Immunohistochemical study of cell proliferation, Bcl-2, p53, and caspase-3 expression on preneoplastic changes induced by cadmium and zinc chloride in the ventral rat prostate

Journal of Histochemistry and Cytochemistry

Volumn 54, Issue 9, 2006, Pages 981-990

  Arriazu, Riánsares ^a   Pozuelo, José M ^a   Henriques Gil, Nuno ^a   Perucho, Teresa ^a   Martín, Rocío ^b   Rodríguez, Rosario ^a   Santamaría, Luis ^c  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

^b HOSPITAL NUESTRA SEÑORA DE SONSOLES   (Spain)

^c AUTONOMOUS UNIVERSITY OF MADRID   (Spain)

Author keywords

Cadmium; Dysplasia; Immunohistochemistry; Rat prostate; Zinc

Indexed keywords

CADMIUM; CASPASE 3; CYCLINE; PROTEIN BCL 2; PROTEIN P53; ZINC CHLORIDE;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DENSITY; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; DYSPLASIA; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRECANCER; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE VENTRAL LOBE; PROTEIN EXPRESSION; RAT;

ANIMALS; APOPTOSIS; CADMIUM CHLORIDE; CARCINOGENS; CASPASE 3; CASPASES; CELL PROLIFERATION; CHLORIDES; IMMUNOHISTOCHEMISTRY; MALE; PRECANCEROUS CONDITIONS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROSTATE; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; ZINC COMPOUNDS;

ANIMALIA;

EID: 33748042956     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/jhc.5A6733.2006     Document Type: Article

References (44)

1. Achanzar WE, Diwan BA, Liu J, Quader ST, Webber MM, Waalkes MP (2001) Cadmium-induced malignant transformation of human prostate epithelial cells. Cancer Res 61:455-458
2. Arai Y, Okubo K, Terada N, Matsuta Y, Egawa S, Kuwao S, Ogura K (2001) Volume-weighted mean nuclear volume predicts tumor biology of clinically organ-confined prostate cancer. Prostate 46:134-141
3. Arriazu R, Pozuelo JM, Martin R, Rodriguez R, Santamaria L (2005a) Quantitative and immunohistochemical evaluation of PCNA, androgen receptor, apoptosis and glutathione-S-transferase P1 on preneoplastic changes induced by cadmium and zinc chloride in the rat ventral prostate. Prostate 63:347-357
4. Arriazu R, Pozuelo JM, Rodriguez R, Henriques-Gil N, Perucho T, Martin R, Santamaria L (2005b) Cadmium and zinc chloride-induced preneoplastic changes in the rat ventral prostate: an immunohistochemical and molecular study. In Li JJ, Li SA, and Llombart-Bosch A, eds. Hormonal Carcinogenesis IV. New York, Springer, 522-528
5. Bosland MC (1999) Use of animal models in defining efficacy of chemoprevention agents against prostate cancer. Eur Urol 35:459-463
6. Bostwick DG (1992) Prostatic intraepithelial neoplasia (PIN): current concepts. J Cell Biochem Suppl 16:10-19
7. Bostwick DG (1996) Progression of prostatic intraepithelial neoplasia to early invasive adenocarcinoma. Eur Urol 30:145-152
8. Bostwick DG, Pacelli A, Lopez-Beltran A (1996) Molecular biology of prostatic intraepithelial neoplasia. Prostate 29:117-134
9. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326:1-16
10. Costello LC, Franklin RB (2000) The intermediary metabolism of the prostate: a key to understanding the pathogenesis and progression of the prostate malignancy. Oncology 59:269-282
11. Downing SR, Russell PJ, Jackson P (2003) Alterations of p53 are common in early stage prostate cancer. Can J Urol 10:1924-1933
12. Feng P, Liang JY, Li TL, Guan ZX, Zou J, Franklin R, Costello LC (2000) Zinc induces mitochondria apoptogenesis in prostate cells. Mol Urol 4:31-36
13. Fischer AH, Bardarov S Jr, Jiang Z (2004) Molecular aspects of diagnostic nucleolar and nuclear envelope changes in prostate cancer. J Cell Biochem 91:170-184
14. Fujikawa K, Sasaki M, Aoyama T, Itoh T, Yoshida O (1995) Prognostic criteria in patients with prostate cancer: correlation with volume weighted mean nuclear volume. J Urol 154:2123-2127
15. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, Nyengaard JR, et al. (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96:379-394
16. Gundersen HJ, Jensen EB (1985) Stereological estimation of the volume-weighted mean volume of arbitrary particles observed on random sections. J Microsc 138:127-142
17. Howard CV, Reed MG (1998) Number estimation. In Howard CV, Reed MG, eds. Unbiased Stereology. Three-Dimensional Measurement in Microscopy. Oxford, Bios Scientific Publishers, 69-105
18. King LM, Banks WA, George WJ (1999) Differences in cadmium transport to the testis, epididymis, and brain in cadmium-sensitive and -resistant murine strains 129/J and A/J. J Pharmacol Exp Ther 289:825-830
19. Knillova J, Kolar Z (2003) The significance of key regulators of apoptosis in the development and prognosis of prostate carcinoma. I. Proteins of the Bcl-2 family and protein p53. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:3-10
20. Marshall JR (2001) High-grade prostatic intraepithelial neoplasia as an exposure biomarker for prostate cancer chemoprevention research. IARC Sci Publ 154:191-198
21. Martin JJ, Martin R, Codesal J, Fraile B, Paniagua R, Santamaria L (2001) Cadmium chloride-induced dysplastic changes in the ventral rat prostate: an immunohistochemical and quantitative study. Prostate 46:11-20
22. Martin R, Sneige N, Vasquez M, Aragon-Flores M, Martin G, Marron C, Santamaria L (1999) Stereologic estimates of volume-weighted mean nuclear volume in aspiration smears of ductal breast carcinoma. Correlation with cytologic grade, tumor size and lymph node status. Anal Quant Cytol Histol 21:185-193
23. Montironi R, Magi-Galluzzi C, Marina S, Diamanti L (1994) Quantitative characterization of the frequency and location of cell proliferation and death in prostate pathology. J Cell Biochem Suppl 19:238-245
24. Morrissey C, Buser A, Scolaro J, O'Sullivan J, Moquin A, Tenniswood M (2002) Changes in hormone sensitivity in the ventral prostate of aging Sprague-Dawley rats. J Androl 23:341-351
25. Munshi A, Pappas G, Honda T, McDonnell TJ, Younes A, Li Y, Meyn RE (2001) TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhibitable by Bcl-2. Oncogene 20:3757-3765
26. Nakamura K, Yasunaga Y, Ko D, Xu LL, Moul JW, Peehl DM, Srivastava S, et al. (2002) Cadmium-induced neoplastic transformation of human prostate epithelial cells. Int J Oncol 3:543-547
27. Nevalainem MT, Valve EM, Ingleton PM, Harkönen PL (1996) Expression and hormone regulation of prolactin receptors in rat dorsal and lateral prostate. Endocrinology 137:3078-3088
28. Nicholson B, Theodorescu D (2003) Molecular therapeutics in prostate cancer. Histol Histopathol 18:275-298
29. O'Neill AJ, Boran SA, O'Keane C, Coffey RN, Hegarty NJ, Hegarty P, Gaffney EF, et al. (2001) Caspase 3 expression in benign prostatic hyperplasia and prostate carcinoma. Prostate 47:183-188
30. Parkinson MC (1995) Pre-neoplastic lesions of the prostate. Histopathology 27:301-311
31. Pollard M, Wolter W (2000) Prevention of spontaneous prostate-related cancer in Lobund-Wistar rats by a soy protein isolate/isoflavone diet. Prostate 45:101-105
32. Pollard M, Woher W, Sun L (2001) Diet and the duration of testosterone-dependent prostate cancer in Lobund-Wistar rats. Cancer Lett 173:127-131
33. Sensibar JA (1995) Analysis of cell death and cell proliferation in embryonic stages, normal adult, and aging prostates in human and animals. Microsc Res Tech 30:342-350
34. Sheffield VC, Beck JS, Kwitek AE, Sandstrom DW, Stone EM (1993) The sensitivity of single-strand conformation polymorphism analysis for the detection of single base substitutions. Genomics 16:325-332
35. Shirai T, Iwasaki S, Masui T, Mori T, Kato T, Ito N (1993) Enhancing effect of cadmium on rat ventral prostate carcinogenesis induced by 3,2′-dimethyl-4-aminobiphenyl. Jpn J Cancer Res 84:1023-1030
36. Shirai T, Takahashi S, Cui L, Futakuchi M, Kato K, Tamano S, Imaida K (2000) Experimental prostate carcinogenesis-rodent models. Mutat Res 462:219-226
37. Sirvent JJ, Aguilar MC, Olona M, Pelegri A, Blazquez S, Gutierrez C (2004) Prognostic value of apoptosis in breast cancer (pT1-pT2). A TUNEL, p53, bcl-2, bag-1 and Bax immunohistochemical study. Histol Histopathol 19:759-770
38. Sorensen FB, Ottosen PD (1991) Stereological estimation of nuclear volume in benign and malignant melanocytic lesions of the skin. Inter- and intraobserver variability of malignancy grading. Am J Derma topathol 13:99-107
39. Visser AJ, Deklerk JN (1978) The effect of dietary cadmium on prostate growth. Trans Am Assoc Genitourin Surg 70:66-68
40. Waalkes MP (2000) Cadmium carcinogenesis in review. J Inorg Biochem 79:241-244
41. Waalkes MP, Coogan TP, Barter RA (1992) Toxicological principles of metal carcinogenesis with special emphasis on cadmium. Crit Rev Toxicol 22:175-201
42. Winter RN, Kramer A, Borkowski A, Kyprianou N (2001) Loss of caspase-1 and caspase-3 protein expression in human prostate cancer. Cancer Res 61:1227-1232
43. Wreford NG (1995) Theory and practice of Stereological techniques applied to the estimation of cell number and nuclear volume in the testis. Microsc Res Tech 32:423-436
44. Kip1, and Smad4 in benign, premalignant, and malignant human prostate. Hum Pathol 35:290-297