Survivin-2B promotes autophagy by accumulating IKK alpha in the nucleus of selenite-treated NB4 cells

Cell Death and Disease

Volumn 5, Issue 2, 2014, Pages

  Shi, K ^a   An, J ^a   Shan, L ^a   Jiang, Q ^a   Li, F ^a   Ci, Y ^a   Wu, P ^a   Duan, J ^a   Hui, K ^a   Yang, Y ^a   Xu, C ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

apoptosis; autophagy; selenite; survivin 2B

Indexed keywords

I KAPPA B KINASE ALPHA; PROTEIN P73; PROTEIN UVRAG; SODIUM SELENITE; SURVIVIN; SURVIVIN 2B; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL NUCLEUS; CONTROLLED STUDY; DOWN REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; TUMOR CELL LINE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CELL NUCLEUS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, LEUKEMIC; HCT116 CELLS; HUMANS; I-KAPPA B KINASE; INHIBITOR OF APOPTOSIS PROTEINS; JURKAT CELLS; LEUKEMIA; MICE; MICE, NUDE; NUCLEAR PROTEINS; RNA INTERFERENCE; SELENIOUS ACID; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84896745482     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2014.34     Document Type: Article

References (40)

1. Wu WK, Coffelt SB, Cho CH, Wang XJ, Lee CW, Chan FK et al. The autophagic paradox in cancer therapy. Oncogene 2012; 31: 939-953.
2. Guan L, Han B, Li J, Li Z, Huang F, Yang Y et al. Exposure of human leukemia NB4 cells to increasing concentrations of selenite switches the signaling from pro-survival to pro-Apoptosis. Ann Hematol 2009; 88: 733-742.
3. Brozmanova J, Manikova D, Vlckova V, Chovanec M. Selenium: A double-edged sword for defense and offence in cancer. Arch Toxicol 2010; 84: 919-938.
4. Guan L, Han B, Li Z, Hua F, Huang F, Wei W et al. Sodium selenite induces apoptosis by ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in human acute promyelocytic leukemia NB4 cells. Apoptosis 2009; 14: 218-225.
5. Han B,Wei W, Hua F, Cao T, Dong H, Yang T et al. Requirement for ERK activity in sodium selenite-induced apoptosis of acute promyelocytic leukemia-derived NB4 cells. J Biochem Mol Biol 2007; 40: 196-204.
6. Shi K, Jiang Q, Li Z, Shan L, Li F, An J et al. Sodium selenite alters microtubule assembly and induces apoptosis in vitro and in vivo. J Hematol Oncol 2013; 6: 7.
7. Ren Y, Huang F, Liu Y, Yang Y, Jiang Q, Xu C. Autophagy inhibition through PI3K/Akt increases apoptosis by sodium selenite in NB4 cells. BMB Rep 2009; 42: 599-604.
8. An JJ, Shi KJ,Wei W, Hua FY, Ci YL, Jiang Q et al. The ROS/JNK/ATF2 pathway mediates selenite-induced leukemia NB4 cell cycle arrest and apoptosis in vitro and in vivo. Cell Death Dis 2013; 4: E973.
9. Jiang Q, Wang Y, Li T, Shi K, Li Z, Ma Y et al. Heat shock protein 90-mediated inactivation of nuclear factor-kappaB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells. Mol Biol Cell 2011; 22: 1167-1180.
10. Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ et al. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 2007; 67: 6314-6324.
11. Kralova V, Benesova S, Cervinka M, Rudolf E. Selenite-induced apoptosis and autophagy in colon cancer cells. Toxicol In Vitro 2012; 26: 258-268.
12. Jiang Q, Li F, Shi K, Yang Y, Xu C. Sodium selenite-induced activation of DAPK promotes autophagy in human leukemia HL60 cells. BMB Rep 2012; 45: 194-199.
13. Park SH, Kim JH, Chi GY, Kim GY, Chang YC, Moon SK et al. Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species. Toxicol Lett 2012; 212: 252-261.
14. Roca H, Varsos ZS, Mizutani K, Pienta KJ. CCL2, survivin and autophagy: New links with implications in human cancer. Autophagy 2008; 4: 969-971.
15. Niu TK, Cheng Y, Ren X, Yang JM. Interaction of Beclin 1 with survivin regulates sensitivity of human glioma cells to TRAIL-induced apoptosis. FEBS Lett 2010; 584: 3519-3524.
16. Wang Q, Chen Z, Diao X, Huang S. Induction of autophagy-dependent apoptosis by the survivin suppressant YM155 in prostate cancer cells. Cancer Lett 2011; 302: 29-36.
17. Chiu HW, Ho YS, Wang YJ. Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin. J Mol Med (Berl) 2011 927-941.
18. Ling X, Cheng Q, Black JD, Li F. Forced expression of survivin-2B abrogates mitotic cells and induces mitochondria-dependent apoptosis by blockade of tubulin polymerization and modulation of Bcl-2, Bax, and survivin. J Biol Chem 2007; 282: 27204-27214.
19. Mahotka C, Wenzel M, Springer E, Gabbert HE, Gerharz CD. Survivin-deltaEx3 and survivin-2B: Two novel splice variants of the apoptosis inhibitor survivin with different antiapoptotic properties. Cancer Res 1999; 59: 6097-6102.
20. Wagner M, Schmelz K, Wuchter C, Ludwig WD, Dorken B, Tamm I. In vivo expression of survivin and its splice variant survivin-2B: Impact on clinical outcome in acute myeloid leukemia. Int J Cancer 2006; 119: 1291-1297.
21. Zhu N, Gu L, Findley HW, Li F, Zhou M. An alternatively spliced survivin variant is positively regulated by p53 and sensitizes leukemia cells to chemotherapy. Oncogene 2004; 23 7551.
22. Li Z, Shi K, Guan L, Cao T, Jiang Q, Yang Y et al. ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells. FEBS Lett 2010; 584: 2291-2297.
23. Livesey KM, Kang R, Vernon P, Buchser W, Loughran P, Watkins SC et al. p53/HMGB1 complexes regulate autophagy and apoptosis. Cancer Res 2012; 72: 1996-2005.
24. Unuma K, Aki T, Matsuda S, Funakoshi T, Yoshida KI, Uemura K. Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver. Hepatol Res 2012 91-96.
25. Young MM, Takahashi Y, Khan O, Park S, Hori T, Yun J et al. Autophagosomal membrane serves as platform for intracellular death-inducing signaling complex (iDISC)-mediated caspase-8 activation and apoptosis. J Biol Chem 2012; 287: 12455-12468.
26. Lee KH, Jang Y, Chung JH. Heat shock protein 90 regulates IkappaB kinase complex and NF-kappaB activation in angiotensin II-induced cardiac cell hypertrophy. Exp Mol Med 2010; 42: 703-711.
27. Criollo A, Senovilla L, Authier H, Maiuri MC, Morselli E, Vitale I et al. IKK connects autophagy to major stress pathways. Autophagy 2010; 6: 189-191.
28. Yoshida K, Ozaki T, Furuya K, Nakanishi M, Kikuchi H, Yamamoto H et al. ATM-dependent nuclear accumulation of IKK-Alpha plays an important role in the regulation of p73-mediated apoptosis in response to cisplatin. Oncogene 2008; 27: 1183-1188.
29. Furuya K, Ozaki T, Hanamoto T, Hosoda M, Hayashi S, Barker PA et al. Stabilization of p73 by nuclear IkappaB kinase-Alpha mediates cisplatin-induced apoptosis. J Biol Chem 2007; 282: 18365-18378.
30. Ozaki T, Nakagawara A. P53-independent apoptosis through a novel ATM/IKK-Alpha/p73-mediated apoptotic pathway. Seikagaku 2008; 80: 409-413.
31. Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB. Histone H3 phosphorylation by IKK-Alpha is critical for cytokine-induced gene expression. Nature 2003; 423: 655-659.
32. Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, Baldwin AS. A nucleosomal function for IkappaB kinase-Alpha in NF-kappaB-dependent gene expression. Nature 2003; 423: 659-663.
33. Okazaki T, Kageji T, Kuwayama K, Kitazato KT, Mure H, Hara K et al. Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma. Cancer Lett 2012; 323: 199-207.
34. Al-Bahlani S, Fraser M, Wong AY, Sayan BS, Bergeron R, Melino G et al. P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism. Oncogene 2011; 30: 4219-4230.
35. Stiewe T, Putzer BM. p73 in apoptosis. Apoptosis 2001; 6: 447-452.
36. Crighton D, O'Prey J, Bell HS, Ryan KM. p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death Differ 2007; 14: 1071-1079.
37. Rosenbluth JM, Pietenpol JA. mTOR regulates autophagy-Associated genes downstream of p73. Autophagy 2009; 5: 114-116.
38. Humbert M, Mueller C, Fey MF, Tschan MP. Inhibition of damage-regulated autophagy modulator-1 (DRAM-1) impairs neutrophil differentiation of NB4 APL cells. Leuk Res 2012 1552-1556.
39. Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 2011; 18: 571-580.
40. Li F, Jiang Q, Shi KJ, Luo H, Yang Y, Xu CM. RhoA modulates functional and physical interaction between ROCK1 and Erk1/2 in selenite-induced apoptosis of leukaemia cells. Cell Death Dis 2013; 4: E708.