Effect of aqueous extract of Crocus sativus L. (saffron) stigma against subacute effect of diazinon on specific biomarkers in rats

Toxicology and Industrial Health

Volumn 30, Issue 2, 2014, Pages 141-146

  Moallem, Seyed Adel ^a   Hariri, Alireza Timcheh ^a   Mahmoudi, Mahmoud ^b   Hosseinzadeh, Hossein ^c  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

diazinon; direct 8 iso prostaglandin F2 ; S100 ; Saffron; TNF ; vitamin E

Indexed keywords

DIAZINON; DIRECT 8-ISO-PROSTAGLANDIN F2Α; S100Β; SAFFRON; TNF-Α; VITAMIN E;

ANIMALS; BIOLOGICAL MARKERS; CROCUS; DIAZINON; DINOPROST; INFLAMMATION; LIPID PEROXIDATION; MALE; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; PLANT EXTRACTS; RATS; RATS, WISTAR; S100 CALCIUM BINDING PROTEIN BETA SUBUNIT; TOXICITY TESTS, SUBACUTE; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN E;

ALPHA TOCOPHEROL; CHOLINESTERASE; CROCUS SATIVUS EXTRACT; DIMPYLATE; PROSTAGLANDIN F2 ALPHA; PROTEIN S100B; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CROCUS SATIVUS; DRUG EFFICACY; ENZYME ACTIVITY; MALE; NONHUMAN; ORGANOPHOSPHATE POISONING; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT;

EID: 84896872540     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233712452609     Document Type: Article

References (27)

1. Abdullaev FI, Espinosa-Aguirre JJ (2004) Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials. Cancer Detection and Prevention 28(6): 426–432.
2. Assimopoulou AN, Sinakos Z, Papageorgiou VP (2005) Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents. Phytotherapy Research 19(11): 997–1000.
3. Bosak A (2006) Organophosphorus compounds: classification and enzyme reactions. Archives of Industrial Hygiene and Toxicology 57(4): 445–457.
4. Donato R (1986) S-100 proteins. Cell Calcium 7(3):123–145.
5. Gresta1 F, Lombardo1 GM, Siracusa L, Ruberto G (2008) Saffron, an alternative crop for sustainable agricultural systems: a review. Agronomy for Sustainable Development 28(1): 95–112.
6. Hariri AT, Moallem SA, Mahmoudi M, Memar B, Hosseinzadeh H (2010) Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: protective effects of crocin and safranal. Food and Chemical Toxicology 48(10): 2803–2808.
7. Hosseinzadeh H, Karimi G, Niapoor M (2004) Antidepressant effect of Crocus sativus L. stigma extracts and their constituents, crocin and safranal, in mice. Acta Horticulturae 650: 435–445.
8. Hosseinzadeh H, Modaghegh MH, Saffari Z (2009a) Crocus sativus L. (saffron) extract and its active constituents (crocin and safranal) on ischemia-reperfusion in rat skeletal muscle. Evidence-Based Complementary and Alternative Medicine 6(3): 343–350.
9. Hosseinzadeh H, Sadeghnia HR (2005) Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus. Journal of Pharmacy and Pharmaceutical Sciences 8(3): 394–399.
10. Hosseinzadeh H, Sadeghnia HR (2007) Protective effect of safranal, an active constituent of Crocus sativus, on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems. Phytomedicine 14(4): 256–262.
11. Hosseinzadeh H, Sadeghnia HR, Ziaee T, Danaee A (2005) Protective effect of aqueous saffron extract (Crocus sativus L.) and crocin, its active constituent, on renal ischemia-reperfusion-induced oxidative damage in rats. Journal of Pharmacy and Pharmaceutical Sciences 8(3): 387–393.
12. Hosseinzadeh H, Shamsaie F, Mehri S (2009b) Antioxidant activity of aqueous and ethanolic extracts of Crocus sativus l. stigma and its bioactive constituent, crocin and safranal. Pharmacognosy Magazine 5(20): 419–424.
13. Hosseinzadeh H, Talebzadeh F (2005) Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice. Fitoterapia 76 (7–8): 722–724.
14. Hosseinzadeh H, Younesi H (2002) Petal and stigma extracts of Crocus sativus L. have antinociceptive and anti-inflammatory effects in mice. BMC Pharmacology 2: 7.
15. Hsieh BH, Deng JF, Ger J, Tsai WJ (2001) Acetylcholinesterase inhibition and the extrapyramidal syndrome: a review of the neurotoxicity of organophosphate. Neurotoxicology 22(4): 423–427.
16. Jokanović M, Kosanović M (2010) Neurotoxic effects in patients poisoned with organophosphorus pesticides. Environmental Toxicology and Pharmacology 29(3): 195–201.
17. Nam KN, Park YM, Jung HJ, Lee JY, Min BD, Park SU et al. (2010) Anti-inflammatory effects of crocin and crocetin in rat brain microglial cells. European Journal of Pharmacology 648 (1–3): 110–116.
18. Probert L, Akassoglou K, Kassiotis G, Pasparakis M, Alexopoulou L, Kollias G (1997) TNF-alpha transgenic and knockout models of CNS inflammation and degeneration. Journal of Neuroimmunology 72(2): 137–141.
19. Rush T, Liu XQ, Hjelmhaug J, Lobner D (2010) Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture. Neuroscience 166(3): 899–906.
20. Shah MD, Iqbal M (2010) Diazinon-induced oxidative stress and renal dysfunction in rats. Food and Chemical Toxicology 48(12): 3345–353.
21. Soeda S, Ochiai T, Paopong L, Tanaka H, Shoyama Y, Shimeno H (2001) Crocin suppresses tumor necrosis factor-α-induced cell death of neuronally differentiated PC-12 cells. Life Science 69(24): 2887–2898.
22. Stroick M, Fatar M, Ragoschke-Schumm A, Fassbender K, Bertsch T, Hennerici MG (2006) Protein S-100B: a prognostic marker for cerebral damage. Current Medicinal Chemistry 13(25): 3053–3060.
23. Townend W, Ingebrigtsen T (2006) Head injury outcome prediction: a role for protein S-100B? Injury 37(12): 1098–1108.
24. Wojtczak-Soska K, Lelonek M (2010) S-100B protein: an early prognostic marker after cardiac arrest. Cardiology Journal 17(5): 532–536.
25. Wood LG, Gibson PG, Garg ML 2003 Biomarkers of lipid peroxidation, airway inflammation and asthma. Europian Respiratory Journal 21(1): 177–186
26. Xi L, Qian Z, Xu G, Zheng S, Sun S, Wen N et al. (2007) Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats. The Journal of Nutritional Biochemistry 18(1): 64–72.
27. Yilmaz N, Yilmaz M, Altuntas I (2011) Diazinon-induced brain toxicity and protection by vitamins E plus C. Toxicology and Industrial Health 28(1):51–57.