Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats

Food and Chemical Toxicology

Volumn 66, Issue , 2014, Pages 185-193

  Rashid, Summya ^a   Ali, Nemat ^a   Nafees, Sana ^a   Hasan, Syed Kazim ^a   Sultana, Sarwat ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

5 FU; Apoptosis; CH; KIM 1; Oxidative stress

Indexed keywords

CASPASE 3; CHRYSIN; CREATININE; FLUOROURACIL; GLUTATHIONE; LACTATE DEHYDROGENASE; PROTEIN BCL 2; PROTEIN P53; UREA; ANTINEOPLASTIC ANTIMETABOLITE; FLAVONOID; MALONALDEHYDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; UPREGULATION; UREA NITROGEN BLOOD LEVEL; ANIMAL; DRUG EFFECTS; ENZYMOLOGY; KIDNEY; METABOLISM; TOXICITY; WISTAR RAT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BLOOD UREA NITROGEN; FLAVONOIDS; FLUOROURACIL; GLUTATHIONE; KIDNEY; L-LACTATE DEHYDROGENASE; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; RATS; RATS, WISTAR;

EID: 84896732293     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2014.01.026     Document Type: Article

References (38)

1. Arriazu R., Pozuelo J.M., Henriques-Gil N., Perucho T., Martin R., Rodriguez R., Santamaria L. Immunohistochemical study of cell proliferation, Bcl-2, p53, and caspase-3 expression on preneoplastic changes induced by cadmium and zinc chloride in the ventral rat prostate. J. Histochem. Cytochem. 2006, 54:981-990.
2. Bosetti C., Rossi M., McLaughlin J.K., Negri E., Talamini R., Lagiou P., Montella M., Ramazzotti V., Franceschi S., LaVecchia C. Flavonoids and the risk of renal cell carcinoma. Cancer Epidemiol. Biomarkers Prev. 2007, 16:98-101.
3. Bowen J.M., Gibson R.J., Cummins A.G., Keefe D.M. Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage. Support Care Cancer 2006, 14:713-731.
4. Carlberg I., Mannervik B. Glutathione reductase. Methods Enzymol. 1985, 113:484-490.
5. Chang C.T., Ho T.Y., Lin H., Liang J.A., Huang H.C., Li C.C., Lo H.Y., Wu S.L., Huang Y.F., Hsiang C.Y. 5-Fluorouracil induced intestinal mucositis via nuclear factor-κB activation by transcriptomic analysis and in vivo bioluminescence imaging. PLoS One 2012, 7:e31808.
6. Cheng M., He B., Wan T., Zhu W., Han J., Zha B., Chen H., Yang F., Li Q., Wang W., Xu H., Ye T. 5-Fluorouracil nanoparticles inhibit hepatocellular carcinoma via activation of the p53 pathway in the orthotopic transplant mouse model. PLoS One 2012, 7:e47115.
7. Chibber S., Farhan M., Hassan I., Naseem I. White light-mediated Cu (II)-5FUinteractionaugmentsthechemotherapeuticpotentialof5-FU: an invitrostudy. Tumour Biol. 2011, 32:881-892.
8. Claiborne A. Catalase activity. CRC Handbook of Methods in Oxygen Radical Research 1985, 283-284. CRC, Boca Raton, RA. R.A. Greenwald (Ed.).
9. David T., Peter H.C., Gregory T., Catherine B., Saurabh S. In vivo effects of immunomodulators in a murine model of fluorouracil-induced mucositis. Curr. Therapeutic Res. 2011, 72:262-272.
10. Hare R.S. Endogenous creatinine in serum and urine. Proc. Soc. Exp. Biol. Med. 1950, 74:148-151.
11. Kanter M.W. Clinical chemistry 1975, The Bobber Merill Company Inc., New York, p. 80.
12. Khan R., Khan AQ., Qama r.W., Lateef A., Tahir M., Rehman M.U., Ali F., Sultana S. Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. Toxicol. Appl. Pharmacol. 2012, 258:315-329.
13. Khan R., Khan A.Q., Qamar W., Lateef A., Ali F., Rehman M.U., Tahir M., Sharma S., Sultana S. Chrysinabrogatescisplatininducedoxidativestress,p53expression,gobletcelldisintegrationandapoptoticresponses in the jejunum of Wistar rats. Br. J. Nutr. 2012, 108:1574-1585.
14. Khan R., Sultana S. Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of Wistar rats. Chem. Biol. Interact. 2011, 192:193-200.
15. Kinhult S., Albertsson M., Eskilsson J., Cwikiel M. Effects of probucol on endothelial damage by 5-fluorouracil. Acta Oncol. 2003, 42:304-308.
16. Lamberti M., Porto S., Marra M., Zappavigna S., Grimaldi A., Feola D., Pesce D., Naviglio S., Spina A., Sannolo N., Caraglia M. 5-Fluorouracil induces apoptosis in rat cardiocytes through intracellular oxidative stress. J. Exp. Clin. Cancer Res. 2012, 19:31-60.
17. Li X., Huang Q., Ong C.N., Yang X.F., Shen H.M. Chrysinsensitizestumor necrosis factor-alpha-inducedapoptosisinhumantumorcellsviasuppressionofnuclearfactor-kappaB. Cancer Lett. 2010, 293:109-116.
18. Lowry O.H., Rosebrough N.J., Farr A., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
19. Marklund S., Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 1974, 47:469-474.
20. Middleton E., Kandaswami C., Theoharides T.C. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 2000, 52:673-751.
21. Mirjolet J.F., Barberi-Heyob M., Didelot C., Peyrat J.P., Abecassis J., Millon R., Merlin J.L. Bcl-2/Bax protein ratio predicts 5-fluorouracil sensitivity independently of p53 status. Br. J. Cancer. 2000, 83:1380-1386.
22. Miura K., Kinouchi M., Ishida K., Fujibuchi W., Naitoh T., Ogawa H., Ando Ti, Yazaki N., Watanabe K., Haneda S., Shibata C., Sasaki I. 5-FU metabolism in cancer and orally-administrable 5-FU drugs. Cancers 2010, 2:1717-1730.
23. Miyamoto S., Kohno H., Suzuki R., Sugie S., Murakami A., Ohigashi H., Tanaka T. Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats. Oncol. Rep. 2006, 15:1169-1173.
24. Mohandas M., Marshall J.J., Duggin G.G., Horvath J.S., Tiller D. Differential distribution of glutathione and glutathione related enzymes in rabbit kidney. Cancer Res. 1984, 44:5086-5091.
25. Nada O. A review of propolis antitumour action in vivo and in vitro. J. ApiProduct ApiMed. Sci. 2010, 2:1-20.
26. Naidu M.U., Ramana G.V., Rani P.U., Mohan I.K., Suman A., Roy P. Chemotherapy-induced and/or radiation therapy-induced oral mucositis-complicating the treatment of cancer. Neoplasia 2004, 6:423-431.
27. Nora E.Ali Protective effect of captopril against 5-fluorouracil-induced hepato and nephrotoxicity in male albino rats. J. Am. Sci. 2012, 8.
28. Ramadori G., Cameron S. Effects of systemic chemotherapy on the liver. Ann. Hepatol. 2010, 9:133-143.
29. Rashid S., Ali N., Nafees S., Ahmad S.Tanveer, Arjumand W., Hasan S.Kazim, Sultana S. Alleviation of doxorubicin induced nephrotoxicity and hepatotoxicity by chrysin in wistar rats. Toxicol. Mech. Methods 2012, 23:337-345.
30. Rashid S., Ali N., Nafees S., Ahmad S.Tanveer, Hasan S.Kazim, Sultana S. Abrogation of 5-flourouracil induced renal toxicity by bee propolis via targeting oxidative stress and inflammation in Wistar rats. J. Pharm. Res. 2013, 7:189-194.
31. Ray Sarbani D. Evaluation of Protective effect of reduced Glutathione on 5-Fluorouracil-induced changes in Cholesterol Profile. Int. J. Pharm. Tech. Res. 2011, 3:580-584.
32. Sultana S., Verma K., Khan R. Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. J. Pharm. Pharmacol. 2012, 64:872-881.
33. Surh Y.J., Chun K.S., Cha H.H. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat. Res. 2001, 1:243-268.
34. Tahir M., Sultana S. Chrysin modulates ethanol metabolism in Wistar rats: a promising role against organ toxicities. Alcohol. Alcoholism. 2011, 46:383-392.
35. Thant A.A., Wu Y., Lee J., Mishra D.K., Garcia H., Koeffler H.P., Vadgama J.V. Role of caspases in 5-FU and selenium-induced growth inhibition of colorectal cancer cells. Anticancer Res. 2008, 28:3579-3592.
36. Wang X., Morris M.E. Effects of the flavaniod chrysin on nitrofurantion pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab Dispos. 2007, 35:268-274.
37. Xian C.J., Howarth G.S., Cool J.C., Foster B.K. Effects of acute 5-fluorouracil chemotherapy and insulin-like growth factor-I pretreatment on growth plate cartilage and metaphyseal bone in rats. Bone 2004, 35:739-749.
38. Zhou Y., Vaidya V.S., Brown R.P., Zhang J., Rosenzweig B.A., Thompson K.L., Miller T.J., Bonventre J.V., Goering P.L. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol. Sci. 2008, 101:59.