Synthesis, in vitro anticancer evaluation and in silico studies of novel imidazo[2,1-b]thiazole derivatives bearing pyrazole moieties

European Journal of Medicinal Chemistry

Volumn 75, Issue , 2014, Pages 492-500

  Ali, Ahmed R ^a   El Bendary, Eman R ^a   Ghaly, Mariam A ^a   Shehata, Ihsan A ^a  

^a Mansoura University 35516   (Egypt)

Author keywords

Aminothiazole; Anticancer evaluation; Imidazo 2,1 b thiazole; In silico studies; Pyrazole

Indexed keywords

1 (3 P TOLYLIMIDAZO[2,1 B]THIAZOL 6 YL)PYRAZOLIDINE 3,5 DIONE; 1 (3 PHENYLIMIDAZO[2,1 B]THIAZOL 6 YL)PYRAZOLIDINE 3,5 DIONE; 1 [3 (4 CHLOROPHENYL)IMIDAZO[2,1 B]THIAZOL 6 YL)PYRAZOLIDINE 3,5 DIONE; 1 [3 (4 CHLOROPHENYL)IMIDAZO[2,1 B]THIAZOL 6 YL] 3 METHYL 1H PYRAZOL 5(4H) ONE; 3 (4 CHLOROPHENYL) 6 (3,5 DIMETHYL 1H PYRAZOL 1 YL) IMIDAZO[2,1 B]THIAZOLE; 3 (4 CHLOROPHENYL) 6 HYDRAZINYLIMIDAZO[2,1 B]THIAZOLE; 3 (4 CHLOROPHENYL)IMIDAZO[2,1 B]THIAZOL 6(5H) ONE; 3 METHYL 1 (3 P TOLYLIMIDAZO[2,1 B]THIAZOL 6 YL) 1H PYRAZOL 5(4H) ONE; 3 METHYL 1 (3 PHENYLIMIDAZO[2,1 B]THIAZOL 6 YL) 1H PYRAZOL 5(4H) ONE; 3 P TOLYLIMIDAZO[2,1 B]THIAZOL 6(5H) ONE; 3 PHENYLIMIDAZO[2,1 B]THIAZOL 6(5H) ONE; 6 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 3 P TOLYLIMIDAZO[2,1 B]THIAZOLE; 6 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 3 PHENYLIMIDAZO[2,1 B]THIAZOLE; 6 HYDRAZINYL 3 P TOLYLIMIDAZO[2,1 B]THIAZOLE; 6 HYDRAZINYL 3 PHENYLIMIDAZO[2,1 B]THIAZOLE; ANTINEOPLASTIC AGENT; IMIDAZO[2,1 B]THIAZOLE DERIVATIVE; PYRAZOLE DERIVATIVE; RAPAMYCIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEATING; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CANCER; LEUKEMIA CELL; LUNG NON SMALL CELL CANCER; MOLECULAR DOCKING; MOLECULAR WEIGHT; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE;

AMINOTHIAZOLE; ANTICANCER EVALUATION; IMIDAZO[2,1-B]THIAZOLE; IN SILICO STUDIES; PYRAZOLE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; IMIDAZOLES; NEOPLASMS; PYRAZOLES; THIAZOLES;

EID: 84896708025     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.12.010     Document Type: Article

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