Filaggrin loss-of-function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: Part II of a prospective cohort study

Contact Dermatitis

Volumn 70, Issue 3, 2014, Pages 139-150

  Visser, Maaike J ^a   Verberk, Maarten M ^a   Campbell, Linda E ^b   McLean, W H Irwin ^b   Calkoen, Florentine ^a   Bakker, Jan G ^a   Van Dijk, Frank J H ^a   Bos, Jan D ^a   Kezic, Sanja ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

atopic dermatitis; filaggrin; hand eczema; nurses; occupational diseases; susceptibility

Indexed keywords

FILAGGRIN;

ADULT; ARTICLE; ATOPIC DERMATITIS; COHORT ANALYSIS; GENOTYPE; HAND ECZEMA; HAND WASHING; HUMAN; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MEDICAL HISTORY; NURSING STUDENT; OCCUPATIONAL EXPOSURE; PROSPECTIVE STUDY; RISK FACTOR; YOUNG ADULT;

ATOPIC DERMATITIS; FILAGGRIN; HAND ECZEMA; NURSES; OCCUPATIONAL DISEASES; SUSCEPTIBILITY;

DERMATITIS, ATOPIC; DERMATITIS, IRRITANT; DERMATITIS, OCCUPATIONAL; GENETIC PREDISPOSITION TO DISEASE; HAND DERMATOSES; HAND DISINFECTION; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MUTATION; NURSES; PERMEABILITY; PROSPECTIVE STUDIES; RISK FACTORS; SKIN; SKIN CREAM;

EID: 84896715427     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/cod.12139     Document Type: Article

References (58)

1. Nicholson P J, Llewellyn D, English J S,. Evidence-based guidelines for the prevention, identification and management of occupational contact dermatitis and urticaria. Contact Dermatitis 2010: 63: 177-186.
2. van der Meer E W, Boot C R, Jungbauer F H, van der Klink J J, Rustemeyer T, Coenraads P J, van der Gulden J W, Anema J R,. Hands4U: a multifaceted strategy to implement guideline-based recommendations to prevent hand eczema in health care workers: design of a randomised controlled trial and (cost) effectiveness evaluation. BMC Public Health 2011: 11: 669.
3. Berndt U, Hinnen U, Iliev D, Elsner P,. Role of the atopy score and of single atopic features as risk factors for the development of hand eczema in trainee metal workers. Br J Dermatol 1999: 140: 922-924.
4. Flyvholm M A, Bach B, Rose M, Jepsen K F,. Self-reported hand eczema in a hospital population. Contact Dermatitis 2007: 57: 110-115.
5. John S M, Uter W, Schwanitz H J,. Relevance of multiparametric skin bioengineering in a prospectively-followed cohort of junior hairdressers. Contact Dermatitis 2000: 43: 161-168.
6. Schmid K, Broding H C, Uter W, Drexler H,. Transepidermal water loss and incidence of hand dermatitis in a prospectively followed cohort of apprentice nurses. Contact Dermatitis 2005: 52: 247-253.
7. Uter W, Pfahlberg A, Gefeller O, Schwanitz H J,. Hand dermatitis in a prospectively-followed cohort of hairdressing apprentices: final results of the POSH study. Prevention of occupational skin disease in hairdressers. Contact Dermatitis 1999: 41: 280-286.
8. Meding B, Swanbeck G,. Predictive factors for hand eczema. Contact Dermatitis 1990: 23: 154-161.
9. Nilsson E, Mikaelsson B, Andersson S,. Atopy, occupation and domestic work as risk factors for hand eczema in hospital workers. Contact Dermatitis 1985: 13: 216-223.
10. Rystedt I,. Factors influencing the occurrence of hand eczema in adults with a history of atopic dermatitis in childhood. Contact Dermatitis 1985: 12: 185-191.
11. Roberts H, Frowen K, Sim M, Nixon R,. Prevalence of atopy in a population of hairdressing students and practising hairdressers in Melbourne, Australia. Australas J Dermatol 2006: 47: 172-177.
12. Thyssen J P, Linneberg A, Menné T, Nielsen N H, Johansen J D,. The effect of tobacco smoking and alcohol consumption on the prevalence of self-reported hand eczema: a cross-sectional population-based study. Br J Dermatol 2010: 162: 619-626.
13. Yngveson M, Svensson A, Johannisson A, Isacsson A,. Hand dermatosis in upper secondary school pupils: 2-year comparison and follow-up. Br J Dermatol 2000: 142: 485-489.
14. Angelova-Fischer I, Mannheimer A C, Hinder A, Ruether A, Franke A, Neubert R H, Fischer T W, Zillikens D,. Distinct barrier integrity phenotypes in filaggrin-related atopic eczema following sequential tape stripping and lipid profiling. Exp Dermatol 2011: 20: 351-356.
15. Jakasa I, de Jongh C M, Verberk M M, Bos J D, Kezic S,. Percutaneous penetration of sodium lauryl sulphate is increased in uninvolved skin of patients with atopic dermatitis compared with control subjects. Br J Dermatol 2006: 155: 104-109.
16. Jakasa I, Koster E S, Calkoen F, McLean W H, Campbell L E, Bos J D, Verberk M M, Kezic S,. Skin barrier function in healthy subjects and patients with atopic dermatitis in relation to filaggrin loss-of-function mutations. J Invest Dermatol 2011: 131: 540-542.
17. Brown S J, McLean W H,. One remarkable molecule: filaggrin. J Invest Dermatol 2011: 132, Pt 2: 751-762.
18. Irvine A D, McLean W H, Leung D Y,. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med 2011: 365: 1315-1327.
19. O'Regan G M, Irvine A D,. The role of filaggrin in the atopic diathesis. Clin Exp Allergy 2010: 40: 965-972.
20. Greisenegger E, Novak N, Maintz L, et al. Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis. J Eur Acad Dermatol Venereol 2010: 24: 607-610.
21. Henderson J, Northstone K, Lee S P, et al. The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study. J Allergy Clin Immunol 2008: 121: 872-877.
22. Sandilands A, Terron-Kwiatkowski A, Hull P R, et al. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet 2007: 39: 650-654.
23. Schuttelaar M L, Kerkhof M, Jonkman M F, et al. Filaggrin mutations in the onset of eczema, sensitization, asthma, hay fever and the interaction with cat exposure. Allergy 2009: 64: 1758-1765.
24. Scharschmidt T C, Man M Q, Hatano Y, et al. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol 2009: 124: 496-506.
25. Gruber R, Elias P M, Crumrine D, et al. Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function. Am J Pathol 2011: 178: 2252-2263.
26. Flohr C, England K, Radulovic S, McLean W H, Campbel L E, Barker J, Perkin M, Lack G,. Filaggrin loss-of-function mutations are associated with early-onset eczema, eczema severity and transepidermal water loss at 3 months of age. Br J Dermatol 2010: 163: 1333-1336.
27. Barker J N, Palmer C N, Zhao Y, et al. Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood. J Invest Dermatol 2007: 127: 564-567.
28. Marenholz I, Nickel R, Ruschendorf F, et al. Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. J Allergy Clin Immunol 2006: 118: 866-871.
29. Stemmler S, Parwez Q, Petrasch-Parwez E, Epplen J T, Hoffjan S,. Two common loss-of-function mutations within the filaggrin gene predispose for early onset of atopic dermatitis. J Invest Dermatol 2007: 127: 722-724.
30. Rodriguez E, Baurecht H, Herberich E, Wagenpfeil S, Brown S J, Cordell H J, Irvine A D, Weidinger S,. Meta-analysis of filaggrin polymorphisms in eczema and asthma: robust risk factors in atopic disease. J Allergy Clin Immunol 2009: 123: 1361-1370.
31. Carlsen B C, Thyssen J P, Menné T, et al. Association between filaggrin null mutations and concomitant atopic dermatitis and contact allergy. Clin Exp Dermatol 2011: 36: 467-472.
32. de Jongh C M, Khrenova L, Verberk M M, Calkoen F, van Dijk F J, Voss H, John S M, Kezic S,. Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: a case-control study. Br J Dermatol 2008: 159: 621-627.
33. Thyssen J P, Carlsen B C, Menné T, et al. Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study. Br J Dermatol 2010: 163: 115-120.
34. Visser M J, Landeck L, Campbell L E, McLean W H, Weidinger S, Calkoen F, John S M, Kezic S,. Impact of loss-of-function mutations in the filaggrin gene and atopic dermatitis on the development of occupational irritant contact dermatitis. Br J Dermatol 2013: 168: 326-332.
35. Bundesanstalt für Arbeitsschutz und Arbeitsmedizin. TRGS 401: Risks resulting from skin contact-determination, evaluation, measures. 2008. Available at: http://www.baua.de/cln-135/en/Topics-from-A-to-Z/Hazardous-Substances/TRGS/ TRGS.html
36. Jungbauer F H, Piebenga W P, ten Berge E E, et al. Guideline Contact Dermatitis-Prevention, Treatment and Counselling by the Occupational Physician NVAB Richtlijn Contacteczeem-Preventie, behandeling en begeleiding door de bedrijfsarts: Nederlandse Vereniging voor Arbeids- en Bedrijfsgeneeskunde (NVAB), April 6, 2006. Available at: http://nvab.artsennet.nl/Artikel-3/ Contacteczeem-1.htm. (last accessed 21 February 2013).
37. Kim B E, Leung D Y,. Epidermal barrier in atopic dermatitis. Allergy Asthma Immunol Res 2012: 4: 12-16.
38. Wolf R, Wolf D,. Abnormal epidermal barrier in the pathogenesis of atopic dermatitis. Clin Dermatol 2012: 30: 329-334.
39. Carlsen B C, Johansen J D, Menné T, Meldgaard M, Szecsi P B, Stender S, Thyssen J P,. Filaggrin null mutations and association with contact allergy and allergic contact dermatitis: results from a tertiary dermatology clinic. Contact Dermatitis 2010: 63: 89-95.
40. Molin S, Vollmer S, Weiss E H, Ruzicka T, Prinz J C,. Filaggrin mutations may confer susceptibility to chronic hand eczema characterized by combined allergic and irritant contact dermatitis. Br J Dermatol 2009: 161: 801-807.
41. Thyssen J P, Johansen J D, Linneberg A, et al. The association between null mutations in the filaggrin gene and contact sensitization to nickel and other chemicals in the general population. Br J Dermatol 2010: 162: 1278-1285.
42. Visser M J, Verberk M M, van Dijk F H J, Bakker J G, Bos J D, Kezic S,. Wet work and hand eczema in apprentice nurses; part I of a prospective cohort study. Contact Dermatitis, accepted.
43. Palmer C N, Irvine A D, Terron-Kwiatkowski A, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006: 38: 441-446.
44. Vermeulen R, Kromhout H, Bruynzeel D P, de Boer E M,. Ascertainment of hand dermatitis using a symptom-based questionnaire; applicability in an industrial population. Contact Dermatitis 2000: 42: 202-206.
45. Berndt U, Hinnen U, Iliev D, Elsner P,. Hand eczema in metalworker trainees-an analysis of risk factors. Contact Dermatitis 2000: 43: 327-332.
46. Coenraads P J, Diepgen T L,. Risk for hand eczema in employees with past or present atopic dermatitis. Int Arch Occup Environ Health 1998: 71: 7-13.
47. Dickel H, Bruckner T M, Schmidt A, Diepgen T L,. Impact of atopic skin diathesis on occupational skin disease incidence in a working population. J Invest Dermatol 2003: 121: 37-40.
48. Lan C C, Tu H P, Lee C H, et al. Hand dermatitis among university hospital nursing staff with or without atopic eczema: assessment of risk factors. Contact Dermatitis 2011: 64: 73-79.
49. Smit H A, van Rijssen A, Vandenbroucke J P, Coenraads P J,. Susceptibility to and incidence of hand dermatitis in a cohort of apprentice hairdressers and nurses. Scand J Work Environ Health 1994: 20: 113-121.
50. Jungersted J M, Scheer H, Mempel M, et al. Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema. Allergy 2010: 65: 911-918.
51. Janssens M, van Smeden J, Gooris G S, et al. Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients. J Lipid Res 2012: 53: 2755-2766.
52. Kezic S, Kemperman P M, Koster E S, et al. Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol 2008: 128: 2117-2119.
53. Kezic S, O'Regan G M, Yau N, et al. Levels of filaggrin degradation products are influenced by both filaggrin genotype and atopic dermatitis severity. Allergy 2011: 66: 934-940.
54. Gutowska-Owsiak D, Schaupp A L, Salimi M, Taylor S, Ogg G S,. Interleukin-22 downregulates filaggrin expression and affects expression of profilaggrin processing enzymes. Br J Dermatol 2011: 165: 492-498.
55. Howell M D, Kim B E, Gao P, et al. Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol 2007: 120: 150-155.
56. Hvid M, Vestergaard C, Kemp K, Christensen G B, Deleuran B, Deleuran M,. IL-25 in atopic dermatitis: a possible link between inflammation and skin barrier dysfunction? J Invest Dermatol 2011: 131: 150-157.
57. Brown S J, Kroboth K, Sandilands A, et al. Intragenic copy number variation within filaggrin contributes to the risk of atopic dermatitis with a dose-dependent effect. J Invest Dermatol 2012: 132: 98-104.
58. Landeck L, Visser M, Skudlik C, Brans R, Kezic S, John S M,. Clinical course of occupational irritant contact dermatitis of the hands in relation to filaggrin genotype status and atopy. Br J Dermatol 2012: 167: 1302-1309.