High antimicrobial effectiveness with low hemolytic and cytotoxic activity for PEG/quaternary copolyoxetanes

Biomacromolecules

Volumn 15, Issue 2, 2014, Pages 456-467

  King, Allison ^a   Chakrabarty, Souvik ^a   Zhang, Wei ^a   Zeng, Xiaomei ^a   Ohman, Dennis E ^b,c   Wood, Lynn F ^b,c   Abraham, Sheena ^a,b   Rao, Raj ^a,b   Wynne, Kenneth J ^a  

^a Virginia Commonwealth University   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATIONIC RING OPENING POLYMERIZATION; COPOLYMER COMPOSITIONS; CYTOTOXIC ACTIVITIES; HUMAN DERMAL FIBROBLASTS; MINIMUM INHIBITORY CONCENTRATION; MODULATED DIFFERENTIAL SCANNING CALORIMETRY; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

BACTERIA; BIOCOMPATIBILITY; CELL CULTURE; CHAIN LENGTH; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; ENZYME INHIBITION; IONIC LIQUIDS; RING OPENING POLYMERIZATION;

ESCHERICHIA COLI;

3 [(4 BROMOBUTOXY)METHYL] 3 METHYLOXETANE; COPOLYMER; IONIC LIQUID; MONOMER; PEGYLATED COPOLYOXETANE; POLYCATION; QUATERNARY AMMONIUM DERIVATIVE; TERTIARY AMINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; MACROGOL DERIVATIVE; POLY(OXETANE); POLYMER; PROPANEDIOL DERIVATIVE;

AMINO ACID SUBSTITUTION; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL MEMBRANE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CYTOTOXICITY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFICACY; HEMOLYSIS; HUMAN; HUMAN CELL; MELTING POINT; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR WEIGHT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROMETER; POLYMERIZATION; PRECURSOR; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SKIN FIBROBLAST; STAPHYLOCOCCUS AUREUS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ESCHERICHIA COLI; FIBROBLAST; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FIBROBLASTS; HEMOLYSIS; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; POLYETHYLENE GLYCOLS; POLYMERS; PROPYLENE GLYCOLS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84896745244     PISSN: 15257797     EISSN: 15264602     Source Type: Journal    
DOI: 10.1021/bm401794p     Document Type: Article

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