Complement mediates a primed inflammatory response after traumatic lung injury

Journal of Trauma and Acute Care Surgery

Volumn 76, Issue 3, 2014, Pages 601-609

  Hoth, J Jason ^a   Wells, Jonathan D ^a   Jones, Sarah E ^b   Yoza, Barbara K ^a   McCall, Charles E ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Complement C5a; Immune priming; Mice; Pulmonary contusion; Second hit

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; CXCL1 CHEMOKINE; HIRUDIN; INTERLEUKIN 10; INTERLEUKIN 6; THROMBIN; TOLL LIKE RECEPTOR 4;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; CORRELATION ANALYSIS; HISTOPATHOLOGY; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; LUNG CONTUSION; LUNG INFECTION; LUNG INJURY; LUNG LAVAGE; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROVOCATION TEST; SIGNAL TRANSDUCTION; THORAX BLUNT TRAUMA;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; COMPLEMENT ACTIVATION; COMPLEMENT C5A; CONTUSIONS; HIRUDINS; HUMANS; INFLAMMATION; LIPOPOLYSACCHARIDES; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; RECEPTOR, ANAPHYLATOXIN C5A; THROMBIN; WOUNDS, NONPENETRATING;

EID: 84896703860     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000129     Document Type: Article

References (38)

1. Lasanianos NG, Kanakaris NK, Giannoudis PV. Intramedullary nailing as a 'second hit' phenomenon in experimental research: lessons learned and future directions. Clin Orthop Relat Res. 2010;468:2514-2529.
2. Murphy TJ, Paterson HM, Kriynovich S, et al. Linking the "two-hit" response following injury to enhanced TLR4 reactivity. J Leukoc Biol. 2005;77:16-23.
3. Paterson HM, Murphy TJ, Purcell EJ, et al. Injury primes the innate immune system for enhanced Toll-like receptor reactivity. J Immunol. 2003;171:1473-1483.
4. Hoth JJ, Martin RS, Yoza BK, Wells JD, Meredith JW, McCall CE. Pulmonary contusion primes systemic innate immunity responses. J Trauma. 2009;67:14-21.
5. Sarma JV, Ward PA. The complement system. Cell Tissue Res. 2011;343: 227-235.
6. Guo RF,Ward PA. Mediators and regulation of neutrophil accumulation in inflammatory responses in lung: insights from the IgG immune complex model. Free Radic Biol Med. 2002;33:303-310.
7. Hecke F, Schmidt U, Kola A, Bautsch W, Klos A, Kohl J. Circulating complement proteins in multiple trauma patientsVcorrelation with injury severity, development of sepsis, and outcome. Crit Care Med. 1997;25: 2015-2024.
8. Burk AM, Martin M, Flierl MA, et al. Early complementopathy after multiple injuries in humans. Shock. 2012;37:348-354.
9. Fosse E, Pillgram-Larsen J, Svennevig JL, et al. Complement activation in injured patients occurs immediately and is dependent on the severity of the trauma. Injury. 1998;29:509-514.
10. Busche MN, Stahl GL. Role of the complement components C5 and C3a in a mouse model of myocardial ischemia and reperfusion injury. Ger Med Sci. 2010;8.
11. Cai C, Gill R, Eum HA, et al. Complement factor 3 deficiency attenuates hemorrhagic shock-related hepatic injury and systemic inflammatory response syndrome. Am J Physiol Regul Integr Comp Physiol. 2010;299: R1175YR1182.
12. Xu DZ, Zaets SB, Chen R, et al. Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs. Shock. 2009;31:493-499.
13. Flierl MA, Perl M, Rittirsch D, et al. The role of C5a in the innate immune response after experimental blunt chest trauma. Shock. 2008;29:25-31.
14. Shushakova N, Skokowa J, Schulman J, et al. C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complexinduced lung disease. J Clin Invest. 2002;110:1823-1830.
15. Hajishengallis G, Lambris JD. Crosstalk pathways between Toll-like receptors and the complement system. Trends Immunol. 2010;31:154-163.
16. Fang C, Zhang X, Miwa T, Song WC. Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and interleukin-6 production. Blood. 2009;114:1005-1015.
17. Riedemann NC, Guo RF, Neff TA, et al. Increased C5a receptor expression in sepsis. J Clin Invest. 2002;110:101-108.
18. Schaeffer V, Cuschieri J, Garcia I, et al. The priming effect of C5a on monocytes is predominantly mediated by the p38 MAPK pathway. Shock. 2007;27:623-630.
19. Wang L, Han G, Wang R, et al. Regulation of IL-8 production by complement-activated product, C5a, in vitro and in vivo during sepsis. Clin Immunol. 2010;137:157-165.
20. Zhang X, Lewkowich IP, Kohl G, Clark JR, Wills-Karp M, Kohl J. A protective role for C5a in the development of allergic asthma associated with altered levels of B7-H1 and B7-DC on plasmacytoid dendritic cells. J Immunol. 2009;182:5123-5130.
21. Becher RD, Colonna AL, Enniss TM, et al. An innovative approach to predict the development of adult respiratory distress syndrome in patients with blunt trauma. J Trauma Acute Care Surg. 2012;73:1229-1235.
22. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med. 1994;149:818-824.
23. Hoth JJ, Hudson WP, Brownlee NA, et al. Toll-like receptor 2 participates in the response to lung injury in a murine model of pulmonary contusion. Shock. 2007;28:447-452.
24. Hoth JJ, Wells JD, Brownlee NA, et al. Toll-like receptor 4 dependent responses to lung injury in a murine model of pulmonary contusion. Shock. 2008;31:376-381.
25. Hoth JJ, Wells JD, Yoza BK, McCall CE. Innate immune response to pulmonary contusion: identification of cell-type specific inflammatory responses. Shock. 2012;37:385-391.
26. Perl M, Gebhard F, Bruckner UB, et al. Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge. Crit Care Med. 2005;33:1351-1358.
27. Amara U, Flierl MA, Rittirsch D, et al. Molecular intercommunication between the complement and coagulation systems. J Immunol. 2010;185: 5628-5636.
28. Huber-Lang M, Sarma JV, Zetoune FS, et al. Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med. 2006;12: 682-687.
29. Fan J, Marshall JC, Jimenez M, Shek PN, Zagorski J, Rotstein OD. Hemorrhagic shock primes for increased expression of cytokine-induced neutrophil chemoattractant in the lung: role in pulmonary inflammation following lipopolysaccharide. J Immunol. 1998;161:440-447.
30. Zhang X, Kimura Y, Fang C, et al. Regulation of Toll-like receptormediated inflammatory response by complement in vivo. Blood. 2007; 110:228-236.
31. Wang M, Krauss JL, Domon H, et al. Microbial hijacking of complementtoll-like receptor crosstalk. Sci Signal. 2010;3:ra11.
32. Rittirsch D, Flierl MA, Nadeau BA, et al. Functional roles for C5a receptors in sepsis. Nat Med. 2008;14:551-557.
33. Gao H, Neff TA, Guo RF, et al. Evidence for a functional role of the second C5a receptor C5L2. FASEB J. 2005;19:1003-1005.
34. Scola AM, Johswich KO, Morgan BP, Klos A, Monk PN. The human complement fragment receptor, C5L2, is a recycling decoy receptor. Mol Immunol. 2009;46:1149-1162.
35. Raby AC, Holst B, Davies J, et al. TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2. Eur J Immunol. 2011;41:2741-2752.
36. Wrann CD, Tabriz NA, Barkhausen T, et al. The phosphatidylinositol 3-kinase signaling pathway exerts protective effects during sepsis by controlling C5a-mediated activation of innate immune functions. J Immunol. 2007;178:5940-5948.
37. Huber-Lang M, Younkin EM, Sarma JV, et al. Generation of C5a by phagocytic cells. Am J Pathol. 2002;161:1849-1859.
38. Huber-Lang M, Denk S, Fulda S, et al. Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro. Mol Immunol. 2012;50:60-65.