Loss-of-function polymorphisms in the filaggrin gene are associated with an increased susceptibility to chronic irritant contact dermatitis: A case-control study

British Journal of Dermatology

Volumn 159, Issue 3, 2008, Pages 621-627

  De Jongh, C M ^a,b   Khrenova, L ^c   Verberk, M M ^a   Calkoen, F ^a   Van Dijk, F J H ^a   Voss, H ^c   John, S M ^c   Kezic, S ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c UNIVERSITY OF OSNABRÜCK   (Germany)

Author keywords

Filaggrin; Genetic susceptibility; Irritant contact dermatitis; Occupational health; Polymorphism

Indexed keywords

FILAGGRIN;

ADULT; ALLELE; ARTICLE; ATOPIC DERMATITIS; CONTACT DERMATITIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL DISEASE; OCCUPATIONAL ECZEMA; PREVALENCE; PRIORITY JOURNAL; QUESTIONNAIRE; RISK FACTOR; SKIN DISEASE;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; DERMATITIS, IRRITANT; DERMATITIS, OCCUPATIONAL; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; INTERMEDIATE FILAMENT PROTEINS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 49749128448     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2008.08730.x     Document Type: Article

References (42)

1. English JS. Current concepts of irritant contact dermatitis. Occup Environ Med 2004 61 : 722 6.
2. Frosch PJ, John SM. Clinical aspects of irritant contact dermatitis. In : Contact Dermatitis (Frosch PJ, Menné T, Lepoittevin J-P, eds 4th edn. Heidelberg : Springer Berlin, 2006 255 94.
3. Cvetkovski RS, Zachariae R, Jensen H et al. Prognosis of occupational hand eczema: a follow-up study. Arch Dermatol 2006 142 : 305 11.
4. Cvetkovski RS, Zachariae R, Jensen H et al. Quality of life and depression in a population of occupational hand eczema patients. Contact Derm 2006 54 : 106 11.
5. Meding B, Wrangsjo K, Jarvholm B. Fifteen-year follow-up of hand eczema: persistence and consequences. Br J Dermatol 2005 152 : 975 80.
6. Agner T, Menné T. Individual predisposition to irritant and allergic contact dermatitis. In : Contact Dermatitis (Frosch PJ, Menné T, Lepoittevin J-P, eds 4th edn. Heidelberg : Springer Berlin, 2006 127 34.
7. Madison KC. Barrier function of the skin: 'la raison d'etre' of the epidermis. J Invest Dermatol 2003 121 : 231 41.
8. Proksch E, Folster-Holst R, Jensen JM. Skin barrier function, epidermal proliferation and differentiation in eczema. J Dermatol Sci 2006 43 : 159 69.
9. Candi E, Schmidt R, Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 2005 6 : 328 40.
10. Rawlings AV, Harding CR. Moisturization and skin barrier function. Dermatol Ther 2004 17 : S43 8.
11. Hoffjan S, Stemmler S. On the role of the epidermal differentiation complex in ichthyosis vulgaris, atopic dermatitis and psoriasis. Br J Dermatol 2007 157 : 441 9.
12. Smith FJ, Irvine AD, Terron-Kwiatkowski A et al. Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris. Nat Genet 2006 38 : 337 42.
13. Palmer CN, Irvine AD, Terron-Kwiatkowski A et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006 38 : 441 6.
14. Leung DY, Bieber T. Atopic dermatitis. Lancet 2003 361 : 151 60.
15. Baurecht H, Irvine AD, Novak N et al. Toward a major risk factor for atopic eczema: meta-analysis of filaggrin polymorphism data. J Allergy Clin Immunol 2007 120 : 1406 12.
16. Gruber R, Janecke AR, Fauth C et al. Filaggrin mutations p.R501X and c.2282del4 in ichthyosis vulgaris. Eur J Hum Genet 2007 15 : 179 84.
17. Howell MD, Kim BE, Gao P et al. Cytokine modulation of atopic dermatitis filaggrin skin expression. J Allergy Clin Immunol 2007 120 : 150 5.
18. Kezic S, Kemperman PM, Koster E et al. Loss-of-function mutations in the filaggrin gene lead to reduced level of natural moisturizing factor in the stratum corneum. J Invest Dermatol 2008 doi
19. Coenraads PJ, Diepgen TL. Risk for hand eczema in employees with past or present atopic dermatitis. Int Arch Occup Environ Health 1998 71 : 7 13.
20. Lerbaek A, Kyvik KO, Ravn H et al. Incidence of hand eczema in a population-based twin cohort: genetic and environmental risk factors. Br J Dermatol 2007 157 : 552 7.
21. Uter W. Epidemiologie und Prävention von Handekzemen in Feuchtberufen am Beispiel des Friseurhandwerks. In : Studien zur Prävention in Allerlogie, Berufs- und Umweltdermatologie (Schwanitz HJ, ed). Osnabrück : Universitätsverlag Rasch, 1999.
22. Skudlik C, Wulfhorst B, Gediga G et al. Tertiary individual prevention of occupational skin diseases: a decade's experience with recalcitrant occupational dermatitis. Int Arch Occup Environ Health 2008 doi
23. Diepgen TL. Die atopische Hautdiathese: Epidemiologie, Klinik und berufsdermatologische Bedeutung. Stuttgart : Gentner Verlag, 1991 1 128.
24. Hanifin JM, Rajka G. Diagnostic features of atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1980 92 : 44 7.
25. Williams HC, Burney PG, Pembroke AC et al. The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. III. Independent hospital validation. Br J Dermatol 1994 131 : 406 16.
26. Schwanitz HJ. Atopic Palmoplantar Eczema. Berlin : Springer Verlag, 1988.
27. Skudlik C, John SM. Irritativ-provoziertes atopisches Ekzem. In : Kontaktekzem (Fuchs S, Aberer W, eds 2nd edn. München-Deisenhofen : Dustri-Verlag, 2007 201 11.
28. de Jongh CM, John SM, Bruynzeel DP et al. Cytokine gene polymorphisms and susceptibility to chronic irritant contact dermatitis. Contact Derm 2008 58 : 269 77.
29. Irvine AD, McLean WH. Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis. J Invest Dermatol 2006 126 : 1200 2.
30. Lerbaek A, Bisgaard H, Agner T et al. Filaggrin null alleles are not associated with hand eczema or contact allergy. Br J Dermatol 2007 157 : 1199 204.
31. Novak N, Baurecht H, Schafer T et al. Loss-of-function mutations in the filaggrin gene and allergic contact sensitization to nickel. J Invest Dermatol 2008 128 : 1430 5.
32. Galassi C, De SM, Biggeri A et al. Changes in prevalence of asthma and allergies among children and adolescents in Italy: 1994-2002. Pediatrics 2006 117 : 34 42.
33. Grize L, Gassner M, Wuthrich B et al. Trends in prevalence of asthma, allergic rhinitis and atopic dermatitis in 5-7-year old Swiss children from 1992 to 2001. Allergy 2006 61 : 556 62.
34. Mohrenschlager M, Schafer T, Huss-Marp J et al. The course of eczema in children aged 5-7 years and its relation to atopy: differences between boys and girls. Br J Dermatol 2006 154 : 505 13.
35. Mortz CG, Lauritsen JM, Bindslev-Jensen C et al. Prevalence of atopic dermatitis, asthma, allergic rhinitis, and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis. Br J Dermatol 2001 144 : 523 32.
36. Olesen AB, Bang K, Juul S et al. Stable incidence of atopic dermatitis among children in Denmark during the 1990s. Acta Derm Venereol 2005 85 : 244 7.
37. Nyren M, Lindberg M, Stenberg B et al. Influence of childhood atopic dermatitis on future worklife. Scand J Work Environ Health 2005 31 : 474 8.
38. Lind ML, Albin M, Brisman J et al. Incidence of hand eczema in female Swedish hairdressers. Occup Environ Med 2007 64 : 191 5.
39. Lerbaek A, Kyvik KO, Mortensen J et al. Heritability of hand eczema is not explained by comorbidity with atopic dermatitis. J Invest Dermatol 2007 127 : 1632 40.
40. Sandilands A, O'Regan GM, Liao H et al. Prevalent and rare mutations in the gene encoding filaggrin cause ichthyosis vulgaris and predispose individuals to atopic dermatitis. J Invest Dermatol 2006 126 : 1770 5.
41. Sandilands A, Terron-Kwiatkowski A, Hull PR et al. Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema. Nat Genet 2007 39 : 650 4.
42. Wulfhorst B, Bock M, Skudlik C et al. Worker education and teaching programs: the German experience. In : Contact Dermatitis (Frosch PJ, Menné T, Lepoittevin J-P, eds 4th edn. Heidelberg : Springer Berlin, 2006 855 61.