Retinoic acid receptor γ (Rarg) and nuclear receptor subfamily 5, group a, member 2 (Nr5a2) promote conversion of fibroblasts to functional neurons

Journal of Biological Chemistry

Volumn 289, Issue 10, 2014, Pages 6415-6428

  Shi, Zixiao ^a,b   Shen, Tianjin ^c   Liu, Yanli ^a   Huang, Yuanyuan ^a   Jiao, Jianwei ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c ANHUI UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; FIBROBLASTS;

NEURONAL FUNCTION; NUCLEAR RECEPTORS; RETINOIC ACID RECEPTORS; TRANS DIFFERENTIATIONS;

NEURONS;

CELL NUCLEUS RECEPTOR; LIVER RECEPTOR HOMOLOG 1; NUCLEAR PROTEIN; RETINOIC ACID RECEPTOR GAMMA; SYNAPSIN; TRANSCRIPTION FACTOR;

ADENOVIRUS; ARTICLE; CELL MATURATION; CELL TRANSDIFFERENTIATION; CELL TYPE; FIBROBLAST; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LENTIVIRINAE; MUTAGENESIS; NERVOUS SYSTEM DEVELOPMENT; PRIORITY JOURNAL; REGENERATIVE MEDICINE; RETROVIRUS; SOMATIC CELL;

ADENOVIRUS; FIBROBLAST; NEURONS; NUCLEAR RECEPTORS; RETINOID;

ADENOVIRIDAE; ANIMALS; CELL TRANSDIFFERENTIATION; CELLS, CULTURED; FIBROBLASTS; MICE; MICE, INBRED C57BL; NEUROGENESIS; NEURONS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, RETINOIC ACID; REGENERATIVE MEDICINE; TRANSCRIPTOME; TRANSFECTION;

EID: 84896776268     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.515601     Document Type: Article

References (28)

1. Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., and Wernig, M. (2010) Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035-1041
2. Pang, Z. P., Yang, N., Vierbuchen, T., Ostermeier, A., Fuentes, D. R., Yang, T. Q., Citri, A., Sebastiano, V., Marro, S., Südhof, T. C., and Wernig, M. (2011) Induction of human neuronal cells by defined transcription factors. Nature 476, 220-223
3. Stadtfeld, M., Nagaya, M., Utikal, J., Weir, G., and Hochedlinger, K. (2008) Induced pluripotent stem cells generated without viral integration. Science 322, 945-949
4. Zhou, W., and Freed, C. R. (2009) Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells. Stem Cells 27, 2667-2674
5. Maden, M. (2002) Retinoid signalling in the development of the central nervous system. Nat Rev. Neurosci. 3, 843-853
6. Lane, M. A., and Bailey, S. J. (2005) Role of retinoid signalling in the adult brain. Prog. Neurobiol. 75, 275-293
7. Zechel, C. (2005) Requirement of retinoic acid receptor isotypes , , and during the initial steps of neural differentiation of PCC7 cells. Mol. Endocrinol. 19, 1629-1645
8. Jacobs, S., Lie, D. C., DeCicco, K. L., Shi, Y., DeLuca, L. M., Gage, F. H., and Evans, R. M. (2006) Retinoic acid is required early during adult neurogenesis in the dentate gyrus. Proc. Natl. Acad. Sci. U.S.A. 103, 3902-3907
9. Rhinn, M., and Dollé, P. (2012) Retinoic acid signalling during development. Development 139, 843-858
10. Lu, J., Tan, L., Li, P., Gao, H., Fang, B., Ye, S., Geng, Z., Zheng, P., and Song, H. (2009) All-trans retinoic acid promotes neural lineage entry by pluripotent embryonic stem cells via multiple pathways. BMC Cell Biol. 10, 57
11. McCaffery, P., Zhang, J., and Crandall, J. E. (2006) Retinoic acid signaling and function in the adult hippocampus. J. Neurobiol. 66, 780-791
12. Giguere, V., Ong, E. S., Segui, P., and Evans, R. M. (1987) Identification of a receptor for the morphogen retinoic acid. Nature 330, 624-629
13. Dräger, U. C. (2006) Retinoic acid signaling in the functioning brain. Science's STKE 2006, pe10
14. Boylan, J. F., Lufkin, T., Achkar, C. C., Taneja, R., Chambon, P., and Gudas, L. J. (1995) Targeted disruption of retinoic acid receptor (RAR ) and RAR results in receptor-specific alterations in retinoic acid-mediated differentiation and retinoic acid metabolism. Mol. Cell. Biol. 15, 843-851
15. Luo, T., Wagner, E., Crandall, J. E., and Dräger, U. C. (2004) A retinoicacid critical period in the early postnatal mouse brain. Biol. Psychiatry 56, 971-980
16. Heng, J. C., Feng, B., Han, J., Jiang, J., Kraus, P., Ng, J. H., Orlov, Y. L., Huss, M., Yang, L., Lufkin, T., Lim, B., and Ng, H. H. (2010) The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell 6, 167-174
17. Wang, W., Yang, J., Liu, H., Lu, D., Chen, X., Zenonos, Z., Campos, L. S., Rad, R., Guo, G., Zhang, S., Bradley, A., and Liu, P. (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor and liver receptor homolog 1. Proc. Natl. Acad. Sci. U.S.A. 108, 18283-18288
18. Meng, F., Chen, S., Miao, Q., Zhou, K., Lao, Q., Zhang, X., Guo, W., and Jiao, J. (2012) Induction of fibroblasts to neurons through adenoviral gene delivery. Cell Res. 22, 436-440
19. Ladewig, J., Mertens, J., Kesavan, J., Doerr, J., Poppe, D., Glaue, F., Herms, S., Wernet, P., Kögler, G., Müller, F. J., Koch, P., and Brüstle, O. (2012) Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nat. Methods 9, 575-578
20. Banker, G., and Goslin, K. (1998) Culturing Nerve Cells, 2nd Ed., pp. 339-370, MIT Press, Cambridge, MA
21. Yoo, A. S., Sun, A. X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., Lee-Messer, C., Dolmetsch, R. E., Tsien, R. W., and Crabtree, G. R. (2011) MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 476, 228-231
22. Ambasudhan, R., Talantova, M., Coleman, R., Yuan, X., Zhu, S., Lipton, S. A., and Ding, S. (2011) Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell 9, 113-118
23. Li, W., Jiang, K., Wei, W., Shi, Y., and Ding, S. (2013) Chemical approaches to studying stem cell biology. Cell Res. 23, 81-91
24. Gianni, M., Zanotta, S., Terao, M., Garattini, S., and Garattini, E. (1993) Effects of synthetic retinoids and retinoic acid isomers on the expression of alkaline phosphatase in F9 teratocarcinoma cells. Biochem. Biophys. Res. Commun. 196, 252-259
25. Lee, J. M., Lee, Y. K., Mamrosh, J. L., Busby, S. A., Griffin, P. R., Pathak, M. C., Ortlund, E. A., and Moore, D. D. (2011) A nuclear-receptor- dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474, 506-510
26. Davis, R. L., Weintraub, H., and Lassar, A. B. (1987) Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51, 987-1000
27. Caiazzo, M., Dell'Anno, M. T., Dvoretskova, E., Lazarevic, D., Taverna, S., Leo, D., Sotnikova, T. D., Menegon, A., Roncaglia, P., Colciago, G., Russo, G., Carninci, P., Pezzoli, G., Gainetdinov, R. R., Gustincich, S., Dityatev, A., and Broccoli, V. (2011) Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 476, 224-227
28. Grgurevic, N., Tobet, S., and Majdic, G. (2005) Widespread expression of liver receptor homolog 1 in mouse brain. Neuroendocrinol. Lett. 26, 541-547