The physiological role of arcuate kisspeptin neurons in the control of reproductive function in female rats

Endocrinology

Volumn 155, Issue 3, 2014, Pages 1091-1098

  Beale, K E ^a   Kinsey Jones, J S ^a   Gardiner, J V ^a   Harrison, E K ^a   Thompson, E L ^a   Hu, M H ^b   Sleeth, M L ^a   Sam, A H ^a   Greenwood, H C ^a   McGavigan, A K ^a   Dhillo, W S ^a   Mora, J M ^a   Li, X F ^b   Franks, S ^a   Bloom, S R ^a   O'Byrne, K T ^b   Murphy, K G ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; FOLLITROPIN; KISSPEPTIN; LUTEINIZING HORMONE; PARVOVIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANTISENSE VECTOR; ARCUATE NUCLEUS; ARTICLE; CELL FUNCTION; CELL POPULATION; ESTRUS CYCLE; FEMALE; GENE SILENCING; LUTEINIZING HORMONE BLOOD LEVEL; LUTEINIZING HORMONE RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; REPRODUCTION; STEREOTACTIC PROCEDURE;

ANIMALS; ARCUATE NUCLEUS; ESTRADIOL; ESTROUS CYCLE; FEEDBACK, PHYSIOLOGICAL; FEMALE; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; IMMUNOASSAY; KISSPEPTINS; LUTEINIZING HORMONE; NEURONS; OLIGONUCLEOTIDES, ANTISENSE; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; REPRODUCTION; TIME FACTORS;

EID: 84896840260     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1544     Document Type: Article

References (43)

1. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA. 2003;100(19):10972-10976. (Pubitemid 37140137)
2. Seminara SB, Messager S, Chatzidaki EE, et al. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349(17):1614-1627. (Pubitemid 37303886)
3. d'Anglemont de Tassigny X, Fagg LA, et al. Hypogonadotropic hypogonadism in mice lacking a functional Kiss1 gene. Proc Natl Acad Sci USA. 2007;104(25):10714-10719. (Pubitemid 47185730)
4. Gottsch ML, Cunningham MJ, Smith JT, et al. Arole for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology. 2004;145(9):4073-4077. (Pubitemid 39120554)
5. Thompson EL, Patterson M, Murphy KG, et al. Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis. J Neuroendocrinol. 2004;16(10):850-858. (Pubitemid 39489998)
6. Dhillo WS, Chaudhri OB, Patterson M, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab. 2005;90(12):6609-6615. (Pubitemid 41759323)
7. Irwig MS, Fraley GS, Smith JT, et al. Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology. 2004;80(4):264-272. (Pubitemid 40187012)
8. Han SK, Gottsch ML, Lee KJ, et al. Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci. 2005;25(49):11349-11356. (Pubitemid 43083709)
9. Kirilov M, Clarkson J, Liu X, et al. Dependence of fertility on kisspeptin-Gpr54 signaling at the GnRH neuron. Nat Commun. 2013;4:2492.
10. Mikkelsen JD, Simonneaux V. The neuroanatomy of the kisspeptin system in the mammalian brain. Peptides. 2009;30(1):26-33.
11. Smith JT, Cunningham MJ, Rissman EF, Clifton DK, Steiner RA. Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology. 2005;146(9):3686-3692. (Pubitemid 41175732)
12. Smith JT, Dungan HM, Stoll EA, et al. Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology. 2005;146(7):2976-2984. (Pubitemid 41002804)
13. Blake CA, Sawyer CH. Effects of hypothalamic deafferentation on the pulsatile rhythm in plasma concentrations of luteinizing hormone in ovariectomized rats. Endocrinology. 1974;94(3):730-736.
14. Ohkura S, Tsukamura H, Maeda K. Effects of various types of hypothalamic deafferentation on luteinizing hormone pulses in ovariectomized rats. J Neuroendocrinol. 1991;3(5):503-508.
15. Li XF, Kinsey-Jones JS, Cheng Y, et al. Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS One. 2009;4(12):e8334.
16. Patterson M, Murphy KG, Thompson EL, Patel S, Ghatei MA, Bloom SR. Administration of kisspeptin-54 into discrete regions of the hypothalamus potently increases plasma luteinising hormone and testosterone in male adult rats. J Neuroendocrinol. 2006;18(5):349-354.
17. Wakabayashi Y, Nakada T, Murata K, et al. Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci. 2010;30(8):3124-3132.
18. Gottsch ML, Popa SM, Lawhorn JK, et al. Molecular properties of Kiss1 neurons in the arcuate nucleus of the mouse. Endocrinology. 2011;152(11):4298- 4309.
19. Kinsey-Jones JS, Li XF, Knox AM, et al. Down-regulation of hypothalamic kisspeptin and its receptor, Kiss1r, mRNA expression is associated with stress-induced suppression of luteinising hormone secretion in the female rat. J Neuroendocrinol. 2009;21(1):20-29.
20. Castellano JM, Bentsen AH, Romero M, et al. Acute inflammation reduces kisspeptin immunoreactivity at the arcuate nucleus and decreases responsiveness to kisspeptin independently of its anorectic effects. Am J Physiol Endocrinol Metab. 2010;299(1):E54-E61.
21. True C, Kirigiti M, Ciofi P, Grove KL, Smith MS. Characterisation of arcuate nucleus kisspeptin/neurokinin B neuronal projections and regulation during lactation in the rat. J Neuroendocrinol. 2011;23(1):52-64.
22. Gardiner JV, Kong WM, Ward H, Murphy KG, Dhillo WS, Bloom SR. AAV mediated expression of anti-sense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake. Biochem Biophys Res Commun. 2005;327(4):1088-1093. (Pubitemid 40137980)
23. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. 2nd ed. Sydney; Orlando: Academic Press; 1986.
24. Goldman JM, Murr AS, Cooper RL. The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies. Birth Defects Res B Dev Reprod Toxicol. 2007;80(2):84-97. (Pubitemid 46762318)
25. Bucci TJ, Bolon B, Warbritton AR, Chen JJ, Heindel JJ. Influence of sampling on the reproducibility of ovarian follicle counts in mouse toxicity studies. Reprod Toxicol. 1997;11(5):689-696. (Pubitemid 29110535)
26. Kinsey-Jones JS, Grachev P, Li XF, et al. The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat. Endocrinology. 2012;153(1):307-315.
27. Neal-Perry GS, Zeevalk GD, Santoro NF, Etgen AM. Attenuation of preoptic area glutamate release correlates with reduced luteinizing hormone secretion in middle-aged female rats. Endocrinology. 2005;146(10):4331-4339. (Pubitemid 41324029)
28. Palkovits M, Brownstein MJ. Maps and Guide to Microdissection of the Rat Brain. New York, NY: Elsevier; 1988.
29. Franceschini I, Lomet D, Cateau M, Delsol G, Tillet Y, Caraty A. Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor α. Neurosci Lett. 2006;401(3):225-230. (Pubitemid 43729526)
30. Biegel LB, Hurtt ME, Frame SR, O'Connor JC, Cook JC. Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats. Toxicol Sci. 2001;60(1):44-55. (Pubitemid 32229826)
31. Van Cauter E. Estimating false-positive and false-negative errors in analyses of hormonal pulsatility. Am J Physiol. 1988;254(6 pt 1):E786-E794.
32. Knobil E. The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res. 1980;36:53-88.
33. Wilson RC, Kesner JS, Kaufman JM, Uemura T, Akema T, Knobil E. Central electrophysiologic correlates of pulsatile luteinizing hormone secretion in the rhesus monkey. Neuroendocrinology. 1984;39(3):256-260. (Pubitemid 14054676)
34. Ohkura S, Takase K, Matsuyama S, et al. Gonadotrophin-releasing hormone pulse generator activity in the hypothalamus of the goat. J Neuroendocrinol. 2009;21(10):813-821.
35. Keen KL, Wegner FH, Bloom SR, Ghatei MA, Terasawa E. An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo. Endocrinology. 2008;149(8):4151-4157.
36. May PC, Kohama SG, Finch CE. N-methyl-aspartic acid lesions of the arcuate nucleus in adult C57BL/6J mice: a new model for age-related lengthening of the estrous cycle. Neuroendocrinology. 1989;50(5):605-612. (Pubitemid 19249107)
37. Navarro VM. New insights into the control of pulsatile GnRH release: the role of Kiss1/neurokinin B neurons. Front Endocrinol. 2012;3:48.
38. Mittelman-Smith MA, Williams H, Krajewski-Hall SJ, et al. Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight. Endocrinology. 2012;153(6):2800-2812.
39. Mayer C, Boehm U. Female reproductive maturation in the absence of kisspeptin/GPR54 signaling. Nat Neurosci. 2011;14(6):704-710.
40. Popa SM, Moriyama RM, Caligioni CS, et al. Redundancy in Kiss1 expression safeguards reproduction in the mouse. Endocrinology. 2013;154(8):2784-2794.
41. Smith JT, Popa SM, Clifton DK, Hoffman GE, Steiner RA. Kiss1 neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge. J Neurosci. 2006;26(25):6687-6694. (Pubitemid 44315230)
42. Adachi S, Yamada S, Takatsu Y, et al. Involvement of anteroventral periventricular metastin/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats. J Reprod Dev. 2007;53(2):367-378. (Pubitemid 46743563)
43. Kinoshita M, Tsukamura H, Adachi S, et al. Involvement of central metastin in the regulation of preovulatory luteinizing hormone surge and estrous cyclicity in female rats. Endocrinology. 2005;146(10):4431-4436. (Pubitemid 41324041)