Characterization of the expression and activity of carboxylesterases 1 and 2 from the beagle dog, cynomolgus monkey, and human

Drug Metabolism and Disposition

Volumn 39, Issue 12, 2011, Pages 2305-2313

  Williams, Eric T ^a,b   Bacon, James A ^a   Bender, David M ^a   Lowinger, Jennifer J ^a,c   Guo, Wen Kai ^a   Ehsani, Mariam E ^a   Wang, Xiliang ^a   Wang, He ^a   Qian, Yue Wei ^a   Ruterbories, Kenneth J ^a   Wrighton, Steven A ^a   Perkins, Everett J ^a  

^a ELI LILLY AND COMPANY   (United States)

^b EISAI INC   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 NITROPHENYL ESTER DERIVATIVE; CARBOXYLESTERASE; CARBOXYLESTERASE 1; CARBOXYLESTERASE 2; ESTER DERIVATIVE; GEMCITABINE; LOPERAMIDE; MESSENGER RNA; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; CYNOMOLGOUS MONKEY; DOG; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITOR INTERACTION; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HAPLORHINI; HUMAN; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HYDROLYSIS; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SPECIES COMPARISON; TISSUE SPECIFICITY; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; CARBOXYLIC ESTER HYDROLASES; DOGS; HUMANS; MACACA FASCICULARIS; MOLECULAR SEQUENCE DATA; REAL-TIME POLYMERASE CHAIN REACTION; SUBSTRATE SPECIFICITY;

CANIS FAMILIARIS; MACACA FASCICULARIS;

EID: 81855217413     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.041335     Document Type: Article

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