메뉴 건너뛰기




Volumn 11, Issue 2, 2014, Pages 95-100

The differential processing of telomeres in response to increased telomeric transcription and RNA-DNA hybrid accumulation

Author keywords

Exo1; R loop; RNA DNA hybrid; RNase H; Senescence; Telomere; TERRA

Indexed keywords

EXO1 PROTEIN; PROTEIN; RAD52 PROTEIN; RIBONUCLEASE H; RNA; TELOMERIC REPEAT CONTAINING RNA; UNCLASSIFIED DRUG;

EID: 84896804371     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: 10.4161/rna.27798     Document Type: Review
Times cited : (40)

References (41)
  • 1
    • 84872181805 scopus 로고    scopus 로고
    • Telomeres at a glance
    • PMID:23135002
    • Sfeir A. Telomeres at a glance. J Cell Sci 2012; 125:4173-8; PMID:23135002; http://dx.doi.org/10.1242/jcs.106831
    • (2012) J Cell Sci , vol.125 , pp. 4173-4178
    • Sfeir, A.1
  • 2
    • 71149093724 scopus 로고    scopus 로고
    • How telomeres solve the end-protection problem
    • PMID:19965504
    • de Lange T. How telomeres solve the end-protection problem. Science 2009; 326:948-52; PMID:19965504; http://dx.doi.org/10.1126/science.1170633
    • (2009) Science , vol.326 , pp. 948-952
    • De Lange, T.1
  • 3
    • 33746211311 scopus 로고    scopus 로고
    • Telomere length homeostasis
    • PMID:16741708
    • Hug N, Lingner J. Telomere length homeostasis. Chromosoma 2006; 115:413-25; PMID:16741708; http://dx.doi.org/10.1007/s00412-006-0067-3
    • (2006) Chromosoma , vol.115 , pp. 413-425
    • Hug, N.1    Lingner, J.2
  • 4
    • 0015515155 scopus 로고
    • Origin of concatemeric T7 DNA
    • PMID:4507727
    • Watson JD. Origin of concatemeric T7 DNA. Nat New Biol 1972; 239:197-201; PMID:4507727; http://dx.doi.org/10.1038/newbio239197a0
    • (1972) Nat New Biol , vol.239 , pp. 197-201
    • Watson, J.D.1
  • 5
    • 0029128798 scopus 로고
    • Telomerase and DNA end replication: No longer a lagging strand problem?
    • PMID:7545310
    • Lingner J, Cooper JP, Cech TR. Telomerase and DNA end replication: no longer a lagging strand problem? Science 1995; 269:1533-4; PMID:7545310; http://dx.doi.org/10.1126/science.7545310
    • (1995) Science , vol.269 , pp. 1533-1534
    • Lingner, J.1    Cooper, J.P.2    Cech, T.R.3
  • 6
    • 0027509950 scopus 로고
    • Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase
    • PMID:8422682
    • Wellinger RJ, Wolf AJ, Zakian VA. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell 1993; 72:51-60; PMID:8422682; http://dx.doi.org/10.1016/0092-8674(93)90049-V
    • (1993) Cell , vol.72 , pp. 51-60
    • Wellinger, R.J.1    Wolf, A.J.2    Zakian, V.A.3
  • 7
    • 0026563895 scopus 로고
    • Saccharomyces telomeres assume a non-nucleosomal chromatin structure
    • PMID:1737616
    • Wright JH, Gottschling DE, Zakian VA. Saccharomyces telomeres assume a non-nucleosomal chromatin structure. Genes Dev 1992; 6:197-210; PMID:1737616; http://dx.doi.org/10.1101/gad.6.2.197
    • (1992) Genes Dev , vol.6 , pp. 197-210
    • Wright, J.H.1    Gottschling, D.E.2    Zakian, V.A.3
  • 8
    • 0035804267 scopus 로고    scopus 로고
    • Telomere looping permits gene activation by a downstream UAS in yeast
    • PMID:11343124
    • de Bruin D, Zaman Z, Liberatore RA, Ptashne M. Telomere looping permits gene activation by a downstream UAS in yeast. Nature 2001; 409:109-13; PMID:11343124; http://dx.doi.org/10.1038/35051119
    • (2001) Nature , vol.409 , pp. 109-113
    • De Bruin, D.1    Zaman, Z.2    Liberatore, R.A.3    Ptashne, M.4
  • 9
    • 84866939030 scopus 로고    scopus 로고
    • Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast
    • PMID:23028367
    • Poschke H, Dees M, Chang M, Amberkar S, Kaderali L, Rothstein R, Luke B. Rif2 promotes a telomere fold-back structure through Rpd3L recruitment in budding yeast. PLoS Genet 2012; 8:e1002960; PMID:23028367; http://dx.doi.org/10. 1371/journal.pgen.1002960
    • (2012) PLoS Genet , vol.8
    • Poschke, H.1    Dees, M.2    Chang, M.3    Amberkar, S.4    Kaderali, L.5    Rothstein, R.6    Luke, B.7
  • 10
    • 84865105439 scopus 로고    scopus 로고
    • Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: Beginning to end
    • PMID:22879408
    • Wellinger RJ, Zakian VA. Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end. Genetics 2012; 191:1073-105; PMID:22879408; http://dx.doi.org/10.1534/genetics.111.137851
    • (2012) Genetics , vol.191 , pp. 1073-1105
    • Wellinger, R.J.1    Zakian, V.A.2
  • 11
    • 68249113719 scopus 로고    scopus 로고
    • A two-step model for senescence triggered by a single critically short telomere
    • PMID:19597486
    • Abdallah P, Luciano P, Runge KW, Lisby M, Géli V, Gilson E, Teixeira MT. A two-step model for senescence triggered by a single critically short telomere. Nat Cell Biol 2009; 11:988-93; PMID:19597486; http://dx.doi.org/10.1038/ncb1911
    • (2009) Nat Cell Biol , vol.11 , pp. 988-993
    • Abdallah, P.1    Luciano, P.2    Runge, K.W.3    Lisby, M.4    Géli, V.5    Gilson, E.6    Teixeira, M.T.7
  • 12
    • 0036677405 scopus 로고    scopus 로고
    • MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae
    • PMID:12181334
    • Enomoto S, Glowczewski L, Berman J. MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae. Mol Biol Cell 2002; 13:2626-38; PMID:12181334; http://dx.doi.org/10.1091/mbc.02-02-0012
    • (2002) Mol Biol Cell , vol.13 , pp. 2626-2638
    • Enomoto, S.1    Glowczewski, L.2    Berman, J.3
  • 13
    • 2042534735 scopus 로고    scopus 로고
    • Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states
    • PMID:15109493
    • Teixeira MT, Arneric M, Sperisen P, Lingner J. Telomere length homeostasis is achieved via a switch between telomerase- extendible and -nonextendible states. Cell 2004; 117:323-35; PMID:15109493; http://dx.doi.org/10.1016/S0092-8674(04)00334-4
    • (2004) Cell , vol.117 , pp. 323-335
    • Teixeira, M.T.1    Arneric, M.2    Sperisen, P.3    Lingner, J.4
  • 14
    • 0030697342 scopus 로고    scopus 로고
    • Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines
    • PMID:9359704
    • Bryan TM, Englezou A, Dalla-Pozza L, Dunham MA, Reddel RR. Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines. Nat Med 1997; 3:1271-4; PMID:9359704; http://dx.doi.org/10.1038/nm1197-1271
    • (1997) Nat Med , vol.3 , pp. 1271-1274
    • Bryan, T.M.1    Englezou, A.2    Dalla-Pozza, L.3    Dunham, M.A.4    Reddel, R.R.5
  • 15
    • 0034012226 scopus 로고    scopus 로고
    • The role of senescence and immortalization in carcinogenesis
    • PMID:10688868
    • Reddel RR. The role of senescence and immortalization in carcinogenesis. Carcinogenesis 2000; 21:477-84; PMID:10688868; http://dx.doi.org/10.1093/carcin/ 21.3.477
    • (2000) Carcinogenesis , vol.21 , pp. 477-484
    • Reddel, R.R.1
  • 16
    • 77951133257 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres: Models, mechanisms and implications
    • PMID:20351727
    • Cesare AJ, Reddel RR. Alternative lengthening of telomeres: models, mechanisms and implications. Nat Rev Genet 2010; 11:319-30; PMID:20351727; http://dx.doi.org/10.1038/nrg2763
    • (2010) Nat Rev Genet , vol.11 , pp. 319-330
    • Cesare, A.J.1    Reddel, R.R.2
  • 17
    • 0027944347 scopus 로고
    • TLC1: Template RNA component of Saccharomyces cerevisiae telomerase
    • PMID:7545955
    • Singer MS, Gottschling DE. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science 1994; 266:404-9; PMID:7545955; http://dx.doi.org/10.1126/science.7545955
    • (1994) Science , vol.266 , pp. 404-409
    • Singer, M.S.1    Gottschling, D.E.2
  • 18
    • 0024973811 scopus 로고
    • A mutant with a defect in telomere elongation leads to senescence in yeast
    • PMID:2655926
    • Lundblad V, Szostak JW. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 1989; 57:633-43; PMID:2655926; http://dx.doi.org/10.1016/0092-8674(89)90132-3
    • (1989) Cell , vol.57 , pp. 633-643
    • Lundblad, V.1    Szostak, J.W.2
  • 19
    • 0030455861 scopus 로고    scopus 로고
    • Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes
    • PMID:8978029
    • Lendvay TS, Morris DK, Sah J, Balasubramanian B, Lundblad V. Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 1996; 144:1399-412; PMID:8978029
    • (1996) Genetics , vol.144 , pp. 1399-1412
    • Lendvay, T.S.1    Morris, D.K.2    Sah, J.3    Balasubramanian, B.4    Lundblad, V.5
  • 20
    • 69849104275 scopus 로고    scopus 로고
    • TERRA: Telomeric repeat-containing RNA
    • PMID:19629047
    • Luke B, Lingner J. TERRA: telomeric repeat-containing RNA. EMBO J 2009; 28:2503-10; PMID:19629047; http://dx.doi.org/10.1038/emboj.2009.166
    • (2009) EMBO J , vol.28 , pp. 2503-2510
    • Luke, B.1    Lingner, J.2
  • 21
    • 37349043972 scopus 로고    scopus 로고
    • Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends
    • PMID:17916692
    • Azzalin CM, Reichenbach P, Khoriauli L, Giulotto E, Lingner J. Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends. Science 2007; 318:798-801; PMID:17916692; http://dx.doi.org/10.1126/science. 1147182
    • (2007) Science , vol.318 , pp. 798-801
    • Azzalin, C.M.1    Reichenbach, P.2    Khoriauli, L.3    Giulotto, E.4    Lingner, J.5
  • 22
    • 55949106494 scopus 로고    scopus 로고
    • The Rat1p 5′ to 3′ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae
    • PMID:19026778
    • Luke B, Panza A, Redon S, Iglesias N, Li Z, Lingner J. The Rat1p 5′ to 3′ exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae. Mol Cell 2008; 32:465-77; PMID:19026778; http://dx.doi.org/10.1016/j.molcel.2008.10.019
    • (2008) Mol Cell , vol.32 , pp. 465-477
    • Luke, B.1    Panza, A.2    Redon, S.3    Iglesias, N.4    Li, Z.5    Lingner, J.6
  • 23
    • 78049386911 scopus 로고    scopus 로고
    • Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways
    • PMID:20713443
    • Porro A, Feuerhahn S, Reichenbach P, Lingner J. Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways. Mol Cell Biol 2010; 30:4808-17; PMID:20713443; http://dx.doi.org/10.1128/MCB.00460-10
    • (2010) Mol Cell Biol , vol.30 , pp. 4808-4817
    • Porro, A.1    Feuerhahn, S.2    Reichenbach, P.3    Lingner, J.4
  • 25
    • 50849099769 scopus 로고    scopus 로고
    • Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions
    • PMID:18558631
    • Yehezkel S, Segev Y, Viegas-Péquignot E, Skorecki K, Selig S. Hypomethylation of subtelomeric regions in ICF syndrome is associated with abnormally short telomeres and enhanced transcription from telomeric regions. Hum Mol Genet 2008; 17:2776-89; PMID:18558631; http://dx.doi.org/10.1093/hmg/ ddn177
    • (2008) Hum Mol Genet , vol.17 , pp. 2776-2789
    • Yehezkel, S.1    Segev, Y.2    Viegas-Péquignot, E.3    Skorecki, K.4    Selig, S.5
  • 26
    • 79957983472 scopus 로고    scopus 로고
    • Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast
    • PMID:21525956
    • Iglesias N, Redon S, Pfeiffer V, Dees M, Lingner J, Luke B. Subtelomeric repetitive elements determine TERRA regulation by Rap1/Rif and Rap1/Sir complexes in yeast. EMBO Rep 2011; 12:587-93; PMID:21525956; http://dx.doi.org/10.1038/ embor.2011.73
    • (2011) EMBO Rep , vol.12 , pp. 587-593
    • Iglesias, N.1    Redon, S.2    Pfeiffer, V.3    Dees, M.4    Lingner, J.5    Luke, B.6
  • 27
    • 84866115963 scopus 로고    scopus 로고
    • Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α
    • PMID:22922742
    • Arnoult N, Van Beneden A, Decottignies A. Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α. Nat Struct Mol Biol 2012; 19:948-56; PMID:22922742; http://dx.doi.org/10.1038/nsmb. 2364
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 948-956
    • Arnoult, N.1    Van Beneden, A.2    Decottignies, A.3
  • 28
    • 68949198783 scopus 로고    scopus 로고
    • TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres
    • PMID:19716786
    • Deng Z, Norseen J, Wiedmer A, Riethman H, Lieberman PM. TERRA RNA binding to TRF2 facilitates heterochromatin formation and ORC recruitment at telomeres. Mol Cell 2009; 35:403-13; PMID:19716786; http://dx.doi.org/10.1016/j.molcel. 2009.06.025
    • (2009) Mol Cell , vol.35 , pp. 403-413
    • Deng, Z.1    Norseen, J.2    Wiedmer, A.3    Riethman, H.4    Lieberman, P.M.5
  • 29
    • 77957243987 scopus 로고    scopus 로고
    • The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase
    • PMID:20460456
    • Redon S, Reichenbach P, Lingner J. The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase. Nucleic Acids Res 2010; 38:5797-806; PMID:20460456; http://dx.doi.org/10.1093/nar/gkq296
    • (2010) Nucleic Acids Res , vol.38 , pp. 5797-5806
    • Redon, S.1    Reichenbach, P.2    Lingner, J.3
  • 30
    • 84863461725 scopus 로고    scopus 로고
    • Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence
    • PMID:22553368
    • Maicher A, Kastner L, Dees M, Luke B. Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence. Nucleic Acids Res 2012; 40:6649-59; PMID:22553368; http://dx.doi.org/10.1093/nar/gks358
    • (2012) Nucleic Acids Res , vol.40 , pp. 6649-6659
    • Maicher, A.1    Kastner, L.2    Dees, M.3    Luke, B.4
  • 31
    • 84860491777 scopus 로고    scopus 로고
    • Telomerase efficiently elongates highly transcribing telomeres in human cancer cells
    • PMID:22558207
    • Farnung BO, Brun CM, Arora R, Lorenzi LE, Azzalin CM. Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. PLoS One 2012; 7:e35714; PMID:22558207; http://dx.doi.org/10.1371/journal.pone. 0035714
    • (2012) PLoS One , vol.7
    • Farnung, B.O.1    Brun, C.M.2    Arora, R.3    Lorenzi, L.E.4    Azzalin, C.M.5
  • 32
    • 84864041566 scopus 로고    scopus 로고
    • TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends
    • PMID:22719262
    • Pfeiffer V, Lingner J. TERRA promotes telomere shortening through exonuclease 1-mediated resection of chromosome ends. PLoS Genet 2012; 8:e1002747; PMID:22719262; http://dx.doi.org/10.1371/journal.pgen.1002747
    • (2012) PLoS Genet , vol.8
    • Pfeiffer, V.1    Lingner, J.2
  • 33
    • 84885429957 scopus 로고    scopus 로고
    • Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence
    • PMID:24013207
    • Balk B, Maicher A, Dees M, Klermund J, Luke-Glaser S, Bender K, Luke B. Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence. Nat Struct Mol Biol 2013; 20:1199-205; PMID:24013207; http://dx.doi.org/10.1038/ nsmb.2662
    • (2013) Nat Struct Mol Biol , vol.20 , pp. 1199-1205
    • Balk, B.1    Maicher, A.2    Dees, M.3    Klermund, J.4    Luke-Glaser, S.5    Bender, K.6    Luke, B.7
  • 34
    • 84884564107 scopus 로고    scopus 로고
    • Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres
    • PMID:24074956
    • Cusanelli E, Romero CA, Chartrand P. Telomeric noncoding RNA TERRA is induced by telomere shortening to nucleate telomerase molecules at short telomeres. Mol Cell 2013; 51:780-91; PMID:24074956; http://dx.doi.org/10.1016/j. molcel.2013.08.029
    • (2013) Mol Cell , vol.51 , pp. 780-791
    • Cusanelli, E.1    Romero, C.A.2    Chartrand, P.3
  • 35
    • 0027988467 scopus 로고
    • Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability
    • PMID:7991584
    • Sandell LL, Gottschling DE, Zakian VA. Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability. Proc Natl Acad Sci U S A 1994; 91:12061-5; PMID:7991584; http://dx.doi.org/10.1073/ pnas.91.25.12061
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 12061-12065
    • Sandell, L.L.1    Gottschling, D.E.2    Zakian, V.A.3
  • 37
    • 84887053583 scopus 로고    scopus 로고
    • The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening
    • PMID:24084588
    • Pfeiffer V, Crittin J, Grolimund L, Lingner J. The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening. EMBO J 2013; 32:2861-71; PMID:24084588; http://dx.doi.org/10.1038/emboj.2013.217
    • (2013) EMBO J , vol.32 , pp. 2861-2871
    • Pfeiffer, V.1    Crittin, J.2    Grolimund, L.3    Lingner, J.4
  • 38
    • 0033781559 scopus 로고    scopus 로고
    • Telomere folding is required for the stable maintenance of telomere position effects in yeast
    • PMID:11027269
    • de Bruin D, Kantrow SM, Liberatore RA, Zakian VA. Telomere folding is required for the stable maintenance of telomere position effects in yeast. Mol Cell Biol 2000; 20:7991-8000; PMID:11027269; http://dx.doi.org/10.1128/MCB.20. 21.7991-8000.2000
    • (2000) Mol Cell Biol , vol.20 , pp. 7991-8000
    • De Bruin, D.1    Kantrow, S.M.2    Liberatore, R.A.3    Zakian, V.A.4
  • 39
    • 84860338675 scopus 로고    scopus 로고
    • R loops: From transcription byproducts to threats to genome stability
    • PMID:22541554
    • Aguilera A, García-Muse T. R loops: from transcription byproducts to threats to genome stability. Mol Cell 2012; 46:115-24; PMID:22541554; http://dx.doi.org/10.1016/j.molcel.2012.04.009
    • (2012) Mol Cell , vol.46 , pp. 115-124
    • Aguilera, A.1    García-Muse, T.2
  • 40
    • 79961031438 scopus 로고    scopus 로고
    • Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles
    • PMID:21701562
    • Gómez-González B, García-Rubio M, Bermejo R, Gaillard H, Shirahige K, Marín A, Foiani M, Aguilera A. Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles. EMBO J 2011; 30:3106-19; PMID:21701562; http://dx.doi.org/10.1038/ emboj.2011.206
    • (2011) EMBO J , vol.30 , pp. 3106-3119
    • Gómez-González, B.1    García-Rubio, M.2    Bermejo, R.3    Gaillard, H.4    Shirahige, K.5    Marín, A.6    Foiani, M.7    Aguilera, A.8
  • 41
    • 84887589423 scopus 로고    scopus 로고
    • Transcription-associated genome instability
    • PMID:23597121
    • Gaillard H, Herrera-Moyano E, Aguilera A. Transcription-associated genome instability. Chem Rev 2013; 113:8638-61; PMID:23597121; http://dx.doi.org/10. 1021/cr400017y
    • (2013) Chem Rev , vol.113 , pp. 8638-8661
    • Gaillard, H.1    Herrera-Moyano, E.2    Aguilera, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.