Molecular properties of kiss1 neurons in the arcuate nucleus of the mouse

Endocrinology

Volumn 152, Issue 11, 2011, Pages 4298-4309

  Gottsch, Michelle L ^a   Popa, Simina M ^b   Lawhorn, Janessa K ^a   Qiu, Jian ^c   Tonsfeldt, Karen J ^c   Bosch, Martha A ^c   Kelly, Martin J ^c   Rønnekleiv, Oline K ^c   Sanz, Elisenda ^a   McKnight, G Stanley ^a   Clifton, Donald K ^a   Palmiter, Richard D ^a,b   Steiner, Robert A ^a,b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; CYCLIC NUCLEOTIDE; ENHANCED GREEN FLUORESCENT PROTEIN; KISSPEPTIN; N METHYL DEXTRO ASPARTIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ARCUATE NUCLEUS; ARTICLE; BRAIN; CALCIUM CURRENT; CONTROLLED STUDY; EXPERIMENTAL MODEL; FEMALE; HYPERPOLARIZATION; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; MALE; MOUSE; NERVE CELL; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SINGLE CELL ANALYSIS;

ANIMALS; ARCUATE NUCLEUS; ESTRADIOL; FEMALE; KISSPEPTINS; MALE; MICE; MICE, TRANSGENIC; NEURONS; ORCHIECTOMY; OVARIECTOMY; REPRODUCTION;

EID: 80054942605     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1521     Document Type: Article

References (47)

1. de Roux N, Genin E, Carel JC, Matsuda F, Chaussain JL, Milgrom E 2003 Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 100:10972-10976 (Pubitemid 37140137)
2. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno Jr JS, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley Jr WF, Aparicio SA, Colledge WH 2003 The GPR54 gene as a regulator of puberty. N Engl J Med 349:1614-1627 (Pubitemid 37303886)
3. Gottsch ML, Cunningham MJ, Smith JT, Popa SM, Acohido BV, Crowley WF, Seminara S, Clifton DK, Steiner RA 2004 A role for kisspeptins in the regulation of gonadotropin secretion in the mouse. Endocrinology 145:4073-4077 (Pubitemid 39120554)
4. Mikkelsen JD, Simonneaux V 2009 The neuroanatomy of the kisspeptin system in the mammalian brain. Peptides 30:26-33
5. Smith JT, Cunningham MJ, Rissman EF, Clifton DK, Steiner RA 2005 Regulation of Kiss1 gene expression in the brain of the female mouse. Endocrinology 146:3686-3692 (Pubitemid 41175732)
6. Smith JT, Dungan HM, Stoll EA, Gottsch ML, Braun RE, Eacker SM, Clifton DK, Steiner RA 2005 Differential regulation of KiSS-1 mRNA expression by sex steroids in the brain of the male mouse. Endocrinology 146:2976-2984 (Pubitemid 41002804)
7. Clarkson J, Herbison AE 2009 Oestrogen, kisspeptin, GPR54 and the pre-ovulatory luteinising hormone surge. J Neuroendocrinol 21: 305-311
8. Dungan HM, Gottsch ML, Zeng H, Gragerov A, Bergmann JE, Vassilatis DK, Clifton DK, Steiner RA 2007 The role of kisspeptin- GPR54 signaling in the tonic regulation and surge release of gonadotropin- releasing hormone/luteinizing hormone. J Neurosci 27: 12088-12095 (Pubitemid 350072118)
9. Glidewell-Kenney C, Weiss J, Hurley LA, Levine JE, Jameson JL 2008 Estrogen receptor α signaling pathways differentially regulate gonadotropin subunit gene expression and serum follicle-stimulating hormone in the female mouse. Endocrinology 149:4168-4176
10. Oakley AE, Clifton DK, Steiner RA 2009 Kisspeptin signaling in the brain. Endocr Rev 30:713-743
11. Clarkson J, d'Anglemont de Tassigny X, Moreno AS, Colledge WH, Herbison AE 2008 Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. J Neurosci 28:8691-8697
12. Irwig MS, Fraley GS, Smith JT, Acohido BV, Popa SM, Cunningham MJ, Gottsch ML, Clifton DK, Steiner RA 2004 Kisspeptin activation of gonadotropin releasing hormone neurons and regulation of KiSS-1 mRNA in the male rat. Neuroendocrinology 80:264-272 (Pubitemid 40187012)
13. Parhar IS 2005 GnRH and gpcr: laser-captured single cell gene profiling. Fish Physiol Biochem 31:153-156 (Pubitemid 44339820)
14. Han SK, Gottsch ML, Lee KJ, Popa SM, Smith JT, Jakawich SK, Clifton DK, Steiner RA, Herbison AE 2005 Activation of gonadotropin- releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty. J Neurosci 25:11349-11356 (Pubitemid 43083709)
15. Pielecka-Fortuna J, Chu Z, Moenter SM 2008 Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol. Endocrinology 149:1979-1986 (Pubitemid 351468349)
16. Zhang C, Roepke TA, Kelly MJ, Rønnekleiv OK 2008 Kisspeptin depolarizes gonadotropin-releasing hormone neurons through activation of TRPC-like cationic channels. J Neurosci 28:4423-4434
17. Liu X, Lee K, Herbison AE 2008 Kisspeptin excites gonadotropinreleasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology 149:4605-4614
18. Wakabayashi Y, Nakada T, Murata K, Ohkura S, Mogi K, Navarro VM, Clifton DK, Mori Y, Tsukamura H, Maeda K, Steiner RA, Okamura H 2010 Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat. J Neurosci 30:3124-3132
19. Keen KL, Wegner FH, Bloom SR, Ghatei MA, Terasawa E 2008 An increase in kisspeptin-54 release occurs with the pubertal increase in luteinizing hormone-releasing hormone-1 release in the stalk-median eminence of female rhesus monkeys in vivo. Endocrinology 149:4151-4157
20. Roseweir AK, Kauffman AS, Smith JT, Guerriero KA, Morgan K, Pielecka-Fortuna J, Pineda R, Gottsch ML, Tena-Sempere M, Moenter SM, Terasawa E, Clarke IJ, Steiner RA, Millar RP 2009 Discovery of potent kisspeptin antagonists delineate physiological mechanisms of gonadotropin regulation. J Neurosci 29:3920-3929
21. Thomas KR, Capecchi MR 1987 Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512
22. Thomas KR, Deng C, Capecchi MR 1992 High-fidelity gene targeting in embryonic stem cells by using sequence replacement vectors. Mol Cell Biol 12:2919-2923
23. Farley FW, Soriano P, Steffen LS, Dymecki SM 2000 Widespread recombinase expression using FLPeR (flipper) mice. Genesis 28: 106-110
24. Qiu J, Fang Y, Rønnekleiv OK, Kelly MJ 2010 Leptin excites proopiomelanocortin neurons via activation of TRPC channels. J Neurosci 30:1560-1565
25. Ibrahim N, Bosch MA, Smart JL, Qiu J, Rubinstein M, Rønnekleiv OK, Low MJ, Kelly MJ 2003 Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels. Endocrinology 144:1331-1340 (Pubitemid 36428475)
26. Zhang C, Bosch MA, Levine JE, Rønnekleiv OK, Kelly MJ 2007 Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition. J Neurosci 27:10153-10164 (Pubitemid 47450463)
27. Nunemaker CS, DeFazio RA, Moenter SM 2003 A targeted extracellular approach for recording long-term firing patterns of excitable cells: a practical guide. Biol Proced Online 5:53-62 (Pubitemid 38097499)
28. Zhang C, Bosch MA, Rick EA, Kelly MJ, Rønnekleiv OK 2009 Beta-estradiol regulation of T-type calcium channels in gonadotropin- releasing hormone neurons. J Neurosci 29:10552-10562
29. Qiu J, Fang Y, Bosch MA, Rønnekleiv OK, Kelly MJ 2011 Guinea pig kisspeptin neurons are depolarized by leptin via activation of TRPC channels. Endocrinology 152:1503-1514
30. Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 25:402-408 (Pubitemid 34164012)
31. Pfaffl MW 2001 A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
32. Erickson KR, Ronnekleiv OK, Kelly MJ 1993 Role of a T-type calcium current in supporting a depolarizing potential, damped oscillations, and phasic firing in vasopressinergic guinea pig supraoptic neurons. Neuroendocrinology 57:789-800 (Pubitemid 23249922)
33. Erickson KR, Ronnekleiv OK, Kelly MJ 1993 Electrophysiology of guinea-pig supraoptic neurones: role of a hyperpolarization-activated cation current in phasic firing. J Physiol 460:407-425 (Pubitemid 23058057)
34. McCormick DA, Huguenard JR 1992 A model of the electrophysiological properties of thalamocortical relay neurons. J Neurophysiol 68:1384-1400
35. Cravo RM, Margatho LO, Osborne-Lawrence S, Donato Jr J, Atkin S, Bookout AL, Rovinsky S, Frazão R, Lee CE, Gautron L, Zigman JM, Elias CF 2011 Characterization of Kiss1 neurons using transgenic mouse models. Neuroscience 173:37-56
36. Mayer C, Acosta-Martinez M, Dubois SL, Wolfe A, Radovick S, Boehm U, Levine JE 2010 Timing and completion of puberty in female mice depend on estrogen receptor α-signaling in kisspeptin neurons. Proc Natl Acad Sci USA 107:22693-22698
37. Padilla SL, Carmody JS, Zeltser LM 2010 Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits. Nat Med 16:403-405
38. Donato Jr J, Cravo RM, Frazão R, Gautron L, Scott MM, Lachey J, Castro IA, Margatho LO, Lee S, Lee C, Richardson JA, Friedman J, Chua Jr S, Coppari R, Zigman JM, Elmquist JK, Elias CF 2011 Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. J Clin Invest 121:355-368
39. Ronnekleiv OK, MA Bosch, C Xhang 18 May 2011 17β-Estradiol regulation of GnRH neuronal excitability. J Neuroendocrinol 10.1111/j.1365-2826. 2011.02160.x
40. Li XF, Kinsey-Jones JS, Cheng Y., Knox AM, Lin Y, Petrou NA, Roseweir A, Lightman SL, Milligan SR, Millar RP, O'Byrne KT 2009 Kisspeptin signalling in the hypothalamic arcuate nucleus regulates GnRH pulse generator frequency in the rat. PLoS One 4:e8334
41. Navarro VM, Castellano JM, McConkey SM, Pineda R, Ruiz-Pino F, Pinilla L, Clifton DK, Tena-Sempere M, Steiner RA 2011 Interactions between kisspeptin and neurokinin B in the control ofGnRH secretion in the female rat. Am J Physiol Endocrinol Metab 300: E202-E210
42. Navarro VM, Gottsch ML, Chavkin C, Okamura H, Clifton DK, Steiner RA 2009 Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/ neurokinin B neurons in the arcuate nucleus of the mouse. J Neurosci 29:11859-11866
43. Ramaswamy S, Seminara SB, Ali B, Ciofi P, Amin NA, Plant TM 2010 Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus. Endocrinology 151:4494-4503
44. Bevan MD, Wilson CJ 1999 Mechanisms underlying spontaneous oscillation and rhythmic firing in rat subthalamic neurons. J Neurosci 19:7617-7628 (Pubitemid 29404617)
45. Santoro B, Tibbs GR 1999 The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels. Ann NY Acad Sci 868:741-764 (Pubitemid 29281192)
46. Chu Z, Takagi H, Moenter SM 2010 Hyperpolarization-activated currents in gonadotropin-releasing hormone (GnRH) neurons contribute to intrinsic excitability and are regulated by gonadal steroid feedback. J Neurosci 30:13373-13383
47. Wagner EJ, Bosch MA, Kelly MJ, Rønnekleiv OK 1999 A powerful GABA(B) receptor-mediated inhibition of GABAergic neurons in arcuate nucleus. Neuroreport 10:2681-2687 (Pubitemid 29418159)