Targeting PKC in human T Cells using sotrastaurin (AEB071) preserves regulatory T Cells and prevents IL-17 production

Journal of Investigative Dermatology

Volumn 134, Issue 4, 2014, Pages 975-983

  He, Xuehui ^a   Koenen, Hans J P M ^a   Smeets, Ruben L ^a   Keijsers, Romy ^a   Van Rijssen, Esther ^a   Koerber, Andreas ^b   Van De Kerkhof, Peter C ^a   Boots, Annemieke M H ^c   Joosten, Irma ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 23; PROTEIN KINASE C; RAPAMYCIN; SOTRASTAURIN; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG TARGETING; EFFECTOR CELL; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LYMPHOCYTE PRESERVATION; PHARMACOLOGICAL STIMULATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD28; BIOPSY; CELL PROLIFERATION; COCULTURE TECHNIQUES; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; HOMEOSTASIS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-1BETA; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LYMPHOCYTE ACTIVATION; PROTEIN KINASE C; PSORIASIS; PYRROLES; QUINAZOLINES; SKIN; T-LYMPHOCYTES, HELPER-INDUCER; T-LYMPHOCYTES, REGULATORY;

EID: 84897070438     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.459     Document Type: Article

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