Immunohistochemical screening for autoantibodies against lateral hypothalamic neurons in human narcolepsy

Journal of Neuroimmunology

Volumn 174, Issue 1-2, 2006, Pages 187-191

  Overeem, Sebastiaan ^a,b   Verschuuren, Jan J ^a   Fronczek, Rolf ^a,c   Schreurs, Liesbeth ^a   den Hertog, Heleen ^a   Hegeman Kleinn, Ingrid M ^a   van Duinen, Sjoerd G ^a   Unmehopa, Unga A ^c   Swaab, Dick F ^c   Lammers, Gert Jan ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

Author keywords

Autoimmunity; HLA; Hypocretin; Hypothalamus; Narcolepsy; Orexin

Indexed keywords

AUTOANTIBODY; OREXIN;

ADULT; ANTIBODY LABELING; ANTIBODY SCREENING; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOHISTOCHEMISTRY; LATERAL HYPOTHALAMUS; MAJOR CLINICAL STUDY; MALE; NARCOLEPSY; NERVE CELL; NERVE ENDING; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STAINING;

ADULT; AUTOANTIBODIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; HYPOTHALAMIC AREA, LATERAL; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; NARCOLEPSY; NEURONS; NEUROPEPTIDES;

EID: 33646087446     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2006.02.010     Document Type: Article

References (21)

1. Black J.L., Krahn L.E., Pankratz V.S., and Michael S. Search for neuron-specific and nonneuron-specific antibodies in narcoleptic patients with and without HLA DQB1*0602. Sleep 25 (2002) 719-723
2. Black III J.L., Avula R.K., Walker D.L., et al. HLA DQB1*0602 positive narcoleptic subjects with cataplexy have CSF lgG reactive to rat hypothalamic protein extract. Sleep 28 (2005) 1191-1192
3. Black III J.L., Silber M.H., Krahn L.E., et al. Studies of humoral immunity to preprohypocretin in human leukocyte antigen DQB1*0602-positive narcoleptic subjects with cataplexy. Biol. Psychiatry 58 (2005) 504-509
4. Black III J.L., Silber M.H., Krahn L.E., et al. Analysis of hypocretin (orexin) antibodies in patients with narcolepsy. Sleep 28 (2005) 427-431
5. Blouin A.M., Thannickal T.C., Worley P.F., Baraban J.M., Reti I.M., and Siegel J.M. Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy. Neurology 65 (2005) 1189-1192
6. Crocker A., Espana R.A., Papadopoulou M., et al. Concomitant loss of dynorphin, NARP, and orexin in narcolepsy. Neurology 65 (2005) 1184-1188
7. Goldstone A.P., Unmehopa U.A., Bloom S.R., and Swaab D.F. Hypothalamic NPY and Agouti-related protein are increased in human illness but not in Prader-Willi syndrome and other obese subjects. J. Clin. Endocrinol. Metab. 87 (2002) 927-937
8. Li Y., Gao X.B., Sakurai T., and van den Pol A.N. Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron-a potential mechanism for orchestrating the hypothalamic arousal system. Neuron 36 (2002) 1169-1181
9. Lin L., Hungs M., and Mignot E. Narcolepsy and the HLA region. J. Neuroimmunol. 117 (2001) 9-20
10. Mignot E. Genetic and familial aspects of narcolepsy. Neurology 50 (1998) S16-S22
11. Nishino S., Ripley B., Overeem S., Lammers G.J., and Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355 (2000) 39-40
12. Overeem S., Mignot E., van Dijk J.G., and Lammers G.J. Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives. J. Clin. Neurophysiol. 18 (2001) 78-105
13. Overeem S., Geleijns K., Garssen M.P., Jacobs B.C., Van Doorn P.A., and Lammers G.J. Screening for anti-ganglioside antibodies in hypocretin-deficient human narcolepsy. Neurosci. Lett. 341 (2003) 13-16
14. Peyron C., Faraco J., Rogers W., et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat. Med. 6 (2000) 991-997
15. Ripley B., Fujiki N., Okura M., Mignot E., and Nishino S. Hypocretin levels in sporadic and familial cases of canine narcolepsy. Neurobiol. Dis. 8 (2001) 525-534
16. Rubin R.L., Hajdukovich R.M., and Mitler M.M. HLA-DR2 association with excessive somnolence in narcolepsy does not generalize to sleep apnea and is not accompanied by systemic autoimmune abnormalities. Clin. Immunol. Immunopathol. 49 (1988) 149-158
17. Scammell T.E. The neurobiology, diagnosis, and treatment of narcolepsy. Ann. Neurol. 53 (2003) 154-166
18. Smith A.J., Jackson M.W., Neufing P., McEvoy R.D., and Gordon T.P. A functional autoantibody in narcolepsy. Lancet 364 (2004) 2122-2124
19. Thannickal T.C., Moore R.Y., Nienhuis R., et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 27 (2000) 469-474
20. Thannickal T.C., Siegel J.M., Nienhuis R., and Moore R.Y. Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy. Brain Pathol. 13 (2003) 340-351
21. Verschuuren J.J., Graus Y.M., Tzartos S.J., van B.V., and De Baets M.H. Paratope- and framework-related cross-reactive idiotopes on anti-acetylcholine receptor antibodies. J. Immunol. 146 (1991) 941-948