Luteolin inhibits SH-SY5Y cell apoptosis through suppression of the nuclear transcription factor-κB, mitogen-activated protein kinase and protein kinase B pathways in lipopolysaccharide-stimulated cocultured BV2 cells

Experimental and Therapeutic Medicine

Volumn 7, Issue 5, 2014, Pages 1065-1070

  Zhu, Lihong ^a   Bi, Wei ^b   Lu, Dan ^a   Zhang, Chanjuan ^a   Shu, Xiaoming ^a   Lu, Daxiang ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF JINAN UNIVERSITY   (China)

Author keywords

Luteolin; Microglia; Mitogen activated protein kinase; Neuroinflammation; Neuroprotection; Nuclear transcription factor B; Protein kinase B; Toll like receptor 4

Indexed keywords

BETA ACTIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUTEOLIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY ASSAY; ENZYME REPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MICROGLIA; NERVOUS SYSTEM INFLAMMATION; NEUROBLASTOMA; NEUROBLASTOMA CELL; NEUROPROTECTION; NICK END LABELING; NONHUMAN; POLYMERASE CHAIN REACTION SYSTEM; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 84896858735     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1564     Document Type: Article

References (32)

1. Bernardi A, Frozza RL, Meneghetti A, Hoppe JB, BattastiniAM, Pohlmann AR, Guterres SS and Salbego CG: Indomethacin-loaded lipid-core nanocapsules reduce the damage triggered by Aβ1-42 in Alzheimer's disease models. Int J Nanomedicine7: 4927-4942, 2012.
2. Yokoyama H, Uchida H, Kuroiwa H, Kasahara J and ArakiT: Role of glial cells in neurotoxin-induced animal models of Parkinson's disease. Neurol Sci 32: 1-7, 2011.
3. Dibaj P, Zschüntzsch J, Steffens H, Scheffel J, GörickeB, WeishauptJH, Le Meur K, Kirchhoff F, Hanisch UK, SchomburgED and Neusch C: Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS. PLoS One7: e43963, 2012.
4. McGeer EG and McGeer PL: Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy. J Alzheimers Dis 19: 355-361, 2010.
5. Mrak RE and Griffin WS: Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging 26: 349-354, 2005.
6. Anisman H: Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder. J Psychiatry Neurosci 34: 4-20, 2009.
7. Ha SK, Lee P, Park JA, Oh HR, Lee SY, Park JH, et al: Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model. Neurochem Int 52: 878-886, 2008.
8. Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH and LynchMA: CD 200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4. J Neurosci 27: 8309-8313, 2007.
9. Qian L, Flood PM and Hong JS: Neuroinflammation is a key player in Parkinson's disease and a prime target for therapy. J Neural Transm 117: 971-979, 2010.
10. Krause DL and Müller N: Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease. Int J Alzheimers Dis 2010: 732806, 2010.
11. Park E, Kum S, Wang C, Park SY, Kim BS and Schuller-LevisG: Anti-inflammatory activity of herbal medicines: Inhibition of nitric oxide production and tumor necrosis factor-alpha secretion in an activated macrophage-like cell line. Am J Chin Med 33: 415-424, 2005.
12. Kim JS and Jobin C: The flavonoid luteolin prevents lipopolysaccharide-induced NF-κB signaling and gene expression by blocking IκB kinase activity in intestinal epithelial cells and bone-marrow derived dendritic cells. Immunology 115: 375-387, 2005.
13. Kim SH, Shin KJ, Kim D, Kim YH, Han MS, Lee TG, etal: Luteolin inhibits the nuclear factor-κB transcriptional activity in Rat-1 fibroblasts. Biochem Pharmacol 66: 955-963, 2003.
14. Gutiérrez-Venegas G, Kawasaki-Cárdenas P, Arroyo-Cruz SR and Maldonado-Frías S: Luteolin inhibits lipopolysaccharide actions on human gingival fibroblasts. Eur J Pharmacol 541: 95-105, 2006.
15. Zhu LH, Bi W, Qi RB, Wang HD and Lu DX: Luteolin inhibits microglial inflammation and improves neuron survival against inflammation. Int J Neurosci 121: 329-336, 2011.
16. Bureau G, Longpré F and Martinoli MG: Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. J Neurosci Res 86: 403-410, 2008.
17. Jang S, Kelley KW and Johnson RW: Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc Natl Acad Sci USA 105: 7534-7539, 2008.
18. Rezai-Zadeh K, Ehrhart J, Bai Y, Sanberg PR, Bickford P, Tan J and Shytle RD: Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. J Neuroinflammation 5: 41, 2008.
19. Dirscherl K, Karlstetter M, Ebert S, Kraus D, Hlawatsch J, Walczak Y, Moehle C, Fuchshofer R and Langmann T: Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype. J Neuroinflammation 7: 3, 2010.
20. Jang S, Dilger RN and Johnson RW: Luteolin inhibits microglia and alters hippocampal-dependent spatial working memory in aged mice. J Nutr 140: 1892-1898, 2010.
21. Willis LM, Bielinski DF, Fisher DR, Matthan NR and JosephJA: Walnut extract inhibits LPS-induced activation of BV-2 microglia via internalization of TLR4: Possible involvement of phospholipase D2. Inflammation 33: 325-333, 2010.
22. Medzhitov R: Toll-like receptors and innate immunity. Nat Rev Immunol 1: 135-145, 2001.
23. Ozato K, Tsujimura H and Tamura T: Toll-like receptor signaling and regulation of cytokine gene expression in the immune system. Biotechniques 33 (4 Suppl): S66-S75, 2002.
24. Bi W, Jing X, Zhu L, Liang Y, Liu J, Yang L, Xiao S, Xu A, Shi Q and Tao E: Inhibition of 26S protease regulatory subunit 7 (MSS1) suppresses neuroinflammation. Plos One 7: e36142, 2012.
25. Bi W, Zhu L, Wang C, Liang Y, Liu J, Shi Q and Tao E: Rifampicin inhibits microglial inflammation and improves neuron survival against inflammation. Brain Res 1395: 12-20, 2011.
26. Xie Z, Smith CJ and Van Eldik LJ: Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38. Glia 45: 170-179, 2004.
27. Bhat NR, Zhang P, Lee JC and Hogan EL: Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-α gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18: 1633-1641, 1998.
28. Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, BaldwinASJr and Mayo MW: Akt suppresses apoptosis by stimulating the transactivation potential of the Rel A/p65 subunit of NF-κB. Mol Cell Biol 20: 1626-1638, 2000.
29. Downward J: Lipid-regulated kinases: some common themes at last. Science 279: 673-674,1998.
30. Li Y, Liu L, Barger SW, Mrak RE and Griffin WS: Vitamin E suppression of microglial activation is neuroprotective. J Neurosci Res 15: 163-170, 2001.
31. Brown GC and Neher JJ: Inflammatory neurodegeneration and mechanisms of microglial killing of neurons. Mol Neurobiol 41: 242-247, 2010.
32. Bi W, Zhu L, Jing X, Liang Y and Tao E: Rifampicin and Parkinson's disease. Neurol Sci 34: 137-141, 2013.