Effect of calstabin1 depletion on calcium transients and energy utilization in muscle fibers and treatment opportunities with RyR1 stabilizers

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Breckner, Anke ^a   Ganz, Magdalena ^b   Marcellin, David ^a   Richter, Jens ^a   Gerwin, Nicole ^a   Rausch, Martin ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 (4 BENZYL 1 PIPERIDINYL)PROPIONYL] 2,3,4,5 TETRAHYDRO 7 METHOXY 1,4 BENZOTHIAZEPINE; CALCIUM ION; CALSTABIN1; FK 506 BINDING PROTEIN; RYANODINE RECEPTOR 1; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TACROLIMUS; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DAMAGE; CELL PROTECTION; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; ENERGY METABOLISM; ENZYME ACTIVITY; MALE; METABOLIC STRESS; MOUSE; MUSCLE CELL; MUSCLE INJURY; MUSCLE TETANIC CONTRACTION; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN DEPLETION; SARCOPLASMIC RETICULUM;

ANIMALS; CALCIUM; CALCIUM SIGNALING; CYTOPLASM; ENERGY METABOLISM; MALE; MICE; MUSCLE, SKELETAL; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; TACROLIMUS; TACROLIMUS BINDING PROTEIN 1A; THIAZEPINES;

EID: 84896698939     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081277     Document Type: Article

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