Diagnostic value of serum leptin and a promising novel diagnostic model for sepsis

Experimental and Therapeutic Medicine

Volumn 7, Issue 4, 2014, Pages 881-886

  Chen, Mingyi ^a   Wang, Bin ^a   Xu, Yaping ^a   Deng, Zihui ^a   Xue, Hui ^a   Wang, Luhuan ^a   He, Lei ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Diagnosis; Leptin; Sepsis; Systemic inflammatory response syndrome

Indexed keywords

C REACTIVE PROTEIN; CREATININE; LEPTIN;

ADULT; ARTICLE; BACTEREMIA; BLOOD CULTURE; BODY TEMPERATURE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; ENZYME IMMUNOASSAY; FEMALE; GENDER; HEART RATE; HUMAN; INTERNATIONAL NORMALIZED RATIO; LEUKOCYTOSIS; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; PROGNOSIS; RADIOIMMUNOASSAY; RECEIVER OPERATING CHARACTERISTIC; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SEPSIS;

EID: 84896724076     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1506     Document Type: Article

References (37)

1. Monneret G: Immunology programs must include sepsis. Science 328: 1106, 2010.
2. Cohen J: The immunopathogenesis of sepsis. Nature 420: 885-891, 2002.
3. Arabi Y, Al Shirawi N, Memish Z, Venkatesh S and Al-Shimemeri A: Assessment of six mortality prediction models in patients admitted with severe sepsis and septic shock to the intensive care unit: a prospective cohort study. Crit Care 7: R116-R122, 2003.
4. Banta JE, Joshi KP, Beeson L and Nguyen HB: Patient and hospital characteristics associated with inpatient severe sepsis mortality in California, 2005-2010. Crit Care Med 40: 2960-2966, 2012.
5. Blanco Quirós A, Casado Flores J, Nieto Moro M, Garrote Adrados JA, Arranz Sanz E and Asensio Antón J: Meningococcal sepsis in pediatrics. Parameters associated with poor outcome. An Pediatr (Barc) 61: 305-313, 2004 (In Spanish).
6. Hotchkiss RS and Opal S: Immunotherapy for sepsis - a new approach against an ancient foe. N Engl J Med 363: 87-89, 2010.
7. Cohen-Wolkowiez M, Benjamin DK Jr and Capparelli E: Immunotherapy in neonatal sepsis: advances in treatment and prophylaxis. Curr Opin Pediatr 21: 177-181, 2009.
8. O'Callaghan A and Redmond HP: Treatment of sepsis: current status of clinical immunotherapy. Surgeon 4: 355-361, 2006.
9. Martin GS: Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomes. Expert Rev Anti Infect Ther 10: 701-706, 2012.
10. Fried E, Weissman C and Sprung C: Postoperative sepsis. Curr Opin Crit Care 17: 396-401, 2011.
11. Müller B, Becker KL, Schächinger H, et al: Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med 28: 977-983, 2000.
12. Andaluz-Ojeda D, Bobillo F, Iglesias V, et al: A combined score of pro- and anti-inflammatory interleukins improves mortality prediction in severe sepsis. Cytokine 57: 332-336, 2012.
13. Song R, Kim J, Yu D, Park C and Park J: Kinetics of IL-6 and TNF-α changes in a canine model of sepsis induced by endotoxin. Vet Immunol Immunopathol 146: 143-149, 2012.
14. Abdel-Hafez NM, Saleh Hassan Y and El-Metwally TH: A study on biomarkers, cytokines, and growth factors in children with burn injuries. Ann Burns Fire Disasters 20: 89-100, 2007.
15. Hoda MR, Theil G, Mohammed N, Fischer K and Fornara P: The adipocyte-derived hormone leptin has proliferative actions on androgen-resistant prostate cancer cells linking obesity to advanced stages of prostate cancer. J Oncol 2012: 280-386, 2012.
16. Miyazaki S, Izawa T, Ogasawara JE, et al: Effect of exercise training on adipocyte-size-dependent expression of leptin and adiponectin. Life Sci 86: 691-698, 2010.
17. Bates SH, Stearns WH, Dundon TA, et al: STAT3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 421: 856-859, 2003.
18. Behnes M, Brueckmann M, Lang S, et al: Alterations of leptin in the course of inflammation and severe sepsis. BMC Infect Dis 12: 217, 2012.
19. Mackey-Lawrence NM and Petri WA Jr: Leptin and mucosal immunity. Mucosal Immunol 5: 472-479, 2012.
20. Conde J, Scotece M, Gómez R, Gómez-Reino JJ, Lago F and Gualillo O: At the crossroad between immunity and metabolism: focus on leptin. Expert Rev Clin Immunol 6: 801-808, 2010.
21. De Rosa V, Procaccini C, Cali G, et al: A key role of leptin in the control of regulatory T cell proliferation. Immunity 26: 241-255, 2007.
22. Hasenkrug KJ: The leptin connection: regulatory T cells and autoimmunity. Immunity 26: 143-145, 2007.
23. Bone RC, Balk RA, Cerra FB, et al: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101: 1644-1655, 1992.
24. Zhang J, She D, Feng D, Jia Y and Xie L: Dynamic changes of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) reflect sepsis severity and can predict prognosis: a prospective study. BMC Infect Dis 11: 53, 2011.
25. Arnalich F, López J, Codoceo R, Jim nez M, Madero R and Montiel C: Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock. J Infect Dis 180: 908-911, 1999.
26. Dellinger RP, Levy MM, Rhodes A, et al: Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 41: 580-637, 2013.
27. Su L, Han B, Liu C, et al: Value of soluble TREM-1, procalcitonin, and C-reactive protein serum levels as biomarkers for detecting bacteremia among sepsis patients with new fever in intensive care units: a prospective cohort study. BMC Infect Dis 12: 157, 2012.
28. Bele N, Darmon M, Coquet I, et al: Diagnostic accuracy of procalcitonin in critically ill immunocompromised patients. BMC Infect Dis 11: 224, 2011.
29. Fu Y, Chen J, Cai B, et al: The use of PCT, CRP, IL-6 and SAA in critically ill patients for an early distinction between candidemia and Gram positive/negative bacteremia. J Infect 64: 438-440, 2012.
30. Abdollahi A, Shoar S, Nayyeri F and Shariat M: Diagnostic value of simultaneous measurement of procalcitonin, interleukin-6 and hs-CRP in prediction of early-onset neonatal sepsis. Mediterr J Hematol Infect Dis 4: e2012028, 2012.
31. Tsangaris I, Plachouras D, Kavatha D, et al: Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay. BMC Infect Dis 9: 213, 2009.
32. Póvoa P, Coelho L, Almeida E, et al: Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study. Crit Care 10: R63, 2006.
33. Noor MK, Shahidullah M, Mutanabbi M, Barua C, Mannan MA and Afroza S: Comparison between CRP and IL-6 as early markers of neonatal sepsis. Mymensingh Med J 17 (Suppl 2): S72-S76, 2008.
34. Chachkhiani I, Gürlich R, Maruna P, et al: The postoperative stress response and its reflection in cytokine network and leptin plasma levels. Physiol Res 54: 279-285, 2005.
35. Cesur S, Irmak H, Eras Z, et al: Prognostic value of serum TNF-alpha, IL-10, leptin and CRP levels in newborns with septicemia. Mikrobiyol Bul 43: 607-612, 2009 (In Turkish).
36. Maruna P, Gürlich R, Frasko R and Haluzík M: Serum leptin levels in septic men correlate well with C-reactive protein (CRP) and TNF-alpha but not with BMI. Physiol Res 50: 589-594, 2001.
37. Bracho-Riquelme RL and Reyes-Romero MA: Leptin in sepsis: a well-suited biomarker in critically ill patients? Crit Care 14: 138, 2010.