Identification of a selective agonist for liver X receptor α (LXRα) via screening of a synthetic compound library

Journal of Biomolecular Screening

Volumn 19, Issue 4, 2014, Pages 566-574

  Li, Ni ^a   Xu, Yanni ^a   Feng, Tingting ^a   Liu, Chang ^a   Li, Yongzhen ^a   Wang, Xiao ^a   Si, Shuyi ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

ABCA1; ABCG1; atherosclerosis; cholesterol efflux; LXR

Indexed keywords

ABC TRANSPORTER A1; ABC TRANSPORTER G1; AMMONIA; GERANYLGERANYL PYROPHOSPHATE; IMB 151; LIVER X RECEPTOR AGONIST; LIVER X RECEPTOR ALPHA; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

ADVERSE OUTCOME; ARTICLE; CHIMERA; CONTROLLED STUDY; DRUG DETERMINATION; DRUG SCREENING; HUMAN; HUMAN CELL; LIPID STORAGE; LIPOGENESIS; MACROPHAGE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ABCA1; ABCG1; ATHEROSCLEROSIS; CHOLESTEROL EFFLUX; LXRΑ;

ANIMALS; ATP BINDING CASSETTE TRANSPORTER 1; CELL LINE; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LIGANDS; LIPID METABOLISM; MACROPHAGES; MICE; ORPHAN NUCLEAR RECEPTORS; SMALL MOLECULE LIBRARIES; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

EID: 84896757139     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113516004     Document Type: Article

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