S-adenosylmethionine inhibits the activated phenotype of human hepatic stellate cells via Rac1 and Matrix metalloproteinases

International Immunopharmacology

Volumn 19, Issue 2, 2014, Pages 193-200

  Zhang, Feng ^a   Zhuge, Yu Zheng ^a   Li, Yu Jiang ^a   Gu, Jian Xiang ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Biological behavior; Hepatic stellate cells; Liver fibrosis; Rac1; S adenosylmethionine

Indexed keywords

CHOLECYSTOKININ OCTAPEPTIDE; GELATINASE A; GELATINASE B; RAC1 PROTEIN; S ADENOSYLMETHIONINE; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ADHERENT CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IN VITRO STUDY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; STELLATE CELL; UPREGULATION; WESTERN BLOTTING; ZYMOGRAPHY;

BIOLOGICAL BEHAVIOR; HEPATIC STELLATE CELLS; LIVER FIBROSIS; RAC1; S-ADENOSYLMETHIONINE;

APOPTOSIS; CELL ADHESION; CELL LINE; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; HEPATIC STELLATE CELLS; HUMANS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MATRIX METALLOPROTEINASES; PHENOTYPE; RAC1 GTP-BINDING PROTEIN; S-ADENOSYLMETHIONINE; SMAD3 PROTEIN; SMAD4 PROTEIN;

EID: 84896730743     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.01.021     Document Type: Article

References (29)

1. S.L. Friedman Mechanisms of hepatic fibrogenesis Gastroenterology 134 2008 1655 1669 (Pubitemid 351615417)
2. K. Ramani, H. Yang, J. Kuhlenkamp, L. Tomasi, H. Tsukamoto, and J.M. Mato et al. Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation Hepatology 51 2010 986 995
3. H. Matsui, and N. Kawada Effect of S-adenosyl-l-methionine on the activation, proliferation and contraction of hepatic stellate cells Eur J Pharmacol 509 2005 31 36 (Pubitemid 40248782)
4. Q. Cao, K.M. Mak, and C.S. Lieber DLPC and SAMe combined prevent leptin-stimulated TIMP-1 production in LX-2 human hepatic stellate cells by inhibiting HO-mediated signal transduction Liver Int 26 2006 221 231
5. K.J. Thompson, A.M. Lakner, B.W. Cross, S. Tsukada, R.A. Rippe, and I.H. McKillop et al. S-adenosyl-l-methionine inhibits collagen secretion in hepatic stellate cells via increased ubiquitination Liver Int 31 2011 891 901
6. N. Nieto, and A.I. Cederbaum S-adenosylmethionine blocks collagen I production by preventing transforming growth factor-beta induction of the COL1A2 promoter J Biol Chem 280 2005 30963 30974 (Pubitemid 41291829)
7. J. Oliva, F. Bardag-Gorce, J. Li, B.A. French, and S.W. French S-adenosylmethionine prevents the up regulation of Toll-like receptor (TLR) signaling caused by chronic ethanol feeding in rats Exp Mol Pathol 90 2011 239 243
8. A. Karaa, K.J. Thompson, I.H. McKillop, M.G. Clemens, and L.W. Schrum S-adenosyl-l-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model Shock 30 2008 197 205
9. L. Xu, A.Y. Hui, E. Albanis, M.J. Arthur, S.M. O'Byrne, and W.S. Blaner et al. Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis Gut 54 2005 142 151 (Pubitemid 40007234)
10. X.M. Wang, D.M. Yu, G.W. McCaughan, and M.D. Gorrell Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line Hepatology 42 2005 935 945 (Pubitemid 41401132)
11. X. Wu, Y. Wang, Y. Cui, Q. Bai, X. Ze, and T. Liu et al. Hepatitis B virus directly promotes collagen I expression of LX-2 cells without infection in vitro Hepatol Res 42 2012 911 921
12. J. Yang, Y. He, Y.X. Du, L.L. Tang, G.J. Wang, and J.P. Fawcett Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers Clin Ther 31 2009 311 320
13. M. Liu, L.G. Lu, A.X. Dou, W.H. Chen, R.D. Zheng, and Y.M. Mao et al. Effects of S-ademetionine on the proliferation, oxidative stress and TGF-β1 expression of human hepatic stellate cells Chin J Hepatol 12 2007 99 102
14. J.L. Goren, A.L. Stoll, K.E. Damico, I.A. Sarmiento, and B.M. Cohen Bioavailability and lack of toxicity of S-adenosyl-l-methionine (SAMe) in humans Pharmacotherapy 24 2004 1501 1507 (Pubitemid 39426345)
15. S. Castillo-Lluva, M.H. Tatham, R.C. Jones, E.G. Jaffray, R.D. Edmondson, and R.T. Hay et al. SUMOylation of the GTPase Rac1 is required for optimal cell migration Nat Cell Biol 12 2010 1078 1085
16. A. Saci, L.C. Cantley, and C.L. Carpenter Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size Mol Cell 42 2011 50 61
17. Y.I. Wu, D. Frey, O.I. Lungu, A. Jaehrig, I. Schlichting, and B. Kuhlman et al. A genetically encoded photoactivatable Rac controls the motility of living cells Nature 461 2009 104 108
18. E.E. Bosco, J.C. Mulloy, and Y. Zheng Rac1 GTPase: a "Rac" of all trades Cell Mol Life Sci 66 2009 370 374
19. N. Muhanna, S. Doron, O. Wald, A. Horani, A. Eid, and O. Pappo et al. Activation of hepatic stellate cells after phagocytosis of lymphocytes: a novel pathway of fibrogenesis Hepatology 48 2008 963 977
20. J.X. Jiang, K. Mikami, V.H. Shah, and N.J. Torok Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism Hepatology 48 2008 1497 1505
21. S.S. Choi, R.P. Witek, L. Yang, A. Omenetti, W.K. Syn, and C.A. Moylan et al. Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells Hepatology 52 2010 278 290
22. E.L. Guimaraes, C. Empsen, A. Geerts, and L.A. van Grunsven Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells J Hepatol 52 2010 389 397
23. W.D. Zheng, L.J. Zhang, M.N. Shi, Z.X. Chen, Y.X. Chen, and Y.H. Huang et al. Expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in hepatic stellate cells during rat hepatic fibrosis and its intervention by IL-10 World J Gastroenterol 11 2005 1753 1758
24. Y.K. Zhu, B.E. Wang, F.J. Shen, J.D. Jia, and H. Ma Dynamic evolution of MMP-2 gene expression and its enzymatic activities in experimental liver fibrosis Chin J Hepatol 13 2005 509 512
25. N. Theret, K. Lehti, O. Musso, and B. Clement MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells Hepatology 30 1999 462 468 (Pubitemid 29357512)
26. I. Onozuka, S. Kakinuma, A. Kamiya, M. Miyoshi, N. Sakamoto, and K. Kiyohashi et al. Cholestatic liver fibrosis and toxin-induced fibrosis are exacerbated in matrix metalloproteinase-2 deficient mice Biochem Biophys Res Commun 406 2011 134 140
27. B.D. Radbill, R. Gupta, M.C. Ramirez, A. DiFeo, J.A. Martignetti, and C.E. Alvarez et al. Loss of matrix metalloproteinase-2 amplifies murine toxin-induced liver fibrosis by upregulating collagen I expression Dig Dis Sci 56 2011 406 416
28. S.N. Hartland, F. Murphy, R.L. Aucott, A. Abergel, X. Zhou, and J. Waung et al. Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin Liver Int 29 2009 966 978
29. S. Hemmann, J. Graf, M. Roderfeld, and E. Roeb Expression of MMPs and TIMPs in liver fibrosis - a systematic review with special emphasis on anti-fibrotic strategies J Hepatol 46 2007 955 975 (Pubitemid 46529049)