewska K., and Harris A.L. Angiogenesis, assessed by platelet/endothelial cell adhesion molecule antibodies, as indicator of node metastases and survival in breast cancer. Lancet 340 (1992) 1120-1124
51. Hylton N. Dynamic contrast-enhanced magnetic resonance imaging as an imaging biomarker. J. Clin. Oncol. 24 (2006) 3293-3298
52. Inada K., Toi M., Hoshina S., Hayashi K., and Tominaga T. Significance of tumor angiogenesis as an independent prognostic factor in axillary node-negative breast cancer. Gan To Kagaku Ryoho. 22 (1995) 59-65
53. Irion L.C., Prolla J.C., Hartmann A., and da Silva V.D. Morphometric intratumoral microvessel area evaluation could be a useful indicator for coadjuvant therapy in ressected NSCLC. Rev. Port. Pneumol. 9 (2003) 19-32
54. Jacob A., Varghese B.E., and Birchall M.B. Validation of laser Doppler fluxmetry as a method of assessing neo-angiogenesis in laryngeal tumours. Eur. Arch. Otorhinolaryngol. 263 (2006) 444-448
55. Jaeger T.M., Weidner N., Chew K., Moore D.H., Kerschmann R.L., Waldman F.M., and Carroll P.R. Tumor angiogenesis correlates with lymph node metastases in invasive bladder cancer. J. Urol. 154 (1995) 59-71
56. Kainz C., Speiser P., Wanner C., Obermair A., Tempfer C., Sliutz G., Reinthaller A., and Breitenecker G. Prognostic value of tumor microvessel density in cancer of the uterine cervix stage IB to IIB. Anticancer Res. 15 (1995) 1549-1551
57. Kohno Y., Iwanari O., and Kitao M. Prognostic importance of histologic vascular density in cervical cancer treated with hypertensive intraarterial chemotherapy. Cancer 72 (1993) 2394-2400
58. Kyzas P.A., Agnantis N.J., and Stefanou D. Endoglin (CD105) as a prognostic factor in head and neck squamous cell carcinoma. Virchows Arch. 448 (2006) 768-775
59. Leedy D.A., Trune D.R., Kronz J.D., Weidner N., and Cohen J.I. Tumor angiogenesis, the p53 antigen, and cervical metastasis in squamous carcinoma. Otolaryngol. Head Neck Surg. 111 (1994) 417-422
60. Lipponen P., Ji H., Aaltomaa S., and Syrjanen K. Tumor vascularity and basement membrane structure in breast cancer as related to tumor histology and prognosis. J. Cancer Res. Clin. Oncol. 120 (1994) 645-650
61. Longacre T.A., and Rouse R.V. CD31: A new marker for vascular neoplasia. Adv. Anat. Pathol. 1 (1994) 16-20
62. Macaron N.C., Cohen C., Chen S.C., and Arbiser J.L. Cutaneous lesions of secondary syphilis are highly angiogenic. J. Am. Acad. Dermatol. 48 (2003) 878-881
63. Macchiarini P., Fontanini G., Dulmet E., de Montpreville V., Chapelier A.R., Cerrin J., Le Roy Ladurie F., and Dartevelle P.G. Angiogenesis: An indicator of metastasis in non-small-cell lung cancer invading the thoracic inlet. Ann. Thorac. Surg. 57 (1994) 1534-1539
64. Macchiarini P., Fontanini G., Hardin M.J., Hardin M.J., Squartini F., and Angeletti C.A. Relation of neovasculature to metastasis of non-small-cell lung cancer. Lancet 340 (1992) 145-146
65. MacLennan G.T., and Bostwick D.G. Microvessel density in renal cell carcinoma: Lack of prognostic significance. Urology 46 (1995) 27-30
66. Maeda K., Chung Y.S., Takatsuka S., Ogawa Y., Sawada Y., Tamashito, Onoda N., Kato Y., Nitta A., Arimoto Y., Kondo Y., and Sowa M. Tumor angiogenesis as a predictor of recurrence in gastric carcinoma. J. Clin. Oncol. 13 (1995) 477-481
67. Meert A.P., Paesmans M., Martin B., Delmotte P., Berghmans T., Verdebout J.M., Lafitte J.J., Mascaux C., and Sculier J.P. The role of microvessel density on the survival of patients with lung cancer: A systematic review of the literature with meta-analysis. Br. J. Cancer 87 (2002) 694-701
68. Mikami Y., Tsukuda M., Mochimatsu I., Kokatsu T., Yago T., and Sawaki S. Angiogenesis in head and neck tumors. Nippon Jibiinkoka Gakkai Kaiho. 96 (1991) 645-650
69. Miliaras D., Kamas A., and Kalekou H. Angiogenesis in invasive breast carcinoma: Is it associated with parameters of prognostic significance?. Histopathology 26 (1995) 165-169
70. Mofidi R., Crotty T.B., McCarthy P., Sheehan S.J., Mehigan D., and Keaveny T.V. Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease. Br. J. Surg. 88 (2001) 945-950
71. Nanashima A., Yano H., Yamaguchi H., Tanaka K., Shibasaki S., Sumida Y., Sawai T., Shindou H., and Nakagoe T. Immunohistochemical analysis of tumor biological factors in hepatocellular carcinoma: Relationship to clinicopathological factors and prognosis after hepatic resection. J. Gastroenterol. 39 (2004) 148-154
72. Nguyen M., Watanabe I.I., and Budson A.E. Elevated levels of an angiogenic peptide, basic fibroblast growth factor, in the urine of patients with a wide spectrum of cancers. J. Natl. Cancer Inst. 86 (1994) 356
73. Obermair A., Czerwenka K., Kurz C., Kaider A., and Sevelda P. Tumor vascular density in breast tumors and their effect on recurrence free survival. Chirurg 65 (1994) 611-615
74. Obermair A., Kurz C., Czerwenka K., Thoma M., Kaider A., Wagner T., Gitsch G., and Sevelda P. Microvessel density and vessel invasion in lymph node negative breast cancer: Effect on recurrence-free survival. Int. J. Cancer 62 (1995) 126-130
75. Offersen B.V., Borre M., and Overgaard J. Quantification of angiogenesis as a prognostic marker in human carcinomas: A critical evaluation of histopathological methods for estimation of vascular density. Eur. J. Cancer 39 (2003) 881-890
76. Ogawa Y., Chung Y.-S., Nakata B., Takatsuka S., Maeda K., Sawada T., Kato Y., Yoshikawa K., Sakurai M., and Sowa M. Microvessel quantitation in invasive beast cancer by staining for factor VIII-related antigen. Br. J. Cancer 71 (1995) 1297-1301
77. Oh-e H., Tanaka S., Kitadai Y., Shimamoto F., Yoshihara M., and Haruma K. Angiogenesis at the site of deepest penetration predicts lymph node metastasis of submucosal colorectal cancer. Dis. Colon Rectum. 44 (2001) 1129-1136
78. Okanobu H., Hata J., Haruma K., Matsumura S., Yoshida S., Kitadai Y., Tanaka S., and Chayama K. Preoperative assessment of gastric cancer vascularity by flash echo imaging. Scand. J. Gastroenterol. 37 (2002) 608-612
79. Olivarez D.D., Ulbright T., DeRiese W., Foster R., Reister T., Einhorn L., and Sledge G. Neovascularization in clinical stage A testicular germ cell tumor: Prediction of metastatic disease. Cancer Res. (1994) 2800-2802
80. Ozalp S., Yalcin O.T., Acikalin M., Tanir H.M., Oner U., and Akkoyunlu A. Microvessel density (MVD) as a prognosticator in endometrial carcinoma. Eur. J. Gynaecol. Oncol. 24 (2003) 305-308
81. Palmer J.E., Sant C., Cassia L.J., Irwin C.J., Morris A.G., and Rollason T.P. Prognostic value of measurements of angiogenesis in serous carcinoma of the ovary. Int. J. Gynecol. Pathol. 26 (2007) 395-403
82. Romani A., Borghetti A.F., Del Rio P., Sianesi M., and Soliani P. The risk of developing metastatic disease in colorectal cancer is related to CD105-positive vessel count. J. Surg. Oncol. 93 (2006) 446-455
83. Rutger J.L., Mattox T.F., and Vargas M.P. Angiogenesis in uterine cervical squamous cell carcinoma. Int. J. Gynecol. Pathol. 14 (1995) 114-118
84. Saad R.S., Kordunsky L., Liu Y.L., Denning K.L., Kandil H.A., and Silverman J.F. Lymphatic microvessel density as prognostic marker in colorectal cancer. Mod. Pathol. 19 (2006) 1317-1323
85. Saclarides T.J., Speziale J.J., Drab E., Szeluga D.J., and Rubin D.B. Tumor angiogenesis and rectal carcinoma. Dis. Colon Rectum. 37 (1994) 921-926
86. Salvesen H.B., Gulluoglu M.G., Stefansson I., and Akslen L.A. Significance of CD 105 expression for tumour angiogenesis and prognosis in endometrial carcinomas. APMIS 111 (2003) 1011-1018
87. Schlenger K., Hockel M., Mitze M., Schaffer U., Weikel W., Knapstein P.G., and Lambert A. Tumor vascularity-A novel prognostic factor in advanced cervical carcinoma. Gynecol. Oncol. 59 (1995) 57-66
88. Schlingemann R.O., Rietveld F.J.R., Kwaspen F., van de Kerkhof P.C.M., de Waal R.M.W., and Ruiter D.J. Differential expression of markers for endothelial cells, pericytes, and basal lamina in the microvasculature of tumors and granulation tissue. Am. J. Pathol. 138 (1991) 1335-1347
89. Scopinaro F., Schillaci O., Scarpini M., Mingazzini P.L., diMacio L., Banci M., Danieli R., Zerilli M., Limiti M.R., and Centi Colella A. Technetium-99m sestamibi: An indicator of breast cancer invasiveness. Eur. J. Nucl. Med. 21 (1994) 984-987
90. Shinyo Y., Kodama J., Hongo A., Yoshinouchi M., and Hiramatsu Y. Heparanase expression is an independent prognostic factor in patients with invasive cervical cancer. Ann. Oncol. 14 (2003) 1505-1510
91. Shirabe K., Shimada M., Tsujita E., Aishima S., Maehara S., Tanaka S., Takenaka K., and Maehara Y. Prognostic factors in node-negative intrahepatic cholangiocarcinoma with special reference to angiogenesis. Am. J. Surg. 187 (2004) 538-542
92. Siitonen S.M., Haapasalo H.K., Rantala I.S., Helin H.J., and Isola J.J. Comparison of different immunohistochemical methods in the assessment of angiogenesis: Lack of prognostic value in a group of 77 selected node-negative breast carcinomas. Mod. Pathol. 8 (1995) 745-752
93. Simpson J.F., Ahn C., Battifora H., and Esteban J.M. Endothelial area as a prognostic indicator for invasive breast carcinoma. Cancer 77 (1996) 2077-2085
94. Smolle J., Soyer H.-P., Hofmann-Wellenhof R., Smolle-Juettner F.M., and Kerl H. Vascular architecture of melanocytic skin tumors. A quantitative immunohistochemical study using automated image analysis. Pathol. Res. Pract. 185 (1989) 740-745
95. Song S.Y., Lee S.K., Kim D.H., Son H.J., Kim H.J., Lim Y.J., Lee W.Y., Chun H.K., and Rhee J.C. Expression of maspin in colon cancers: its relationship with p53 expression and microvessel density. Dig. Dis. Sci. 47 (2002) 1831-1835
96. Srivastava A., Laidler P., Davies R., Horgan K., and Hughes L.E. The prognostic significance of tumor vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma. Am. J. Pathol. 133 (1988) 419-423
97. Srivastava A., Laidler P., Hughes L.E., Woodcock J., and Shedden E.J. Neovascularization in human cutaneous melanoma: A quantitative morphological and Doppler ultrasound study. Eur. J. Cancer Clin. Oncol. 22 (1986) 1205-1209
98. Starnes S.L., Duncan B.W., Fraga C.H., Desai S.Y., Jones T.K., Mathur S.K., Rosenthal G.L., and Lupinetti F.M. Rat model of pulmonary arteriovenous malformations after right superior cavopulmonary anastomosis. Am. J. Physiol. Heart Circ. Physiol. 283 (2002) H2151-H2156
99. Stefanou D., Batistatou A., Arkoumani E., Ntzani E., and Agnantis N.J. Expression of vascular endothelial growth factor (VEGF) and association with microvessel density in small-cell and non-small-cell lung carcinomas. Histol. Histopathol 19 (2004) 37-42
100. Tahan S.R., and Stein A.L. Angiogenesis in invasive squamous cell carcinoma of the lip: tumor vascularity is not an indicator of metastatic risk. J. Cut. Pathol. 22 (1995) 236-240
101. Takebayashi Y., Akiytama S.-I., Yamada K., Akiba S., and Aikou T. Angiogenesis as an unfavorable prognostic factor in human colorectal carcinoma. Cancer 78 (1996) 226-231
102. Tian Y., Zhu L.L., Guo R.X., and Fan C.F. Correlation of P-glycoprotein expression with poor vascularization in human gallbladder carcinomas. World J. Gastroenterol. 9 (2003) 2817-2820
103. Toi M., Hoshina S., Takayanagi T., and Tominaga T. Association of vascular endothelial growth factor expression with tumor angiogenesis and with early relaps in primary breast cancer. Jpn. J. Cancer Res. 85 (1994) 1045-1049
104. Toi M., Hoshina S., Yamamoto Y., Ishii T., Hayashi K., and Tominaga T. Tumor angiogenesis in breast carcinoma: significance of vessel density as a prognostic indicator. Gan To Kagaku Ryoho 21 Suppl 2 (1994) 178-182
105. Toi M., Inada K., Suzuki H., and Tominaga T. Tumor angiogenesis in breast cancer: its improtance as a prognostic indicator and the association with vascular endothelial growth factor expression. Breast Res. Treat. 36 (1995) 193-204
106. Toi M., Kashitani J., and Tominaga T. Tumor angiogenesis is an independent prognostic indicator of primary breast carcinoma. Int. J. Cancer 55 (1993) 371-374
107. Traweek S.T., Kandalaft P.L., Mehta P., and Battifora H. The human hematopoietic progenitor cell antigen (CD34) in vascular neoplasia. Am. J. Clin. Pathol. 96 (1991) 25-31
108. Tsuji T., Sasaki Y., Tanaka M., Hanabata N., Hada R., and Munakata A. Microvessel morphology and vascular endothelial growth factor expression in human colonic carcinoma with or without metastasis. Lab. Invest. 82 (2002) 555-562
109. Uzzan B., Nicolas P., Cucherat M., and Perret G.Y. Microvessel density as a prognostic factor in women with breast cancer: A systematic review of the literature and meta-analysis. Cancer Res. 64 (2004) 2941-2955
110. Vacca A., Ribatti D., Roncali L., Lospalluti M., Serio G., Carrel S., and Dammacco F. Melanocyte tumor progression is associated with changes in angiogenesis and expression of the 67-kilodalton laminin receptor. Cancer 72 (1993) 455-461
111. Vacca A., Ribatti D., Roncali L., Ranieri G., Serio G., Silvestris F., and Dammacco F. Bone marrow angiogenesis and progression in multiple myeloma. Br. J. Haematol. 87 (1994) 503-508
112. van de Rijn M., and Rouse R.V. CD34: A review. Appl. Immunohistochem. 2 (1994) 71-80
113. van Diest P.J., Zevering J.P., Zevering L.C., and Baak J.P.A. Prognostic value of microvessel quantitation in cisplatin treated Figo 3 and 4 ovarian cancer patients. Pathol. Res. Pract. 191 (1995) 25-30
114. Van Hoef M.E.H.M., Knox W.F., Dhesi S.S., Howell A., and Schor A.M. Assessment of tumor vascularity as a prognostic factor in lymph node negative invasive breast cancer. Eur. J. Cancer 29A (1993) 1141-1145
115. Vesalainen S., Lipponen P., Talja M., Alhava E., and Syrjanen K. Tumor vascularity and basement membrane structure as prognostic factors in T1-2M0 prostatic adenocarcinoma. Anticancer Res. 14 (1994) 709-714
116. Visscher D.W., Smilanetz S., Drozdowicz S., and Wykes S.M. Prognostic significance of image morphometric microvessel enumeration in breast carcinoma. Anal. Quant. Cytol. Histol. 15 (1993) 88-92
117. Volm M., Koomagi R., Kaufmann M., Mattern J., and Stammler G. Microvessel density, expression of proto-oncogenes, and resistance-related proteins and incidence of metastases in primary ovarian carcinomas. Clin. Exp. Metastasis 14 (1996) 209-214
118. Wakui S., Furusato M., Itoh T., Sasaki H., Akiyama A., Kinoshita I., Asano K., Tokuda T., Aizawa S., and Ushigome S. Tumor angiogenesis in prostatic carcinoma with and without bone marrow metastasis: A morphometric study. J. Pathol. 168 (1992) 257-262
119. Wang J.M., Kumar S., Pye D., Haboubi N., and Al-Nakib L. Breast carcinoma: comparative study of tumor vasculature using two endothelial-cell markers. J. Natl. Cancer Inst. 86 (1994) 386-388
120. Wang J.M., Kumar S., Pye D., van Agthoven A.J., Krupinski J., and Hunter R.D. A monoclonal antibody detects heterogeneity in vascular endothelium of tumors and normal tissues. Int. J. Cancer 54 (1993) 363-370
121. Watanabe I.I., Nguyen M., and Schizer M. Basic fibroblast growth factor in human serum - a prognostic test for breast cancer. Mol. Biol. Cell 3 (1992) 324a
122. Weidner N. The relationship of tumor angiogenesis and metastasis with emphasis on invasive breast carcinoma. In: Weinstein R.S. (Ed). Advances in Pathology and Laboratory Medicine 5 (1992), Mosby Year Book, Chicago 101-121
123. Weidner N., Carroll P.R., Flax J., Blumenfeld W., and Folkman J. Tumor angiogenesis correlates with metastasis in invasive prostate carcinoma. Am. J. Pathol. 143 (1993) 401-409
124. Weidner N., Folkman J., Pozza F., Bevilacqua P., Allred E.N., Moore D.H., Meli S., and Gasparini G. Tumor angiogenesis: A new significant and independent prognostic indicator in early-stage breast carcinoma. J. Natl. Cancer Inst. 84 (1992) 1875-1887
125. Weidner N., Semple J.P., Welch W.R., and Folkman J. Tumor angiogenesis and metastasis - correlation in invasive breast carcinoma. N. Engl. J. Med. 324 (1991) 1-8
126. Wiggins D.L., Granai C.O., Steinhoff M.M., and Calabresi P. Tumor angiogenesis as a prognostic factor in cervical carcinoma. Gynecol. Oncol. 56 (1995) 353-356
127. Williams J.K., Carlson G.W., Cohen C., Derose P.B., Hunter S., and Jurkiewicz J.J. Tumor angiogenesis as a prognostic factor in oral cavity tumors. Am. J. Surg. 168 (1994) 373-380
128. Yabuuchi H., Fukuya T., Tajima T., Hachitanda Y., Tomita K., and Koga M. Salivary gland tumors: diagnostic value of gadolinium-enhanced dynamic MR imaging with histopathologic correlation. Radiology 226 (2003) 345-354
129. Yamazaki K., Abe S., Takekawa H., Sukoh N., Watanabe N., Ogura S., Nakajima I., Isobe H., Inoue K., and Kawakami Y. Tumor angiogenesis in human lung adenocarcinoma. Cancer 74 (1994) 2245-2250
130. Yang W.T., Tse G.M., Lam P.K., Metreweli C., and Chang J. Correlation between color power Doppler sonographic measurement of breast tumor vasculature and immunohistochemical analysis of microvessel density for the quantitation of angiogenesis. J. Ultrasound Med. 21 (2002) 1227-1235
131. Yonenaga Y., Mori A., Onodera H., Yasuda S., Oe H., Fujimoto A., Tachibana T., and Imamura M. Absence of smooth muscle actin-positive pericyte coverage of tumor vessels correlates with hematogenous metastasis and prognosis of colorectal cancer patients. Oncology 69 (2005) 159-166
132. Yoshino S., Kato M., and Okada K. Prognostic significance of microvessel count in low stage renal cell carcinoma. Int. J. Urol. 2 (1995) 156-160
133. Yuan A., Yang P.-C., Yu C.-J., Yao Y.-T., Lee Y.-C., Kuo S.-H., and Luh K.-T. Tumor angiogenesis correlates with histologic type and nodal metastasis in non-small cell lung carcinoma. Am. J. Resp. Crit. Care Med. 152 (1995) 2157-2162
134. Zatterstrom U.K., Brun E., Willen R., Kjellen E., and Wennerberg J. Tumor angiogenesis and prognosis in squamous cell carcinoma of the head and neck. Head Neck 17 (1995) 312-318