Benzothiazinones mediate killing of Corynebacterineae by blocking decaprenyl phosphate recycling involved in cell wall biosynthesis

Journal of Biological Chemistry

Volumn 289, Issue 9, 2014, Pages 6177-6187

  Grover, Shipra ^a   Alderwick, Luke J ^a   Mishra, Arun K ^a,c   Krumbach, Karin ^b   Marienhagen, Jan ^b   Eggeling, Lothar ^b   Bhatt, Apoorva ^a   Besra, Gurdyal S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL WALL BIOSYNTHESIS; CORYNEBACTERIUM GLUTAMICUM; EPIMERIZATION; HETEROCYCLIC COMPOUND; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; WILD TYPES; WILD-TYPE STRAIN;

BIOCHEMISTRY; CELL DEATH; GENE ENCODING; RECYCLING;

BIOSYNTHESIS;

ANTIINFECTIVE AGENT; ARABINOGALACTAN; BENZOTHIAZINONE 043; DECAPRENYL DIPHOSPHATE SYNTHASE; DECAPRENYL PHOSPHATE; LIPOARABINOMANNAN; PEPTIDOGLYCAN; PHOSPHATE; SYNTHETASE; UNCLASSIFIED DRUG;

ACTINOMYCETALES; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BIOACCUMULATION; BIOSYNTHESIS; CELL DEATH; CONTROLLED STUDY; CORYNEBACTERINEAE GLUTAMICUM; DRUG STRUCTURE; ENZYME INHIBITION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; UPREGULATION;

BACTERIAL METABOLISM; CARBOHYDRATE METABOLISM; CELL WALL; DRUG RESISTANCE; POLYSACCHARIDE;

BACTERIAL PROTEINS; CORYNEBACTERIUM GLUTAMICUM; ENZYME INHIBITORS; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; POLYISOPRENYL PHOSPHATES; SPIRO COMPOUNDS; THIAZINES;

EID: 84896887977     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.522623     Document Type: Article

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