A 1.8-Mb-reduced Streptomyces clavuligerus genome: Relevance for secondary metabolism and differentiation

Applied Microbiology and Biotechnology

Volumn 98, Issue 5, 2014, Pages 2183-2195

  Alvarez Alvarez R ^a,b   Rodriguez Garcia A ^a,b   Martinez Burgo Y ^a   Robles Reglero, V ^a,b   Santamarta, I ^b   Perez Redondo R ^b   Martin J F ^a   Liras, P ^a,b  

^a UNIVERSITY OF LEÓN   (Spain)

^b Institute of Biotechnology INBIOTEC Parque Científico de León   (Spain)

Author keywords

Clavulanic acid; Holomycin; Linear plasmids; pSCL4; Streptomyces clavuligerus

Indexed keywords

CLAVULANIC ACID; HOLOMYCIN; LINEAR PLASMIDS; PSCL4; STREPTOMYCES CLAVULIGERUS;

BACTERIA; BIOCHEMISTRY; CARBOXYLIC ACIDS; METABOLITES; POLYMERASE CHAIN REACTION;

GENES;

CLAVULANIC ACID; HOLOMYCIN; NATURAL PRODUCT; UNCLASSIFIED DRUG;

BACTERIUM; GENOME; MUTATION; ORGANIC ACID; PLASMID; POLYMERASE CHAIN REACTION; SECONDARY METABOLITE;

ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL GENE; BACTERIAL GENOME; BACTERIAL SPORE; BIOSYNTHESIS; CELL DIFFERENTIATION; CONTROLLED STUDY; COPY NUMBER VARIATION; DRUG MANUFACTURE; GENE EXPRESSION; MEGAPLASMID; MYCELIUM; NONHUMAN; OPPA2 BACTERIAL GENE; PARB BACTERIAL GENE; POLYMERASE CHAIN REACTION; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECONDARY METABOLISM; SPOROGENESIS; STREPTOMYCES CLAVULIGERUS; TRANSCRIPTOMICS;

STREPTOMYCES CLAVULIGERUS;

CLAVULANIC ACID; GENOME, BACTERIAL; MUTATION; PLASMIDS; SECONDARY METABOLISM; SEQUENCE DELETION; SPORES, BACTERIAL; STREPTOMYCES;

EID: 84896734110     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-013-5382-z     Document Type: Article

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