Obesity is associated with lower coronary microvascular density

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Campbell, Duncan J ^a,b   Somaratne, Jithendra B ^c   Prior, David L ^b,c   Yii, Michael ^b,c   Kenny, James F ^c   Newcomb, Andrew E ^b,c   Kelly, Darren J ^b   Black, Mary Jane ^d  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c Monash University ^*  (Australia)

^d MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BODY MASS; CAPILLARY DENSITY; CARDIOMETABOLIC RISK; CARDIOVASCULAR PARAMETERS; CORONARY ARTERY BYPASS SURGERY; DIASTOLIC DYSFUNCTION; DIFFUSION; DISEASE ASSOCIATION; FEMALE; FIBROSING ALVEOLITIS; HEART ATRIUM SIZE; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE FILLING PRESSURE; HEART MUSCLE; HEART MUSCLE BLOOD FLOW; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; HEART SIZE; HISTOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; LOWER CORONARY MICROVASCULAR DENSITY; MAJOR CLINICAL STUDY; MALE; OBESITY; PERIVASCULAR FIBROSIS; PULMONARY ARTERY OCCLUSION PRESSURE; VASCULAR FIBROSIS; COMPLICATION; CORONARY ARTERY BLOOD FLOW; DIASTOLE; HEART LEFT VENTRICLE FUNCTION; MICROVASCULATURE; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PRESSURE; RISK;

CORONARY CIRCULATION; DIASTOLE; FEMALE; HEART FAILURE; HUMANS; MALE; MICROVESSELS; MIDDLE AGED; OBESITY; PRESSURE; RISK; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84896717976     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081798     Document Type: Article

References (46)

1. Russo C, Jin Z, Homma S, Rundek T, Elkind MS et al. (2011) Effect of obesity and overweight on left ventricular diastolic function: a community-based study in an elderly cohort. J Am Coll Cardiol 57: 1368-1374. doi:10.1016/S0735-1097(11)61368-5. PubMed: 21414533.
2. Cil H, Bulur S, Türker Y, Kaya A, Alemdar R et al. (2012) Impact of body mass index on left ventricular diastolic dysfunction. Echocardiography 29: 647-651. doi:10.1111/j.1540-8175.2012.01688.x. PubMed: 22486526.
3. Kane GC, Karon BL, Mahoney DW, Redfield MM, Roger VL et al. (2011) Progression of left ventricular diastolic dysfunction and risk of heart failure. JAMA 306: 856-863. doi:10.1001/jama.2011.1201. PubMed: 21862747.
4. Horwich TB, Fonarow GC (2010) Glucose, obesity, metabolic syndrome, and diabetes relevance to incidence of heart failure. J Am Coll Cardiol 55: 283-293. doi:10.1016/j.jacc.2009.07.029. PubMed: 20117431.
5. Bombelli M, Facchetti R, Sega R, Carugo S, Fodri D et al. (2011) Impact of body mass index and waist circumference on the long-term risk of diabetes mellitus, hypertension, and cardiac organ damage. Hypertension 58: 1029-1035. doi:10.1161/HYPERTENSIONAHA.111.175125. PubMed: 22025375.
6. Turkbey EB, McClelland RL, Kronmal RA, Burke GL, Bild DE et al. (2010) The impact of obesity on the left ventricle: the Multi-Ethnic Study of Atherosclerosis (MESA). JACC Cardiovasc Imaging 3: 266-274. doi: 10.1016/j.jcmg.2009.10.012. PubMed: 20223423.
7. Rider OJ, Cox P, Tyler D, Clarke K, Neubauer S (2013) Myocardial substrate metabolism in obesity. Int J Obes, 37: 972-9. doi:10.1038/ijo. 2012.170. PubMed: 23069666.
8. Niemann B, Chen Y, Teschner M, Li L, Silber RE et al. (2011) Obesity induces signs of premature cardiac aging in younger patients: the role of mitochondria. J Am Coll Cardiol 57: 577-585. doi:10.1016/S0735-1097(11)60577-9. PubMed: 21272749.
9. Szczepaniak LS, Victor RG, Orci L, Unger RH (2007) Forgotten but not gone: the rediscovery of fatty heart, the most common unrecognized disease in America. Circ Res 101: 759-767. doi:10.1161/CIRCRESAHA.107.160457. PubMed: 17932333. (Pubitemid 350287190)
10. Toblli JE, Cao G, DeRosa G, Di Gennaro F, Forcada P (2004) Angiotensin-converting enzyme inhibition and angiogenesis in myocardium of obese Zucker rats. Am J Hypertens 17: 172-180. doi: 10.1016/j.amjhyper.2004.03.452. PubMed: 14751661. (Pubitemid 38125136)
11. Gruber C, Kohlstedt K, Loot AE, Fleming I, Kummer W et al. (2012) Stereological characterization of left ventricular cardiomyocytes, capillaries, and innervation in the nondiabetic, obese mouse. Cardiovasc Pathol 21: 346-354. doi:10.1016/j.carpath.2011.11.003. PubMed: 22197049.
12. Sugawara T, Fujii S, Zaman AK, Goto D, Furumoto T et al. (2003) Coronary capillary network remodeling and hypofibrinolysis in aged obese diabetic rats: implications for increased myocardial vulnerability to ischemia. Mol Cell Biochem 248: 165-170. doi:10.1023/A:1024196504666. PubMed: 12870669. (Pubitemid 36833655)
13. Qin F, Siwik DA, Luptak I, Hou X, Wang L, et al. (2012) The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Circulation 125: 1757-1764, S1751-1756
14. Li ZL, Woollard JR, Ebrahimi B, Crane JA, Jordan KL et al. (2012) Transition from obesity to metabolic syndrome is associated with altered myocardial autophagy and apoptosis. Arterioscler Thromb Vasc Biol 32: 1132-1141. doi:10.1161/ATVBAHA.111.244061. PubMed: 22383702.
15. Leopoldo AS, Sugizaki MM, Lima-Leopoldo AP, do Nascimento AF, Luvizotto Rde A et al. (2010) Cardiac remodeling in a rat model of diet-induced obesity. Can J Cardiol 26: 423-429. doi:10.1016/S0828-282X(10)70440-2. PubMed: 20931095.
16. Burlá AK, Lobato NS, Fortes ZB, Oigman W, Neves MF (2013) Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats. Int J Cardiol, 165: 483-487. doi:10.1016/j.ijcard.2011.09.012. PubMed: 21945710.
17. Schindler TH, Cardenas J, Prior JO, Facta AD, Kreissl MC et al. (2006) Relationship between increasing body weight, insulin resistance, inflammation, adipocytokine leptin, and coronary circulatory function. J Am Coll Cardiol 47: 1188-1195. doi:10.1016/j.jacc.2005.10.062. PubMed: 16545651.
18. Quercioli A, Pataky Z, Montecucco F, Carballo S, Thomas A et al. (2012) Coronary vasomotor control in obesity and morbid obesity: contrasting flow responses with endocannabinoids, leptin, and inflammation. JACC Cardiovasc Imaging 5: 805-815. doi:10.1016/j.jcmg.2012.01.020. PubMed: 22897994.
19. Oka T, Komuro I (2008) Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure. Circ J 72 Suppl A: A13-A16. doi:10.1253/circj.CJ-08-0481. PubMed: 18772527.
20. Walsh K, Shiojima I (2007) Cardiac growth and angiogenesis coordinated by intertissue interactions. J Clin Invest 117: 3176-3179. doi:10.1172/JCI34126. PubMed: 17975662. (Pubitemid 350096973)
21. Campbell DJ, Somaratne JB, Jenkins AJ, Prior DL, Yii M et al. (2011) Impact of type 2 diabetes and the metabolic syndrome on myocardial structure and microvasculature of men with coronary artery disease. Cardiovasc Diabetol 10: 80. doi:10.1186/1475-2840-10-80. PubMed: 21929744.
22. Campbell DJ, Somaratne JB, Jenkins AJ, Prior DL, Yii M et al. (2012) Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels. PLOS ONE 7: e49813. doi:10.1371/journal.pone.0049813. PubMed: 23189164.
23. Campbell DJ, Somaratne JB, Jenkins AJ, Prior DL, Yii M et al. (2011) Differences in myocardial structure and coronary microvasculature between men and women with coronary artery disease. Hypertension 57: 186-192. doi:10.1161/HYPERTENSIONAHA.110.165043. PubMed: 21135353.
24. Ryan JJ, Rich JD, Thiruvoipati T, Swamy R, Kim GH et al. (2012) Current practice for determining pulmonary capillary wedge pressure predisposes to serious errors in the classification of patients with pulmonary hypertension. Am Heart J 163: 589-594. doi:10.1016/j.ahj.2012.01.024. PubMed: 22520524.
25. Alberti KG, Zimmet P, Shaw J (2006) Metabolic syndrome - a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 23: 469-480. doi:10.1007/BF02706751. PubMed: 16681555.
26. Zhu S, Heshka S, Wang Z, Shen W, Allison DB et al. (2004) Combination of BMI and waist circumference for identifying cardiovascular risk factors in whites. Obes Res 12: 633-645. doi: 10.1038/oby.2004.73. PubMed: 15090631. (Pubitemid 41132506)
27. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (2003) Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 26 Suppl 1: S5-S20. doi:10.2337/diacare.26.2007.S5. PubMed: 12502614.
28. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N et al. (1999) A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 130: 461-470. doi: 10.7326/0003-4819-130-6-199903160-00002. PubMed: 10075613. (Pubitemid 29135798)
29. Wallace TM, Levy JC, Matthews DR (2004) Use and abuse of HOMA modeling. Diabetes Care 27: 1487-1495. doi:10.2337/diacare.27.6.1487. PubMed: 15161807. (Pubitemid 38680001)
30. Rakusan K, Flanagan MF, Geva T, Southern J, Van Praagh R (1992) Morphometry of human coronary capillaries during normal growth and the effect of age in left ventricular pressure-overload hypertrophy. Circulation 86: 38-46. doi:10.1161/01.CIR.86.1.38. PubMed: 1535573.
31. Tomanek RJ (1992) Age as a modulator of coronary capillary angiogenesis. Circulation 86: 320-321. doi:10.1161/01.CIR.86.1.320. PubMed: 1617782.
32. Messer JV, Wagman RJ, Levine HJ, Neill WA, Krasnow N et al. (1962) Patterns of human myocardial oxygen extraction during rest and exercise. J Clin Invest 41: 725-742. doi:10.1172/JCI104531. PubMed: 14472965.
33. Anversa P, Sonnenblick EH (1990) Ischemic cardiomyopathy: pathophysiologic mechanisms. Prog Cardiovasc Dis 33: 49-70. doi: 10.1016/0033-0620(90)90039-5. PubMed: 2142312. (Pubitemid 20220009)
34. Campbell DJ, Somaratne JB, Jenkins AJ, Prior DL, Yii M et al. (2012) Reduced microvascular density in non-ischaemic myocardium of patients with recent non-ST-segment-elevation myocardial infarction. Int J Cardiol. doi:10.1016/j.ijcard.2012.03.075.
35. Johnson BL, Blackhurst DW, Latham BB, Cull DL, Bour ES et al. (2013) Bariatric surgery Is associated with a reduction in major macrovascular and microvascular complications in moderately to severely obese patients with type 2 diabetes mellitus. J Am Coll Surg 216: 545-556. doi:10.1016/j.jamcollsurg.2012. 12.019. PubMed: 23391591.
36. De Ciuceis C, Rossini C, Porteri E, La Boria E, Corbellini C et al. (2013) Circulating endothelial progenitor cells, microvascular density and fibrosis in obesity before and after bariatric surgery. Blood Press 22: 165-172. doi:10.3109/08037051.2012.749584. PubMed: 23286244.
37. Levy BI, Schiffrin EL, Mourad JJ, Agostini D, Vicaut E et al. (2008) Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus. Circulation 118: 968-976. doi:10.1161/CIRCULATIONAHA.107. 763730. PubMed: 18725503.
38. Aellen J, Dabiri A, Heim A, Liaudet L, Burnier M et al. (2012) Preserved capillary density of dorsal finger skin in treated hypertensive patients with or without type 2 diabetes. Microcirculation 19: 554-562. doi: 10.1111/j.1549-8719.2012.00188.x. PubMed: 22578093.
39. Abel ED (2011) Obesity stresses cardiac mitochondria even when you are young. J Am Coll Cardiol 57: 586-589. doi:10.1016/S0735-1097(11)60586-X. PubMed: 21272750.
40. Peterson LR, Herrero P, Schechtman KB, Racette SB, Waggoner AD et al. (2004) Effect of obesity and insulin resistance on myocardial substrate metabolism and efficiency in young women. Circulation 109: 2191-2196. doi:10.1161/01.CIR.0000127959.28627.F8. PubMed: 15123530. (Pubitemid 38625396)
41. Ingelsson E, Sundström J, Arnlöv J, Zethelius B, Lind L (2005) Insulin resistance and risk of congestive heart failure. JAMA 294: 334-341. doi: 10.1001/jama.294.3.334. PubMed: 16030278. (Pubitemid 41043777)
42. Voulgari C, Tentolouris N, Dilaveris P, Tousoulis D, Katsilambros N et al. (2011) Increased heart failure risk in normal-weight people with metabolic syndrome compared with metabolically healthy obese individuals. J Am Coll Cardiol 58: 1343-1350. doi:10.1016/j.jacc.2011.04.047. PubMed: 21920263.
43. Ahmed Q, Chung-Park M, Tomashefski JF Jr. (1997) Cardiopulmonary pathology in patients with sleep apnea/obesity hypoventilation syndrome. Hum Pathol 28: 264-269. doi:10.1016/S0046-8177(97)90122-2. PubMed: 9042788. (Pubitemid 27106076)
44. Wong CY, O'Moore-Sullivan T, Leano R, Byrne N, Beller E et al. (2004) Alterations of left ventricular myocardial characteristics associated with obesity. Circulation 110: 3081-3087. doi:10.1161/01.CIR.0000147184.13872.0F. PubMed: 15520317. (Pubitemid 39492002)
45. Kosmala W, Jedrzejuk D, Derzhko R, Przewlocka-Kosmala M, Mysiak A et al. (2012) Left ventricular function impairment in patients with normal-weight obesity: contribution of abdominal fat deposition, profibrotic state, reduced insulin sensitivity, and proinflammatory activation. Circ Cardiovasc Imaging 5: 349-356. doi:10.1161/CIRCIMAGING.111.969956. PubMed: 22407472.
46. Rentrop KP, Cohen M, Blanke H, Phillips RA (1985) Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol 5: 587-592. doi:10.1016/S0735-1097(85)80380-6. PubMed: 3156171. (Pubitemid 15141963)