Taurolidine lock solutions for the prevention of catheter-related bloodstream infections: A systematic review and meta-analysis of randomized controlled trials

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Liu, Yong ^a   Zhang, An Qiang ^b   Cao, Lin ^a   Xia, Hong Tao ^a   Ma, Jun Jie ^a  

^a SUINING CENTRAL HOSPITAL   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; TAUROLIDINE; TAUROLINE; TAURULTAM; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CATHETER INFECTION; CATHETER THROMBOSIS; DISEASE ASSOCIATION; DRUG EFFICACY; HUMAN; INCIDENCE; META ANALYSIS; NAUSEA; OUTCOME ASSESSMENT; QUALITY CONTROL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SAMPLE SIZE; SYSTEMATIC REVIEW; TASTE DISORDER; VOMITING;

ANTI-INFECTIVE AGENTS; CATHETER-RELATED INFECTIONS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TAURINE; THIADIAZINES;

EID: 84896695974     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079417     Document Type: Article

References (53)

1. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, et al. (2002) Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention. MMWR Recomm Rep 51: 1-29.
2. Tacconelli E, Smith G, Hieke K, Lafuma A, Bastide P (2009) Epidemiology, medical outcomes and costs of catheter-related bloodstream infections in intensive care units of four European countries: literature- and registry-based estimates. J Hosp Infect 72: 97-103.
3. Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, et al. (2009) Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 49: 1-45.
4. Yahav D, Rozen-Zvi B, Gafter-Gvili A, Leibovici L, Gafter U, et al. (2008) Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: systematic review and meta-analysis of randomized, controlled trials. Clin Infect Dis 47: 83-93. (Pubitemid 351920592)
5. O'Horo JC, Silva GL, Safdar N (2011) Anti-infective locks for treatment of central line-associated bloodstream infection: a systematic review and meta-analysis. Am J Nephrol 34: 415-422.
6. Novikov A, Lam MY, Mermel LA, Casey AL, Elliott TS, et al. (2012) Impact of catheter antimicrobial coating on species-specific risk of catheter colonization: a meta-analysis. Antimicrob Resist Infect Control 1: 40.
7. Oliveira C, Nasr A, Brindle M, Wales PW (2012) Ethanol locks to prevent catheter-related bloodstream infections in parenteral nutrition: a meta-analysis. Pediatrics 129: 318-329.
8. van de Wetering MD, van Woensel JB (2007) Prophylactic antibiotics for preventing early central venous catheter Gram positive infections in oncology patients. Cochrane Database Syst Rev: CD003295.
9. Bradshaw JH, Puntis JW (2008) Taurolidine and catheter-related bloodstream infection: a systematic review of the literature. J Pediatr Gastroenterol Nutr 47: 179-186.
10. Labriola L, Crott R, Jadoul M (2008) Preventing haemodialysis catheter-related bacteraemia with an antimicrobial lock solution: A meta-analysis of prospective randomized trials. Nephrology Dialysis Transplantation 23: 1666-1672. (Pubitemid 351767750)
11. Yahav D, Rozen-Zvi B, Gafter-Gvili A, Leibovici L, Gafter U, et al. (2008) Antimicrobial lock solutions for the prevention of infections associated with intravascular catheters in patients undergoing hemodialysis: Systematic review and meta-analysis of randomized, controlled trials. Clinical Infectious Diseases 47: 83-93. (Pubitemid 351920592)
12. Schiffer CA, Mangu PB, Wade JC, Camp-Sorrell D, Cope DG, et al. (2013) Central Venous Catheter Care for the Patient With Cancer: American Society of Clinical Oncology Clinical Practice Guideline. J Clin Oncol.
13. Torres-Viera C, Thauvin-Eliopoulos C, Souli M, DeGirolami P, Farris MG, et al. (2000) Activities of taurolidine in vitro and in experimental enterococcal endocarditis. Antimicrob Agents Chemother 44: 1720-1724. (Pubitemid 30340825)
14. Gorman SP, McCafferty DF, Woolfson AD, Jones DS (1987) Reduced adherence of micro-organisms to human mucosal epithelial cells following treatment with Taurolin, a novel antimicrobial agent. J Appl Bacteriol 62: 315-320.
15. Shah CB, Mittelman MW, Costerton JW, Parenteau S, Pelak M, et al. (2002) Antimicrobial activity of a novel catheter lock solution. Antimicrob Agents Chemother 46: 1674-1679. (Pubitemid 34535182)
16. Simon A, Ammann RA, Wiszniewsky G, Bode U, Fleischhack G, et al. (2008) Taurolidine-citrate lock solution (TauroLock) significantly reduces CVAD-associated grampositive infections in pediatric cancer patients. BMC Infect Dis 8: 102.
17. Taylor C, Cahill J, Gerrish M, Little J (2008) A new haemodialysis catheterlocking agent reduces infections in haemodialysis patients. J Ren Care 34: 116-120.
18. Bisseling TM, Willems MC, Versleijen MW, Hendriks JC, Vissers RK, et al. (2010) Taurolidine lock is highly effective in preventing catheter-related bloodstream infections in patients on home parenteral nutrition: a heparin-controlled prospective trial. Clin Nutr 29: 464-468.
19. Solomon LR, Cheesbrough JS, Ebah L, Al-Sayed T, Heap M, et al. (2010) A randomized double-blind controlled trial of taurolidine-citrate catheter locks for the prevention of bacteremia in patients treated with hemodialysis. Am J Kidney Dis 55: 1060-1068.
20. Filiopoulos V, Hadjiyannakos D, Koutis I, Trompouki S, Micha T, et al. (2011) Approaches to prolong the use of uncuffed hemodialysis catheters: results of a randomized trial. Am J Nephrol 33: 260-268.
21. Chu HP, Brind J, Tomar R, Hill S (2012) Significant reduction in central venous catheter-related bloodstream infections in children on HPN after starting treatment with taurolidine line lock. J Pediatr Gastroenterol Nutr 55: 403-407.
22. Dumichen MJ, Seeger K, Lode HN, Kuhl JS, Ebell W, et al. (2012) Randomized controlled trial of taurolidine citrate versus heparin as catheter lock solution in paediatric patients with haematological malignancies. J Hosp Infect 80: 304-309.
23. Solomon LR, Cheesbrough JS, Bhargava R, Mitsides N, Heap M, et al. (2012) Observational study of need for thrombolytic therapy and incidence of bacteremia using taurolidine-citrate-heparin, taurolidine-citrate and heparin catheter locks in patients treated with hemodialysis. Semin Dial 25: 233-238.
24. Toure A, Lauverjat M, Peraldi C, Boncompain-Gerard M, Gelas P, et al. (2012) Taurolidine lock solution in the secondary prevention of central venous catheter-associated bloodstream infection in home parenteral nutrition patients. Clin Nutr 31: 567-570.
25. Handrup MM, Moller JK, Schroder H (2013) Central venous catheters and catheter locks in children with cancer: A prospective randomized trial of taurolidine versus heparin. Pediatr Blood Cancer.
26. Zwiech R, Adelt M, Chrul S (2013) A Taurolidine-Citrate-Heparin Lock Solution Effectively Eradicates Pathogens From the Catheter Biofilm in Hemodialysis Patients. Am J Ther.
27. Moher D, Liberati A, Tetzlaff J, Altman DG (2010) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 8: 336-341.
28. Thompson SG, Higgins JP (2002) How should meta-regression analyses be undertaken and interpreted? Stat Med 21: 1559-1573. (Pubitemid 34746063)
29. Higgins JPT, Green S, Cochrane Collaboration. (2008) Cochrane handbook for systematic reviews of interventions. Chichester, England; Hoboken, NJ: Wiley-Blackwell. xxi, 649 p. p.
30. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327: 557-560. (Pubitemid 37088507)
31. Geron R, Tanchilevski O, Kristal B (2006) [Catheter lock solution-taurolock for prevention of catheter-related bacteremia in hemodialysis patients]. Harefuah 145: 881-884, 943.
32. Akyuz C, Kupeli S, Yagci-Kupeli B, Buyukpamukcu M (2010) Prophylactic taurolidine use in central venous catheters of pediatric cancer patients: A prospective randomized study from single center. Pediatric Blood and Cancer 55: 949.
33. Jonkers C, Looman KI, Tabbers MM, Tas TA, Serlie MJ (2012) Incidence of central venous catheter related bloodstream infections in adults and children on home parenteral nutrition: Heparin versus taurolidine catheter lock. Clinical Nutrition, Supplement 7: 203-204.
34. Olthof ED, Huisman-de Waal G, Vissers R, Wanten GJ (2012) A 55% reduction in hospital admission rate of patients on home parenteral nutrition after introduction of taurolidine catheter locking: A follow-up of nearly 200,000 days. Clinical Nutrition, Supplement 7: 149.
35. Hill SM, Chu HP, Koeglmeier J, Brind J, Turner S, et al. (2011) Significant reduction in catheter-related bloodstream infections with taurolidine lock in children treated with intravenous nutrition for 16,000 catheter days. Journal of Pediatric Gastroenterology and Nutrition 52: E64-E65.
36. Handrup MM, Fuursted K, Funch P, Moller JK, Schroder H (2012) Biofilm formation in long-term central venous catheters in children with cancer: a randomized controlled open-labelled trial of taurolidine versus heparin. APMIS 120: 794-801.
37. Rommes JH, Rios G, Zandstra DF (2001) Therapy of infection. Current Anaesthesia and Critical Care 12: 25-33. (Pubitemid 32520018)
38. Sweet S, Gobeille S, Landry D, Haessler S, Vaidya C, et al. (2009) Emergence of gentamicin-resistant bacteremia in hemodialysis patients receiving gentamicin lock catheter prophylaxis. American Journal of Kidney Diseases 53: A74.
39. Schiavone PA, Stoner NE, Compher CW, Kinosian BP, Boullata JI (2010) Management of catheter-related infection in patients receiving home parenteral nutrition. Practical Gastroenterology 34: 22-34.
40. Haag GM, Berger AK, Jager D (2011) Treatment of long-term catheter-related bloodstream infections with a taurolidine block: a single cancer center experience. J Vasc Access 12: 244-247.
41. Jurewitsch B, Lee T, Park J, Jeejeebhoy K (1998) Taurolidine 2% as an antimicrobial lock solution for prevention of recurrent catheter-related bloodstream infections. JPEN J Parenter Enteral Nutr 22: 242-244. (Pubitemid 28307589)
42. Braumann C, Stuhldreier B, Bobrich E, Menenakos C, Rogalla S, et al. (2005) High doses of taurolidine inhibit advanced intraperitoneal tumor growth in rats. Journal of Surgical Research 129: 129-135. (Pubitemid 41501865)
43. Branger B, Marion K, Bergeron E, Perret C, Zabadani B, et al. (2008) Using detachment-promoting agents for the prevention of chronic peritoneal dialysis-associated infections. Artif Organs 32: 918-924.
44. Weber M, Meyer F, Halloul Z (2009) Spectrum of Indications and perioperative management in i. v. Port-a-Cath Explantation alternative administration of Taurolin in Case of i.v. Port-a-Cath Infection. Zentralblatt fur Chirurgie - Zeitschrift fur Allgemeine, Viszeral- und Gefasschirurgie 134: 350-356.
45. Al-Amin A, Sarveswaran J, Wood J, Donnellan C, Burke D (2012) Efficacy of Taurolidine in prevention of catheter related bloodstream infections in patients on Home Parenteral Nutrition. British Journal of Surgery 99: 158-158.
46. Jurewitsch B, Jeejeebhoy KN (2005) Taurolidine lock: the key to prevention of recurrent catheter-related bloodstream infections. Clin Nutr 24: 462-465. (Pubitemid 40668434)
47. Allon M (2003) Prophylaxis against dialysis catheter-related bacteremia with a novel antimicrobial lock solution. Clin Infect Dis 36: 1539-1544.
48. Vernon MA, Goddard J (2006) The targeted use of Taurolock (R) in reduction of episodes of line sepsis in the haemodialysis population. Scottish Medical Journal 51: 54-54.
49. Rafferty GP, Nightingale J, Small M, Eastwood J, UgarteCano C, et al. (2010) The Targeted Use of Taurolock (R) to Reduce Central Venous Catheter Sepsis in a Home Parenteral Nutrition Cohort. Gut 59: A35-A35.
50. Betjes MG, van Agteren M (2004) Prevention of dialysis catheter-related sepsis with a citrate-taurolidine-containing lock solution. Nephrol Dial Transplant 19: 1546-1551. (Pubitemid 38786749)
51. O'Grady NP, Alexander M, Burns LA, Dellinger EP, Garland J, et al. (2011) Summary of recommendations: Guidelines for the Prevention of Intravascular Catheter-related Infections. Clin Infect Dis 52: 1087-1099.
52. Olthof ED, Rentenaar RJ, Rijs AJMM, Wanten GJA (2012) Absence of microbial adaptation to taurolidine in patients on home parenteral nutrition who develop catheter related bloodstream infections and use taurolidine locks. Clinical Nutrition.
53. Meyer B, Cookson B (2010) Does microbial resistance or adaptation to biocides create a hazard in infection prevention and control? J Hosp Infect 76: 200-205.