Prevalence in the United States of aac(6′)-Ib-cr encoding a ciprofloxacin-modifying enzyme

Antimicrobial Agents and Chemotherapy

Volumn 50, Issue 11, 2006, Pages 3953-3955

  Park, Chi Hye ^a   Robicsek, Ari ^b   Jacoby, George A ^c   Sahm, Daniel ^d   Hooper, David C ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b EVANSTON NORTHWESTERN HEALTHCARE   (United States)

^c LAHEY HOSPITAL AND MEDICAL CENTER   (United States)

^d Focus Bio Inova Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; CEFTAZIDIME; CIPROFLOXACIN; ENZYME VARIANT; GENE PRODUCT;

AAC(6') IB CR; AAC(6') IB GENE; ADULT; AGED; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIUM ISOLATE; CONTROLLED STUDY; ENTEROBACTERIACEAE; ENZYME MODIFICATION; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; PROTEIN VARIANT; QNR GENE; UNITED STATES;

ACETYLTRANSFERASES; ANTI-BACTERIAL AGENTS; CIPROFLOXACIN; CROSS-SECTIONAL STUDIES; DRUG RESISTANCE, BACTERIAL; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; ESCHERICHIA COLI; KLEBSIELLA PNEUMONIAE; MICROBIAL SENSITIVITY TESTS; ODDS RATIO; UNITED STATES;

EID: 33750597138     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00915-06     Document Type: Article

References (13)

1. Casin, I., F. Bordon, P. Bertin, A. Coutrot, I. Podglajen, R. Brasseur, and E. Collatz. 1998. Aminoglycoside 6′-N-acetyltransferase variants of the Ib type with altered substrate profile in clinical isolates of Enterobacter cloacae and Citrobacter freundii. Antimicrob. Agents Chemother. 42:209-215.
2. Clinical and Laboratory Standards Institute. 2005. Performance standards for antimicrobial susceptibility testing; 15th informational supplement. CLSI/NCCLS M100-S15. Clinical and Laboratory Standards Institute, Wayne, Pa.
3. Hata, M., M. Suzuki, M. Matsumoto, M. Takahashi, K. Sato, S. Ibe, and K. Sakae. 2005. Cloning of a novel gene for quinolone resistance from a transferable plasmid in Shigella flexneri 2b. Antimicrob. Agents Chemother. 49:801-803.
4. Hooper, D. C. 1999. Mechanisms of quinolone resistance. Drug Resist. Updates 2:38-55.
5. Hooper, D. C. 2000. Mechanisms of action and resistance of older and newer fluoroquinolones. Clin. Infect. Dis. 31:S24-S28.
6. Jacoby, G. A., K. E. Walsh, D. M. Mills, V. J. Walker, H. Oh, A. Robicsek, and D. C. Hooper. 2006. qnrB, another plasmid-mediated gene for quinolone resistance. Antimicrob. Agents Chemother. 50:1178-1182.
7. Martínez-Martínez, L., A. Pascual, and G. A. Jacoby. 1998. Quinolone resistance from a transferable plasmid. Lancet 351:797-799.
8. Nordmann, P., and L. Poirel. 2005. Emergence of plasmid-mediated resistance to quinolones in Enterobacteriaceae. J. Antimicrob. Chemother. 56:463-469.
9. Robicsek, A., J. Strahilevitz, G. A. Jacoby, M. Macielag, D. Abbanat, K. Bush, and D. C. Hooper. 2006. Fluoroquinolone modifying enzyme: a novel adaptation of a common aminoglycoside acetyltransferase. Nat. Med. 12:83-88.
10. Robicsek, A., J. Strahilevitz, D. F. Sahm, G. A. Jacoby, and D. C. Hooper. 2006. qnr prevalence in ceftazidime-resistant Enterobacteriaceae isolates from the United States. Antimicrob. Agents Chemother. 50:2872-2874.
11. Tran, J. H., and G. A. Jacoby. 2002. Mechanism of plasmid-mediated quinolone resistance. Proc. Natl. Acad. Sci. USA 99:5638-5642.
12. Wang, M., D. F. Sahm, G. A. Jacoby, and D. C. Hooper. 2004. Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States. Antimicrob. Agents Chemother. 48:1295-1299.
13. Wang, M., J. H. Tran, G. A. Jacoby, Y. Zhang, F. Wang, and D. C. Hooper. 2003. Plasmid-mediated quinolone resistance in clinical isolates of Escherichia coli from Shanghai, China. Antimicrob. Agents Chemother. 47:2242-2248.