메뉴 건너뛰기




Volumn 289, Issue 12, 2014, Pages 8462-8472

Ras protein activation is a key event in activity-dependent survival of cerebellar granule neurons

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELL DEATH; GRANULATION; PHOSPHORYLATION; PROTEINS;

EID: 84896926741     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.536375     Document Type: Article
Times cited : (11)

References (47)
  • 1
    • 0028147323 scopus 로고
    • Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus
    • Gould, E., Cameron, H. A., and McEwen, B. S. (1994) Blockade of NMDA receptors increases cell death and birth in the developing rat dentate gyrus. J. Comp. Neurol. 340, 551-565 (Pubitemid 24045565)
    • (1994) Journal of Comparative Neurology , vol.340 , Issue.4 , pp. 551-565
    • Gould, E.1    Cameron, H.A.2    McEwen, B.S.3
  • 3
    • 7044231118 scopus 로고    scopus 로고
    • Pronounced cell death in the absence of NMDA receptors in the developing somatosensory thalamus
    • DOI 10.1523/JNEUROSCI.3290-04.2004
    • Adams, S. M., de Rivero Vaccari, J. C., and Corriveau, R. A. (2004) Pronounced cell death in the absence of NMDA receptors in the developing somatosensory thalamus. J. Neurosci. 24, 9441-9450 (Pubitemid 39426180)
    • (2004) Journal of Neuroscience , vol.24 , Issue.42 , pp. 9441-9450
    • Adams, S.M.1    De Rivero, V.J.C.2    Corriveau, R.A.3
  • 4
    • 0023804295 scopus 로고
    • N-Methyl-D-aspartate promotes the survival of cerebellar granule neurons in culture
    • Balázs, R., Jørgensen, O. S., and Hack, N. (1988) N-Methyl-D-aspartate promotes the survival of cerebellar granule neurons in culture. Neuroscience 27, 437-451
    • (1988) Neuroscience , vol.27 , pp. 437-451
    • Balázs, R.1    Jørgensen, O.S.2    Hack, N.3
  • 5
    • 0023244774 scopus 로고
    • The role of depolarization in the survival and differentiation of cerebellar granule cells in culture
    • Gallo, V., Kingsbury, A., Balázs, R., and Jørgensen, O. S. (1987) The role of depolarization in the survival and differentiation of cerebellar granule neurons in culture. J. Neurosci. 7, 2203-2213 (Pubitemid 17114929)
    • (1987) Journal of Neuroscience , vol.7 , Issue.7 , pp. 2203-2213
    • Gallo, V.1    Kingsbury, A.2    Balazs, R.3    Jorgensen, O.S.4
  • 6
    • 0027367292 scopus 로고
    • Neurotrophic effects of NMDA receptor activation on developing cerebellar granule cells
    • Burgoyne, R.D., Graham, M.E., and Cambray-Deakin, M. (1993) Neurotrophic effects of NMDA receptor activation on developing cerebellar granule neurons. J. Neurocytol. 22, 689-695 (Pubitemid 23294617)
    • (1993) Journal of Neurocytology , vol.22 , Issue.9 , pp. 689-695
    • Burgoyne, R.D.1    Graham, M.E.2    Cambray-Deakin, M.3
  • 7
    • 0028133050 scopus 로고
    • Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons
    • DOI 10.1016/0006-8993(94)91364-1
    • Yan, G.M., Ni, B., Weller, M., Wood, K.A., and Paul, S.M. (1994) Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons. Brain Res. 656, 43-51 (Pubitemid 24263028)
    • (1994) Brain Research , vol.656 , Issue.1 , pp. 43-51
    • Yan, G.-M.1    Ni, B.2    Weller, M.3    Wood, K.A.4    Paul, S.M.5
  • 8
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., and Greenberg, M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 9
    • 0032698075 scopus 로고    scopus 로고
    • Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms
    • Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., and Greenberg, M. E. (1999) Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286, 1358-1362
    • (1999) Science , vol.286 , pp. 1358-1362
    • Bonni, A.1    Brunet, A.2    West, A.E.3    Datta, S.R.4    Takasu, M.A.5    Greenberg, M.E.6
  • 10
    • 0034700111 scopus 로고    scopus 로고
    • The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule neurons is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32
    • Vaudry, D., Gonzalez, B. J., Basille, M., Pamantung, T. F., Fontaine, M., Fournier, A., and Vaudry, H. (2000) The neuroprotective effect of pituitary adenylate cyclase-activating polypeptide on cerebellar granule neurons is mediated through inhibition of the CED3-related cysteine protease caspase-3/CPP32. Proc. Natl. Acad. Sci. U.S.A. 97, 13390-13395
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 13390-13395
    • Vaudry, D.1    Gonzalez, B.J.2    Basille, M.3    Pamantung, T.F.4    Fontaine, M.5    Fournier, A.6    Vaudry, H.7
  • 11
    • 0030938816 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization- and insulin-like growth factor I-mediated survival of cerebellar granule cells
    • DOI 10.1074/jbc.272.15.9847
    • Miller, T. M., Tansey, M. G., Johnson, E. M., Jr., and Creedon, D. J. (1997) Inhibition of phosphatidylinositol 3-kinase activity blocks depolarization-and insulin-like growth factor I-mediated survival of cerebellar granule neurons. J. Biol. Chem. 272, 9847-9853 (Pubitemid 27171651)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.15 , pp. 9847-9853
    • Miller, T.M.1    Tansey, M.G.2    Johnson Jr., E.M.3    Creedon, D.J.4
  • 12
    • 0032500670 scopus 로고    scopus 로고
    • N-methyl-D-aspartate inhibits apoptosis through activation of phosphatidylinositol 3-kinase in cerebellar granule neurons. A role for insulin receptor substrate-1 in the neurotrophic action of N-methyl-D- aspartate and its inhibition by ethanol
    • DOI 10.1074/jbc.273.41.26596
    • Zhang, F. X., Rubin, R., and Rooney, T. A. (1998) N-Methyl-D-aspartate inhibits apoptosis through activation of phosphatidylinositol 3-kinase in cerebellar granule neurons. A role for insulin receptor substrate-1 in the neurotrophic action of N-methyl-D-aspartate and its inhibition by ethanol. J. Biol. Chem. 273, 26596-26602 (Pubitemid 28471671)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.41 , pp. 26596-26602
    • Zhang, F.X.1    Rubin, R.2    Rooney, T.A.3
  • 13
    • 0033134890 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: Signal transduction cascades and site of ethanol action
    • Bhave, S. V., Ghoda, L., and Hoffman, P. L. (1999) Brain-derived neurotrophic factor mediates the antiapoptotic effect of NMDA in cerebellar granule neurons. Signal transduction cascades and site of ethanol action. J. Neurosci. 19, 3277-3286 (Pubitemid 29203107)
    • (1999) Journal of Neuroscience , vol.19 , Issue.9 , pp. 3277-3286
    • Bhave, S.V.1    Ghoda, L.2    Hoffman, P.L.3
  • 14
    • 0033524740 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N- terminal kinase activity in apoptosis of cultured cerebellar granule neurons
    • DOI 10.1016/S0165-3806(98)00172-2, PII S0165380698001722
    • Shimoke, K., Yamagishi, S., Yamada, M., Ikeuchi, T., and Hatanaka, H. (1999) Inhibition of phosphatidylinositol 3-kinase activity elevates c-Jun N-terminal kinase activity in apoptosis of cultured cerebellar granule neurons. Brain Res. Dev. Brain. Res. 112, 245-253 (Pubitemid 29083269)
    • (1999) Developmental Brain Research , vol.112 , Issue.2 , pp. 245-253
    • Shimoke, K.1    Yamagishi, S.2    Yamada, M.3    Ikeuchi, T.4    Hatanaka, H.5
  • 15
    • 0036460434 scopus 로고    scopus 로고
    • Akt mediates the anti-apoptotic effect of NMDA but not that induced by potassium depolarization in cultured cerebellar granule cells
    • DOI 10.1046/j.1460-9568.2002.02124.x
    • Lafon-Cazal, M., Perez, V., Bockaert, J., and Marin, P. (2002) Akt mediates the anti-apoptotic effect of NMDA but not that induced by potassium depolarization in cultured cerebellar granule neurons. Eur. J. Neurosci. 16, 575-583 (Pubitemid 35471828)
    • (2002) European Journal of Neuroscience , vol.16 , Issue.4 , pp. 575-583
    • Lafon-Cazal, M.1    Perez, V.2    Bockaert, J.3    Marin, P.4
  • 16
    • 0031054670 scopus 로고    scopus 로고
    • Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: Possible involvement of PI 3-kinase in IGF-1 signaling
    • D'Mello, S. R., Borodezt, K., and Soltoff, S. P. (1997) Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways. Possible involvement of PI 3-kinase in IGF-1 signaling. J. Neurosci. 17, 1548-1560 (Pubitemid 27089801)
    • (1997) Journal of Neuroscience , vol.17 , Issue.5 , pp. 1548-1560
    • D'Mello, S.R.1    Borodezt, K.2    Soltoff, S.P.3
  • 19
    • 0032499282 scopus 로고    scopus 로고
    • Rap1 mediates sustained MAP kinase activation induced by nerve growth factor
    • DOI 10.1038/33451
    • York, R.D., Yao, H., Dillon, T., Ellig, C.L., Eckert, S.P., McCleskey, E.W., and Stork, P.J. (1998) Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392, 622-626 (Pubitemid 28207722)
    • (1998) Nature , vol.392 , Issue.6676 , pp. 622-626
    • York, R.D.1    Yao, H.2    Dillon, T.3    Ellig, C.L.4    Eckert, S.P.5    McCleskey, E.W.6    Stork, P.J.S.7
  • 20
    • 0033776498 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1
    • York, R.D., Molliver, D.C., Grewal, S.S., Stenberg, P.E., McCleskey, E.W., and Stork, P.J. (2000) Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1. Mol. Cell. Biol. 20, 8069-8083
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8069-8083
    • York, R.D.1    Molliver, D.C.2    Grewal, S.S.3    Stenberg, P.E.4    McCleskey, E.W.5    Stork, P.J.6
  • 21
    • 0035947724 scopus 로고    scopus 로고
    • Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells
    • Kao, S., Jaiswal, R.K., Kolch, W., and Landreth, G.E. (2001) Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells. J. Biol. Chem. 276, 18169-18177
    • (2001) J. Biol. Chem. , vol.276 , pp. 18169-18177
    • Kao, S.1    Jaiswal, R.K.2    Kolch, W.3    Landreth, G.E.4
  • 22
    • 0037205044 scopus 로고    scopus 로고
    • Signaling pathways for PC12 cell differentiation: Making the right connections
    • DOI 10.1126/science.1071552
    • Vaudry, D., Stork, P. J., Lazarovici, P., and Eiden, L.E. (2002) Signaling pathways for PC12 cell differentiation. Making the right connections. Science 296, 1648-1649 (Pubitemid 34579153)
    • (2002) Science , vol.296 , Issue.5573 , pp. 1648-1649
    • Vaudry, D.1    Stork, P.J.S.2    Lazarovici, P.3    Eiden, L.E.4
  • 23
    • 44249121484 scopus 로고    scopus 로고
    • A cAMP-dependent, protein kinase A-independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells
    • DOI 10.1124/mol.107.044792
    • Ravni, A., Vaudry, D., Gerdin, M.J., Eiden, M.V., Falluel-Morel, A., Gonzalez, B.J., Vaudry, H., and Eiden, L.E. (2008) A cAMP-dependent, protein kinase A-independent signaling pathway mediating neuritogenesis through Egr1 in PC12 cells. Mol. Pharmacol. 73, 1688-1708 (Pubitemid 351724358)
    • (2008) Molecular Pharmacology , vol.73 , Issue.6 , pp. 1688-1708
    • Ravni, A.1    Vaudry, D.2    Gerdin, M.J.3    Eiden, M.V.4    Falluel-Morel, A.5    Gonzalez, B.J.6    Vaudry, H.7    Eiden, L.E.8
  • 24
    • 0035448956 scopus 로고    scopus 로고
    • Requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons
    • Iida, N., Namikawa, K., Kiyama, H., Ueno, H., Nakamura, S., and Hattori, S. (2001) The requirement of Ras for the activation of mitogen-activated protein kinase by calcium influx, cAMP, and neurotrophin in hippocampal neurons. J. Neurosci. 21, 6459-6466 (Pubitemid 32781089)
    • (2001) Journal of Neuroscience , vol.21 , Issue.17 , pp. 6459-6466
    • Iida, N.1    Namikawa, K.2    Kiyama, H.3    Ueno, H.4    Nakamura, S.5    Hattori, S.6
  • 25
    • 34047166458 scopus 로고    scopus 로고
    • The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells
    • DOI 10.1111/j.1471-4159.2006.04390.x
    • Obara, Y., Horgan, A. M., and Stork, P. J. (2007) The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule neurons. J. Neurochem. 101, 470-482 (Pubitemid 46525282)
    • (2007) Journal of Neurochemistry , vol.101 , Issue.2 , pp. 470-482
    • Obara, Y.1    Horgan, A.M.2    Stork, P.J.S.3
  • 26
    • 16244409485 scopus 로고    scopus 로고
    • Brief exposure to NMDA produces long-term protection of cerebellar granule cells from apoptosis
    • DOI 10.1111/j.1460-9568.2005.03935.x
    • Xifro, X., Malagelada, C., Miñano, A., and Rodríguez- Alvarez, J. (2005) Brief exposure to NMDA produces long-term protection of cerebellar granule neurons from apoptosis. Eur. J. Neurosci. 21, 827-840 (Pubitemid 40461037)
    • (2005) European Journal of Neuroscience , vol.21 , Issue.4 , pp. 827-840
    • Xifro, X.1    Malagelada, C.2    Minano, A.3    Rodriguez-Alvarez, J.4
  • 28
    • 0032957682 scopus 로고    scopus 로고
    • Calcium influx activates extracellular-regulated kinase/mitogen- activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cells
    • DOI 10.1074/jbc.274.1.75
    • Egea, J., Espinet, C., and Comella J. X. (1999) Calcium influx activates extracellular-regulated kinase/mitogen-activated protein kinase pathway through a calmodulin-sensitive mechanism in PC12 cells. J. Biol. Chem. 274, 75-85 (Pubitemid 29035032)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.1 , pp. 75-85
    • Egea, J.1    Espinet, C.2    Comella, J.X.3
  • 29
    • 0031014969 scopus 로고    scopus 로고
    • 2+-mediated activation of Rap1in human platelets
    • 2+-mediated activation of Rap1in human platelets. EMBO J. 16, 252-259
    • (1997) EMBO J , vol.16 , pp. 252-259
    • Franke, B.1    Akkerman, J.W.2    Bos, J.L.3
  • 31
    • 0036274818 scopus 로고    scopus 로고
    • Integration of calcium and Ras signalling
    • DOI 10.1038/nrm808
    • Cullen, P.J., and Lockyer, P.J. (2002) Integration of calcium and Ras signalling. Nat. Rev. Mol. Cell Biol. 3, 339-348 (Pubitemid 34619268)
    • (2002) Nature Reviews Molecular Cell Biology , vol.3 , Issue.5 , pp. 339-348
    • Cullen, P.J.1    Lockyer, P.J.2
  • 32
    • 84896915252 scopus 로고    scopus 로고
    • The neurochemistry of neuronal death: Survival of cerebellar granule neurons: Role of protein kinases pathways
    • Xifró, X., Miñano, A., and Rodríguez-Alvarez, J. (2007) The neurochemistry of neuronal death: Survival of cerebellar granule neurons: Role of protein kinases pathways. Res. Signpost. 1, 157-174
    • (2007) Res. Signpost. , vol.1 , pp. 157-174
    • Xifró, X.1    Miñano, A.2    Rodríguez-Alvarez, J.3
  • 33
    • 34249828655 scopus 로고    scopus 로고
    • Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways. Two approaches with therapeutic potential in the treatment of neurodegenerative disease
    • Burke, R. E. (2007) Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways. Two approaches with therapeutic potential in the treatment of neurodegenerative disease. Pharmacol. Ther. 114, 261-277
    • (2007) Pharmacol. Ther. , vol.114 , pp. 261-277
    • Burke, R.E.1
  • 34
    • 79959311956 scopus 로고    scopus 로고
    • Ras family small GTPase-mediated neuroprotective signaling in stroke
    • Shi, G.X., Andres, D.A., and Cai, W. (2011) Ras family small GTPase-mediated neuroprotective signaling in stroke. Cent. Nerv. Syst. Agents Med. Chem. 11, 114-137
    • (2011) Cent. Nerv. Syst. Agents Med. Chem. , vol.11 , pp. 114-137
    • Shi, G.X.1    Andres, D.A.2    Cai, W.3
  • 35
    • 84863107192 scopus 로고    scopus 로고
    • Kinases and kinase signaling pathways. Potential therapeutic targets in Parkinson's disease
    • Wang, G., Pan, J., and Chen, S.D. (2012) Kinases and kinase signaling pathways. Potential therapeutic targets in Parkinson's disease. Prog. Neurobiol. 98, 207-221
    • (2012) Prog. Neurobiol. , vol.98 , pp. 207-221
    • Wang, G.1    Pan, J.2    Chen, S.D.3
  • 36
    • 0032491387 scopus 로고    scopus 로고
    • Activity-dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate
    • DOI 10.1074/jbc.273.45.29394
    • Marini, A. M., Rabin, S. J., Lipsky, R. H., and Mocchetti, I. (1998) Activity dependent release of brain-derived neurotrophic factor underlies the neuroprotective effect of N-methyl-D-aspartate. J. Biol. Chem. 273, 29394-29399 (Pubitemid 28509940)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.45 , pp. 29394-29399
    • Marini, A.M.1    Rabin, S.J.2    Lipsky, R.H.3    Mocchetti, I.4
  • 37
    • 33846891790 scopus 로고    scopus 로고
    • Role of brain-derived neurotrophic factor in the protective action of N-methyl-D-Role aspartate in the apoptotic death of cerebellar granule neurons induced by low potassium
    • Bazán-Peregrino, M., Gutiérrez-Kobeh, L., and Morán, J. (2007) Role of brain-derived neurotrophic factor in the protective action of N-methyl-D-Role aspartate in the apoptotic death of cerebellar granule neurons induced by low potassium. J. Neurosci. Res. 85, 332-341
    • (2007) J. Neurosci. Res. , vol.85 , pp. 332-341
    • Bazán-Peregrino, M.1    Gutiérrez-Kobeh, L.2    Morán, J.3
  • 38
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
    • DOI 10.1210/er.22.2.153
    • Pearson, G., Robinson, F., Beers Gibson, T., Xu, B. E., Karandikar, M., Berman, K., and Cobb, M. H. (2001) Mitogen-activated protein (MAP) kinase pathways. Regulation and physiological functions. Endocr. Rev. 22, 153-183 (Pubitemid 32458157)
    • (2001) Endocrine Reviews , vol.22 , Issue.2 , pp. 153-183
    • Pearson, G.1    Robinson, F.2    Gibson, T.B.3    Xu, B.-E.4    Karandikar, M.5    Berman, K.6    Cobb, M.H.7
  • 39
    • 0036431640 scopus 로고    scopus 로고
    • NMDA receptor-dependent CREB activation in survival of cerebellar granule cells during in vivo and in vitro development
    • DOI 10.1046/j.1460-9568.2002.02232.x
    • Monti, B., Marri, L., and Contestabile, A. (2002) NMDA receptor-dependent CREB activation in survival of cerebellar granule cells during in vivo and in vitro development. Eur. J. Neurosci. 16, 1490-1498 (Pubitemid 35339407)
    • (2002) European Journal of Neuroscience , vol.16 , Issue.8 , pp. 1490-1498
    • Monti, B.1    Marri, L.2    Contestabile, A.3
  • 40
    • 0035998270 scopus 로고    scopus 로고
    • SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus
    • DOI 10.1046/j.1365-2443.2002.00546.x
    • Roy, B.C., Kohu, K., Matsuura, K., Yanai, H., and Akiyama, T. (2002) SPAL, a rap-specific GTPase activating protein, is present in the NMDA-receptor-PSD-95 complex in the hippocampus. Genes Cells. 7, 607-617 (Pubitemid 34679057)
    • (2002) Genes to Cells , vol.7 , Issue.6 , pp. 607-617
    • Roy, B.C.1    Kohu, K.2    Matsuura, K.3    Yanai, H.4    Akiyama, T.5
  • 41
    • 0042244245 scopus 로고    scopus 로고
    • Possible involvement of Rap1 and Ras in glutamatergic synaptic transmission
    • DOI 10.1097/00001756-200307010-00003
    • Imamura, Y., Matsumoto, N., Kondo, S., Kitayama, H., and Noda, M. (2003) Possible involvement of Rap1 and Ras in glutamatergic synaptic transmission. Neuroreport. 14, 1203-1207 (Pubitemid 36934454)
    • (2003) NeuroReport , vol.14 , Issue.9 , pp. 1203-1207
    • Imamura, Y.1    Matsumoto, N.2    Kondo, S.3    Kitayama, H.4    Noda, M.5
  • 43
    • 0032535276 scopus 로고    scopus 로고
    • p21 Ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons
    • Klesse, L.J., and Parada, L.F. (1998) p21 ras and phosphatidylinositol-3 kinase are required for survival of wild-type and NF1 mutant sensory neurons. J. Neurosci. 18, 10420-10428 (Pubitemid 29016561)
    • (1998) Journal of Neuroscience , vol.18 , Issue.24 , pp. 10420-10428
    • Klesse, L.J.1    Parada, L.F.2
  • 44
    • 0034708456 scopus 로고    scopus 로고
    • The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons
    • DOI 10.1074/jbc.275.12.8817
    • Xue, L., Murray, J.H., and Tolkovsky, A.M. (2000) The Ras/phosphatidy-linositol-3 kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons. J. Biol. Chem. 275, 8817-8824 (Pubitemid 30180237)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.12 , pp. 8817-8824
    • Xue, L.1    Murray, J.H.2    Tolkovsky, A.M.3
  • 45
    • 79960055459 scopus 로고    scopus 로고
    • Ras interaction with PI3K. More than just another effector pathway
    • Castellano, E., and Downward, J. (2011) Ras interaction with PI3K. More than just another effector pathway. Genes Cancer 2, 261-274
    • (2011) Genes Cancer , vol.2 , pp. 261-274
    • Castellano, E.1    Downward, J.2
  • 46
    • 0036316691 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erkl/2), Akt/PKB and CREB in striatal neurones
    • DOI 10.1046/j.0022-3042.2001.00699.x
    • Perkinton, M.S., Ip, J.K., Wood, G.L., Crossthwaite, A.J., Williams, R.J. (2002) Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones. J. Neurochem. 80, 239-254 (Pubitemid 34809369)
    • (2002) Journal of Neurochemistry , vol.80 , Issue.2 , pp. 239-254
    • Perkinton, M.S.1    Ip, J.K.2    Wood, G.L.3    Crossthwaite, A.J.4    Williams, R.J.5
  • 47
    • 0036724203 scopus 로고    scopus 로고
    • Activity-dependent NMDA receptor-mediated activation of protein kinase B/Akt in cortical neuronal cultures
    • DOI 10.1046/j.1471-4159.2002.01031.x
    • Sutton, G., and Chandler, L.J. (2002) Activity-dependent NMDA receptor-mediated activation of protein kinase B/Akt in cortical neuronal cultures. J. Neurochem. 82, 1097-1105 (Pubitemid 34966622)
    • (2002) Journal of Neurochemistry , vol.82 , Issue.5 , pp. 1097-1105
    • Sutton, G.1    Chandler, L.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.