메뉴 건너뛰기




Volumn 347, Issue 1, 2014, Pages 15-21

Recent advances in personalized colorectal cancer research

Author keywords

Biomarkers; Colorectal cancer (CRC); Epigenetic markers; KRAS; Monoclonal antibodies (mAbs); Oncotype

Indexed keywords

B RAF KINASE; CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; CD24 ANTIGEN; CELECOXIB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR MARKER;

EID: 84897054309     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2014.01.025     Document Type: Review
Times cited : (46)

References (67)
  • 2
    • 84897055944 scopus 로고    scopus 로고
    • National Cancer Institute. SEER Stat Fact Sheets: Colon and Rectum
    • National Cancer Institute. SEER Stat Fact Sheets: Colon and Rectum, 2012; http://seer.cancer.gov/statfacts/html/colorect.html.
    • (2012)
  • 4
    • 52749099497 scopus 로고    scopus 로고
    • Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
    • Linardou H., Dahabreh I.J., Kanaloupiti D., Siannis F., Bafaloukos D., Kosmidis P., Papadimitriou C.A., Murray S. Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer. Lancet Oncol. 2008, 9:962-972.
    • (2008) Lancet Oncol. , vol.9 , pp. 962-972
    • Linardou, H.1    Dahabreh, I.J.2    Kanaloupiti, D.3    Siannis, F.4    Bafaloukos, D.5    Kosmidis, P.6    Papadimitriou, C.A.7    Murray, S.8
  • 5
    • 84897106035 scopus 로고    scopus 로고
    • National Comprehensive Cancer Network, Colon Cancer. NCCN Clinical Practice Guidelines in, Oncology
    • National Comprehensive Cancer Network, Colon Cancer. NCCN Clinical Practice Guidelines in, Oncology, 2009; http://www.nccn.org/professionals/physician_gls/PDF/colon.pdf.
    • (2009)
  • 6
    • 84885616262 scopus 로고    scopus 로고
    • Gappnet KRAS mutational analysis for colorectal cancer: application pharmacogenomic
    • Wang G., Kelley R.K. Gappnet KRAS mutational analysis for colorectal cancer: application pharmacogenomic. PLoS Curr. 2010, 2.
    • (2010) PLoS Curr. , vol.2
    • Wang, G.1    Kelley, R.K.2
  • 7
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • Schubbert S., Shannon K., Bollag G. Hyperactive Ras in developmental disorders and cancer. Nat. Rev. Cancer 2007, 7:295-308.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 9
    • 30644480321 scopus 로고    scopus 로고
    • Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study
    • Gruppo Oncologico dell'Italia Meridionale (GOIM)
    • Bazan V., Agnese V., Corsale S., Calò V., Valerio M.R., Latteri M.A., Vieni S., Grassi N., Cicero G., Dardanoni G., Tomasino R.M., Colucci G., Gebbia N., Russo A. Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Gruppo Oncologico dell'Italia Meridionale (GOIM) prospective study. Ann. Oncol. 2005, 16(Suppl. 4):50-55. Gruppo Oncologico dell'Italia Meridionale (GOIM).
    • (2005) Ann. Oncol. , vol.16 , Issue.Suppl. 4 , pp. 50-55
    • Bazan, V.1    Agnese, V.2    Corsale, S.3    Calò, V.4    Valerio, M.R.5    Latteri, M.A.6    Vieni, S.7    Grassi, N.8    Cicero, G.9    Dardanoni, G.10    Tomasino, R.M.11    Colucci, G.12    Gebbia, N.13    Russo, A.14
  • 12
    • 61449202998 scopus 로고    scopus 로고
    • The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer
    • Hurwitz H.I., Yi J., Ince W., Novotny W.F., Rosen O. The clinical benefit of bevacizumab in metastatic colorectal cancer is independent of K-ras mutation status: analysis of a phase III study of bevacizumab with chemotherapy in previously untreated metastatic colorectal cancer. Oncologist 2009, 14:22-28.
    • (2009) Oncologist , vol.14 , pp. 22-28
    • Hurwitz, H.I.1    Yi, J.2    Ince, W.3    Novotny, W.F.4    Rosen, O.5
  • 14
    • 79957523828 scopus 로고    scopus 로고
    • KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer
    • De Roock W., De Vriendt V., Normanno N., Ciardiello F., Tejpar S. KRAS, BRAF, PIK3CA, and PTEN mutations: implications for targeted therapies in metastatic colorectal cancer. Lancet Oncol. 2011, 12:594-603.
    • (2011) Lancet Oncol. , vol.12 , pp. 594-603
    • De Roock, W.1    De Vriendt, V.2    Normanno, N.3    Ciardiello, F.4    Tejpar, S.5
  • 17
    • 53149097362 scopus 로고    scopus 로고
    • BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
    • Velho S., Moutinho C., Cirnes L., Albuquerque C., Hamelin R., Schmitt F., Carneiro F., Oliveira C., Seruca R. BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?. BMC Cancer 2008, 8:255.
    • (2008) BMC Cancer , vol.8 , pp. 255
    • Velho, S.1    Moutinho, C.2    Cirnes, L.3    Albuquerque, C.4    Hamelin, R.5    Schmitt, F.6    Carneiro, F.7    Oliveira, C.8    Seruca, R.9
  • 18
    • 79959974471 scopus 로고    scopus 로고
    • Targeting PI3K signaling as a therapeutic approach for colorectal cancer
    • Zhang J., Roberts T.M., Shivdasani R.A. Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology 2011, 141:50-61.
    • (2011) Gastroenterology , vol.141 , pp. 50-61
    • Zhang, J.1    Roberts, T.M.2    Shivdasani, R.A.3
  • 20
    • 13944269898 scopus 로고    scopus 로고
    • The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin
    • Agarwal A., Das K., Lerner N., Sathe S., Cicek M., Casey G., Sizemore N. The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene. 2005, 24:1021-1031.
    • (2005) Oncogene. , vol.24 , pp. 1021-1031
    • Agarwal, A.1    Das, K.2    Lerner, N.3    Sathe, S.4    Cicek, M.5    Casey, G.6    Sizemore, N.7
  • 22
    • 78449241791 scopus 로고    scopus 로고
    • PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac
    • Kaur J., Sanyal S.N. PI3-kinase/Wnt association mediates COX-2/PGE(2) pathway to inhibit apoptosis in early stages of colon carcinogenesis: chemoprevention by diclofenac. Tumour Biol. 2010, 31:623-631.
    • (2010) Tumour Biol. , vol.31 , pp. 623-631
    • Kaur, J.1    Sanyal, S.N.2
  • 27
    • 84875210929 scopus 로고    scopus 로고
    • Neuroendocrine tumors of the colo and rectum: prognostic relevance and comparative performance of current staging systems
    • Chagpar R., Chiang Y.J., Xing Y., Cormier J.N., Feig B.W., Rashid A., Chang G.J., You Y.N. Neuroendocrine tumors of the colo and rectum: prognostic relevance and comparative performance of current staging systems. Ann. Surg. Oncol. 2013, 20:1170-1178.
    • (2013) Ann. Surg. Oncol. , vol.20 , pp. 1170-1178
    • Chagpar, R.1    Chiang, Y.J.2    Xing, Y.3    Cormier, J.N.4    Feig, B.W.5    Rashid, A.6    Chang, G.J.7    You, Y.N.8
  • 28
    • 79959357339 scopus 로고    scopus 로고
    • Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?
    • Kelley R.K., Vennok A.P. Prognostic and predictive markers in stage II colon cancer: is there a role for gene expression profiling?. Clin. Colorectal. Cancer 2011, 10:73-80.
    • (2011) Clin. Colorectal. Cancer , vol.10 , pp. 73-80
    • Kelley, R.K.1    Vennok, A.P.2
  • 29
    • 84867019805 scopus 로고    scopus 로고
    • ColoGuideEX: a robust gene classifier specific for stage II colorectal cancer prognosis
    • Agesen T.H., Sveen A., Merok M.A., Lind G.E., Nesbakken A., Skotheim R.I., Lothe R.A. ColoGuideEX: a robust gene classifier specific for stage II colorectal cancer prognosis. Gut 2012, 61:1560-1567.
    • (2012) Gut , vol.61 , pp. 1560-1567
    • Agesen, T.H.1    Sveen, A.2    Merok, M.A.3    Lind, G.E.4    Nesbakken, A.5    Skotheim, R.I.6    Lothe, R.A.7
  • 31
    • 84897104159 scopus 로고    scopus 로고
    • Genomic Health. Press release Genomic Health's Oncotype DX® Colon Cancer Test Predicts Individualized Recurrence Risk for Stage II Colon Cancer Patients. May 14. Available at:
    • Genomic Health. Press release Genomic Health's Oncotype DX® Colon Cancer Test Predicts Individualized Recurrence Risk for Stage II Colon Cancer Patients. May 14, 2009. Available at: http://investor.genomichealth.com/releasedetail.cfm?ReleaseID=384226.
    • (2009)
  • 32
    • 84879469711 scopus 로고    scopus 로고
    • Molecular pathways: Extracting medical knowledge from high throughput genomic data
    • Goldstein T., Paull E.O., Ellis M.J., Stuart J.M. Molecular pathways: Extracting medical knowledge from high throughput genomic data. Clin. Cancer Res. 2013, 19:3114-3120.
    • (2013) Clin. Cancer Res. , vol.19 , pp. 3114-3120
    • Goldstein, T.1    Paull, E.O.2    Ellis, M.J.3    Stuart, J.M.4
  • 35
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Network Cancer.Genome.Atlas. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012, 487:330-337.
    • (2012) Nature , vol.487 , pp. 330-337
    • Network, C.1
  • 37
    • 35448992849 scopus 로고    scopus 로고
    • Blood markers for early detection of colorectal cancer: a systematic review
    • Hundt S., Haug U., Brenner H. Blood markers for early detection of colorectal cancer: a systematic review. Cancer Epidemiol. Biomarkers Prev. 2007, 16:1935-1953.
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , pp. 1935-1953
    • Hundt, S.1    Haug, U.2    Brenner, H.3
  • 38
    • 33750102527 scopus 로고    scopus 로고
    • CEA monitoring in colorectal cancer. What you should know
    • Fakih M.G., Padmanabhan A. CEA monitoring in colorectal cancer. What you should know. Oncology (Williston Park) 2006, 20:579-587.
    • (2006) Oncology (Williston Park) , vol.20 , pp. 579-587
    • Fakih, M.G.1    Padmanabhan, A.2
  • 39
    • 0032845735 scopus 로고    scopus 로고
    • Carcinoembryonic antigen screening: pros and cons
    • Macdonald J.S. Carcinoembryonic antigen screening: pros and cons. Semin. Oncol. 1999, 26:556-560.
    • (1999) Semin. Oncol. , vol.26 , pp. 556-560
    • Macdonald, J.S.1
  • 40
    • 0035059972 scopus 로고    scopus 로고
    • Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful?
    • Duffy M.J. Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful?. Clin. Chem. 2001, 47:624-630.
    • (2001) Clin. Chem. , vol.47 , pp. 624-630
    • Duffy, M.J.1
  • 41
    • 0022657730 scopus 로고
    • Carcinoembryonic antigen
    • Fletcher R.H. Carcinoembryonic antigen. Ann. Intern. Med. 1986, 104:66-73.
    • (1986) Ann. Intern. Med. , vol.104 , pp. 66-73
    • Fletcher, R.H.1
  • 42
    • 33846595479 scopus 로고    scopus 로고
    • ASCO 2006 Update of recommendations for the use of tumor markers in gastrointestinal cancer
    • Locker G.Y., Hamilton S., Harris J. ASCO 2006 Update of recommendations for the use of tumor markers in gastrointestinal cancer. J. Clin. Oncol. 2006, 24(2006):5313-5327.
    • (2006) J. Clin. Oncol. , vol.24 , Issue.2006 , pp. 5313-5327
    • Locker, G.Y.1    Hamilton, S.2    Harris, J.3
  • 43
    • 0037375994 scopus 로고    scopus 로고
    • Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines
    • Duffy M.J., van Dalen A., Haglund C., et al. Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines. Eur. J. Cancer 2003, 39:718-727.
    • (2003) Eur. J. Cancer , vol.39 , pp. 718-727
    • Duffy, M.J.1    van Dalen, A.2    Haglund, C.3
  • 44
    • 33746490800 scopus 로고    scopus 로고
    • CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis
    • Sagiv E., Memeo L., Karin A., et al. CD24 is a new oncogene, early at the multistep process of colorectal cancer carcinogenesis. Gastroenterology 2006, 131:630-639.
    • (2006) Gastroenterology , vol.131 , pp. 630-639
    • Sagiv, E.1    Memeo, L.2    Karin, A.3
  • 45
    • 78649274495 scopus 로고    scopus 로고
    • Blood-based peptide, genetic, and epigenetic biomarkers for diagnosing gastrointestinal cancers
    • Kraus S., Goel A., Arber N. Blood-based peptide, genetic, and epigenetic biomarkers for diagnosing gastrointestinal cancers. Expert Opin. Med. Diagn. 2010, 4:459-471.
    • (2010) Expert Opin. Med. Diagn. , vol.4 , pp. 459-471
    • Kraus, S.1    Goel, A.2    Arber, N.3
  • 46
    • 24744451447 scopus 로고    scopus 로고
    • Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer
    • Goldstein M.J., Mitchell E.P. Carcinoembryonic antigen in the staging and follow-up of patients with colorectal cancer. Cancer Invest. 2005, 23:338-351.
    • (2005) Cancer Invest. , vol.23 , pp. 338-351
    • Goldstein, M.J.1    Mitchell, E.P.2
  • 47
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: past, present and future
    • Yoo C.B., Jones P.A. Epigenetic therapy of cancer: past, present and future. Nat. Rev. Drug Discov. 2006, 5:37-50.
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 48
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird P.W. The power and the promise of DNA methylation markers. Nat. Rev. Cancer 2003, 3:253-266.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 49
    • 44849132638 scopus 로고    scopus 로고
    • Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer
    • Nagasaka T., Koi M., Kloor M., et al. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology 2008, 134:1950-1960.
    • (2008) Gastroenterology , vol.134 , pp. 1950-1960
    • Nagasaka, T.1    Koi, M.2    Kloor, M.3
  • 50
    • 0035117962 scopus 로고    scopus 로고
    • Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer
    • Grady W.M., Rajput A., Lutterbaugh J.D., Markowitz S.D. Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer. Cancer Res. 2001, 61:900-902.
    • (2001) Cancer Res. , vol.61 , pp. 900-902
    • Grady, W.M.1    Rajput, A.2    Lutterbaugh, J.D.3    Markowitz, S.D.4
  • 51
    • 27744526931 scopus 로고    scopus 로고
    • Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer
    • Leung W.K., To K.F., Man E.P., et al. Quantitative detection of promoter hypermethylation in multiple genes in the serum of patients with colorectal cancer. Am. J. Gastroenterol. 2005, 100:2274-2279.
    • (2005) Am. J. Gastroenterol. , vol.100 , pp. 2274-2279
    • Leung, W.K.1    To, K.F.2    Man, E.P.3
  • 52
    • 33846209151 scopus 로고    scopus 로고
    • Methylation of serum DNA is an independent prognostic marker in colorectal cancer
    • Wallner M., Herbst A., Behrens A., et al. Methylation of serum DNA is an independent prognostic marker in colorectal cancer. Clin. Cancer Res. 2006, 12:7347-7352.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 7347-7352
    • Wallner, M.1    Herbst, A.2    Behrens, A.3
  • 53
    • 70249147655 scopus 로고    scopus 로고
    • Sensitive digital quantification of DNA methylation in clinical samples
    • Li M., Chen W.D., Papadopoulos N., et al. Sensitive digital quantification of DNA methylation in clinical samples. Nat. Biotechnol. 2009, 27:858-863.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 858-863
    • Li, M.1    Chen, W.D.2    Papadopoulos, N.3
  • 54
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N. Engl. J. Med. 2008, 358:1148-1159.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 55
    • 79958116641 scopus 로고    scopus 로고
    • Genetic-based biomarkers and next-generation sequencing: the future of personalized care in colorectal cancer
    • Kim R.Y., Xu H., Myllykangas S., Ji H. Genetic-based biomarkers and next-generation sequencing: the future of personalized care in colorectal cancer. Per. Med. 2011, 8:331-345.
    • (2011) Per. Med. , vol.8 , pp. 331-345
    • Kim, R.Y.1    Xu, H.2    Myllykangas, S.3    Ji, H.4
  • 56
    • 77956309446 scopus 로고    scopus 로고
    • Genome-wide association studies of cancer
    • Stadler Z.K., Thom P., Robson M.E., et al. Genome-wide association studies of cancer. J. Clin. Oncol. 2010, 28:4255-4267.
    • (2010) J. Clin. Oncol. , vol.28 , pp. 4255-4267
    • Stadler, Z.K.1    Thom, P.2    Robson, M.E.3
  • 57
    • 58049221094 scopus 로고    scopus 로고
    • A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities
    • Garman K.S., Acharya C.R., Edelman E., et al. A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities. Proc. Natl Acad. Sci. USA 2008, 105:19432-19437.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 19432-19437
    • Garman, K.S.1    Acharya, C.R.2    Edelman, E.3
  • 63
    • 41349120334 scopus 로고    scopus 로고
    • A review of gene-drug interactions for nonsteroidal anti-inflammatory drug use in preventing colorectal neoplasia
    • Cross J.T., Poole E.M., Ulrich C.M. A review of gene-drug interactions for nonsteroidal anti-inflammatory drug use in preventing colorectal neoplasia. Pharmacogenomics J. 2008, 8:237-247.
    • (2008) Pharmacogenomics J. , vol.8 , pp. 237-247
    • Cross, J.T.1    Poole, E.M.2    Ulrich, C.M.3
  • 64
    • 34447328733 scopus 로고    scopus 로고
    • Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps
    • Poole E.M., Bigler J., Whitton J., Sibert J.G., Kulmacz R.J., Potter J.D., et al. Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps. Carcinogenesis 2007, 28:1259-1263.
    • (2007) Carcinogenesis , vol.28 , pp. 1259-1263
    • Poole, E.M.1    Bigler, J.2    Whitton, J.3    Sibert, J.G.4    Kulmacz, R.J.5    Potter, J.D.6
  • 67
    • 76149096488 scopus 로고    scopus 로고
    • Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma
    • A Publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
    • Poole E.M., Hsu L., Xiao L., Kulmacz R.J., Carlson C.S., Rabinovitch P.S., et al. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. Cancer Epidemiol. Biomarkers Prevention 2010, 19:547-557. A Publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
    • (2010) Cancer Epidemiol. Biomarkers Prevention , vol.19 , pp. 547-557
    • Poole, E.M.1    Hsu, L.2    Xiao, L.3    Kulmacz, R.J.4    Carlson, C.S.5    Rabinovitch, P.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.