S1PR1 Is Crucial for Accumulation of Regulatory T Cells in Tumors via STAT3

Cell Reports

Volumn 6, Issue 6, 2014, Pages 992-999

  Priceman, Saul J ^a   Shen, Shudan ^a   Wang, Lin ^a,b   Deng, Jiehui ^a   Yue, Chanyu ^a   Kujawski, Maciej ^a   Yu, Hua ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FINGOLIMOD; JANUS KINASE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; STAT3 PROTEIN; UNCLASSIFIED DRUG; CD69 ANTIGEN; GAMMA INTERFERON; GRANZYME B; TRANSCRIPTION FACTOR FOXP3; LYSOPHOSPHOLIPID; S1PR1 PROTEIN, HUMAN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE; STAT3 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INFILTRATION; CONTROLLED STUDY; FEMALE; GENE; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE FUNCTION; METASTASIS; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ACTIVATION; PROTEIN FUNCTION; PROTEIN MODIFICATION; REGULATORY T LYMPHOCYTE; S1PR1 GENE; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE RECRUITMENT; TUMOR GROWTH; BREAST CARCINOMA; CELL FUNCTION; CELL MIGRATION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE SUBPOPULATION; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; BLADDER TUMOR; C57BL MOUSE; EXPERIMENTAL MELANOMA; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; PATHOLOGY; TRANSGENIC MOUSE;

ANIMALS; FEMALE; HUMANS; JANUS KINASES; LYMPHOCYTE ACTIVATION; LYSOPHOSPHOLIPIDS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, LYSOSPHINGOLIPID; SIGNAL TRANSDUCTION; SPHINGOSINE; STAT3 TRANSCRIPTION FACTOR; T-LYMPHOCYTES, REGULATORY; URINARY BLADDER NEOPLASMS;

EID: 84897070044     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.02.016     Document Type: Article

References (30)

1. Arnon T.I., Xu Y., Lo C., Pham T., An J., Coughlin S., Dorn G.W., Cyster J.G. GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science 2011, 333:1898-1903.
2. Chaudhry A., Rudensky A.Y. Control of inflammation by integration of environmental cues by regulatory Tcells. J.Clin. Invest. 2013, 123:939-944.
3. Chen A., Liu S., Park D., Kang Y., Zheng G. Depleting intratumoral CD4+CD25+ regulatory Tcells via FasL protein transfer enhances the therapeutic efficacy of adoptive Tcell transfer. Cancer Res. 2007, 67:1291-1298.
4. Darrasse-Jèze G., Bergot A.S., Durgeau A., Billiard F., Salomon B.L., Cohen J.L., Bellier B., Podsypanina K., Klatzmann D. Tumor emergence is sensed by self-specific CD44hi memory Tregs that create a dominant tolerogenic environment for tumors in mice. J.Clin. Invest. 2009, 119:2648-2662.
5. Deng J., Liu Y., Lee H., Herrmann A., Zhang W., Zhang C., Shen S., Priceman S.J., Kujawski M., Pal S.K., et al. S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell 2012, 21:642-654.
6. Durant L., Watford W.T., Ramos H.L., Laurence A., Vahedi G., Wei L., Takahashi H., Sun H.W., Kanno Y., Powrie F., O'Shea J.J. Diverse targets of the transcription factor STAT3 contribute to Tcell pathogenicity and homeostasis. Immunity 2010, 32:605-615.
7. Fujita M., Zhu X., Sasaki K., Ueda R., Low K.L., Pollack I.F., Okada H. Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma. J.Immunol. 2008, 180:2089-2098.
8. Goetzl E.J., Liao J.J., Huang M.C. Regulation of the roles of sphingosine 1-phosphate and its type 1G protein-coupled receptor in Tcell immunity and autoimmunity. Biochim. Biophys. Acta 2008, 1781:503-507.
9. Gräler M.H., Huang M.C., Watson S., Goetzl E.J. Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes. J.Immunol. 2005, 174:1997-2003.
10. Hedvat M., Huszar D., Herrmann A., Gozgit J.M., Schroeder A., Sheehy A., Buettner R., Proia D., Kowolik C.M., Xin H., et al. The JAK2 inhibitor AZD1480 potently blocks Stat3 signaling and oncogenesis in solid tumors. Cancer Cell 2009, 16:487-497.
11. Josefowicz S.Z., Lu L.F., Rudensky A.Y. Regulatory Tcells: mechanisms of differentiation and function. Annu. Rev. Immunol. 2012, 30:531-564.
12. Kortylewski M., Xin H., Kujawski M., Lee H., Liu Y., Harris T., Drake C., Pardoll D., Yu H. Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell 2009, 15:114-123.
13. Kujawski M., Zhang C., Herrmann A., Reckamp K., Scuto A., Jensen M., Deng J., Forman S., Figlin R., Yu H. Targeting STAT3 in adoptively transferred Tcells promotes their invivo expansion and antitumor effects. Cancer Res. 2010, 70:9599-9610.
14. Lee H., Deng J., Kujawski M., Yang C., Liu Y., Herrmann A., Kortylewski M., Horne D., Somlo G., Forman S., et al. STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors. Nat. Med. 2010, 16:1421-1428.
15. Liu G., Burns S., Huang G., Boyd K., Proia R.L., Flavell R.A., Chi H. The receptor S1P1 overrides regulatory Tcell-mediated immune suppression through Akt-mTOR. Nat. Immunol. 2009, 10:769-777.
16. Liu G., Yang K., Burns S., Shrestha S., Chi H. The S1P(1)-mTOR axis directs the reciprocal differentiation of T(H)1 and T(reg) cells. Nat. Immunol. 2010, 11:1047-1056.
17. Mailloux A.W., Young M.R. Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression. Crit. Rev. Immunol. 2010, 30:435-447.
18. Mandala S., Hajdu R., Bergstrom J., Quackenbush E., Xie J., Milligan J., Thornton R., Shei G.J., Card D., Keohane C., et al. Alteration oflymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002, 296:346-349.
19. Matloubian M., Lo C.G., Cinamon G., Lesneski M.J., Xu Y., Brinkmann V., Allende M.L., Proia R.L., Cyster J.G. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 2004, 427:355-360.
20. Ménétrier-Caux C., Curiel T., Faget J., Manuel M., Caux C., Zou W. Targeting regulatory Tcells. Target Oncol 2012, 7:15-28.
21. Mougiakakos D., Choudhury A., Lladser A., Kiessling R., Johansson C.C. Regulatory Tcells in cancer. Adv. Cancer Res. 2010, 107:57-117.
22. Nishikawa H., Sakaguchi S. Regulatory Tcells in tumor immunity. Int. J. Cancer 2010, 127:759-767.
23. Pallandre J.R., Brillard E., Créhange G., Radlovic A., Remy-Martin J.P., Saas P., Rohrlich P.S., Pivot X., Ling X., Tiberghien P., Borg C. Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity. J.Immunol. 2007, 179:7593-7604.
24. Rivera J., Proia R.L., Olivera A. The alliance of sphingosine-1-phosphate and its receptors in immunity. Nat. Rev. Immunol. 2008, 8:753-763.
25. Spiegel S., Milstien S. The outs and the ins of sphingosine-1-phosphate in immunity. Nat. Rev. Immunol. 2011, 11:403-415.
26. Wei J., Wang F., Kong L.Y., Xu S., Doucette T., Ferguson S.D., Yang Y., McEnery K., Jethwa K., Gjyshi O., et al. miR-124 inhibits STAT3 signaling to enhance Tcell-mediated immune clearance of glioma. Cancer Res. 2013, 73:3913-3926.
27. Yamaguchi T., Sakaguchi S. Regulatory Tcells in immune surveillance and treatment of cancer. Semin. Cancer Biol. 2006, 16:115-123.
28. Yu H., Kortylewski M., Pardoll D. Crosstalk between cancer andimmune cells: role of STAT3 in the tumour microenvironment. Nat. Rev. Immunol. 2007, 7:41-51.
29. Yu H., Pardoll D., Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 2009, 9:798-809.
30. Zou W. Regulatory Tcells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 2006, 6:295-307.