Synthesis and anticancer activity of novel tetralin-6-ylpyridine and tetralin-6-ylpyrimidine derivatives

Acta Poloniae Pharmaceutica - Drug Research

Volumn 66, Issue 3, 2009, Pages 279-291

  Amin, Kamelia M ^a   El Zahar, Magdi I ^b   Anwar, Manal M ^b   Kamel, Mohsen M ^b   Mohamed, Maaly H ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

Anti cancer activity; Oxadiazole; Pyrazoline; Pyridine; Pyrimidine; Tetralin; Thiadiazole; Thiazolidinone; Triazole

Indexed keywords

1 (1,2,3,4 TETRAHYDRONAPHTHALEN 6 YL)ETHANONE; 3 CYANO 4 (4 FLUOROPHENYL) 6 (1,2,3,4 TETRAHYDRONAPHTHALEN 6 YL)PYRIDIN 2 YLOXYACETYL DITHIOCARBAZATE POTASSIUM SALT; 4 (4 FLUOROPHENYL) 2 [(2,3 DIHYDRO 2 THIOXO 1,3,4 OXADIAZOL 5 YL)METHOXY] 6 (1,2,3,4 TETRAHYDRONAPHTHALEN 6 YL)PYRIDINE 3 CARBONITRILE; 4 (4 FLUOROPHENYL) 2 [(2,3 DIHYDRO 3 METHYL 2 THIOXO 1,3,4 THIADIAZOL 5 YL)METHOXY] 6 (1,2,3,4 TETRAHYDRONAPHTHALEN 6 YL)PYRIDINE 3 CARBONITRILE; 4 (4 FLUOROPHENYL) 2 [(3 AMINOMETHYL 2,3 DIHYDRO 2 THIOXO 1,3,4 THIADIAZOL 5 YL)METHOXY] 6 (1,2,3,4 TETRAHYDRONAPHTHALEN 6 YL)PYRIDINE 3 CARBONITRILE; 4 (4 FLUOROPHENYL) 2 [(4 AMINO 4,5 DIHYDRO 5 THIOXO 1H 1,2,4 TRIAZOL 3 YL)METHOXY] 6 (1,2,3,4 TETRAHYDRONAPHTHALEN 6 YL)PYRIDINE 3 CARBONITRILE; 4 (4 FLUOROPHENYL) 2 [(5,6 DIHYDRO 6 OXOTHIAZOLO[3,2 B][1,2,4]TRIAZOL 2 YL)METHOXY] 6 (1,2,3,4 TETRAHYDRONAPHTHALEN 6 YL)PYRIDINE 3 CARBONITRILE; PYRIDINE DERIVATIVE; TETRALIN DERIVATIVE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PYRIMIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIVER CANCER; STRUCTURE ACTIVITY RELATION; BREAST TUMOR; COMPARATIVE STUDY; DRUG SCREENING; FEMALE; LIVER TUMOR; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; PYRIDINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES;

EID: 68949204204     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Ferrante A., Augliera J., Lewis K.: Proc. Natl. Acad. Sci. USA 92, 7617 (1995).
2. Hara H., Fujihashi T., Sakata T.: AIDS Res. Hum. Retroviruses 13, 695 (1997).
3. Stigliani J.L., Boustie J., Montanha J.: Pharm. Pharmacol. Commun. 4, 65 (1998).
4. Ebeid M.Y., El-Ansary A.K., Kamel M.M., Kassem E.M., Zaghary W.A.: Bull. Fac. Pharm. Cairo Univ. 30, 293 (1992).
5. El-Zahar M.I., Kamel M.M., Anwar M.M.: Pharmazie 49, 616 (1994).
6. Nabih I., Zayed A.A., Metri J., Kamel M.M., Motawie M.S.: Pharmazie 39, 862 (1984).
7. Kamel M.M., Kassem E.M., Fahmy H.H., Abdou W.A.: Egypt. J. Chem. 39, 271 (1996).
8. Nabih I., Zayed A.A., Metri J., Kamel M.M., Motawie M.S.: Egypt. J. Chem. 29, 101 (1986).
9. Kamel M.M., Fathalla O.A., Rizk M.Z., Kassem E.M., Abdou W.A.: Egypt. J. Pharm. Sci. 35, 355 (1994).
10. Ebeid M.Y., Fathalla O.A., El-Zahar M.I., Kamel M.M., Abdou W.A., Anwar M.M.: Bull. Fac. Pharm. Cairo Univ. 34, 125 (1996).
11. Murphy P.R., Hubbard R.E., Manallack A.T., Mantana J.G., Taylor J. K.: Tetrahedron Lett. 39, 3273 (1998).
12. Ebeid M.Y., Kamel M.M., Abdalla N.A., Kassem E.M., Abdou W.A.: Bull. Fac. Pharm. Cairo Univ. 29, 15 (1991).
13. Newman M.S., Zahm H. V.: J. Am. Chem. Soc. 65, 1097 (1943).
14. El-Zahar M.I.: Al-Azhar Bull. Sci. 3, 735 (1992).
15. Hamdy N.A.: Egypt. J. Chem. 48, 749 (2005).
16. Attia A., Kamel M.M.: Egypt. J. Chem. 28, 427 (1985).
17. Padhyay J.C., Basu S.K.: Ind. J. Chem. 29B, 98 (1990).
18. El-Zahar M.I., Kamel M.M., Mohei El-Deen E.M.: Egypt. J. Chem. 45, 323 (2002).
19. Mahomed E.A., El-Deen I.M., Ismail M.M., Mahomed S.M.: Ind. J. Chem. 32B, 933 (1993).
20. Bonte J.: Eur. J. Cancer 36 (S4), 114 (2000).
21. Lonning P.E.: Breast 5, 202 (1996).
22. Lonning P.E.: Breast 10, 198 (2001).
23. Fathalla O.A., Kamel M.M., El-Zahar M.I., Refai M., Mohei El-Deen E.M.: Egypt. J. Chem. 46, 135 (2003).
24. Haiba M.E.: Egypt. Pharm. J. NRC 4, 623 (2005).
25. El-Gazzar A.B.A., Abu-Zied Kh.M., Hassan N.A.: Egypt. J. Chem. 49, 185 (2006).
26. Burchhalter J.H., Wells J.N., Mayer W.J.: Tetrahedron Lett. 1353 (1964).
27. Kamel M.M., Nasr M.: Pharmazie 34, 441 (1979).
28. Ackland S.P., Clarke S.J., Beale P., Peters G.J.: Update Cancer Ther. 1, 403 (2006).
29. Sayed G.H., El-Kady M., El-Hashash M.A.: Rev. Roum. Chim. 25, 1375 (1980).
30. Ebeid M.Y., El-Zahar M.I., Kamel M.M., Omar M.T., Anwar M. M.: Egypt. Pharm. J. 3, 49 (2004).
31. Skehan P., Storeng R., Scudiero D., et al.: J. Natl. Cancer Inst. 82, 1107 (1990).