Deprotonation of the Asp1-Ala2 peptide bond induces modification of the dynamic copper(II) environment in the amyloid-β peptide near physiological pH

Angewandte Chemie - International Edition

Volumn 48, Issue 50, 2009, Pages 9522-9525

  Hureau, Christelle ^a,b   Coppel, Yannick ^a,b   Dorlet, Pierre ^c,d   Solari, Pier Lorenzo ^e   Sayen, Stéphanie ^f   Guillon, Emmanuel ^f   Sabater, Laurent ^a,b   Faller, Peter ^a,b  

^a LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c CNRS   (France)

^d DIF   (France)

^e SYNCHROTRON SOLEIL   (France)

^f UFR des Sciences Exactes et Naturelles   (France)

Author keywords

Amyloid peptides; Binding sites; Copper; Deprotonation; Nmr spectroscopy

Indexed keywords

CHEMICAL EQUATIONS; NMR SPECTROSCOPY; PEPTIDE BONDS; PHYSIOLOGICAL PH;

BINDING ENERGY; BIOCHEMISTRY; COPPER; DEPROTONATION; GLYCOPROTEINS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; PH EFFECTS;

BINDING SITES;

ALANINE; AMYLOID BETA PROTEIN; ASPARTIC ACID; COPPER; DIPEPTIDE;

ALZHEIMER DISEASE; ARTICLE; BINDING SITE; CHEMISTRY; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH;

ALANINE; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ASPARTIC ACID; BINDING SITES; COPPER; DIPEPTIDES; HUMANS; HYDROGEN-ION CONCENTRATION; MAGNETIC RESONANCE SPECTROSCOPY;

EID: 73249137909     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200904512     Document Type: Article

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