Thromboxane A2 exerts promoting effects on cell proliferation through mediating cyclooxygenase-2 signal in lung adenocarcinoma cells

Journal of Cancer Research and Clinical Oncology

Volumn 140, Issue 3, 2014, Pages 375-386

  Huang, Run Yue ^a   Li, Shan Shan ^a   Guo, Hui Zhen ^a   Huang, Yu ^a   Zhang, Xian ^a   Li, Ming Yue ^b   Chen, George Gong ^b   Zeng, Xing ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Apoptosis; Cell cycle; Cyclooxygenase 2; Dual block of TXA2 synthesis and action; Lung cancer

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; BM 567; BROXURIDINE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FUREGRELATE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PTXA 2; SMALL INTERFERING RNA; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; THROMBOXANE B2; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE ASSAY; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LUNG CARCINOGENESIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZOFURANS; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; HYDRAZINES; IMMUNOENZYME TECHNIQUES; LUNG NEOPLASMS; NITROBENZENES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, THROMBOXANE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SULFONAMIDES; SULFONYLUREA COMPOUNDS; THROMBOXANE A2; THROMBOXANE-A SYNTHASE;

EID: 84896718003     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-013-1573-3     Document Type: Article

References (38)

1. Abramovitz M, Adam M, Boie Y, Carriere M, Denis D, Godbout C, Lamontagne S, Rochette C, Sawyer N, Tremblay NM, Belley M, Gallant M, Dufresne C, Gareau Y, Ruel R, Juteau H, Labelle M, Ouimet N, Metters KM (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483(2):285-293
2. Belvisi MG, Saunders M, Yacoub M, Mitchell JA (1998) Expression of cyclo-oxygenase-2 in human airway smooth muscle is associated with profound reductions in cell growth. Br J Pharmacol 125(5):1102-1108
3. Brodskii V, Vasil'ev AV, Terskikh VV, Zvezdina ND, Fateeva VI, Mal'chenko LA, Kiseleva EV, Bueverova EI (2012) Mesenchymal stromal cells synchronize the rhythm of protein synthesis under the effect of an exogenous signal. Ontogenez 43(3):229-232
4. Cathcart MC, Reynolds JV, O'Byrne KJ, Pidgeon GP (2010) The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer. Biochim Biophys Acta 1805(2):153-166. doi: 10.1016/j.bbcan.2010.01.006
5. Cathcart MC, Gately K, Cummins R, Kay E, O'Byrne KJ, Pidgeon GP (2011) Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer. Mol Cancer 10:25. doi: 10.1186/1476-4598-10-25
6. Cheng L, Alexander RE, Maclennan GT, Cummings OW, Montironi R, Lopez-Beltran A, Cramer HM, Davidson DD, Zhang S (2012) Molecular pathology of lung cancer: key to personalized medicine. Mod Pathol 25(3):347-369. doi: 10.1038/modpathol.2011.215
7. Cufer T, Ovcaricek T, O'Brien ME (2013) Systemic therapy of advanced non-small cell lung cancer: major-developments of the last 5-years. Eur J Cancer 49(6):1216-1225. doi: 10.1016/j.ejca.2012.11.021
8. de Leval X, Dassesse T, Dogne JM, Waltregny D, Bellahcene A, Benoit V, Pirotte B, Castronovo V (2006) Evaluation of original dual thromboxane A2 modulators as antiangiogenic agents. J Pharmacol Exp Ther 318(3):1057-1067. doi: 10.1124/jpet.106.101188
9. Ekambaram P, Lambiv W, Cazzolli R, Ashton AW, Honn KV (2011) The thromboxane synthase and receptor signaling pathway in cancer: an emerging paradigm in cancer progression and metastasis. Cancer Metastasis Rev 30(3-4):397-408. doi: 10.1007/s10555-011-9297-9
10. Ermert L, Dierkes C, Ermert M (2003) Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. Clin Cancer Res 9(5):1604-1610
11. Gee J, Lee IL, Grossman HB, Sabichi AL (2008) Forced COX-2 expression induces PGE(2) and invasion in immortalized urothelial cells. Urol Oncol 26(6):641-645. doi: 10.1016/j.urolonc.2007.05.015
12. Hinz B, Brune K, Pahl A (2000) Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages. Biochem Biophys Res Commun 272(3):744-748. doi: 10.1006/bbrc.2000.2859
13. Huang RY, Chen GG (2011) Cigarette smoking, cyclooxygenase-2 pathway and cancer. Biochim Biophys Acta 1815(2):158-169. doi: 10.1016/j.bbcan.2010.11.005
14. Huang RY, Li MY, Hsin MK, Underwood MJ, Ma LT, Mok TS, Warner TD, Chen GG (2011) 4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor. Oncogene 30(1):106-116. doi: 10.1038/onc.2010.390
15. Huang RY, Li MY, Ng CS, Wan IY, Kong AW, Du J, Long X, Underwood MJ, Mok TS, Chen GG (2013) Thromboxane A2 receptor alpha promotes tumor growth through an autoregulatory feedback pathway. J Mol Cell Biol 5(6):380-390. doi: 10.1093/jmcb/mjt038
16. Kim Y-M, Pyo H (2013) Different cell cycle modulation by celecoxib at different concentrations. Cancer Biother Radiopharm 28(2):138-145
17. Larzabal L, Nguewa PA, Pio R, Blanco D, Sanchez B, Rodriguez MJ, Pajares MJ, Catena R, Montuenga LM, Calvo A (2011) Overexpression of TMPRSS4 in non-small cell lung cancer is associated with poor prognosis in patients with squamous histology. Br J Cancer 105(10):1608-1614. doi: 10.1038/bjc.2011.432
18. Leung KC, Hsin MK, Chan JS, Yip JH, Li M, Leung BC, Mok TS, Warner TD, Underwood MJ, Chen GG (2009) Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27. Exp Cell Res 315(17):2974-2981. doi: 10.1016/j.yexcr.2009.06.025
19. Li X, Tai HH (2012) Increased expression of matrix metalloproteinases mediates thromboxane A2-induced invasion in lung cancer cells. Curr Cancer Drug Targets 12(6):703-715
20. Li X, Tai HH (2013) Thromboxane A receptor-mediated release of matrix metalloproteinase-1 (MMP-1) induces expression of monocyte chemoattractant protein-1 (MCP-1) by activation of protease-activated receptor 2 (PAR2) in A549 human lung adenocarcinoma cells. Mol Carcinog. doi: 10.1002/mc.22020
21. Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I (2003) Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth. Am J Clin Oncol 26(4):S103-S109. doi: 10.1097/01.COC.0000074147.22064.67
22. McLemore TL, Hubbard WC, Litterst CL, Liu MC, Miller S, McMahon NA, Eggleston JC, Boyd MR (1988) Profiles of prostaglandin biosynthesis in normal lung and tumor tissue from lung cancer patients. Cancer Res 48(11):3140-3147
23. Minghetti L, Polazzi E, Nicolini A, Creminon C, Levi G (1997) Up-regulation of cyclooxygenase-2 expression in cultured microglia by prostaglandin E2, cyclic AMP and non-steroidal anti-inflammatory drugs. Eur J Neurosci 9(5):934-940
24. Moussa O, Ashton AW, Fraig M, Garrett-Mayer E, Ghoneim MA, Halushka PV, Watson DK (2008a) Novel role of thromboxane receptors beta isoform in bladder cancer pathogenesis. Cancer Res 68(11):4097-4104. doi: 10.1158/0008-5472.CAN-07- 6560
25. Moussa O, Riker JM, Klein J, Fraig M, Halushka PV, Watson DK (2008b) Inhibition of thromboxane synthase activity modulates bladder cancer cell responses to chemotherapeutic agents. Oncogene 27(1):55-62. doi: 10.1038/sj.onc.1210629
26. Moussa O, Ciupek A, Watson DK, Halushka PV (2011) Urinary thromboxane B2 and thromboxane receptors in bladder cancer: opportunity for detection and monitoring. Prostaglandins Other Lipid Mediat 96(1-4):41-44. doi: 10.1016/j.prostaglandins.2011.09.002
27. Nakahata N (2008) Thromboxane A2: physiology/pathophysiology, cellular signal transduction and pharmacology. Pharmacol Ther 118(1):18-35. doi: 10.1016/j.pharmthera.2008.01.001
28. Nie D, Guo Y, Yang D, Tang Y, Chen Y, Wang MT, Zacharek A, Qiao Y, Che M, Honn KV (2008) Thromboxane A2 receptors in prostate carcinoma: expression and its role in regulating cell motility via small GTPase Rho. Cancer Res 68(1):115-121. doi: 10.1158/0008-5472.CAN-07-1018
29. Patscheke H (1990) Current concepts for a drug-induced inhibition of formation and action of thromboxane A2. Blut 60(5):261-268
30. Rosch S, Ramer R, Brune K, Hinz B (2005) Prostaglandin E2 induces cyclooxygenase-2 expression in human non-pigmented ciliary epithelial cells through activation of p38 and p42/44 mitogen-activated protein kinases. Biochem Biophys Res Commun 338(2):1171-1178. doi: 10.1016/j.bbrc.2005.10.051
31. Strillacci A, Griffoni C, Valerii MC, Lazzarini G, Tomasi V, Spisni E (2010) RNAi-based strategies for cyclooxygenase-2 inhibition in cancer. J Biomed Biotechnol 2010:828045. doi: 10.1155/2010/828045
32. Setia S, Sanyal SN (2012) Downregulation of NF-κB and PCNA in the regulatory pathways of apoptosis by cyclooxygenase-2 inhibitors in experimental lung cancer. Mol Cell Biochem 369(1-2):75-86. doi: 10.1007/s11010-012-1370-3
33. Su JL, Shih JY, Yen ML, Jeng YM, Chang CC, Hsieh CY, Wei LH, Yang PC, Kuo ML (2004) Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. Cancer Res 64(2):554-564
34. Wang D, Dubois RN (2006) Prostaglandins and cancer. Gut 55(1):115-122. doi: 10.1136/gut.2004.047100
35. Wei J, Yan W, Li X, Chang WC, Tai HH (2007) Activation of thromboxane receptor alpha induces expression of cyclooxygenase-2 through multiple signaling pathways in A549 human lung adenocarcinoma cells. Biochem Pharmacol 74(5):787-800. doi: 10.1016/j.bcp.2007.06.008
36. Wei J, Yan W, Li X, Ding Y, Tai HH (2010) Thromboxane receptor alpha mediates tumor growth and angiogenesis via induction of vascular endothelial growth factor expression in human lung cancer cells. Lung Cancer 69(1):26-32. doi: 10.1016/j.lungcan.2009.09.009
37. Wu YC, Su LJ, Wang HW, Jeff Lin CF, Hsu WH, Chou TY, Huang CY, Lu CL, Hsueh CT (2010) Co-overexpression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 adversely affects the postoperative survival in non-small cell lung cancer. J Thorac Oncol 5(8):1167-1174. doi: 10.1097/JTO.0b013e3181e2f4f5
38. Yucel-Lindberg T, Ahola H, Carlstedt-Duke J, Modeer T (1999) Involvement of tyrosine kinases on cyclooxygenase expression and prostaglandin E2 production in human gingival fibroblasts stimulated with interleukin-1beta and epidermal growth factor. Biochem Biophys Res Commun 257(2):528-532. doi: 10.1006/bbrc