Increased plasma arginase activity in human sepsis: Association with increased circulating neutrophils

Clinical Chemistry and Laboratory Medicine

Volumn 52, Issue 4, 2014, Pages 573-581

  Darcy, Christabelle J ^a   Woodberry, Tonia ^a   Davis, Joshua S ^a,b   Piera, Kim A ^a   McNeil, Yvette R ^a   Chen, Youwei ^c   Yeo, Tsin W ^a,b   Weinberg, J Brice ^c   Anstey, Nicholas M ^a,b  

^a MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^b ROYAL DARWIN HOSPITAL   (Australia)

^c DURHAM VA MEDICAL CENTER   (United States)

Author keywords

hypoargininemia; L arginine; plasma arginase activity; sepsis

Indexed keywords

ARGINASE; ARGININE; AMINO ACID;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CELL ACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; MIDDLE AGED; NEUTROPHIL COUNT; PRIORITY JOURNAL; RADIOMETRY; SEPSIS; SHOCK; BLOOD; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; NEUTROPHIL;

ADULT; AMINO ACIDS; ARGINASE; ARGININE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME ACTIVATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUTROPHILS; RADIOMETRY; SEPSIS;

EID: 84896791065     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2013-0698     Document Type: Article

References (44)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001;29:1303-10. (Pubitemid 32641789)
2. McGown CC, Brookes ZL. Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. Br J Anaesth 2007;98:163-75. (Pubitemid 47071995)
3. Trzeciak S, Cinel I, Phillip Dellinger R, Shapiro NI, Arnold RC, Parrillo JE, et al. Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 2008;15:399-413.
4. Davis JS, Anstey NM. Is plasma arginine concentration decreased in patients with sepsis? A systematic review and meta-analysis. Crit Care Med 2011;39:380-5.
5. Moncada S, Higgs EA. Nitric oxide and the vascular endothelium. Handb Exper Pharmacol 2006(176 Pt 1):213-54.
6. Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol 2005;5:641-54. (Pubitemid 41113195)
7. Darcy CJ, Davis JS, Woodberry T, McNeil YR, Stephens DP, Yeo TW, et al. An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function. PloS One 2011;6:e21185.
8. Yeo TW, Lampah DA, Gitawati R, Tjitra E, Kenangalem E, McNeil YR, et al. Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. J Exp Med 2007;204:2693-704. (Pubitemid 350044792)
9. Luiking YC, Poeze M, Ramsay G, Deutz NE. Reduced citrulline production in sepsis is related to diminished de novo arginine and nitric oxide production. Am J Clin Nutr 2009;89: 142-52.
10. Arraes SM, Freitas MS, da Silva SV, de Paula Neto HA, Alves-Filho JC, Auxiliadora Martins M, et al. Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation. Blood 2006;108:2906-13.
11. Munder M, Mollinedo F, Calafat J, Canchado J, Gil-Lamaignere C, Fuentes JM, et al. Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood 2005;105:2549-56. (Pubitemid 40387058)
12. Abebe T, Takele Y, Weldegebreal T, Cloke T, Closs E, Corset C, et al. Arginase activity-a marker of disease status in patients with visceral leishmaniasis in ethiopia. PLoS Negl Trop Dis 2013;7:e2134.
13. Jacobsen LC, Theilgaard-Monch K, Christensen EI, Borregaard N. Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils. Blood 2007;109:3084-7. (Pubitemid 46482111)
14. Rodriguez PC, Ernstoff MS, Hernandez C, Atkins M, Zabaleta J, Sierra R, et al. Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res 2009;69: 1553-60.
15. Stone E, Chantranupong L, Gonzalez C, O′Neal J, Rani M, VanDenBerg C, et al. Strategies for optimizing the serum persistence of engineered human arginase I for cancer therapy. J Control Release 2012;158:171-9.
16. Reyero C, Dorner F. Purification of arginases from human-leukemic lymphocytes and granulocytes: study of their physicochemical and kinetic properties. Eur J Biochem 1975;56:137-47.
17. Folley SJ, Greenbaum AL. Determination of the arginase activities of homogenates of liver and mammary gland: effects of pH and substrate concentration and especially of activation by divalent metal ions. Biochem J 1948;43:537-49.
18. Rotondo R, Bertolotto M, Barisione G, Astigiano S, Mandruzzato S, Ottonello L, et al. Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation. J Leukoc Biol 2011;89:721-7.
19. Munder M, Schneider H, Luckner C, Giese T, Langhans CD, Fuentes JM, et al. Suppression of T-cell functions by human granulocyte arginase. Blood 2006;108:1627-34. (Pubitemid 44316131)
20. Ihi T, Nakazato M, Mukae H, Matsukura S. Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections. Clin Infect Dis 1997;25:1134-40.
21. Panyutich AV, Panyutich EA, Krapivin VA, Baturevich EA, Ganz T. Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis. J Lab Clin Med 1993;122:202-7. (Pubitemid 23239152)
22. Cheng PN, Leung YC, Lo WH, Tsui SM, Lam KC. Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepato-cellular carcinoma. Cancer Lett 2005;224:67-80. (Pubitemid 40720368)
23. Davis JS, Yeo TW, Thomas JH, McMillan M, Darcy CJ, McNeil YR, et al. Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study. Crit Care 2009;13:R155.
24. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992;101:1644-55.
25. Davis JS, Darcy CJ, Piera K, McNeil YR, Woodberry T, Anstey NM. Ex-vivo changes in amino acid concentrations from blood stored at room temperature or on ice: implications for arginine and taurine measurements. BMC Clin Pathol 2009; 9:10.
26. Fairbanks VF, Ziesmer SC, O′Brien PC. Methods for measuring plasma hemoglobin in micromolar concentration compared. Clin Chem 1992;38:132-40.
27. Wang H, McNeil YR, Yeo TW, Anstey NM. Simultaneous determination of multiple amino acids in plasma in critical illness by high performance liquid chromatography with ultraviolet and fluorescence detection. J Chromatogr B 2013 (in press).
28. Jones CE, Darcy CJ, Woodberry T, Anstey NM, McNeil YR. HPLC analysis of asymmetric dimethylarginine, symmetric dimethyl-arginine, homoarginine and arginine in small plasma volumes using a Gemini-NX column at high pH. J Chromatogr B Analyt Technol Biomed Life Sci 2010;878:8-12.
29. Morris CR, Kato GJ, Poljakovic M, Wang X, Blackwelder WC, Sachdev V, et al. Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease. J Am Med Assoc 2005;294:81-90. (Pubitemid 41002842)
30. Grisham MB, Everse J, Janssen HF. Endotoxemia and neutrophil activation in vivo. Am J Physiol 1988;254(5 Pt 2):H1017-22.
31. Wong HR, Doughty LA, Wedel N, White M, Nelson BJ, Havrilla N, et al. Plasma bactericidal/permeability-increasing protein concentrations in critically ill children with the sepsis syndrome. Pediatr Infect Dis J 1995;14:1087-91. (Pubitemid 26008462)
32. Xu SY, Pauksen K, Venge P. Serum measurements of human neutrophil lipocalin (HNL) discriminate between acute bacterial and viral infections. Scand J Clin Lab Invest 1995;55:125-31.
33. Nuijens JH, Abbink JJ, Wachtfogel YT, Colman RW, Eerenberg AJ, Dors D, et al. Plasma elastase alpha 1-antitrypsin and lactoferrin in sepsis: evidence for neutrophils as mediators in fatal sepsis. J Lab Clin Med 1992;119:159-68.
34. Ertel W, Jarrar D, Jochum M, Thiele V, Kenney J, Faist E, et al. Enhanced release of elastase is not concomitant with increased secretion of granulocyte-activating cytokines in whole blood from patients with sepsis. Arch Surg 1994;129:90-7; discussion 7-8.
35. Rodriguez-Garcia M, Oliva H, Climent N, Garcia F, Gatell JM, Gallart T. Human immature monocyte-derived dendritic cells produce and secrete alpha-defensins 1-3. J Leukoc Biol 2007;82:1143-6. (Pubitemid 350133510)
36. Morris SM Jr. Recent advances in arginine metabolism: roles and regulation of the arginases. Br J Pharmacol 2009;157: 922-30.
37. Ochoa JB, Bernard AC, O′Brien WE, Griffen MM, Maley ME, Rockich AK, et al. Arginase I expression and activity in human mononuclear cells after injury. Ann Surg 2001;233:393-9. (Pubitemid 32187819)
38. Zea AH, Culotta KS, Ali J, Mason C, Park HJ, Zabaleta J, et al. Decreased expression of CD3zeta and nuclear transcription factor kappa B in patients with pulmonary tuberculosis: potential mechanisms and reversibility with treatment. J Infect Dis 2006;194:1385-93. (Pubitemid 44706506)
39. Corraliza I, Moncada S. Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide. J Rheumatol 2002;29:2261-5. (Pubitemid 35266014)
40. Zimmermann N, King NE, Laporte J, Yang M, Mishra A, Pope SM, et al. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest 2003;111:1863-74. (Pubitemid 38057731)
41. Bruch-Gerharz D, Schnorr O, Suschek C, Beck KF, Pfeilschifter J, Ruzicka T, et al. Arginase 1 overexpression in psoriasis: limitation of inducible nitric oxide synthase activity as a molecular mechanism for keratinocyte hyperproliferation. Am J Pathol 2003;162:203-11. (Pubitemid 36042002)
42. Rouzaut A, Subira ML, de Miguel C, Domingo-de-Miguel E, Gonzalez A, Santiago E, et al. Co-expression of inducible nitric oxide synthase and arginases in different human monocyte subsets. Apoptosis regulated by endogenous NO. Biochim Biophys Acta 1999;1451:319-33. (Pubitemid 29518248)
43. Brown KA, Brain SD, Pearson JD, Edgeworth JD, Lewis SM, Treacher DF. Neutrophils in development of multiple organ failure in sepsis. Lancet 2006;368:157-69.
44. Nast-Kolb D, Waydhas C, Gippner-Steppert C, Schneider I, Trupka A, Ruchholtz S, et al. Indicators of the posttraumatic inflammatory response correlate with organ failure in patients with multiple injuries. J Trauma 1997;42:446-54; discussion 54-5.