DEC1 coordinates with HDAC8 to differentially regulate TAp73 and ΔNp73 expression

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Qian, Yingjuan ^a,b   Zhang, Jin ^a,b   Jung, Yong Sam ^a,b   Chen, Xinbin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HISTONE DEACETYLASE 8; PROTEIN P73; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DEC1; UNCLASSIFIED DRUG;

ARTICLE; CODON; ENZYME REPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; POINT MUTATION; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TUMOR CELL; UPREGULATION; WESTERN BLOTTING;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HOMEODOMAIN PROTEINS; HUMANS; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN ISOFORMS; REPRESSOR PROTEINS; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 84896792949     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084015     Document Type: Article

References (40)

1. Harms K, Nozell S, Chen X (2004) The common and distinct target genes of the p53 family transcription factors. Cell Mol Life Sci 61: 822-842. (Pubitemid 38651002)
2. Fontemaggi G, Kela I, Amariglio N, Rechavi G, Krishnamurthy J, et al. (2002) Identification of direct p73 target genes combining DNA microarray and chromatin immunoprecipitation analyses. J Biol Chem 277: 43359-43368. (Pubitemid 35285724)
3. Grob TJ, Novak U, Maisse C, Barcaroli D, Luthi AU, et al. (2001) Human delta Np73 regulates a dominant negative feedback loop for TAp73 and p53. Cell Death Differ 8: 1213-1223. (Pubitemid 34048476)
4. Kartasheva NN, Contente A, Lenz-Stoppler C, Roth J, Dobbelstein M (2002) p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop. Oncogene 21: 4715-4727. (Pubitemid 34879447)
5. Nakagawa T, Takahashi M, Ozaki T, Watanabe Ki K, Todo S, et al. (2002) Autoinhibitory regulation of p73 by Delta Np73 to modulate cell survival and death through a p73-specific target element within the Delta Np73 promoter. Mol Cell Biol 22: 2575-2585. (Pubitemid 34262980)
6. Liu G, Nozell S, Xiao H, Chen X (2004) DeltaNp73beta is active in transactivation and growth suppression. Mol Cell Biol 24: 487-501. (Pubitemid 38057903)
7. Cui R, Nguyen TT, Taube JH, Stratton SA, Feuerman MH, et al. (2005) Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription. J Biol Chem 280: 39152-39160. (Pubitemid 41713866)
8. Goldschneider D, Million K, Meiller A, Haddada H, Puisieux A, et al. (2005) The neurogene BTG2TIS21/PC3 is transactivated by DeltaNp73alpha via p53 specifically in neuroblastoma cells. J Cell Sci 118: 1245-1253. (Pubitemid 40528694)
9. Murray-Zmijewski F, Lane DP, Bourdon JC (2006) p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress. Cell Death Differ 13: 962-972.
10. Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, et al. (2008) TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev 22: 2677-2691.
11. Rufini A, Niklison-Chirou MV, Inoue S, Tomasini R, Harris IS, et al. (2012) TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev 26: 2009-2014.
12. Tissir F, Ravni A, Achouri Y, Riethmacher D, Meyer G, et al. (2009) DeltaNp73 regulates neuronal survival in vivo. Proc Natl Acad Sci U S A 106: 16871-16876.
13. Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, et al. (2010) Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev 24: 549-560.
14. Yamada K, Miyamoto K (2005) Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli. Front Biosci 10: 3151-3171. (Pubitemid 40910554)
15. Li Y, Xie M, Song X, Gragen S, Sachdeva K, et al. (2003) DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter. J Biol Chem 278: 16899-16907. (Pubitemid 36799562)
16. Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI (2001) Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway. J Biol Chem 276: 15306-15315.
17. Zawel L, Yu J, Torrance CJ, Markowitz S, Kinzler KW, et al. (2002) DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities. Proc Natl Acad Sci U S A 99: 2848-2853. (Pubitemid 34240549)
18. Shen M, Yoshida E, Yan W, Kawamoto T, Suardita K, et al. (2002) Basic helixloop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages. J Biol Chem 277: 50112-50120. (Pubitemid 36014464)
19. Li Y, Xie M, Yang J, Yang D, Deng R, et al. (2006) The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter. Oncogene 25: 3296-3306. (Pubitemid 43846314)
20. Qian Y, Jung YS, Chen X (2011) DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem 286: 12033-12041.
21. Honma S, Kawamoto T, Takagi Y, Fujimoto K, Sato F, et al. (2002) Dec1 and Dec2 are regulators of the mammalian molecular clock. Nature 419: 841-844. (Pubitemid 35238570)
22. Qian Y, Chen X (2008) ID1, inhibitor of differentiation/DNA binding, is an effector of the p53-dependent DNA damage response pathway. J Biol Chem 283: 22410-22416.
23. Qian Y, Zhang J, Yan B, Chen X (2008) DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence. J Biol Chem 283: 2896-2905.
24. Li Y, Zhang H, Xie M, Hu M, Ge S, et al. (2002) Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivationinduced apoptosis and selective inhibition of procaspase activation. Biochem J 367: 413-422. (Pubitemid 35216815)
25. Qian Y, Jung YS, Chen X (2012) Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. Proc Natl Acad Sci U S A 109: 11300-11305.
26. Ivanov SV, Salnikow K, Ivanova AV, Bai L, Lerman MI (2007) Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13. Oncogene 26: 802-812.
27. Zhang J, Xu E, Chen X (2013) TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function. J Biol Chem 288: 7727-7737.
28. Yan W, Liu S, Xu E, Zhang J, Zhang Y, et al. (2013) Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8. Oncogene 32: 599-609.
29. Zheng X, Chen X (2001) Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family. FEBS Lett 489: 4-7. (Pubitemid 32175995)
30. Sayan BS, Yang AL, Conforti F, Tucci P, Piro MC, et al. (2010) Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. Proc Natl Acad Sci U S A 107: 12877-12882.
31. Toh WH, Siddique MM, Boominathan L, Lin KW, Sabapathy K (2004) c-Jun regulates the stability and activity of the p53 homologue, p73. J Biol Chem 279: 44713-44722. (Pubitemid 39430881)
32. Dulloo I, Gopalan G, Melino G, Sabapathy K (2010) The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway. Proc Natl Acad Sci U S A 107: 4902-4907.
33. Chakrabarti J, Turley H, Campo L, Han C, Harris AL, et al. (2004) The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers. Br J Cancer 91: 954-958. (Pubitemid 39273790)
34. Rufini A, Agostini M, Grespi F, Tomasini R, Sayan BS, et al. (2011) p73 in Cancer. Genes Cancer 2: 491-502.
35. Chen X, Zheng Y, Zhu J, Jiang J, Wang J (2001) p73 is transcriptionally regulated by DNA damage, p53, and p73. Oncogene 20: 769-774. (Pubitemid 32179345)
36. Harms KL, Chen X (2005) The C terminus of p53 family proteins is a cell fate determinant. Mol Cell Biol 25: 2014-2030. (Pubitemid 40280163)
37. Jung YS, Kim HY, Kim J, Lee MG, Pouyssegur J, et al. (2008) Physical interactions and functional coupling between Daxx and sodium hydrogen exchanger 1 in ischemic cell death. J Biol Chem 283: 1018-1025.
38. Yan W, Zhang J, Zhang Y, Jung YS, Chen X (2012) p73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability. Mol Cell Biol 32: 2336-2348.
39. Liu G, Xia T, Chen X (2003) The activation domains, the proline-rich domain, and the C-terminal basic domain in p53 are necessary for acetylation of histones on the proximal p21 promoter and interaction with p300/CREB-binding protein. J Biol Chem 278: 17557-17565. (Pubitemid 36799644)
40. Liu G, Chen X (2005) The C-terminal sterile alpha motif and the extreme C terminus regulate the transcriptional activity of the alpha isoform of p73. J Biol Chem 280: 20111-20119. (Pubitemid 41379541)