Neurotoxic effects in patients poisoned with organophosphorus pesticides

Environmental Toxicology and Pharmacology

Volumn 29, Issue 3, 2010, Pages 195-201

  Jokanović, Milan ^a,b   Kosanović, Melita ^c  

^a University of Nish   (Serbia)

^b Academy of Sciences and Arts of Republic Srpska   (Bosnia and Herzegovina)

^c Management of Scientific Centres and Presidential Camels ^*  (United Arab Emirates)

Author keywords

Chronic organophosphate induced neuropsychiatric disorder; Intermediate syndrome; Organophosphate induced neurotoxic effects; Organophosphorus

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ATROPINE; CHLORPYRIFOS; CHOLINESTERASE; DIAZEPAM; DICHLORVOS; FENTHION; ISOFENPHOS; LEPTOPHOS; MALATHION; METHAMIDOPHOS; METRIFONATE; MEVINPHOS; MIPAFOX; OBIDOXIME; OMETHOATE; ORGANOPHOSPHATE PESTICIDE; OXIME DERIVATIVE; PARATHION; PHOSPHAMIDON; PRALIDOXIME; TRIBUTYL PHOSPHOROTRITHIOITE; TRIMEDOXIME;

ANXIETY DISORDER; ATAXIA; BRADYCARDIA; BRONCHOSPASM; BRONCHUS SECRETION; CLINICAL FEATURE; COMA; CONVULSION; DIARRHEA; DIZZINESS; DROWSINESS; DYSARTHRIA; ENVIRONMENTAL EXPOSURE; ENZYME INHIBITION; HEADACHE; HEALTH EDUCATION; HEART ARRHYTHMIA; HUMAN; HYPERREFLEXIA; LACRIMATION; MENTAL DISEASE; MIOSIS; MOLECULAR MECHANICS; MUSCLE TWITCH; MUSCLE WEAKNESS; NAUSEA AND VOMITING; NEUROLOGIC DISEASE; NEUROTOXICITY; PARALYSIS; PATHOGENESIS; POLYNEUROPATHY; PRIORITY JOURNAL; PROTECTIVE CLOTHING; PSYCHOSIS; RESPIRATION DEPRESSION; REVIEW; SALIVATION; SLURRED SPEECH; TREMOR;

EID: 77951978856     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2010.01.006     Document Type: Review

References (72)

1. Ahmed G.M., Davies D.R. Chronic organophosphate exposure: toward the definition of a neuropsychiatric syndrome. J. Nutr. Environ. Med. 1997, 7:169-176.
2. Antonijević B., Stojiljković M.P. Unequal efficacy of pyridinium oximes in organophosphate poisoning. Clin. Med. Res. 2007, 5:71-82.
3. Baker E.L., Warren M., Zack M., Dobbin R.D., Miles J.W., Miller S., Alderman L., Teeters W.R. Epidemic malathion poisoning in Pakistan malaria workers. Lancet 1978, 1:31-34.
4. Baker D.J., Sedgwick F.M. Single fiber electromyographic changes in man after organophosphate exposure. Hum. Exp. Toxicol. 1996, 15:369-375.
5. Bessler C.L., Stallones L. A cohort study of pesticide poisoning and depression in Colorado farm residents. Ann. Epidemiol. 2008, 18:768-774.
6. Clark R.F. Insecticides: organic phosphorus compounds and carbamates. Goldfrank's Toxicological Emergencies 2002, McGraw-Hill Professional, New York, pp. 1346-1360. 7 ed.
7. Dhandapani M., Zachariah A., Kavitha M.R., Jeyaseelan L., Oommen A. Oxidative damage in intermediate syndrome of acute organophosphorus poisoning. Ind. J. Med. Res. 2003, 117:253-259.
8. Davies R., Ghouse A., Tegwedd F. Chronic exposure to organophosphates: background and clinical picture. Adv. Psychiatr. Treat. 2000, 6:187-192.
9. Davies R., Ghouse A., Tegwedd F. Psychiatric aspects of chronic exposure to organophosphates: diagnosis and management. Adv. Psychiatr. Treat. 2000, 6:356-361.
10. De Bleecker J., Van Den Neucker K., Colardyn F. Intermediate syndrome in organophosphorus poisoning: a prospective study. Crit. Care Med. 1993, 21:1706-1711.
11. De Bleecker J. The intermediate syndrome in organophosphate poisoning: an overview of experimental and clinical observations. J. Toxicol. Clin. Toxicol. 1995, 33:683-686.
12. De Bleecker J.L. Intermediate syndrome in organophosphate poisoning. Toxicology of Organophosphate and Carbamate Compounds 2006, 371-380. Elsevier Academic Press, Amsterdam, (Chapter 26). R.C. Gupta (Ed.).
13. Dési I., Nagymajtényi L. Electrophysiological biomarkers of an organophosphorous pesticide, dichlorvos. Toxicol. Lett. 1999, 107:55-64.
14. De Silva H.J., Samarawickrema N.A., Wickremasinghe A.R. Toxicity due to organophosphorus compounds: what about chronic exposure?. Trans. Roy. Soc. Trop. Med. Hyg. 2006, 100:803-806.
15. Eddleston M. Patterns and problems of deliberate self-poisoning in the developing world. QJM 2000, 93:715-731.
16. Eddleston M., Juszczak E., Buckley N.A., Senarathna L., Mohamed F., Dissanayake W., Hittarage A., Azher S., Jeganathan K., Jayamanne S., Sheriff M.H.R., Warrell D.A. Multiple-dose activated charcoal in self-poisoning: a randomised controlled trial. Lancet 2008, 371:579-587.
17. Eddleston M., Phillips M.R. Self poisoning with pesticides. BMJ 2004, 328:42-44.
18. Glynn P. Neuropathy target esterase. Biochem. J. 1999, 344:625-631.
19. Glynn P. A mechanism for organophosphate-induced delayed neuropathy. Toxicol. Lett. 2006, 162:94-97.
20. Gronseth G.S. Gulf war syndrome: a toxic exposure? A systematic review. Neurol. Clin. 2005, 23:523-540.
21. IPCS Organophosphorus Pesticides. International Programme on Chemical Safety Poisons Information Monograph G001 1998, World Health Organization, Geneva, 1989, updated 1998. Available online at: http://www.inchem.org/documents/pims/chemical/pimg001.htm.
22. Jaga K., Dharmani C. The interrelation between organophosphate toxicity and the epidemiology of depression and suicide. Rev. Environ. Health 2007, 22:57-73.
23. Jamal G.A. Neurological syndromes of organophosphorus compounds. Adverse drug reaction. Toxicol. Rev. 1997, 16:133-170.
24. Jamal G.A., Hansen S., July P.O.O. Low level exposures to organophosphorus esters may cause neurotoxicity. Toxicology 2002, 181-182:23-33.
25. Jayawardane P., Dawson A.H., Weerasinghe V., Karalliedde L., Buckley N.A., Senanayake N. The spectrum of intermediate syndrome following organophosphate poisoning: a prospective cohort study from Sri Lanka. PLoS Med. 2008, 5:1143-1154.
26. Jayawardane P., Senanayake N., Dawson A. Electrophysiological correlates of intermediate syndrome following organophosphate poisoning. Clin. Toxicol. (Phila) 2009, 47:193-205.
27. Jeyaratnam J. Pesticide poisoning: a major global health problem. World Health Statist. Quart. 1990, 43:139-144.
28. John M., Oommen A., Zachariah A. Muscle injury in organophosphorous poisoning and its role in the development of intermediate syndrome. NeuroToxicology 2003, 24:43-53.
29. Johnson M.K. The target for initiation of delayed neurotoxicity by organophosphorus esters: biochemical studies and toxicological applications. Reviews in Biochemical Toxicology 1982, vol. 4:141-212. Elsevier, New York.
30. Jokanović M., Maksimović M. Abnormal cholinesterase activity: understanding and interpretation. Eur. J. Clin. Chem. Clin. Biochem. 1997, 35:11-16.
31. Jokanović M., Stukalov P.V., Kosanović M. Organophosphate induced delayed polyneuropathy. Curr. Drug Targets - CNS & Neurol. Disorders 2002, 1:591-600.
32. Jokanović M., Kosanović M., Stukalov P.V. Organophosphate induced delayed polyneuropathy. Med. Chem. Rev. Online 2004, 1:123-131.
33. Jokanović M., Stojiljković M.P. Current understanding of the application of pyridinium oximes as cholinesterase reactivators in treatment of organophosphate poisoning. Eur. J. Pharmacol. 2006, 553:10-17.
34. Jokanović M. Medical treatment of acute poisoning with organophosphorus and carbamate pesticides. Toxicol. Lett. 2009, 190:107-115.
35. Jokanović M. Neuropathy: chemically-induced. Encyclopedia of Neuroscience 2009, 759-765. Elsevier, (Chapter 515). L. Squire, T. Albright, F. Bloom, F. Gage, N. Spitzer (Eds.).
36. Jokanović M., Prostran M. Pyridinium oximes as cholinesterase reactivators. Structure-activity relationship and efficacy in the treatment of poisoning with organophosphorus compounds. Curr. Med. Chem. 2009, 16:2177-2188.
37. Jokanović, M., Antonijević, B., Vučinić, S., 2010. Epidemiology of anticholinesterase pesticide poisoning in Serbia. In: Satoh, T., Gupta, R., (Eds.), Anticholinesterase Pesticides: Metabolism, Neurotoxicity and Epidemiology. John Wiley & Sons, accepted for publications.
38. Kamel F., Hoppin J.A. Association of pesticide exposure with neurologic dysfunction and disease. Environ. Health Perspect. 2004, 112:950-958.
39. Karchmar A.G. Anticholinesterases and war gases. Exploring the Vertebrate Central Cholinergic Nervous System 2007, 237-310. Springer, (Chapter 7). A.G. Karchmar (Ed.).
40. Kamel F., Engel L.S., Gladen B.C., Hoppin J.A., Alavanja M.C.R., Sandler D.P. Neurologic symptoms in licensed private pesticide applicators in the Agricultural Health study. Environ. Health Perspect. 2005, 113:877-882.
41. Kohen G.L., Henderson G., Karczmar A.G. Di-isopropyl phosphofluoridate-induced antinociception: possible role of endogenous opioids. Eur. J. Pharmacol. 1980, 61:167-173.
42. Kubek M.J., Shih T.M., Meyerhoff J.L. Thyrotropin-releasing hormone (TRH) is markedly increased in the rat brain following soman-induced convulsions. Brain Res. 1997, 747(2):328-331.
43. Khan S., Hemalatha R., Jeyaseelan L., Oommen A., Zachariah A. Neuroparalysis and oxime efficacy in organophosphate poisoning; a study of butyrylcholinesterase. Hum. Exp. Toxicol. 2001, 20:169-174.
44. Levin H.S., Rodnitzky R.L., Mick D.L. Anxiety associated with exposure to organophosphorus compounds. Arch. Gen. Psychiatr. 1976, 33:225-228.
45. London L., Nell V., Thompson M.L., Myers J.E. Effects of long term organophosphate exposures on neurological symptoms, vibration sense and tremor among South African farm workers. Scand. J. Work Environ. Health 1998, 24:18-29.
46. London L., Flisher A.J., Wesseling C., Mergler D., Kromhout H. Suicide and exposure to organophosphate pesticides: cause or effect?. Am. J. Ind. Med 2005, 47:308-321.
47. Lotti M. The pathogenesis of organophosphate delayed polyneuropathy. Crit. Rev. Toxicol. 1992, 21:465-487.
48. Lotti M., Moretto A. Organophosphate-induced delayed polyneuropathy. Toxicol. Rev. 2005, 24:37-49.
49. Marrs T.C. Diazepam. Antidotes for Poisoning by Organophosphorus Pesticides. International Programme on Chemical Safety 2004, World Health Organization.
50. Marrs T.C., Vale J.A. Management of organophosphorus pesticide poisoning. Toxicology of Organophosphorus and Carbamate Compounds 2006, 715-733. Elsevier Academic Press, Amsterdam, (Chapter 49). R.C. Gupta (Ed.).
51. Morgan J.P. The Jamaica ginger paralysis. JAMA 1982, 248:1864-1867.
52. Parrón T., Hernández A.F., Pla A., Villanueva E. Clinical and biochemical changes in greenhouse sprayers chronically exposed to pesticides. Hum. Exp. Toxicol. 1996, 12:957-963.
53. Pope C.N., Chakraborti T.K., Chapman M.L., Farrar J.D. Long-term neurochemical and behavioral effects induced by chlorpyrifos treatment. Pharmacol. Biochem. Behav. 1992, 42:251-256.
54. Ray D.E. Chronic effects of low level exposure to anticholinesterases-a mechanistic review. Toxicol. Lett. 1998, 102-103:527-533.
55. Ray D.E., Richards P.G. The potential for toxic effects of chronic, low-dose exposure to organophosphates. Toxicol. Teratol. 2001, 120:343-351.
56. Reiner E., Pleština R. Regeneration of cholinesterase activities in humans and rats after inhibition by O,O-dimethyl-O-dimethyl-2,2-dichlorvinyl phosphate. Toxicol. Appl. Pharmacol. 1979, 49:451-454.
57. Roldan-Tapia L., Parron T., Sanchez-Santed F. Neuropsychological effects of long-term exposure to organophosphate pesticides. Neurotoxicol. Teratol. 2005, 27:59-266.
58. Rosenstock L., Keifer M., Daniell W., McConnell R., Claypoole K. Chronic central nervous system effects of acute organophosphate pesticide intoxication. Lancet 1991, 338:223-227.
59. Salvi R.M., Lara D.R., Ghisolfi E.S., Portela L.V., Dias R.D., Souza D.O. Neuropsychiatric evaluation in subjects chronically exposed to organophosphate pesticides. Toxicol. Sci. 2003, 72:267-271.
60. Savage E.P., Keefe T.J., Mounce L.M., Heaton R.K., Lewis J.A., Burcar P.J. Chronic neurological sequelae of organophosphate pesticide poisoning. Arch. Environ. Health 1988, 43:38-45.
61. Sellström A. Anticonvulsants in anticholinesterase poisoning. Clinical Experimental Toxicology of Organophosphates & Carbamates 1992, 578-586. Butterworth-Heinemann, Oxford. B. Ballantyne, T.C. Marrs (Eds.).
62. Senanayake N., Karalliedde L. Neurotoxic effects of organophosphate insecticides: an intermediate syndrome. N. Engl. J. Med. 1987, 316:761-763.
63. Singh S., Sharma N. Neurological syndromes following organophosphate poisoning. Neurol. India 2000, 48:308-313.
64. Shailesh K.K., Pais P., Vengamma B., Muthane U. Clinical and electrophysiological study of intermediate syndrome in patients with organophosphorous poisoning. J. Assoc. Phys. India 1994, 42:451-453.
65. Steenland K., Jenkins B., Ames R.G., O'Maley M., Chrislip D., Russo J. Chronic neurological sequelae to organophosphate poisoning. Am. J. Pub. Health 1994, 84:731-736.
66. Tan D.H., Peng S.Q., Wub Y.L., Wang Y.M., Lu C.F., Yan C.H. Chronic organophosphate (OP)-induced neuropsychiatric disorder is a withdrawal syndrome. Med. Hypotheses 2009, 72:405-406.
67. van Dongen C.J., Wolthuis O.L. On the development of behavioral tolerance to organophosphates. I: behavioral and biochemical aspects. Pharmacol. Biochem. Behav. 1989, 34:473-481.
68. van der Hoek W., Konradsen F., Athukorala K., Wanigadewa T. Pesticide poisoning: a major health problem in Sri Lanka. Soc. Sci. Med. 1998, 46:495-504.
69. van Tienhoven M., Atkins J., Li Y., Glynn P. Human neuropathy target esterase catalyses hydrolysis of membrane lipids. J. Biol. Chem. 2002, 277:20942-20948.
70. Worek F., Diepold C., Eyer P. Dimethylphosphoryl-inhibited human cholinesterases: inhibition, reactivation, and aging kinetics. Arch. Toxicol. 1999, 73:7-14.
71. World Health Organization Organophosphorus Insecticides: A General Introduction 1986, vol. 63. Environmental Health Criteria, Geneva.
72. Yang C.-C., Deng J.-F. Intermediate syndrome following organophosphate insecticide poisoning. J. Chin. Med. Assoc. 2007, 70:467-472.