Redefining the TGR5 Triterpenoid Binding Pocket at the C-3 Position

ChemMedChem

Volumn 5, Issue 12, 2010, Pages 1983-1988

  Genet, Cédric ^a,b   Schmidt, Céline ^c   Strehle, Axelle ^c   Schoonjans, Kristina ^d   Auwerx, Johan ^d   Saladin, Régis ^c   Wagner, Alain ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b Novalix   (France)

^c PhytoDia Bioparc   (France)

^d EPFL   (Switzerland)

Author keywords

Structure activity relationships; Terpenoids; TGR5; Triterpenes; Type 2 diabetes

Indexed keywords

1 DIA 2; 2 DIA 2; BETULIC ACID; FARNESOID X RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCOSE; KETONE; PALLADIUM; TGR5; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; DRUG SYNTHESIS; ENERGY EXPENDITURE; GLUCOSE HOMEOSTASIS; GRIGNARD REACTION; HYDROGENATION; MICROWAVE IRRADIATION; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATION; OZONOLYSIS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MOLECULAR CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 78651487587     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000329     Document Type: Article

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