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Volumn 58, Issue 4, 2014, Pages 1943-1951

Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; GS 6620; UNCLASSIFIED DRUG;

EID: 84896950299     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02350-13     Document Type: Article
Times cited : (36)

References (23)
  • 1
    • 24344503816 scopus 로고    scopus 로고
    • HCV natural history: The retrospective and prospective in perspective
    • Alter HJ. 2005. HCV natural history: the retrospective and prospective in perspective. J. Hepatol. 43: 550 -552. http://dx.doi.org/10.1016/j.jhep.2005. 07.002.
    • (2005) J. Hepatol. , vol.43 , pp. 550-552
    • Alter, H.J.1
  • 2
    • 84860287080 scopus 로고    scopus 로고
    • Epidemiology of viral hepatitis and hepatocellular carcinoma
    • El-Serag HB. 2012. Epidemiology of viral hepatitis and hepatocellular carcinoma. Gastroenterology 142: 1264-1273.e1. http://dx.doi.org/10.1053/j. gastro.2011.12.061.
    • (2012) Gastroenterology , vol.142
    • El-Serag, H.B.1
  • 6
    • 33846690778 scopus 로고    scopus 로고
    • Cathepsin A is a major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131
    • Birkus G, Wang R, Liu X, Kutty N, MacArthur H, Cihlar T, Gibbs C, Swaminathan S, Lee W, McDermott M. 2007. Cathepsin A is a major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131. Antimicrob. Agents Chemother. 51: 1-7. http://dx.doi.org/10.1128/AAC.01367-06.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 1-7
    • Birkus, G.1    Wang, R.2    Liu, X.3    Kutty, N.4    MacArthur, H.5    Cihlar, T.6    Gibbs, C.7    Swaminathan, S.8    Lee, W.9    McDermott, M.10
  • 10
    • 34247380394 scopus 로고    scopus 로고
    • Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins
    • DOI 10.1021/mp060070y
    • Chou TF, Baraniak J, Kaczmarek R, Zhou X, Cheng J, Ghosh B, Wagner CR. 2007. Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins. Mol. Pharm. 4:208-217. http://dx.doi.org/10.1021/mp060070y. (Pubitemid 46640597)
    • (2007) Molecular Pharmaceutics , vol.4 , Issue.2 , pp. 208-217
    • Chou, T.-F.1    Baraniak, J.2    Kaczmarek, R.3    Zhou, X.4    Cheng, J.5    Ghosh, B.6    Wagner, C.R.7
  • 11
    • 34447526880 scopus 로고    scopus 로고
    • Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate
    • DOI 10.1074/jbc.M606972200
    • Chou TF, Tikh IB, Horta BA, Ghosh B, De Alencastro RB, Wagner CR. 2007. Engineered monomeric human histidine triad nucleotide-binding protein 1 hydrolyzes fluorogenic acyl-adenylate and lysyl-tRNA synthetase-generated lysyl-adenylate. J. Biol. Chem. 282:15137-15147. http://dx.doi.org/10.1074/jbc. M606972200. (Pubitemid 47093345)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.20 , pp. 15137-15147
    • Chou, T.-F.1    Tikh, I.B.2    Horta, B.A.C.3    Ghosh, B.4    De Alencastro, R.B.5    Wagner, C.R.6
  • 12
    • 33749030999 scopus 로고    scopus 로고
    • Human carboxylesterase isozymes: Catalytic properties and rational drug design
    • Imai T. 2006. Human carboxylesterase isozymes: catalytic properties and rational drug design. Drug Metab. Pharmacokinet. 21:173-185. http://dx.doi.org/10.2133/dmpk.21.173.
    • (2006) Drug Metab. Pharmacokinet. , vol.21 , pp. 173-185
    • Imai, T.1
  • 13
    • 33748901615 scopus 로고    scopus 로고
    • Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine
    • DOI 10.1124/dmd.106.009381
    • Imai T, Taketani M, Shii M, Hosokawa M, Chiba K. 2006. Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine. Drug Metab. Dispos. 34: 1734-1741. http://dx.doi.org/10.1124/dmd.106.009381. (Pubitemid 44427476)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.10 , pp. 1734-1741
    • Imai, T.1    Taketani, M.2    Shii, M.3    Hosokawa, M.4    Chiba, K.5
  • 14
    • 34548498086 scopus 로고    scopus 로고
    • Carboxylesterase in the liver and small intestine of experimental animals and human
    • DOI 10.1016/j.lfs.2007.07.026, PII S0024320507005620
    • Taketani M, Shii M, Ohura K, Ninomiya S, Imai T. 2007. Carboxylesterase in the liver and small intestine of experimental animals and human. Life Sci. 81:924-932. http://dx.doi.org/10.1016/j.lfs.2007.07.026. (Pubitemid 47374212)
    • (2007) Life Sciences , vol.81 , Issue.11 , pp. 924-932
    • Taketani, M.1    Shii, M.2    Ohura, K.3    Ninomiya, S.4    Imai, T.5
  • 15
    • 0033385805 scopus 로고    scopus 로고
    • Cathepsin A/protective protein: An unusual lysosomal multifunctional protein
    • DOI 10.1007/s000180050482
    • Hiraiwa M. 1999. Cathepsin A/protective protein: an unusual lysosomal multifunctional protein. Cell. Mol. Life Sci. 56:894-907. http://dx.doi.org/10. 1007/s000180050482. (Pubitemid 30019209)
    • (1999) Cellular and Molecular Life Sciences , vol.56 , Issue.11-12 , pp. 894-907
    • Hiraiwa, M.1
  • 17
    • 84866329673 scopus 로고    scopus 로고
    • Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro
    • Lepist EI, Phan TK, Roy A, Tong L, Maclennan K, Murray B, Ray AS. 2012. Cobicistat boosts the intestinal absorption of transport substrates, including HIV protease inhibitors and GS-7340, in vitro. Antimicrob. Agents Chemother. 56: 5409 -5413. http://dx.doi.org/10.1128/AAC.01089-12.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 5409-5413
    • Lepist, E.I.1    Phan, T.K.2    Roy, A.3    Tong, L.4    Maclennan, K.5    Murray, B.6    Ray, A.S.7
  • 19
    • 0031764896 scopus 로고    scopus 로고
    • Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T)
    • McGuigan C, Sutton PW, Cahard D, Turner K, O'Leary G, Wang Y, Gumbleton M, De Clercq E, Balzarini J. 1998. Synthesis, anti-human immunodeficiency virus activity and esterase lability of some novel carboxylic ester-modified phosphoramidate derivatives of stavudine (d4T). Antivir. Chem. Chemother. 9:473-479. (Pubitemid 28556662)
    • (1998) Antiviral Chemistry and Chemotherapy , vol.9 , Issue.6 , pp. 473-479
    • McGuigan, C.1    Sutton, P.W.2    Canard, D.3    Turner, K.4    O'Leary, G.5    Wang, Y.6    Gumbleton, M.7    De Clercq, E.8    Balzarini, J.9
  • 20
    • 0031946728 scopus 로고    scopus 로고
    • Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): Esterase hydrolysis as a rapid predictive test for antiviral potency
    • McGuigan C, Tsang HW, Sutton PW, De Clercq E, Balzarini J. 1998. Synthesis and anti-HIV activity of some novel chain-extended phosphoramidate derivatives of d4T (stavudine): esterase hydrolysis as a rapid predictive test for antiviral potency. Antivir. Chem. Chemother. 9:109-115. (Pubitemid 28160956)
    • (1998) Antiviral Chemistry and Chemotherapy , vol.9 , Issue.2 , pp. 109-115
    • McGuigan, C.1    Tsang, H.-W.2    Sutton, P.W.3    De Clercq, E.4    Balzarini, J.5
  • 21
    • 54349121297 scopus 로고    scopus 로고
    • Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis
    • Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF. 2008. Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. Endocrinology 149: 5461-5469. http://dx.doi.org/10.1210/en.2008-0400.
    • (2008) Endocrinology , vol.149 , pp. 5461-5469
    • Lenglet, S.1    Antigny, F.2    Vetterli, L.3    Dufour, J.F.4    Rossier, M.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.