Leptin gene therapy attenuates neuronal damages evoked by amyloid-β and rescues memory deficits in APP/PS1 mice

Gene Therapy

Volumn 21, Issue 3, 2014, Pages 298-308

  Perez Gonzalez R ^a,b   Alvira Botero, M X ^c   Robayo, O ^d   Antequera, D ^a,b   Garzon M ^c   Martin Moreno A M ^b,e,f   Brera, B ^b,e   De Ceballos, M L ^b,e   Carro, E ^a,b  

^a Instituto de Investigacion Hospital 12 de Octubre ^*  (Spain)

^b CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^d Universidad Pedagó Gica y Tecnoló Gica de Colombia   (Colombia)

^e INSTITUTO CAJAL   (Spain)

^f MD ANDERSON CANCER CENTER   (Spain)

Author keywords

animal model; brain; cell culture; electron microscopy; leptin

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; CASPASE 3; LENTIVIRUS VECTOR; LEPTIN; SELF INACTIVATING HUMAN IMMUNODEFICIENCY VIRUS 1 VECTOR; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; ELECTRON MICROSCOPY; MALE; MEMORY DISORDER; MOUSE; NERVE CELL CULTURE; NERVE FIBER GROWTH; NONHUMAN; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; SYNAPSE; SYNAPTIC DENSITY; TREATMENT OUTCOME; VASCULAR AMYLOIDOSIS; VIRAL GENE THERAPY;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS; MUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CASPASE 3; GENETIC THERAPY; GENETIC VECTORS; HIV-1; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MEMORY DISORDERS; MICE; NEURONS; PRESENILIN-1; SYNAPSES; SYNAPTOPHYSIN;

EID: 84896732087     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2013.85     Document Type: Article

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