-
1
-
-
0003269455
-
A G protein-coupled receptor responsive to bile acids
-
DOI 10.1074/jbc.M209706200
-
Kawamata, Y., Fujii, R., Hosoya, M., Harada, M., Yoshida, H., Miwa, M., Fukusumi, S., Habata, Y., Itoh, T., Shintani, Y. et al. (2003) A G protein-coupled receptor responsive to bile acids. J. Biol. Chem. 278, 9435-9440 (Pubitemid 36800434)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.11
, pp. 9435-9440
-
-
Kawamata, Y.1
Fujii, R.2
Hosoya, M.3
Harada, M.4
Yoshida, H.5
Miwa, M.6
Fukusumi, S.7
Habata, Y.8
Itoh, T.9
Shintani, Y.10
Hinuma, S.11
Fujisawa, Y.12
Fujino, M.13
-
2
-
-
0036432845
-
Identification of membrane-type receptor for bile acids (M-BAR)
-
DOI 10.1016/S0006-291X(02)02550-0, PII S0006291X02025500
-
Maruyama, T., Miyamoto, Y., Nakamura, T., Tamai, Y., Okada, H., Sugiyama, E., Nakamura, T., Itadani, H. and Tanaka, K. (2002) Identification of membrane-type receptor for bile acids (M-BAR). Biochem. Biophys. Res. Commun. 298, 714-719 (Pubitemid 35356798)
-
(2002)
Biochemical and Biophysical Research Communications
, vol.298
, Issue.5
, pp. 714-719
-
-
Maruyama, T.1
Miyamoto, Y.2
Nakamura, T.3
Tamai, Y.4
Okada, H.5
Sugiyama, E.6
Nakamura, T.7
Itadani, H.8
Tanaka, K.9
-
3
-
-
79956088562
-
The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
-
Pols, T.W., Noriega, L.G., Nomura, M., Auwerx, J. and Schoonjans, K. (2011) The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation. J. Hepatol. 54, 1263-1272
-
(2011)
J. Hepatol.
, vol.54
, pp. 1263-1272
-
-
Pols, T.W.1
Noriega, L.G.2
Nomura, M.3
Auwerx, J.4
Schoonjans, K.5
-
4
-
-
84868360297
-
Perspective: TGR5 (Gpbar-1) in liver physiology and disease
-
Keitel, V. and Haussinger, D. (2012) Perspective: TGR5 (Gpbar-1) in liver physiology and disease. Clin. Res. Hepatol. Gastroenterol. 36, 412-419
-
(2012)
Clin. Res. Hepatol. Gastroenterol.
, vol.36
, pp. 412-419
-
-
Keitel, V.1
Haussinger, D.2
-
5
-
-
48749113401
-
Targeting bile-acid signalling for metabolic diseases
-
Thomas, C., Pellicciari, R., Pruzanski, M., Auwerx, J. and Schoonjans, K. (2008) Targeting bile-acid signalling for metabolic diseases. Nat. Rev. Drug Discov. 7, 678-693
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 678-693
-
-
Thomas, C.1
Pellicciari, R.2
Pruzanski, M.3
Auwerx, J.4
Schoonjans, K.5
-
6
-
-
58249110568
-
Role of bile acids and bile acid receptors in metabolic regulation
-
Lefebvre, P., Cariou, B., Lien, F., Kuipers, F. and Staels, B. (2009) Role of bile acids and bile acid receptors in metabolic regulation. Physiol. Rev. 89, 147-191
-
(2009)
Physiol. Rev.
, vol.89
, pp. 147-191
-
-
Lefebvre, P.1
Cariou, B.2
Lien, F.3
Kuipers, F.4
Staels, B.5
-
7
-
-
31444454037
-
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
-
DOI 10.1038/nature04330, PII NATURE04330
-
Watanabe, M., Houten, S.M., Mataki, C., Christoffolete, M.A., Kim, B.W., Sato, H., Messaddeq, N., Harney, J.W., Ezaki, O., Kodama, T. et al. (2006) Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation. Nature 439, 484-489 (Pubitemid 43152840)
-
(2006)
Nature
, vol.439
, Issue.7075
, pp. 484-489
-
-
Watanabe, M.1
Houten, S.M.2
Mataki, C.3
Christoffolete, M.A.4
Kim, B.W.5
Sato, H.6
Messaddeq, N.7
Harney, J.W.8
Ezaki, O.9
Kodama, T.10
Schoonjans, K.11
Bianco, A.C.12
Auwerx, J.13
-
8
-
-
13844299425
-
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
-
DOI 10.1016/j.bbrc.2005.01.139
-
Katsuma, S., Hirasawa, A. and Tsujimoto, G. (2005) Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1. Biochem. Biophys. Res. Commun. 329, 386-390 (Pubitemid 40255465)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.329
, Issue.1
, pp. 386-390
-
-
Katsuma, S.1
Hirasawa, A.2
Tsujimoto, G.3
-
9
-
-
69149083245
-
TGR5-mediated bile acid sensing controls glucose homeostasis
-
Thomas, C., Gioiello, A., Noriega, L., Strehle, A., Oury, J., Rizzo, G., Macchiarulo, A., Yamamoto, H., Mataki, C., Pruzanski, M. et al. (2009) TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 10, 167-177
-
(2009)
Cell Metab.
, vol.10
, pp. 167-177
-
-
Thomas, C.1
Gioiello, A.2
Noriega, L.3
Strehle, A.4
Oury, J.5
Rizzo, G.6
Macchiarulo, A.7
Yamamoto, H.8
Mataki, C.9
Pruzanski, M.10
-
10
-
-
84861682490
-
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
-
Harach, T., Pols, T.W., Nomura, M., Maida, A., Watanabe, M., Auwerx, J. and Schoonjans, K. (2012) TGR5 potentiates GLP-1 secretion in response to anionic exchange resins. Sci. Rep. 2, 430
-
(2012)
Sci. Rep.
, vol.2
, pp. 430
-
-
Harach, T.1
Pols, T.W.2
Nomura, M.3
Maida, A.4
Watanabe, M.5
Auwerx, J.6
Schoonjans, K.7
-
11
-
-
77956276608
-
Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels
-
Lavoie, B., Balemba, O.B., Godfrey, C., Watson, C.A., Vassileva, G., Corvera, C.U., Nelson, M.T. and Mawe, G.M. (2010) Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels. J. Physiol. 588, 3295-3305
-
(2010)
J. Physiol.
, vol.588
, pp. 3295-3305
-
-
Lavoie, B.1
Balemba, O.B.2
Godfrey, C.3
Watson, C.A.4
Vassileva, G.5
Corvera, C.U.6
Nelson, M.T.7
Mawe, G.M.8
-
12
-
-
79957663467
-
The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling
-
Li, T., Holmstrom, S.R., Kir, S., Umetani, M., Schmidt, D.R., Kliewer, S.A. and Mangelsdorf, D.J. (2011) The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Mol. Endocrinol. 25, 1066-1071
-
(2011)
Mol. Endocrinol.
, vol.25
, pp. 1066-1071
-
-
Li, T.1
Holmstrom, S.R.2
Kir, S.3
Umetani, M.4
Schmidt, D.R.5
Kliewer, S.A.6
Mangelsdorf, D.J.7
-
13
-
-
70349255713
-
The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders
-
Keitel, V., Cupisti, K., Ullmer, C., Knoefel, W.T., Kubitz, R. and Haussinger, D. (2009) The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders. Hepatology 50, 861-870
-
(2009)
Hepatology
, vol.50
, pp. 861-870
-
-
Keitel, V.1
Cupisti, K.2
Ullmer, C.3
Knoefel, W.T.4
Kubitz, R.5
Haussinger, D.6
-
14
-
-
77954569180
-
The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
-
Keitel, V., Ullmer, C. and Haussinger, D. (2010) The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes. Biol. Chem. 391, 785-789
-
(2010)
Biol. Chem.
, vol.391
, pp. 785-789
-
-
Keitel, V.1
Ullmer, C.2
Haussinger, D.3
-
15
-
-
33748757234
-
Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation
-
DOI 10.1042/BJ20060537
-
Vassileva, G., Golovko, A., Markowitz, L., Abbondanzo, S.J., Zeng, M., Yang, S., Hoos, L., Tetzloff, G., Levitan, D., Murgolo, N.J. et al. (2006) Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochem. J. 398, 423-430 (Pubitemid 44453386)
-
(2006)
Biochemical Journal
, vol.398
, Issue.3
, pp. 423-430
-
-
Vassileva, G.1
Golovko, A.2
Markowitz, L.3
Abbondanzo, S.J.4
Zeng, M.5
Yang, S.6
Hoos, L.7
Tetzloff, G.8
Levitan, D.9
Murgolo, N.J.10
Keane, K.11
Davis Jr., H.R.12
Hedrick, J.13
Gustafson, E.L.14
-
16
-
-
77149120776
-
Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma
-
Hong, J., Behar, J., Wands, J., Resnick, M., Wang, L.J., DeLellis, R.A., Lambeth, D., Souza, R.F., Spechler, S.J. and Cao, W. (2010) Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma. Gut 59, 170-180
-
(2010)
Gut
, vol.59
, pp. 170-180
-
-
Hong, J.1
Behar, J.2
Wands, J.3
Resnick, M.4
Wang, L.J.5
DeLellis, R.A.6
Lambeth, D.7
Souza, R.F.8
Spechler, S.J.9
Cao, W.10
-
17
-
-
41149144697
-
Novel potent and selective bile acid derivatives as TGR5 agonists: Biological screening, structure-activity relationships, and molecular modeling studies
-
DOI 10.1021/jm7015864
-
Sato, H., Macchiarulo, A., Thomas, C., Gioiello, A., Une, M., Hofmann, A.F., Saladin, R., Schoonjans, K., Pellicciari, R. and Auwerx, J. (2008) Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies. J. Med. Chem. 51, 1831-1841 (Pubitemid 351438866)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.6
, pp. 1831-1841
-
-
Sato, H.1
Macchiarulo, A.2
Thomas, C.3
Gioiello, A.4
Une, M.5
Hofmann, A.F.6
Saladin, R.7
Schoonjans, K.8
Pellicciari, R.9
Auwerx, J.10
-
18
-
-
77952698279
-
Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor
-
Iguchi, Y., Yamaguchi, M., Sato, H., Kihira, K., Nishimaki-Mogami, T. and Une, M. (2010) Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor. J. Lipid Res. 51, 1432-1441
-
(2010)
J. Lipid Res.
, vol.51
, pp. 1432-1441
-
-
Iguchi, Y.1
Yamaguchi, M.2
Sato, H.3
Kihira, K.4
Nishimaki-Mogami, T.5
Une, M.6
-
19
-
-
34548611093
-
Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea
-
DOI 10.1016/j.bbrc.2007.06.130, PII S0006291X07013538
-
Sato, H., Genet, C., Strehle, A., Thomas, C., Lobstein, A., Wagner, A., Mioskowski, C., Auwerx, J. and Saladin, R. (2007) Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea. Biochem. Biophys. Res. Commun. 362, 793-798 (Pubitemid 47398870)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.362
, Issue.4
, pp. 793-798
-
-
Sato, H.1
Genet, C.2
Strehle, A.3
Thomas, C.4
Lobstein, A.5
Wagner, A.6
Mioskowski, C.7
Auwerx, J.8
Saladin, R.9
-
20
-
-
74849119709
-
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: Potential impact in diabetes
-
Genet, C., Strehle, A., Schmidt, C., Boudjelal, G., Lobstein, A., Schoonjans, K., Souchet, M., Auwerx, J., Saladin, R. and Wagner, A. (2010) Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J. Med. Chem. 53, 178-190
-
(2010)
J. Med. Chem.
, vol.53
, pp. 178-190
-
-
Genet, C.1
Strehle, A.2
Schmidt, C.3
Boudjelal, G.4
Lobstein, A.5
Schoonjans, K.6
Souchet, M.7
Auwerx, J.8
Saladin, R.9
Wagner, A.10
-
21
-
-
78651487587
-
Redefining the TGR5 triterpenoid binding pocket at the C-3 position
-
Genet, C., Schmidt, C., Strehle, A., Schoonjans, K., Auwerx, J., Saladin, R. and Wagner, A. (2010) Redefining the TGR5 triterpenoid binding pocket at the C-3 position. ChemMedChem 5, 1983-1988
-
(2010)
ChemMedChem
, vol.5
, pp. 1983-1988
-
-
Genet, C.1
Schmidt, C.2
Strehle, A.3
Schoonjans, K.4
Auwerx, J.5
Saladin, R.6
Wagner, A.7
-
22
-
-
78649386642
-
The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain
-
Keitel, V., Gorg, B., Bidmon, H.J., Zemtsova, I., Spomer, L., Zilles, K. and Haussinger, D. (2010) The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain. Glia 58, 1794-1805
-
(2010)
Glia
, vol.58
, pp. 1794-1805
-
-
Keitel, V.1
Gorg, B.2
Bidmon, H.J.3
Zemtsova, I.4
Spomer, L.5
Zilles, K.6
Haussinger, D.7
-
23
-
-
84890471058
-
Probing the binding site of bile acids in TGR5
-
Macchiarulo, A., Gioiello, A., Thomas, C., Pols, T.W., Nuti, R., Ferrari, C., Giacchè, N., De Franco, F., Pruzanski, M., Auwerx, J. et al. (2013) Probing the binding site of bile acids in TGR5. ACS Med. Chem. Lett. 4, 1158-1162
-
(2013)
ACS Med. Chem. Lett.
, vol.4
, pp. 1158-1162
-
-
Macchiarulo, A.1
Gioiello, A.2
Thomas, C.3
Pols, T.W.4
Nuti, R.5
Ferrari, C.6
Giacchè, N.7
De Franco, F.8
Pruzanski, M.9
Auwerx, J.10
-
24
-
-
84881464516
-
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts
-
Jensen, D.D., Godfrey, C.B., Niklas, C., Canals, M., Kocan, M., Poole, D.P., Murphy, J.E., Alemi, F., Cottrell, G.S., Korbmacher, C. et al. (2013) The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts. J. Biol. Chem. 288, 22942-22960
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 22942-22960
-
-
Jensen, D.D.1
Godfrey, C.B.2
Niklas, C.3
Canals, M.4
Kocan, M.5
Poole, D.P.6
Murphy, J.E.7
Alemi, F.8
Cottrell, G.S.9
Korbmacher, C.10
-
25
-
-
33846345695
-
Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells
-
DOI 10.1016/j.bbrc.2006.12.168, PII S0006291X06028439
-
Yasuda, H., Hirata, S., Inoue, K., Mashima, H., Ohnishi, H. and Yoshiba, M. (2007) Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. Biochem. Biophys. Res. Commun. 354, 154-159 (Pubitemid 46131451)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.354
, Issue.1
, pp. 154-159
-
-
Yasuda, H.1
Hirata, S.2
Inoue, K.3
Mashima, H.4
Ohnishi, H.5
Yoshiba, M.6
-
26
-
-
44649092024
-
Expression and function of the bile acid receptor TGR5 in Kupffer cells
-
DOI 10.1016/j.bbrc.2008.04.171, PII S0006291X08008619
-
Keitel, V., Donner, M., Winandy, S., Kubitz, R. and Haussinger, D. (2008) Expression and function of the bile acid receptor TGR5 in Kupffer cells. Biochem. Biophys. Res. Commun. 372, 78-84 (Pubitemid 351778164)
-
(2008)
Biochemical and Biophysical Research Communications
, vol.372
, Issue.1
, pp. 78-84
-
-
Keitel, V.1
Donner, M.2
Winandy, S.3
Kubitz, R.4
Haussinger, D.5
-
27
-
-
73249142867
-
Discovery of 6α-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity
-
Pellicciari, R., Gioiello, A., Macchiarulo, A., Thomas, C., Rosatelli, E., Natalini, B., Sardella, R., Pruzanski, M., Roda, A., Pastorini, E. et al. (2009) Discovery of 6α-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J. Med. Chem. 52, 7958-7961
-
(2009)
J. Med. Chem.
, vol.52
, pp. 7958-7961
-
-
Pellicciari, R.1
Gioiello, A.2
Macchiarulo, A.3
Thomas, C.4
Rosatelli, E.5
Natalini, B.6
Sardella, R.7
Pruzanski, M.8
Roda, A.9
Pastorini, E.10
-
28
-
-
82955168360
-
TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading
-
Pols, T.W., Nomura, M., Harach, T., Lo, S.G., Oosterveer, M.H., Thomas, C., Rizzo, G., Gioiello, A., Adorini, L., Pellicciari, R. et al. (2011) TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. Cell Metab. 14, 747-757
-
(2011)
Cell Metab.
, vol.14
, pp. 747-757
-
-
Pols, T.W.1
Nomura, M.2
Harach, T.3
Lo, S.G.4
Oosterveer, M.H.5
Thomas, C.6
Rizzo, G.7
Gioiello, A.8
Adorini, L.9
Pellicciari, R.10
-
29
-
-
80053308007
-
The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice
-
Wang, Y.D., Chen, W.D., Yu, D., Forman, B.M. and Huang, W. (2011) The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology 54, 1421-1432
-
(2011)
Hepatology
, vol.54
, pp. 1421-1432
-
-
Wang, Y.D.1
Chen, W.D.2
Yu, D.3
Forman, B.M.4
Huang, W.5
-
30
-
-
80055090450
-
The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis
-
Cipriani, S., Mencarelli, A., Chini, M.G., Distrutti, E., Renga, B., Bifulco, G., Baldelli, F., Donini, A. and Fiorucci, S. (2011) The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis. PLoS ONE 6, e25637
-
(2011)
PLoS ONE
, vol.6
-
-
Cipriani, S.1
Mencarelli, A.2
Chini, M.G.3
Distrutti, E.4
Renga, B.5
Bifulco, G.6
Baldelli, F.7
Donini, A.8
Fiorucci, S.9
-
31
-
-
84888798215
-
Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages
-
Haselow, K., Bode, J.G., Wammers, M., Ehlting, C., Keitel, V., Kleinebrecht, L., Schupp, A.K., Haussinger, D. and Graf, D. (2013) Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages. J. Leukoc. Biol. 94, 1253-1264
-
(2013)
J. Leukoc. Biol.
, vol.94
, pp. 1253-1264
-
-
Haselow, K.1
Bode, J.G.2
Wammers, M.3
Ehlting, C.4
Keitel, V.5
Kleinebrecht, L.6
Schupp, A.K.7
Haussinger, D.8
Graf, D.9
-
32
-
-
84876041065
-
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease
-
Yoneno, K., Hisamatsu, T., Shimamura, K., Kamada, N., Ichikawa, R., Kitazume, M.T., Mori, M., Uo, M., Namikawa, Y., Matsuoka, K. et al. (2013) TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease. Immunology 139, 19-29
-
(2013)
Immunology
, vol.139
, pp. 19-29
-
-
Yoneno, K.1
Hisamatsu, T.2
Shimamura, K.3
Kamada, N.4
Ichikawa, R.5
Kitazume, M.T.6
Mori, M.7
Uo, M.8
Namikawa, Y.9
Matsuoka, K.10
-
33
-
-
84860253913
-
Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway
-
Ichikawa, R., Takayama, T., Yoneno, K., Kamada, N., Kitazume, M.T., Higuchi, H., Matsuoka, K., Watanabe, M., Itoh, H., Kanai, T. et al. (2012) Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway. Immunology 136, 153-162
-
(2012)
Immunology
, vol.136
, pp. 153-162
-
-
Ichikawa, R.1
Takayama, T.2
Yoneno, K.3
Kamada, N.4
Kitazume, M.T.5
Higuchi, H.6
Matsuoka, K.7
Watanabe, M.8
Itoh, H.9
Kanai, T.10
-
34
-
-
33947383769
-
The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells
-
DOI 10.1002/hep.21458
-
Keitel, V., Reinehr, R., Gatsios, P., Rupprecht, C., Gorg, B., Selbach, O., Haussinger, D. and Kubitz, R. (2007) The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells. Hepatology 45, 695-704 (Pubitemid 46450621)
-
(2007)
Hepatology
, vol.45
, Issue.3
, pp. 695-704
-
-
Keitel, V.1
Reinehr, R.2
Gatsios, P.3
Rupprecht, C.4
Gorg, B.5
Selbach, O.6
Haussinger, D.7
Kubitz, R.8
-
35
-
-
84879103477
-
Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells
-
Kida, T., Tsubosaka, Y., Hori, M., Ozaki, H. and Murata, T. (2013) Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells. Arterioscler. Thromb. Vasc. Biol. 33, 1663-1669
-
(2013)
Arterioscler. Thromb. Vasc. Biol.
, vol.33
, pp. 1663-1669
-
-
Kida, T.1
Tsubosaka, Y.2
Hori, M.3
Ozaki, H.4
Murata, T.5
-
36
-
-
84879569545
-
Immune effector mechanisms implicated in atherosclerosis: From mice to humans
-
Libby, P., Lichtman, A.H. and Hansson, G.K. (2013) Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Immunity 38, 1092-1104
-
(2013)
Immunity
, vol.38
, pp. 1092-1104
-
-
Libby, P.1
Lichtman, A.H.2
Hansson, G.K.3
-
37
-
-
77957674664
-
Postprandial plasma bile acid responses in normal weight and obese subjects
-
Glicksman, C., Pournaras, D.J., Wright, M., Roberts, R., Mahon, D., Welbourn, R., Sherwood, R., Alaghband-Zadeh, J. and le Roux, C.W. (2010) Postprandial plasma bile acid responses in normal weight and obese subjects. Ann. Clin. Biochem. 47, 482-484
-
(2010)
Ann. Clin. Biochem.
, vol.47
, pp. 482-484
-
-
Glicksman, C.1
Pournaras, D.J.2
Wright, M.3
Roberts, R.4
Mahon, D.5
Welbourn, R.6
Sherwood, R.7
Alaghband-Zadeh, J.8
Le Roux, C.W.9
-
38
-
-
81155153943
-
Bile acid metabolites in serum: Intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitus
-
Steiner, C., Othman, A., Saely, C.H., Rein, P., Drexel, H., von, E.A. and Rentsch, K.M. (2011) Bile acid metabolites in serum: intraindividual variation and associations with coronary heart disease, metabolic syndrome and diabetes mellitus. PLoS ONE 6, e25006
-
(2011)
PLoS ONE
, vol.6
-
-
Steiner, C.1
Othman, A.2
Saely, C.H.3
Rein, P.4
Drexel, H.5
Von, E.A.6
Rentsch, K.M.7
-
39
-
-
84870526387
-
Crosstalk between the hepatologist and the cardiologist: A future place for the lithocholic acid as a coronary atheroma risk factor?
-
Duboc, H., Aelion, H., Rainteau, D., Rajca, S., Sokol, H., Humbert, L., Farabos, D., Coffin, B., Weber, S., Porcher, R. et al. (2012) Crosstalk between the hepatologist and the cardiologist: a future place for the lithocholic acid as a coronary atheroma risk factor? Hepatology 56, 2426
-
(2012)
Hepatology
, vol.56
, pp. 2426
-
-
Duboc, H.1
Aelion, H.2
Rainteau, D.3
Rajca, S.4
Sokol, H.5
Humbert, L.6
Farabos, D.7
Coffin, B.8
Weber, S.9
Porcher, R.10
-
40
-
-
77957877682
-
Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis
-
Hov, J.R., Keitel, V., Laerdahl, J.K., Spomer, L., Ellinghaus, E., ElSharawy, A., Melum, E., Boberg, K.M., Manke, T., Balschun, T. et al. (2010) Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis. PLoS ONE 5, e12403
-
(2010)
PLoS ONE
, vol.5
-
-
Hov, J.R.1
Keitel, V.2
Laerdahl, J.K.3
Spomer, L.4
Ellinghaus, E.5
ElSharawy, A.6
Melum, E.7
Boberg, K.M.8
Manke, T.9
Balschun, T.10
-
41
-
-
84884644197
-
Are GPCRs still a source of new targets?
-
Garland, S.L. (2013) Are GPCRs still a source of new targets? J. Biomol. Screen. 18, 947-966
-
(2013)
J. Biomol. Screen.
, vol.18
, pp. 947-966
-
-
Garland, S.L.1
-
42
-
-
84869755410
-
Patented TGR5 modulators: A review (2006-present)
-
Gioiello, A., Rosatelli, E., Nuti, R., Macchiarulo, A. and Pellicciari, R. (2012) Patented TGR5 modulators: a review (2006-present). Expert Opin. Ther. Pat. 22, 1399-1414
-
(2012)
Expert Opin. Ther. Pat.
, vol.22
, pp. 1399-1414
-
-
Gioiello, A.1
Rosatelli, E.2
Nuti, R.3
Macchiarulo, A.4
Pellicciari, R.5
-
43
-
-
84875848761
-
The TGR5 receptor mediates bile acid-induced itch and analgesia
-
Alemi, F., Kwon, E., Poole, D.P., Lieu, T., Lyo, V., Cattaruzza, F., Cevikbas, F., Steinhoff, M., Nassini, R., Materazzi, S. et al. (2013) The TGR5 receptor mediates bile acid-induced itch and analgesia. J. Clin. Invest. 123, 1513-1530
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 1513-1530
-
-
Alemi, F.1
Kwon, E.2
Poole, D.P.3
Lieu, T.4
Lyo, V.5
Cattaruzza, F.6
Cevikbas, F.7
Steinhoff, M.8
Nassini, R.9
Materazzi, S.10
-
44
-
-
84871304988
-
The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice
-
Alemi, F., Poole, D.P., Chiu, J., Schoonjans, K., Cattaruzza, F., Grider, J.R., Bunnett, N.W. and Corvera, C.U. (2013) The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice. Gastroenterology 144, 145-154
-
(2013)
Gastroenterology
, vol.144
, pp. 145-154
-
-
Alemi, F.1
Poole, D.P.2
Chiu, J.3
Schoonjans, K.4
Cattaruzza, F.5
Grider, J.R.6
Bunnett, N.W.7
Corvera, C.U.8
-
45
-
-
84864383668
-
Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation
-
Casaburi, I., Avena, P., Lanzino, M., Sisci, D., Giordano, F., Maris, P., Catalano, S., Morelli, C. and Ando, S. (2012) Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle 11, 2699-2710
-
(2012)
Cell Cycle
, vol.11
, pp. 2699-2710
-
-
Casaburi, I.1
Avena, P.2
Lanzino, M.3
Sisci, D.4
Giordano, F.5
Maris, P.6
Catalano, S.7
Morelli, C.8
Ando, S.9
-
46
-
-
75149187435
-
Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1
-
Perides, G., Laukkarinen, J.M., Vassileva, G. and Steer, M.L. (2010) Biliary acute pancreatitis in mice is mediated by the G-protein-coupled cell surface bile acid receptor Gpbar1. Gastroenterology 138, 715-725
-
(2010)
Gastroenterology
, vol.138
, pp. 715-725
-
-
Perides, G.1
Laukkarinen, J.M.2
Vassileva, G.3
Steer, M.L.4
-
47
-
-
84862776738
-
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR
-
Liu, J.J., Horst, R., Katritch, V., Stevens, R.C. and Wüthrich, K. (2012) Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR. Science 335, 1106-1110
-
(2012)
Science
, vol.335
, pp. 1106-1110
-
-
Liu, J.J.1
Horst, R.2
Katritch, V.3
Stevens, R.C.4
Wüthrich, K.5
-
48
-
-
84876896348
-
Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease
-
McMahan, R.H., Wang, X.X., Cheng, L.L., Krisko, T., Smith, M., El Kasmi, K., Pruzanski, M., Adorini, L., Golden-Mason, L., Levi, M. and Rosen, H.R. (2013) Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease. J. Biol. Chem. 288, 11761-11770
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 11761-11770
-
-
McMahan, R.H.1
Wang, X.X.2
Cheng, L.L.3
Krisko, T.4
Smith, M.5
El Kasmi, K.6
Pruzanski, M.7
Adorini, L.8
Golden-Mason, L.9
Levi, M.10
Rosen, H.R.11
-
49
-
-
84884982788
-
The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice
-
Péan, N., Doignon, I., Garcin, I., Besnard, A., Julien, B., Liu, B., Branchereau, S., Spraul, A., Guettier, C., Humbert, L. et al. (2013) The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice. Hepatology 58, 1451-1460
-
(2013)
Hepatology
, vol.58
, pp. 1451-1460
-
-
Péan, N.1
Doignon, I.2
Garcin, I.3
Besnard, A.4
Julien, B.5
Liu, B.6
Branchereau, S.7
Spraul, A.8
Guettier, C.9
Humbert, L.10
|