Serum MMP-8 and TIMP-1 in critically ill patients with acute respiratory failure: TIMP-1 is associated with increased 90-day mortality

Anesthesia and Analgesia

Volumn 118, Issue 4, 2014, Pages 790-798

  Hästbacka, Johanna ^a   Linko, Rita ^a   Tervahartiala, Taina ^b   Varpula, Tero ^a   Hovilehto, Seppo ^c   Parviainen, Ilkka ^d   Vaara, Suvi T ^a   Sorsa, Timo ^b   Pettilä, Ville ^a  

^a JORVI HOSPITAL   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c SOUTH KARELIA CENTRAL HOSPITAL   (Finland)

^d KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTROPHIL COLLAGENASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1;

ABDOMINAL AORTA ANEURYSM; ACUTE RESPIRATORY FAILURE; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AREA UNDER THE CURVE; ARTIFICIAL VENTILATION; COMPARATIVE STUDY; CONFERENCE PAPER; CORRELATION ANALYSIS; CRITICALLY ILL PATIENT; DISEASE COURSE; DISEASE SEVERITY; ELECTIVE SURGERY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTROINTESTINAL TUMOR; GENERAL CONDITION DETERIORATION; HEART DISEASE; HUMAN; HYPOXEMIA; IMMUNOASSAY; IMMUNOFLUOROMETRY; INTENSIVE CARE UNIT; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEOPLASM; OBSERVATIONAL STUDY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; SEPSIS; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; SIMPLIFIED ACUTE PHYSIOLOGY SCORE; TRACHEAL ASPIRATION PROCEDURE;

ACUTE DISEASE; AGED; BIOLOGICAL MARKERS; COHORT STUDIES; CRITICAL ILLNESS; CROSS INFECTION; EMERGENCY MEDICAL SERVICES; ENDPOINT DETERMINATION; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; MATRIX METALLOPROTEINASE 8; MIDDLE AGED; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; RESPIRATORY FUNCTION TESTS; RESPIRATORY INSUFFICIENCY; ROC CURVE; SEPSIS; SURGICAL PROCEDURES, ELECTIVE; SURVIVORS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 84896993554     PISSN: 00032999     EISSN: 15267598     Source Type: Journal    
DOI: 10.1213/ANE.0000000000000120     Document Type: Conference Paper

References (51)

1. Vincent JL, Akca S, De Mendonca A, Haji-Michael P, Sprung C, Moreno R, Antonelli M, Suter PM. The epidemiology of acute respiratory failure in critically ill patients. Chest 2002;121: 1602-9
2. Ranieri VM, Rubenfeld GD, Thompson BT, Ferguson ND, Caldwell E, Fan E, Camporota L, Slutsky AS. Acute respiratory distress syndrome: the Berlin definition. JAMA 2012;307: 2526-33
3. Grommes J, Soehnlein O. Contribution of neutrophils to acute lung injury. Mol Med 2011;17: 293-307
4. Owen CA, Campbell EJ. The cell biology of leukocyte-mediated proteolysis. J Leukoc Biol 1999;65: 137-50
5. Sternlicht MD, Werb Z. How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001;17: 463-516
6. Van Lint P, Libert C. Matrix metalloproteinase-8: cleavage can be decisive. Cytokine Growth Factor Rev 2006;17: 217-23
7. Vanlaere I, Libert C. Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock. Clin Microbiol Rev 2009;22: 224-39
8. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res 2003;92: 827-39
9. Elkington PT, O'Kane CM, Friedland JS. The paradox of matrix metalloproteinases in infectious disease. Clin Exp Immunol 2005;142: 12-20
10. Kong MY, Li Y, Oster R, Gaggar A, Clancy JP. Early elevation of matrix metalloproteinase-8 and -9 in pediatric ARDS is associated with an increased risk of prolonged mechanical ventilation. PLoS One 2011;6:e22596
11. Hoffmann U, Bertsch T, Dvortsak E, Liebetrau C, Lang S, Liebe V, Huhle G, Borggrefe M, Brueckmann M. Matrix- metalloproteinases and their inhibitors are elevated in severe sepsis: prognostic value of TIMP-1 in severe sepsis. Scand J Infect Dis 2006;38: 867-72
12. Lauhio A, Hästbacka J, Pettilä V, Tervahartiala T, Karlsson S, Varpula T, Varpula M, Ruokonen E, Sorsa T, Kolho E. Serum MMP-8, -9 and TIMP-1 in sepsis: high serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines. Pharmacol Res 2011;64: 590-4
13. Lorente L, Martín MM, Labarta L, Díaz C, Solé-Violán J, Blanquer J, Orbe J, Rodríguez JA, Jiménez A, Borreguero-León JM, Belmonte F, Medina JC, Llimiñana MC, Ferrer-Agüero JM, Ferreres J, Mora ML, Lubillo S, Sánchez M, Barrios Y, Sierra A, Páramo JA. Matrix metalloproteinase-9, -10, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis. Crit Care 2009;13:R158
14. Davey A, McAuley DF, O'Kane CM. Matrix metalloproteinases in acute lung injury: mediators of injury and drivers of repair. Eur Respir J 2011;38: 959-70
15. Linko R, Okkonen M, Pettilä V, Perttilä J, Parviainen I, Ruokonen E, Tenhunen J, Ala-Kokko T, Varpula T. Acute respiratory failure in intensive care units. FINNALI: A prospective cohort study. Intensive Care Med 2009;35: 1352-61
16. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. The American- European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149: 818-24
17. Hanemaaijer R, Sorsa T, Konttinen YT, Ding Y, Sutinen M, Visser H, van Hinsbergh VW, Helaakoski T, Kainulainen T, Rönkä H, Tschesche H, Salo T. Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J Biol Chem 1997;272: 31504-9
18. Tuomainen AM, Nyyssönen K, Laukkanen JA, Tervahartiala T, Tuomainen TP, Salonen JT, Sorsa T, Pussinen PJ. Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men. Arterioscler Thromb Vasc Biol 2007;27: 2722-8
19. Divine G, Norton HJ, Hunt R, Dienemann J. A review of analysis and sample size calculation considerations for Wilcoxon tests. Anesth Analg 2013;117: 699-710
20. Youden WJ. Index for rating diagnostic tests. Cancer 1950;3: 32-5
21. Ricou B, Nicod L, Lacraz S, Welgus HG, Suter PM, Dayer JM. Matrix metalloproteinases and TIMP in acute respiratory distress syndrome. Am J Respir Crit Care Med 1996;154: 346-52
22. Lanchou J, Corbel M, Tanguy M, Germain N, Boichot E, Theret N, Clement B, Lagente V, Malledant Y. Imbalance between matrix metalloproteinases (MMP-9 and MMP-2) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in acute respiratory distress syndrome patients. Crit Care Med 2003;31: 536-42
23. Murate T, Hayakawa T. Multiple functions of tissue inhibitors of metalloproteinases (TIMPs): new aspects in hematopoiesis. Platelets 1999;10: 5-16
24. Lambert E, Dassé E, Haye B, Petitfrère E. TIMPs as multifacial proteins. Crit Rev Oncol Hematol 2004;49: 187-98
25. Guedez L, Stetler-Stevenson WG, Wolff L, Wang J, Fukushima P, Mansoor A, Stetler-Stevenson M. In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1. J Clin Invest 1998;102: 2002-10
26. Apparailly F, Noël D, Millet V, Baker AH, Lisignoli G, Jacquet C, Kaiser MJ, Sany J, Jorgensen C. Paradoxical effects of tissue inhibitor of metalloproteinases 1 gene transfer in collagen- induced arthritis. Arthritis Rheum 2001;44: 1444-54
27. Mostafa Mtairag E, Chollet-Martin S, Oudghiri M, Laquay N, Jacob MP, Michel JB, Feldman LJ. Effects of interleukin-10 on monocyte/endothelial cell adhesion and MMP-9/TIMP-1 secretion. Cardiovasc Res 2001;49: 882-90
28. Ward NS, Waxman AB, Homer RJ, Mantell LL, Einarsson O, Du Y, Elias JA. Interleukin-6-induced protection in hyperoxic acute lung injury. Am J Respir Cell Mol Biol 2000;22: 535-42
29. Veness-Meehan KA, Cheng ER, Mercier CE, Blixt SL, Johnston CJ, Watkins RH, Horowitz S. Cell-specific alterations in expression of hyperoxia-induced mRNAs of lung. Am J Respir Cell Mol Biol 1991;5: 516-21
30. Henke C, Marineili W, Jessurun J, Fox J, Harms D, Peterson M, Chiang L, Doran P. Macrophage production of basic fibroblast growth factor in the fibroproliferative disorder of alveolar fibrosis after lung injury. Am J Pathol 1993;143: 1189-99
31. Walsh J, Absher M, Kelley J. Variable expression of platelet- derived growth factor family proteins in acute lung injury. Am J Respir Cell Mol Biol 1993;9: 637-44
32. Pardo A, Barrios R, Maldonado V, Meléndez J, Pérez J, Ruiz V, Segura-Valdez L, Sznajder JI, Selman M. Gelatinases A and B are up-regulated in rat lungs by subacute hyperoxia: pathogenetic implications. Am J Pathol 1998;153: 833-44
33. Moore R, Hawley A, Sigler R, Farris D, Wrobleski S, Ramacciotti E, Myers D. Tissue inhibitor of metalloproteinase-1 is an early marker of acute endothelial dysfunction in a rodent model of venous oxidative injury. Ann Vasc Surg 2009;23: 498-505
34. Fligiel SE, Standiford T, Fligiel HM, Tashkin D, Strieter RM, Warner RL, Johnson KJ, Varani J. Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury. Hum Pathol 2006;37: 422-30
35. Hartog CM, Wermelt JA, Sommerfeld CO, Eichler W, Dalhoff K, Braun J. Pulmonary matrix metalloproteinase excess in hospital-acquired pneumonia. Am J Respir Crit Care Med 2003;167: 593-8
36. O'Kane CM, McKeown SW, Perkins GD, Bassford CR, Gao F, Thickett DR, McAuley DF. Salbutamol up-regulates matrix metalloproteinase-9 in the alveolar space in the acute respiratory distress syndrome. Crit Care Med 2009;37: 2242-9
37. Hästbacka J, Hynninen M, Kolho E, Pettilä V, Tervahartiala T, Sorsa T, Lauhio A. Collagenase 2/matrix metalloproteinase 8 in critically ill patients with secondary peritonitis. Shock 2007;27: 145-50
38. Ratjen F, Hartog CM, Paul K, Wermelt J, Braun J. Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alpha. Thorax 2002;57: 930-4
39. Segura-Valdez L, Pardo A, Gaxiola M, Uhal BD, Becerril C, Selman M. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest 2000;117: 684-94
40. Sepper R, Konttinen YT, Ding Y, Takagi M, Sorsa T. Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease. Chest 1995;107: 1641-7
41. Yao PM, Maitre B, Delacourt C, Buhler JM, Harf A, Lafuma C. Divergent regulation of 92-kDa gelatinase and TIMP-1 by HBECs in response to IL-1beta and TNF-alpha. Am J Physiol 1997;273:L866-74
42. Overall CM. Regulation of tissue inhibitor of matrix metalloproteinase expression. Ann N Y Acad Sci 1994;732: 51-64
43. Sottrup-Jensen L, Birkedal-Hansen H. Human fibroblast collagenase- alpha-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian alpha- macroglobulins. J Biol Chem 1989;264: 393-401
44. Owen CA, Hu Z, Lopez-Otin C, Shapiro SD. Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase. J Immunol 2004;172: 7791-803
45. Albaiceta GM, Gutierrez-Fernández A, García-Prieto E, Puente XS, Parra D, Astudillo A, Campestre C, Cabrera S, Gonzalez- Lopez A, Fueyo A, Taboada F, López-Otin C. Absence or inhibition of matrix metalloproteinase-8 decreases ventilator- induced lung injury. Am J Respir Cell Mol Biol 2010;43: 555-63
46. Albaiceta GM, Gutiérrez-Fernández A, Parra D, Astudillo A, García-Prieto E, Taboada F, Fueyo A. Lack of matrix metalloproteinase- 9 worsens ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2008;294:L535-43
47. Calfee C, Ware L, Glidden D, Eisner M, Parsons P, Thompson B, Matthay M; National heart, blood, and lung institute acute respiratory distress network: Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med 2011;39: 711-7
48. Kelly D, Squire IB, Khan SQ, Dhillon O, Narayan H, Ng KH, Quinn P, Davies JE, Ng LL. Usefulness of plasma tissue inhibitors of metalloproteinases as markers of prognosis after acute myocardial infarction. Am J Cardiol 2010;106: 477-82
49. Cavusoglu E, Ruwende C, Chopra V, Yanamadala S, Eng C, Clark LT, Pinsky DJ, Marmur JD. Tissue inhibitor of metalloproteinase- 1 (TIMP-1) is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction. Am Heart J 2006;151: 1101.e1-8
50. Nichol A, Bailey M, Egi M, Pettila V, French C, Stachowski E, Reade MC, Cooper DJ, Bellomo R. Dynamic lactate indices as predictors of outcome in critically ill patients. Crit Care 2011;15:R242
51. Haase M, Bellomo R, Devarajan P, Ma Q, Bennett MR, Möckel M, Matalanis G, Dragun D, Haase-Fielitz A. Novel biomarkers early predict the severity of acute kidney injury after cardiac surgery in adults. Ann Thorac Surg 2009;88: 124-30