Evaluation of p53, HoxD10, and E-cadherin status in breast cancer and correlation with histological grade and other prognostic factors

Journal of Oncology

Volumn , Issue , 2014, Pages

  Sekar, Preethi ^a   Bharti, Jyotsna Naresh ^b   Nigam, Jitendra Singh ^a   Sharma, Ankit ^a   Soni, Priyanka Bhatia ^a  

^a Deen Dayal Upadhyaya Hospital   (India)

^b MAULANA AZAD MEDICAL COLLEGE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HOX PROTEIN; HOXD10 PROTEIN; MESSENGER RNA; PROTEIN P53; UNCLASSIFIED DRUG; UVOMORULIN;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CANCER PROGNOSIS; CANCER SIZE; DOWN REGULATION; EVALUATION STUDY; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPH VESSEL METASTASIS; LYMPHOCYTIC INFILTRATION; MAJOR CLINICAL STUDY; MIDDLE AGED; PROSPECTIVE STUDY; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR NECROSIS;

EID: 84896816476     PISSN: 16878450     EISSN: 16878469     Source Type: Journal    
DOI: 10.1155/2014/702527     Document Type: Article

References (24)

1. Agarwal G., Ramakant P., Breast cancer care in India: the current scenario and the challenges for the future. Breast Care 2008 3 1 21 27 2-s2.0-40549113972 10.1159/000115288
2. Breast Cancer Estimated Incidence, Mortality and Prevalence Worldwide in 2012, http://globocan.iarc.fr/Pages/fact-sheets-cancer.aspx
3. Rivlin N., Brosh R., Oren M., Rotter V., Mutations in the p53 tumor suppressor gene: important milestones at the various steps of tumorigenesis. Genes and Cancer 2011 2 4 466 474 2-s2.0-80053039210 10.1177/1947601911408889
4. Norberg T., Klaar S., Kärf G., Nordgren H., Holmberg L., Bergh J., Increased p53 mutation frequency during tumor progression-results from a breast cancer cohort. Cancer Research 2001 61 22 8317 8321 2-s2.0-0035890360
5. Cox L. S., Lane D. P., Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. BioEssays 1995 17 6 501 508 2-s2.0-0029315510
6. Lowe S. W., Lin A. W., Apoptosis in cancer. Carcinogenesis 2000 21 3 485 495 2-s2.0-0034057320
7. Pharaoh P. D. P., Day N. E., Caldas C., Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis. British Journal of Cancer 1999 80 12 1968 1973 2-s2.0-0032814777 10.1038/sj.bjc.6690628
8. Berx G., Van Roy F., The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression. Breast Cancer Research 2001 3 5 289 293 2-s2.0-0034852853 10.1186/bcr309
9. Qureshi H. S., Linden M. O., Divine G., Raju U. B., E-cadherin status in breast cancer correlates with histologic type but does not correlate with established prognostic parameters. American Journal of Clinical Pathology 2006 125 3 377 385 2-s2.0-33644644574 10.1309/WMX7-DRWT-FVQP-2LQT
10. Blick T., Widodo E., Hugo H., Waltham M., Lenburg M. E., Neve R. M., Thompson E. W., Epithelial mesenchymal transition traits in human breast cancer cell lines. Clinical and Experimental Metastasis 2008 25 6 629 642 2-s2.0-47549102418 10.1007/s10585-008-9170-6
11. Cleton-Jansen A., E-cadherin and loss of heterozygosity at chromosome 16 in breast cancinogenesis: different genetic pathways in ductal and lobular breast cancer? Breast Cancer Research 2002 4 1 5 8 2-s2.0-0036146659 10.1186/bcr416
12. Celebiler C. A., Sevinc A. I., Saydam S., Canda T., Baskan Z., Kilic Y., Sakizli M., Promoter methylation and expression changes of CDH1 and P16 genes in invasive breast cancer and adjacent normal breast tissue. Neoplasma 2010 57 5 465 472 2-s2.0-79251594654 10.4149/neo-2010-05-465
13. Cillo C., Deregulation of the Hox gene network and cancer. HOX Gene Expression 2007 121 133
14. Cantile M., Pettinato G., Procino A., Feliciello I., Cindolo L., Cillo C., In vivo expression of the whole HOX gene network in human breast cancer. European Journal of Cancer 2003 39 2 257 264 2-s2.0-0037222588 10.1016/S0959-8049(02)00599-3
15. Cantile M., Schiavo G., Terracciano L., Cillo C., The HOX gene network as a potential target for cancer therapy. Current Cancer Therapy Reviews 2007 3 1 17 24 2-s2.0-34047122624 10.2174/157339407780126593
16. Makiyama K., Hamada J., Takada M., Murakawa K., Takahashi Y., Tada M., Tamoto E., Shindo G., Matsunaga A., Teramoto K., Komuro K., Kondo S., Katoh H., Koike T., Moriuchi T., Aberrant expression of HOX genes in human invasive breast carcinoma. Oncology Reports 2005 13 4 673 679 2-s2.0-23844473412
17. Berx G., Cleton-Jansen A., Nollet F., De Leeuw W. J. F., Van De Vijver M. J., Cornelisse C., Van Roy F., E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. EMBO Journal 1995 14 24 6107 6115 2-s2.0-0029558476
18. Song H. S., Do Y. R., Kang S. H., Jeong K. Y., Kim Y. S., Prognostic significance of immunohistochemical expression of p53 gene product in operable breast cancer. Cancer Treatment and Research 2006 38 4 218 223 10.4143/crt.2006.38.4.218
19. Al-Joudi F. S., Iskandar Z. A., Rusli J., The expression of p53 in invasive ductal carcinoma of the breast: a study in the North-East States of Malaysia. Medical Journal of Malaysia 2008 63 2 96 99 2-s2.0-55049101253
20. Aziz Z. W., Saleem H. S., p53 in breast carcinoma: an immunohistochemical study. Annals of the College of Medicine Mosul 2011 37 34 41
21. Ma L., Teruya-Feldstein J., Weinberg R. A., Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007 449 7163 682 688 2-s2.0-35148886434 10.1038/nature06174
22. Reddy S. D., Ohshiro K., Rayala S. K., Kumar R., MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Research 2008 68 20 8195 8200 2-s2.0-54249093368 10.1158/0008-5472.CAN-08-2103
23. Rasti M., Entezam M., Monabati A., Hypermethylation of E-cadherin and estrogen receptor- α gene promoter and its association with clinicopathological features of breast cancer in Iranian patients. Iranian Journal of Medical Sciences 2009 34 3 186 192 2-s2.0-67749091262
24. Shargh S. A., Sakizli M., Farajnia S., Montazer-Saheb S., Evaluation of methylation pattern in promoter region of E-cadherin gene and its relation to tumor grade and stage in breast cancer. African Journal of Biotechnology 2011 10 10 1745 1751 2-s2.0-79952688351