An integrated study of the affinities of the Aβ16 peptide for Cu(I) and Cu(II): Implications for the catalytic production of reactive oxygen species

Metallomics

Volumn 6, Issue 3, 2014, Pages 505-517

  Young, Tessa R ^a,b   Kirchner, Angie ^a,b,c   Wedd, Anthony G ^a,b   Xiao, Zhiguang ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; CATALYTIC PRODUCTION; FLUORESCENCE INTENSITIES; NEW FLUORESCENT PROBES; REACTIVE OXYGEN SPECIES; REDOX THERMODYNAMICS; SENSITIVE DETECTION; STRUCTURAL INTERPRETATION;

ACETYLATION; BINDING ENERGY; COPPER; LIGANDS; PEPTIDES; PH;

COPPER COMPOUNDS;

AMYLOID BETA 16 PEPTIDE; AMYLOID PRECURSOR PROTEIN; ASCORBIC ACID; BUFFER; COPPER COMPLEX; COPPER ION; CUPRIC ION; FLUORESCENT DYE; GLYCINE; HISTIDINE DERIVATIVE; IMIDAZOLE; LIGAND; NITRILOTRIACETIC ACID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ACETYLATION; ALZHEIMER DISEASE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; COMPLEX FORMATION; CURVE FITTING; DISSOCIATION CONSTANT; EQUILIBRIUM CONSTANT; FLUORESCENCE; METAL BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION; OXIDATIVE STRESS; PH; PRIORITY JOURNAL; PROTON TRANSPORT; SENSITIVITY AND SPECIFICITY; STOICHIOMETRY; THERMODYNAMICS; TITRIMETRY; ULTRAVIOLET SPECTROSCOPY; X RAY ABSORPTION SPECTROSCOPY;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ASCORBIC ACID; BINDING SITES; COPPER; HUMANS; HYDROGEN PEROXIDE; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PROTEIN BINDING; REACTIVE OXYGEN SPECIES; THERMODYNAMICS;

EID: 84896897049     PISSN: 17565901     EISSN: 1756591X     Source Type: Journal    
DOI: 10.1039/c4mt00001c     Document Type: Article

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