Differential regulation of mitochondrial pyruvate carrier genes modulates respiratory capacity and stress tolerance in yeast

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Timoń Gómez, Alba ^a   Proft, Markus ^b   Pascual Ahuir, Amparo ^a  

^a UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

^b CSIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; MITOCHONDRIAL PYRUVATE CARRIER 2; MITOCHONDRIAL PYRUVATE CARRIER 3; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; AMINO ACID; AMINO ACID TRANSPORTER; ANION TRANSPORT PROTEIN; CRC1 PROTEIN, S CEREVISIAE; FMP43 PROTEIN, S CEREVISIAE; GPI13 PROTEIN, S CEREVISIAE; MEMBRANE PROTEIN; MESSENGER RNA; MITOCHONDRIAL PROTEIN; PHOSPHOTRANSFERASE; PYRUVATE TRANSPORT PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CONTROLLED STUDY; FERMENTATION; FUNGAL GENE; FUNGAL METABOLISM; GENE CONTROL; GENE EXPRESSION; MITOCHONDRIAL RESPIRATION; MPC GENE; MPC3 GENE; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; SALT TOLERANCE; YEAST; BIOSYNTHESIS; CELL RESPIRATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOCHONDRION; MULTIGENE FAMILY; PHYSIOLOGICAL STRESS;

AMINO ACID TRANSPORT SYSTEMS; AMINO ACIDS; ANION TRANSPORT PROTEINS; CELL RESPIRATION; GENE EXPRESSION REGULATION, FUNGAL; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MULTIGENE FAMILY; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRESS, PHYSIOLOGICAL;

EID: 84896711181     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079405     Document Type: Article

References (27)

1. Murphy MP (2009) How mitochondria produce reactive oxygen species. Biochem J 417: 1-13.
2. Pan Y (2011) Mitochondria, reactive oxygen species, and chronological aging: a message from yeast. Exp Gerontol 46: 847-852.
3. Perrone GG, Tan SX, Dawes IW (2008) Reactive oxygen species and yeast apoptosis. Biochim Biophys Acta 1783: 1354-1368.
4. Galdieri L, Mehrotra S, Yu S, Vancura A (2010) Transcriptional regulation in yeast during diauxic shift and stationary phase. OMICS 14: 629-638.
5. Broach JR (2012) Nutritional control of growth and development in yeast. Genetics 192: 73-105.
6. Hedbacker K, Carlson M (2008) SNF1/AMPK pathways in yeast. Front Biosci 13: 2408-2420. (Pubitemid 351599694)
7. Martinez-Pastor M, Proft M, Pascual-Ahuir A (2010) Adaptive changes of the yeast mitochondrial proteome in response to salt stress. OMICS 14: 541-552.
8. Pastor MM, Proft M, Pascual-Ahuir A (2009) Mitochondrial function is an inducible determinant of osmotic stress adaptation in yeast. J Biol Chem 284: 30307-30317.
9. Saito H, Posas F (2012) Response to hyperosmotic stress. Genetics 192: 289-318.
10. Ruiz-Roig C, Noriega N, Duch A, Posas F, de Nadal E (2012) The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms. Mol Biol Cell 23: 4286-4296.
11. Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, et al. (2012) A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 337: 96-100.
12. Herzig S, Raemy E, Montessuit S, Veuthey JL, Zamboni N, et al. (2012) Identification and functional expression of the mitochondrial pyruvate carrier. Science 337: 93-96.
13. Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, et al. (1999) Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285: 901-906. (Pubitemid 29381993)
14. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, et al. (2003) Global analysis of protein expression in yeast. Nature 425: 737-741. (Pubitemid 37314318)
15. Alberti S, Gitler AD, Lindquist S (2007) A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast 24: 913-919. (Pubitemid 47611130)
16. Westermann B, Neupert W (2000) Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae. Yeast 16: 1421-1427.
17. Hong HY, Yoo GS, Choi JK (2000) Direct Blue 71 staining of proteins bound to blotting membranes. Electrophoresis 21: 841-845.
18. Nakai T, Yasuhara T, Fujiki Y, Ohashi A (1995) Multiple genes, including a member of the AAA family, are essential for degradation of unassembled subunit 2 of cytochrome c oxidase in yeast mitochondria. Mol Cell Biol 15: 4441-4452.
19. Boubekeur S, Bunoust O, Camougrand N, Castroviejo M, Rigoulet M, et al. (1999) A mitochondrial pyruvate dehydrogenase bypass in the yeast Saccharomyces cerevisiae. J Biol Chem 274: 21044-21048.
20. Palmieri L, Lasorsa FM, Iacobazzi V, Runswick MJ, Palmieri F, et al. (1999) Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae. FEBS Lett 462: 472-476.
21. Martinez-Montanes F, Pascual-Ahuir A, Proft M (2010) Toward a genomic view of the gene expression program regulated by osmostress in yeast. OMICS 14: 619-627.
22. Proft M, Gibbons FD, Copeland M, Roth FP, Struhl K (2005) Genomewide identification of Sko1 target promoters reveals a regulatory network that operates in response to osmotic stress in Saccharomyces cerevisiae. Eukaryot Cell 4: 1343-1352. (Pubitemid 41176688)
23. Schuller HJ (2003) Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae. Curr Genet 43: 139-160.
24. Divakaruni AS, Murphy AN (2012) Cell biology. A mitochondrial mystery, solved. Science 337: 41-43.
25. Smith RA, Hartley RC, Cocheme HM, Murphy MP (2012) Mitochondrial pharmacology. Trends Pharmacol Sci 33: 341-352.
26. Poteet E, Choudhury GR, Winters A, Li W, Ryou MG, et al. (2013) Reversing the warburg effect as a treatment for glioblastoma. J Biol Chem 288: 9153-9164.
27. Soga T (2013) Cancer metabolism: key players in metabolic reprogramming. Cancer Sci 104: 275-281.