Interleukin 1β attenuates vascular α1 adrenergic receptors expression following lipopolysaccharide-induced endotoxemia in rabbits: Involvement of JAK2-STAT3 pathway

Journal of Trauma and Acute Care Surgery

Volumn 76, Issue 3, 2014, Pages 762-770

  Liang, Jia Lin ^a   Yang, Guang Ming ^a   Li, Tao ^a   Liu, Liang Ming ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

1 adrenergic receptors; Endotoxemia; Interleukin 1 ; JAK2 STAT3 pathway; Rabbits

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; BETA ACTIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; JANUS KINASE 2; LIPOPOLYSACCHARIDE; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHENYLEPHRINE; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; ENDOTOXEMIA; GENE EXPRESSION; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RABBIT; RECEPTOR DOWN REGULATION; SUPERIOR MESENTERIC ARTERY;

ADRENERGIC ALPHA-1 RECEPTOR AGONISTS; ANIMALS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENDOTOXEMIA; FEMALE; INTERLEUKIN-1BETA; JANUS KINASE 2; LIPOPOLYSACCHARIDES; MALE; MESENTERIC ARTERY, SUPERIOR; PHENYLEPHRINE; RABBITS; RECEPTORS, ADRENERGIC, ALPHA-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84896710870     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e3182ab0723     Document Type: Article

References (40)

1. Nduka OO, Parrillo JE. The pathophysiology of septic shock. Crit Care Nurs Clin North Am. 2011;23:41-66.
2. Christaki E, Opal SM. Is the mortality rate for septic shock really decreasing? Curr Opin Crit Care. 2008;14:580-586.
3. Russell JA. Management of sepsis. N Engl J Med. 2006;355:1699-1713.
4. Price SA, Spain DA,Wilson MA, Harris PD, Garrison RN. Subacute sepsis impairs vascular smooth muscle contractile machinery and alters vasoconstrictor and dilator mechanisms. J Surg Res. 1999;83:75-80.
5. Awe SO, Adeagbo AS. Vascular alpha1-adrenoceptors in isolated perfused rat kidney: influence of ageing. Auton Autacoid Pharmacol. 2007;27:19-26.
6. Aziz M, Jacob A, Yang WL, Matsuda A, Wang P. Current trends in inflammatory and immunomodulatory mediators in sepsis. J Leukoc Biol. 2013;93:329-342.
7. Okusawa S, Gelfand JA, Ikejima T, Connolly RJ, Dinarello CA. Interleukin 1 induces a shock-like state in rabbits synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition. J Clin Invest. 1988;81:1162-1172.
8. Birnbaum J, Lehmann Ch, Klotz E, Hein OV, Blume A, Jubin F, Polze N, Luther D, Spies CD. Effects of N-acetylcysteine and tirilazad mesylate on intestinal functional capillary density, leukocyte adherence, mesenteric plasma extravasation and cytokine levels in experimental endotoxemia in rats. Clin Hemorheol Microcirc. 2008;39:99-111.
9. Vila E, Salaices M. Cytokines and vascular reactivity in resistance arteries. Am J Physiol Heart Circ Physiol. 2005;288:1016-1021.
10. Takizawa S, Ozaki H, Karaki H. Interleukin-1betaYinduced, nitric oxideYdependent and Yindependent inhibition of vascular smooth muscle contraction. Eur J Pharmacol. 1997;330:143-150.
11. Takizawa S, Ozaki H, Karaki H. Possible involvement of K+ channel opening to the interleukin-1 betaYinduced inhibition of vascular smooth muscle contraction. J Vet Med Sci. 1999;61:357-360.
12. Gao Y, Yang Y, Guan Q, Pang X, Zhang H, Zeng D. IL-1beta modulate the Ca(2+)-activated big-conductance K channels (BK) via reactive oxygen species in cultured rat aorta smooth muscle cells. Mol Cell Biochem. 2010;338:59-68.
13. Pedoto A, Tassiopoulos AK, Oler A, McGraw DJ, Hoffmann SP, Camporesi EM, Hakim TS. Treatment of septic shock in rats with nitric oxide synthase inhibitors and inhaled nitric oxide. Crit Care Med. 1998; 26:2021-2028.
14. Scott JA, McCormack DG. Selective in vivo inhibition of inducible nitric oxide synthase in a rat model of sepsis. J Appl Physiol. 1999;86: 1739-1744.
15. Fox GA, Paterson NAM, McCormack DG. Effect of inhibition of NO synthase on vascular reactivity in a rat model of hyperdynamic sepsis. Am J Physiol. 1994;267:H1377YH1382.
16. Bucher M, Kees F, Taeger K, Kurtz A. Cytokines down-regulate alpha1-adrenergic receptor expression during endotoxemia. Crit Care Med. 2003; 31:566-571.
17. Schmidt C, Kurt B, Höcherl K, Bucher M. Inhibition of NF-kappaB activity prevents downregulation of alpha1-adrenergic receptors and circulatory failure during CLP-induced sepsis. Shock. 2009;32:239-246.
18. Ravichandran K, Tyagi A, Deep G, Agarwal C, Agarwal R. Interleukin-1beta-induced iNOS expression in human lung carcinoma A549 cells: involvement of STAT and MAPK pathways. Indian J Exp Biol. 2011;49: 840-847.
19. Farlik M, Reutterer B, Schindler C, Greten F, Vogl C, Müller M, Decker T. Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity. 2010;33:25-34.
20. Atkinson GP, Nozell SE, Benveniste ET. NF-kappaB and STAT3 signaling in glioma: targets for future therapies. Expert Rev Neurother. 2010;10: 575-586.
21. Ivanenkov YA, Balakin KV, Lavrovsky Y. Small molecule inhibitors of NF-kappaB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics. Mini Rev Med Chem. 2011;11:55-78.
22. Shankar E, Vykhovanets EV, Vykhovanets OV, Maclennan GT, Singh R, Bhaskaran N, Shukla S, Gupta S. High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-kappaB. Prostate. 2012;72:233-243.
23. Lv N, Kim EK, Song MY, Choi HN, Moon WS, Park SJ, Park JW, Kwon KB, Park BH. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Exp Cell Res. 2009;315:2064-2071.
24. Wu Z, Zhang X, Yang J, Zhang Y, YuanY, Jin C, Chang Z,Wang J, Yang X, He F. Nuclear protein IkappaB-zeta inhibits the activity of STAT3. Biochem Biophys Res Commun. 2009;387:348-352.
25. Liu Z, Hazan-Halevy I, Harris DM, Li P, Ferrajoli A, Faderl S, Keating MJ, Estrov Z. STAT-3 activates NF-kappaB in chronic lymphocytic leukemia cells. Mol Cancer Res. 2011;9:507-515.
26. Xiang B, Zhang Y, Li YM, Zhang K, Zhang YY, Wu LL, Yu GY. Effects of phenylephrine on transplanted submandibular gland. J Dent Res. 2006;85:1106-1111.
27. Nakamura S, Taniguchi T, Suzuki F, Akagi Y, Muramatsu I. Evaluation of alpha1-adrenoceptors in the rabbit iris: pharmacological characterization and expression of mRNA. Br J Pharmacol. 1999;127:1367-1374.
28. Mo JS, Matsukawa A, Ohkawara S, Yoshinaga M. Involvement of TNF alpha, IL-1 beta and IL-1 receptor antagonist in LPS-induced rabbit uveitis. Exp Eye Res. 1998;66:547-557.
29. Matsukawa A, Yoshimura T, Miyamoto K, Ohkawara S, Yoshinaga M. Analysis of the inflammatory cytokine network among TNF alpha, IL-1 beta, IL-1 receptor antagonist, and IL-8 in LPS-induced rabbit arthritis. Lab Invest. 1997;76:629-638.
30. Cao Q, Mak KM, Ren C, Lieber CS. Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: respective roles of the JAK/STAT and JAK-mediated H2O2-dependant MAPK pathways. J Biol Chem. 2004;279:4292-4304.
31. Rezende LF, Vieira AS, Negro A, Langone F, Boschero AC. Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis. Cytokine. 2009;46:65-71.
32. Huang C, Cao J, Huang KJ, Zhang F, Jiang T, Zhu L, Qiu ZJ. Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro. Cancer Sci. 2006;97:1417-1423.
33. Tanabe K, Matsushima-Nishiwaki R, Yamaguchi S, Iida H, Dohi S, Kozawa O.Mechanisms of tumor necrosis factor-alphaYinduced interleukin-6 synthesis in glioma cells. J Neuroinflammation. 2010;7:16.
34. Arend WP. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 2002;13:323-340.
35. de Jong HK, van der Poll T,Wiersinga WJ. The systemic pro-inflammatory response in sepsis. J Innate Immun. 2010;2:422-430.
36. Minghini A, Britt LD, Hill MA. Interleukin-1 and interleukin-6 mediated skeletal muscle arteriolar vasodilation: in vitro versus in vivo studies. Shock. 1998;9:210-215.
37. Dinarello CA. Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock. Chest. 1997;112:321S-329S.
38. Esmon CT. Why do animal models (sometimes) fail to mimic human sepsis? Crit Care Med. 2004;32:S219-S222.
39. Stahl O, Löffler B, Haier J, Mardin WA, Mees ST. Mimicry of human sepsis in a rat modelVprospects and limitations. J Surg Res. 2013; 179:e167-e175.
40. Liu LM, Ward JA, Dubick MA. Hemorrhagic shock induced vascular hyporeactivity to norepinephrine in select vasculatures of rats and the roles of nitric oxide and endothelin. Shock. 2003;19:208-214.