Synthesis, ultra-short acting hypnotic activity, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a] [1,3]diazepin-3-carboxylate (HIE-124)

Archiv der Pharmazie

Volumn 341, Issue 2, 2008, Pages 81-89

  Kadi, Adnan A ^a   El Kashef, Hassan A ^b   Abdel Aziz, Alaa A M ^a   Hassan, Ghada S ^b   Tettey, Justice ^c   Grant, Mary H ^c   Lehmann, Jochen ^d   El Subbagh, Hussein I ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b MANSOURA UNIVERSITY   (Egypt)

^c UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^d FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Metabolic profile; Synthesis; Thiazolo 3,2 a 1,3 diazepine; Ultra short acting hypnotic

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; ETHYL 8 OXO 5,6,7,8 TETRAHYDROTHIAZOLO[3,2 A][1,3]DIAZEPIN 3 CARBOXYLATE; HIE 124; HYPNOTIC AGENT; SHORT ACTING DRUG; THIOPENTAL; UNCLASSIFIED DRUG; 8 OXO 5,6,7,8 TETRAHYDRO THIAZOLO(3,2 A)(1,3)DIAZEPIN 3 CARBOXYLATE; 8-OXO-5,6,7,8-TETRAHYDRO-THIAZOLO(3,2-A)(1,3)DIAZEPIN-3-CARBOXYLATE; AZEPINE DERIVATIVE; CARBOXYLIC ACID; HYPNOTIC SEDATIVE AGENT; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATAXIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG METABOLISM; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERANCE; DYSPNEA; ELECTROSPRAY; ENZYME ACTIVITY; FEMALE; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SLEEP TIME; TACHYPNEA; URINE; ANIMAL; ELECTROSPRAY MASS SPECTROMETRY; METABOLISM; RAT; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; AZEPINES; CARBOXYLIC ACIDS; CHROMATOGRAPHY, LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEPATOCYTES; HYPNOTICS AND SEDATIVES; MALE; MICE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 43149083065     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200700132     Document Type: Article

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