MYCN gene expression is required for the onset of the differentiation programme in neuroblastoma cells

Cell Death and Disease

Volumn 5, Issue 2, 2014, Pages

  Guglielmi, L ^a   Cinnella, C ^a   Nardella, M ^a   Maresca, G ^a   Valentini, A ^b   Mercanti, D ^a   Felsani, A ^a   D'Agnano, I ^a  

^a CNR   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

differentiation; miRNA; MYCN; neuroblastoma

Indexed keywords

MICRORNA; MICRORNA 20A; MICRORNA 9; MICRORNA 92A; RETINOIC ACID; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

APOPTOSIS; ARTICLE; BRAIN CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO CELL; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MYCN GENE; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA CELL; ONCOGENE C MYB; PRIORITY JOURNAL; STEM CELL; UPREGULATION;

APOPTOSIS; CELL DIFFERENTIATION; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; NEURAL STEM CELLS; NEUROBLASTOMA; NUCLEAR PROTEINS; ONCOGENE PROTEINS; RNA INTERFERENCE; TIME FACTORS; TRANSFECTION; TRETINOIN; TUMOR MARKERS, BIOLOGICAL;

EID: 84896791619     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.42     Document Type: Article

References (52)

1. Brodeur GM. Neuroblastoma: Biological insights into a clinical enigma. Nat Rev Cancer 2003; 3: 203-216.
2. Hill DP, Robertson KA. Characterization of the cholinergic neuronal differentiation of the human neuroblastoma cell line LA-N-5 after treatment with retinoic acid. Brain Res Dev Brain Res 1997; 102: 53-67.
3. Munoz J, Vendrell E, Aiza G, Nistal M, Pestana A, Peinado MA et al. Determination of genomic damage in neuroblastic tumors by arbitrarily primed PCR: MYCN amplification as a marker for genomic instability in neuroblastomas. Neuropathology 2006; 26: 165-169.
4. Eilers M, Eisenman RN. Myc's broad reach. Genes Dev 2008; 22: 2755-2766.
5. Westermark UK, Wilhelm M, Frenzel A, Henriksson MA. The MYCN oncogene and differentiation in neuroblastoma. Semin Cancer Biol 2011; 21: 256-266.
6. Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA et al. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev 2000; 14: 1390-1399.
7. Murphy DM, Buckley PG, Bryan K, Watters KM, Koster J, van SP et al. Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesis. Mol Carcinog 2011; 50: 403-411.
8. Pelengaris S, Khan M, Evan G. c-MYC: More than just a matter of life and death. Nat Rev Cancer 2002; 2: 764-776.
9. Hui AB, Lo KW, Yin XL, Poon WS, Ng HK. Detection of multiple gene amplifications in glioblastoma multiforme using array-based comparative genomic hybridization. Lab Invest 2001; 81: 717-723.
10. Nau MM, Brooks Jr. BJ, Carney DN, Gazdar AF, Battey JF, Sausville EA et al. Human small-cell lung cancers show amplification and expression of the N-myc gene. Proc Natl Acad Sci USA 1986; 83: 1092-1096.
11. Charron J, Malynn BA, Fisher P, Stewart V, Jeannotte L, Goff SP et al. Embryonic lethality in mice homozygous for a targeted disruption of the N-myc gene. Genes Dev 1992; 6: 2248-2257.
12. Moens CB, Auerbach AB, Conlon RA, Joyner AL, Rossant J. A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. Genes Dev 1992; 6: 691-704.
13. Moens CB, Stanton BR, Parada LF, Rossant J. Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development 1993; 119: 485-499.
14. Sawai S, Shimono A, Hanaoka K, Kondoh H. Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes. New Biol 1991; 3: 861-869.
15. Sawai S, Shimono A, Wakamatsu Y, Palmes C, Hanaoka K, Kondoh H. Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse. Development 1993; 117: 1445-1455.
16. Stanton BR, Perkins AS, Tessarollo L, Sassoon DA, Parada LF. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev 1992; 6: 2235-2247.
17. Squire J, Goddard AD, Canton M, Becker A, Phillips RA, Gallie BL. Tumour induction by the retinoblastoma mutation is independent of N-myc expression. Nature 1986; 322: 555-557.
18. Zimmerman KA, Yancopoulos GD, Collum RG, Smith RK, Kohl NE, Denis KA et al. Differential expression of myc family genes during murine development. Nature 1986; 319: 780-783.
19. Thiele CJ, Deutsch LA, Israel MA. The expression of multiple proto-oncogenes is differentially regulated during retinoic acid induced maturation of human neuroblastoma cell lines. Oncogene 1988; 3: 281-288.
20. Melotte V, Qu X, Ongenaert M, van CW, de Bruine AP, Baldwin HS et al. The N-myc downstream regulated gene (NDRG) family: Diverse functions, multiple applications. FASEB J 2010; 24: 4153-4166.
21. Suenaga Y, Kaneko Y, Matsumoto D, Hossain MS, Ozaki T, Nakagawara A. Positive auto-regulation of MYCN in human neuroblastoma. Biochem Biophys Res Commun 2009; 390: 21-26.
22. Dweep H, Sticht C, Pandey P, Gretz N. miRWalk-database: Prediction of possible miRNA binding sites by "walking" the genes of three genomes. J Biomed Inform 2011; 44: 839-847.
23. Davis A, Bradley A. Mutation of N-myc in mice: What does the phenotype tell us? Bioessays 1993; 15: 273-275.
24. Knoepfler PS, Cheng PF, Eisenman RN. N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev 2002; 16: 2699-2712.
25. Strieder V, Lutz W. E2F proteins regulate MYCN expression in neuroblastomas. J Biol Chem 2003; 278: 2983-2989.
26. Amatruda III TT, Sidell N, Ranyard J, Koeffler HP. Retinoic acid treatment of human neuroblastoma cells is associated with decreased N-myc expression. Biochem Biophys Res Commun 1985; 126: 1189-1195.
27. Sidell N. Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro. J Natl Cancer Inst 1982; 68: 589-596.
28. Ribatti D, Raffaghello L, Pastorino F, Nico B, Brignole C, Vacca A et al. In vivo angiogenic activity of neuroblastoma correlates with MYCN oncogene overexpression. Int J Cancer 2002; 102: 351-354.
29. Edsjo A, Nilsson H, Vandesompele J, Karlsson J, Pattyn F, Culp LA et al. Neuroblastoma cells with overexpressed MYCN retain their capacity to undergo neuronal differentiation. Lab Invest 2004; 84: 406-417.
30. Pahlman S, Ruusala AI, Abrahamsson L, Mattsson ME, Esscher T. Retinoic acid-induced differentiation of cultured human neuroblastoma cells: A comparison with phorbolesterinduced differentiation. Cell Differ 1984; 14: 135-144.
31. Sundelacruz S, Levin M, Kaplan DL. Role of membrane potential in the regulation of cell proliferation and differentiation. Stem Cell Rev 2009; 5: 231-246.
32. Schulte JH, Horn S, Otto T, Samans B, Heukamp LC, Eilers UC et al. MYCN regulates oncogenic MicroRNAs in neuroblastoma. Int J Cancer 2008; 122: 699-704.
33. Stallings RL. MicroRNA involvement in the pathogenesis of neuroblastoma: Potential for microRNA mediated therapeutics. Curr Pharm Des 2009; 15: 456-462.
34. Li G, Luna C, Qiu J, Epstein DL, Gonzalez P. Alterations in microRNA expression in stress-induced cellular senescence. Mech Ageing Dev 2009; 130: 731-741.
35. Liu DZ, Ander BP, Tian Y, Stamova B, Jickling GC, Davis RR et al. Integrated analysis of mRNA and microRNA expression in mature neurons, neural progenitor cells and neuroblastoma cells. Gene 2012; 495: 120-127.
36. Chen Y, Stallings RL. Differential patterns of microRNA expression in neuroblastoma are correlated with prognosis, differentiation, and apoptosis. Cancer Res 2007; 67: 976-983.
37. Haug BH, Henriksen JR, Buechner J, Geerts D, Tomte E, Kogner P et al. MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma. Carcinogenesis 2011; 32: 1005-1012.
38. Jee MK, Jung JS, Im YB, Jung SJ, Kang SK. Silencing of miR20a is crucial for Ngn1-mediated neuroprotection in injured spinal cord. Hum Gene Ther 2012; 23: 508-520.
39. Yoo AS, Staahl BT, Chen L, Crabtree GR. MicroRNA-mediated switching of chromatinremodelling complexes in neural development. Nature 2009; 460: 642-646.
40. O'Donnell KA, Wentzel EA, Zeller KI, Dang CV, Mendell JT. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 2005; 435: 839-843.
41. Coller HA, Forman JJ, Legesse-Miller A"Myc'ed messages": Myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron. PLoS Genet 2007; 3: E146.
42. Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W et al. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 2000; 407: 645-648.
43. Stiewe T, Putzer BM. Role of the p53-homologue p73 in E2F1-induced apoptosis. Nat. Genet 2000; 26: 464-469.
44. Zaika A, Irwin M, Sansome C, Moll UM. Oncogenes induce and activate endogenous p73 protein. J Biol Chem 2001; 276: 11310-11316.
45. De L V, Raschella G, Barcaroli D, Annicchiarico-Petruzzelli M, Ranalli M, Catani MV et al. Induction of neuronal differentiation by p73 in a neuroblastoma cell line. J Biol Chem 2000; 275: 15226-15231.
46. Eijkelenboom A, Burgering BM. FOXOs: Signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol 2013; 14: 83-97.
47. Senyuk V, Zhang Y, Liu Y, Ming M, Premanand K, Zhou L et al. Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis. Proc Natl Acad Sci USA 2013; 110: 5594-5599.
48. Oppenheim RW. Cell death during development of the nervous system. Annu Rev Neurosci 1991; 14: 453-501.
49. Kim WR, Sun W. Programmed cell death during postnatal development of the rodent nervous system. Dev Growth Differ 2011; 53: 225-235.
50. Cacci E, Ajmone-Cat MA, Anelli T, Biagioni S, Minghetti L. In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia. Glia 2008; 56: 412-425.
51. Gatti G, Maresca G, Natoli M, Florenzano F, Nicolin A, Felsani A et al. MYC prevents apoptosis and enhances endoreduplication induced by paclitaxel. PLoS One 2009; 4: E5442.
52. Maresca G, Natoli M, Nardella M, Arisi I, Trisciuoglio D, Desideri M et al. LMNA knock-down affects differentiation and progression of human neuroblastoma cells. PLoS One 2012; 7: E45513.